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Vulvar Large Cell Neuroendocrine Carcinoma

MedGen UID:
925538
•Concept ID:
C4288006
•
Neoplastic Process

Definition

A high grade neuroendocrine carcinoma that arises from the vulva. It is characterized by the presence of malignant large cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVulvar Large Cell Neuroendocrine Carcinoma

Recent clinical studies

Etiology

High-grade Neuroendocrine Carcinomas of the Vulva: A Clinicopathologic Study of 16 Cases.
Chen PP, Ramalingam P, Alvarado-Cabrero I, Euscher ED, Nagarajan P, Lawson BC, Malpica A
Am J Surg Pathol 2021 Mar 1;45(3):304-316. doi: 10.1097/PAS.0000000000001558. PMID: 32826525
Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group.
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
Small cell cancers of the female genital tract: Molecular and clinical aspects.
Patibandla JR, Fehniger JE, Levine DA, Jelinic P
Gynecol Oncol 2018 May;149(2):420-427. Epub 2018 Feb 17 doi: 10.1016/j.ygyno.2018.02.004. PMID: 29458976

Diagnosis

Emerging Therapeutic Concepts and Latest Diagnostic Advancements Regarding Neuroendocrine Tumors of the Gynecologic Tract.
Georgescu TA, Bohiltea RE, Munteanu O, Furtunescu F, Lisievici AC, Grigoriu C, Gherghiceanu F, Vlădăreanu EM, Berceanu C, Ducu I, Iordache AM
Medicina (Kaunas) 2021 Dec 7;57(12) doi: 10.3390/medicina57121338. PMID: 34946283Free PMC Article
High-grade Neuroendocrine Carcinomas of the Vulva: A Clinicopathologic Study of 16 Cases.
Chen PP, Ramalingam P, Alvarado-Cabrero I, Euscher ED, Nagarajan P, Lawson BC, Malpica A
Am J Surg Pathol 2021 Mar 1;45(3):304-316. doi: 10.1097/PAS.0000000000001558. PMID: 32826525
Small cell cancers of the female genital tract: Molecular and clinical aspects.
Patibandla JR, Fehniger JE, Levine DA, Jelinic P
Gynecol Oncol 2018 May;149(2):420-427. Epub 2018 Feb 17 doi: 10.1016/j.ygyno.2018.02.004. PMID: 29458976
Neuroendocrine tumors of the gynecologic tract: select topics.
Rouzbahman M, Clarke B
Semin Diagn Pathol 2013 Aug;30(3):224-33. doi: 10.1053/j.semdp.2013.06.007. PMID: 24144291

Therapy

Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group.
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
Targeted therapies for rare gynaecological cancers.
Manchana T, Ittiwut C, Mutirangura A, Kavanagh JJ
Lancet Oncol 2010 Jul;11(7):685-93. Epub 2010 Mar 31 doi: 10.1016/S1470-2045(09)70368-7. PMID: 20362508

Prognosis

Emerging Therapeutic Concepts and Latest Diagnostic Advancements Regarding Neuroendocrine Tumors of the Gynecologic Tract.
Georgescu TA, Bohiltea RE, Munteanu O, Furtunescu F, Lisievici AC, Grigoriu C, Gherghiceanu F, Vlădăreanu EM, Berceanu C, Ducu I, Iordache AM
Medicina (Kaunas) 2021 Dec 7;57(12) doi: 10.3390/medicina57121338. PMID: 34946283Free PMC Article
High-grade Neuroendocrine Carcinomas of the Vulva: A Clinicopathologic Study of 16 Cases.
Chen PP, Ramalingam P, Alvarado-Cabrero I, Euscher ED, Nagarajan P, Lawson BC, Malpica A
Am J Surg Pathol 2021 Mar 1;45(3):304-316. doi: 10.1097/PAS.0000000000001558. PMID: 32826525
Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group.
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681
Small cell cancers of the female genital tract: Molecular and clinical aspects.
Patibandla JR, Fehniger JE, Levine DA, Jelinic P
Gynecol Oncol 2018 May;149(2):420-427. Epub 2018 Feb 17 doi: 10.1016/j.ygyno.2018.02.004. PMID: 29458976
Neuroendocrine tumors of the genital tract.
Eichhorn JH, Young RH
Am J Clin Pathol 2001 Jun;115 Suppl:S94-112. doi: 10.1309/64CW-WKGK-49EF-BYD1. PMID: 11993694

Clinical prediction guides

High-grade Neuroendocrine Carcinomas of the Vulva: A Clinicopathologic Study of 16 Cases.
Chen PP, Ramalingam P, Alvarado-Cabrero I, Euscher ED, Nagarajan P, Lawson BC, Malpica A
Am J Surg Pathol 2021 Mar 1;45(3):304-316. doi: 10.1097/PAS.0000000000001558. PMID: 32826525
Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: a report from the ESMO Precision Medicine Working Group.
Mosele F, Remon J, Mateo J, Westphalen CB, Barlesi F, Lolkema MP, Normanno N, Scarpa A, Robson M, Meric-Bernstam F, Wagle N, Stenzinger A, Bonastre J, Bayle A, Michiels S, Bièche I, Rouleau E, Jezdic S, Douillard JY, Reis-Filho JS, Dienstmann R, André F
Ann Oncol 2020 Nov;31(11):1491-1505. Epub 2020 Aug 24 doi: 10.1016/j.annonc.2020.07.014. PMID: 32853681

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