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Large cell neuroendocrine carcinoma

MedGen UID:
220402
•Concept ID:
C1265996
•
Neoplastic Process
Synonyms: Large Cell NEC; large cell NEC; Large Cell Neuroendocrine Carcinoma; large cell neuroendocrine carcinoma; Large-cell neuroendocrine carcinoma; large-cell neuroendocrine carcinoma; LCNEC
SNOMED CT: Large cell neuroendocrine carcinoma (128628002)
 
Monarch Initiative: MONDO:0005057

Definition

An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation. It is composed of malignant large cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLarge cell neuroendocrine carcinoma

Professional guidelines

PubMed

Multidisciplinary management of newly diagnosed pediatric large cell neuroendocrine carcinoma of the lung causing hemoptysis.
Marquez CP, Violari EG, Sodji Q, Jiang AL, Donaldson SS, Josephs S, Hiniker SM
Pediatr Blood Cancer 2021 Oct;68(10):e29182. Epub 2021 Jun 14 doi: 10.1002/pbc.29182. PMID: 34125484
Detection of pseudoprogression with [(18)F]-FDG-PET in a patient with pulmonary large cell neuroendocrine carcinoma who received anti-PD-1 treatment.
Yamaguchi O, Kaira K, Hashimoto K, Kagamu H
Eur J Nucl Med Mol Imaging 2021 Apr;48(4):1268-1270. Epub 2020 Oct 22 doi: 10.1007/s00259-020-05069-2. PMID: 33094431
Large cell neuroendocrine carcinoma of the lung: chemotherapy regimen depends on how "large" your diagnostic criteria are.
Rossi G, Longo L, Barbieri F, Bertolini F, Spagnolo P
Eur Respir J 2017 Oct;50(4) Epub 2017 Oct 26 doi: 10.1183/13993003.01292-2017. PMID: 29074547

Recent clinical studies

Etiology

Exploration of genetic characterization in hyperprogressive disease after immunotherapy retreatment in a patient with LCNEC: A case report.
Zhang Y, Yang J, Shao T, Chen J, Shu Q, Shou L
Hum Vaccin Immunother 2024 Dec 31;20(1):2313281. Epub 2024 Feb 13 doi: 10.1080/21645515.2024.2313281. PMID: 38348622Free PMC Article
Pulmonary Combined Large Cell Neuroendocrine Carcinoma.
Li M, Yang L, Lu H
Pathol Oncol Res 2022;28:1610747. Epub 2022 Nov 23 doi: 10.3389/pore.2022.1610747. PMID: 36507119Free PMC Article
Pulmonary Neuroendocrine Tumors.
Borczuk AC
Surg Pathol Clin 2020 Mar;13(1):35-55. Epub 2019 Nov 29 doi: 10.1016/j.path.2019.10.002. PMID: 32005434
Next-Generation Sequencing of Pulmonary Large Cell Neuroendocrine Carcinoma Reveals Small Cell Carcinoma-like and Non-Small Cell Carcinoma-like Subsets.
Rekhtman N, Pietanza MC, Hellmann MD, Naidoo J, Arora A, Won H, Halpenny DF, Wang H, Tian SK, Litvak AM, Paik PK, Drilon AE, Socci N, Poirier JT, Shen R, Berger MF, Moreira AL, Travis WD, Rudin CM, Ladanyi M
Clin Cancer Res 2016 Jul 15;22(14):3618-29. Epub 2016 Mar 9 doi: 10.1158/1078-0432.CCR-15-2946. PMID: 26960398Free PMC Article
Neuroendocrine carcinomas (carcinoid, atypical carcinoid, small cell carcinoma, and large cell neuroendocrine carcinoma): current concepts.
Moran CA, Suster S
Hematol Oncol Clin North Am 2007 Jun;21(3):395-407; vii. doi: 10.1016/j.hoc.2007.04.011. PMID: 17548031

Diagnosis

Pulmonary Large Cell Neuroendocrine Carcinoma.
Yang L, Fan Y, Lu H
Pathol Oncol Res 2022;28:1610730. Epub 2022 Oct 11 doi: 10.3389/pore.2022.1610730. PMID: 36304941Free PMC Article
Combined large-cell neuroendocrine carcinoma and atypical carcinoid of the thymus presenting as ectopic Cushing syndrome.
Maciejewski A, Gut P, Stajgis P, Woliński K, Komarnicki P, Ruchała M
Pol Arch Intern Med 2022 Nov 25;132(11) Epub 2022 Aug 4 doi: 10.20452/pamw.16312. PMID: 35930234
Lung neuroendocrine neoplasms: recent progress and persistent challenges.
Rekhtman N
Mod Pathol 2022 Jan;35(Suppl 1):36-50. Epub 2021 Oct 18 doi: 10.1038/s41379-021-00943-2. PMID: 34663914Free PMC Article
Lung Cancer Pathology: Current Concepts.
Travis WD
Clin Chest Med 2020 Mar;41(1):67-85. Epub 2020 Jan 2 doi: 10.1016/j.ccm.2019.11.001. PMID: 32008630
Pulmonary Neuroendocrine Tumors.
Borczuk AC
Surg Pathol Clin 2020 Mar;13(1):35-55. Epub 2019 Nov 29 doi: 10.1016/j.path.2019.10.002. PMID: 32005434

Therapy

Exploration of genetic characterization in hyperprogressive disease after immunotherapy retreatment in a patient with LCNEC: A case report.
Zhang Y, Yang J, Shao T, Chen J, Shu Q, Shou L
Hum Vaccin Immunother 2024 Dec 31;20(1):2313281. Epub 2024 Feb 13 doi: 10.1080/21645515.2024.2313281. PMID: 38348622Free PMC Article
Colorectal Large-Cell Neuroendocrine Carcinoma: Case Report and Literature Review for Potential Novel Therapeutic Options.
Chen X, Wang X, Abadi M, Kumar A
Clin Colorectal Cancer 2020 Mar;19(1):61-64. Epub 2019 Oct 31 doi: 10.1016/j.clcc.2019.10.005. PMID: 31761668
A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo.
Saunders LR, Bankovich AJ, Anderson WC, Aujay MA, Bheddah S, Black K, Desai R, Escarpe PA, Hampl J, Laysang A, Liu D, Lopez-Molina J, Milton M, Park A, Pysz MA, Shao H, Slingerland B, Torgov M, Williams SA, Foord O, Howard P, Jassem J, Badzio A, Czapiewski P, Harpole DH, Dowlati A, Massion PP, Travis WD, Pietanza MC, Poirier JT, Rudin CM, Stull RA, Dylla SJ
Sci Transl Med 2015 Aug 26;7(302):302ra136. doi: 10.1126/scitranslmed.aac9459. PMID: 26311731Free PMC Article
Neuroendocrine differentiation in prostate cancer: novel morphological insights and future therapeutic perspectives.
Santoni M, Conti A, Burattini L, Berardi R, Scarpelli M, Cheng L, Lopez-Beltran A, Cascinu S, Montironi R
Biochim Biophys Acta 2014 Dec;1846(2):630-7. Epub 2014 Nov 4 doi: 10.1016/j.bbcan.2014.10.008. PMID: 25450825
Large cell/neuroendocrine carcinoma.
Gollard R, Jhatakia S, Elliott M, Kosty M
Lung Cancer 2010 Jul;69(1):13-8. Epub 2010 Feb 4 doi: 10.1016/j.lungcan.2009.12.011. PMID: 20133008

Prognosis

PD-L1 predicts chemotherapy resistance in large-cell neuroendocrine carcinoma.
Che Y, Luo Z, Cao Y, Sun N, Xue Q, He J
Br J Surg 2023 Jun 12;110(7):749-752. doi: 10.1093/bjs/znac335. PMID: 36205121
Pulmonary Large Cell Neuroendocrine Carcinoma.
Yang L, Fan Y, Lu H
Pathol Oncol Res 2022;28:1610730. Epub 2022 Oct 11 doi: 10.3389/pore.2022.1610730. PMID: 36304941Free PMC Article
Lung neuroendocrine neoplasms: recent progress and persistent challenges.
Rekhtman N
Mod Pathol 2022 Jan;35(Suppl 1):36-50. Epub 2021 Oct 18 doi: 10.1038/s41379-021-00943-2. PMID: 34663914Free PMC Article
Classification and Pathology of Lung Cancer.
Zheng M
Surg Oncol Clin N Am 2016 Jul;25(3):447-68. doi: 10.1016/j.soc.2016.02.003. PMID: 27261908
Neuroendocrine neoplasms of the lung: Concepts and terminology.
Wick MR, Marchevsky AM
Semin Diagn Pathol 2015 Nov;32(6):445-55. Epub 2015 Sep 25 doi: 10.1053/j.semdp.2015.09.012. PMID: 26500079

Clinical prediction guides

Spread Through Air Spaces in Stage I Pulmonary Large Cell Neuroendocrine Carcinoma.
Wan S, Shen Z, Hu S, Zhang L, Yu H, Chen Y, Wang J, Wang D, Zhang J, Zhang P
Ann Thorac Surg 2024 Aug;118(2):385-393. Epub 2024 Jan 17 doi: 10.1016/j.athoracsur.2024.01.002. PMID: 38242341
PD-L1 predicts chemotherapy resistance in large-cell neuroendocrine carcinoma.
Che Y, Luo Z, Cao Y, Sun N, Xue Q, He J
Br J Surg 2023 Jun 12;110(7):749-752. doi: 10.1093/bjs/znac335. PMID: 36205121
Lung neuroendocrine neoplasms: recent progress and persistent challenges.
Rekhtman N
Mod Pathol 2022 Jan;35(Suppl 1):36-50. Epub 2021 Oct 18 doi: 10.1038/s41379-021-00943-2. PMID: 34663914Free PMC Article
Neuroendocrine neoplasms of the lung: Concepts and terminology.
Wick MR, Marchevsky AM
Semin Diagn Pathol 2015 Nov;32(6):445-55. Epub 2015 Sep 25 doi: 10.1053/j.semdp.2015.09.012. PMID: 26500079
A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo.
Saunders LR, Bankovich AJ, Anderson WC, Aujay MA, Bheddah S, Black K, Desai R, Escarpe PA, Hampl J, Laysang A, Liu D, Lopez-Molina J, Milton M, Park A, Pysz MA, Shao H, Slingerland B, Torgov M, Williams SA, Foord O, Howard P, Jassem J, Badzio A, Czapiewski P, Harpole DH, Dowlati A, Massion PP, Travis WD, Pietanza MC, Poirier JT, Rudin CM, Stull RA, Dylla SJ
Sci Transl Med 2015 Aug 26;7(302):302ra136. doi: 10.1126/scitranslmed.aac9459. PMID: 26311731Free PMC Article

Recent systematic reviews

Clinicopathological characteristics and survival outcomes of patients with large cell neuroendocrine carcinoma of the uterine cervix: A systematic review and meta-analysis.
Prodromidou A, Phelps DL, Pergialiotis V, Cunnea P, Thomakos N, Rodolakis A, Fotopoulou C, Haidopoulos D
Eur J Obstet Gynecol Reprod Biol 2022 Mar;270:212-220. Epub 2022 Jan 17 doi: 10.1016/j.ejogrb.2022.01.014. PMID: 35093830
Small cell and large cell neuroendocrine carcinoma of the larynx: A comparative analysis.
Strojan P, Hernandez-Prera JC, Beitler JJ, Eisbruch A, Saba NF, Mendenhall WM, Nieto CS, Smee R, Rinaldo A, Ferlito A
Cancer Treat Rev 2019 Aug;78:42-51. Epub 2019 Aug 8 doi: 10.1016/j.ctrv.2019.08.002. PMID: 31437725
Large Cell Neuroendocrine Carcinoma of the Prostate: A Systematic Review and Pooled Analysis.
Tu X, Chang T, Nie L, Qiu S, Xu H, Huang Y, Bao Y, Liu Z, Yang L, Wei Q
Urol Int 2019;103(4):383-390. Epub 2019 Apr 9 doi: 10.1159/000499883. PMID: 30965328
A systematic review and meta-analysis on the attribution of human papillomavirus (HPV) in neuroendocrine cancers of the cervix.
Castle PE, Pierz A, Stoler MH
Gynecol Oncol 2018 Feb;148(2):422-429. Epub 2017 Dec 14 doi: 10.1016/j.ygyno.2017.12.001. PMID: 29248196
Neuroendrocrine tumors of the uterine cervix: A therapeutic challenge for gynecologic oncologists.
Gadducci A, Carinelli S, Aletti G
Gynecol Oncol 2017 Mar;144(3):637-646. Epub 2017 Jan 3 doi: 10.1016/j.ygyno.2016.12.003. PMID: 28057354

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