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Germ cell tumor of the vulva

MedGen UID:
925540
•Concept ID:
C4288008
•
Neoplastic Process
Synonyms: germ cell tumor of the vulva; Vulvar Germ Cell Tumor
 
Monarch Initiative: MONDO:0020650

Definition

A rare germ cell tumor that arises from the vulva. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGerm cell tumor of the vulva

Professional guidelines

PubMed

Vulvar Melanoma: Molecular Characteristics, Diagnosis, Surgical Management, and Medical Treatment.
Wohlmuth C, Wohlmuth-Wieser I
Am J Clin Dermatol 2021 Sep;22(5):639-651. Epub 2021 Jun 14 doi: 10.1007/s40257-021-00614-7. PMID: 34125416Free PMC Article
Diagnosis and management of vulvar cancer: A review.
Tan A, Bieber AK, Stein JA, Pomeranz MK
J Am Acad Dermatol 2019 Dec;81(6):1387-1396. Epub 2019 Jul 23 doi: 10.1016/j.jaad.2019.07.055. PMID: 31349045
Organ sparing management for carcinoma of the vulva & vagina.
Look KY
Eur J Gynaecol Oncol 2000;21(5):439-46. PMID: 11198029

Recent clinical studies

Etiology

Clinicopathological demographics of malignant melanomas of the vulva and vagina in Japan.
Ogata D, Nishio S, Hatta N, Kaji T, Fujii K, Mikami M, Kiyohara Y, Enomoto T
Melanoma Res 2023 Aug 1;33(4):300-308. Epub 2023 May 26 doi: 10.1097/CMR.0000000000000894. PMID: 37162526Free PMC Article
Non-human-papillomavirus-related malignancies of the vulva: A clinicopathological study.
Furlan K, Rohra P, Mir F, Gattuso P
J Cutan Pathol 2020 Oct;47(10):917-922. Epub 2020 Jul 29 doi: 10.1111/cup.13768. PMID: 32511773
Germ Cell Tumors of the Female Genital Tract.
Euscher ED
Surg Pathol Clin 2019 Jun;12(2):621-649. doi: 10.1016/j.path.2019.01.005. PMID: 31097117
Melanomas of the vulva and vagina.
Skovsted S, Nielsen K, Blaakær J
Dan Med J 2017 Mar;64(3) PMID: 28260594
Melanoma of the vulva.
Yackel DB, Symmonds RE, Kempers RD
Obstet Gynecol 1970 Apr;35(4):625-31. PMID: 5438156

Diagnosis

Vulvar Melanoma: Molecular Characteristics, Diagnosis, Surgical Management, and Medical Treatment.
Wohlmuth C, Wohlmuth-Wieser I
Am J Clin Dermatol 2021 Sep;22(5):639-651. Epub 2021 Jun 14 doi: 10.1007/s40257-021-00614-7. PMID: 34125416Free PMC Article
Cancer of the Vulva: A Review.
Michalski BM, Pfeifer JD, Mutch D, Council ML
Dermatol Surg 2021 Feb 1;47(2):174-183. doi: 10.1097/DSS.0000000000002584. PMID: 32947298
Germ Cell Tumors of the Female Genital Tract.
Euscher ED
Surg Pathol Clin 2019 Jun;12(2):621-649. doi: 10.1016/j.path.2019.01.005. PMID: 31097117
Vulva choriocarcinoma.
Boufettal H
Pan Afr Med J 2016;24:328. Epub 2016 Aug 30 doi: 10.11604/pamj.2016.24.328.10482. PMID: 28154683Free PMC Article
Melanoma of the vulva.
Morrow CP, Rutledge FN
Obstet Gynecol 1972 May;39(5):745-52. PMID: 5023258

Therapy

Cancer of the Vulva: A Review.
Michalski BM, Pfeifer JD, Mutch D, Council ML
Dermatol Surg 2021 Feb 1;47(2):174-183. doi: 10.1097/DSS.0000000000002584. PMID: 32947298
Management of vulvar and vaginal melanomas: current and future strategies.
Leitao MM Jr
Am Soc Clin Oncol Educ Book 2014:e277-81. doi: 10.14694/EdBook_AM.2014.34.e277. PMID: 24857113
Primary malignant melanoma of the vagina and vulva.
Ragni MV, Tobon H
Obstet Gynecol 1974 May;43(5):658-64. PMID: 4822650
Melanomas of vulva and vagina.
Fenn ME, Abell MR
Obstet Gynecol 1973 Jun;41(6):902-11. PMID: 4708486
Treatment of cancer of the vulva with high energy electrons.
Frischbier HJ, Thomsen K
Am J Obstet Gynecol 1971 Oct 1;111(3):431-5. doi: 10.1016/0002-9378(71)90790-3. PMID: 4999391

Prognosis

Clinicopathological demographics of malignant melanomas of the vulva and vagina in Japan.
Ogata D, Nishio S, Hatta N, Kaji T, Fujii K, Mikami M, Kiyohara Y, Enomoto T
Melanoma Res 2023 Aug 1;33(4):300-308. Epub 2023 May 26 doi: 10.1097/CMR.0000000000000894. PMID: 37162526Free PMC Article
Vulvar Melanoma: Molecular Characteristics, Diagnosis, Surgical Management, and Medical Treatment.
Wohlmuth C, Wohlmuth-Wieser I
Am J Clin Dermatol 2021 Sep;22(5):639-651. Epub 2021 Jun 14 doi: 10.1007/s40257-021-00614-7. PMID: 34125416Free PMC Article
Vulvar melanoma.
Panizzon RG
Semin Dermatol 1996 Mar;15(1):67-70. doi: 10.1016/s1085-5629(96)80021-6. PMID: 8723827
Cancer of the vulva.
Cavanagh D, Praphat H, Ruffolo EH
Obstet Gynecol Annu 1982;11:303-39. PMID: 6287375
BASAL CELL CANCER OF THE VULVA.
SCHUELLER EF
Am J Obstet Gynecol 1965 Sep 15;93:199-208. doi: 10.1016/0002-9378(65)90659-9. PMID: 14336649

Clinical prediction guides

Clinicopathological demographics of malignant melanomas of the vulva and vagina in Japan.
Ogata D, Nishio S, Hatta N, Kaji T, Fujii K, Mikami M, Kiyohara Y, Enomoto T
Melanoma Res 2023 Aug 1;33(4):300-308. Epub 2023 May 26 doi: 10.1097/CMR.0000000000000894. PMID: 37162526Free PMC Article
TRPS1 expression is sensitive and specific for primary extramammary Paget disease.
Cook EE, Harrison BT, Hirsch MS
Histopathology 2023 Jul;83(1):104-108. Epub 2023 Mar 27 doi: 10.1111/his.14908. PMID: 36971374
High-grade Neuroendocrine Carcinomas of the Vulva: A Clinicopathologic Study of 16 Cases.
Chen PP, Ramalingam P, Alvarado-Cabrero I, Euscher ED, Nagarajan P, Lawson BC, Malpica A
Am J Surg Pathol 2021 Mar 1;45(3):304-316. doi: 10.1097/PAS.0000000000001558. PMID: 32826525
Malignant Melanoma of the Vulva and Vagina: A US Population-Based Study of 1863 Patients.
Wohlmuth C, Wohlmuth-Wieser I, May T, Vicus D, Gien LT, Laframboise S
Am J Clin Dermatol 2020 Apr;21(2):285-295. doi: 10.1007/s40257-019-00487-x. PMID: 31784896Free PMC Article
Radicality of initial surgery for primary malignant melanoma of the vagina.
Todo Y, Okamoto K, Suzuki Y, Minobe S, Kato H
Melanoma Res 2016 Apr;26(2):173-80. doi: 10.1097/CMR.0000000000000239. PMID: 26825038

Recent systematic reviews

Molecular Features of Preinvasive and Invasive Vulvar Neoplasms.
Deb PQ, Heller DS
J Low Genit Tract Dis 2023 Jan 1;27(1):40-46. Epub 2022 Sep 9 doi: 10.1097/LGT.0000000000000701. PMID: 36083687
Primary yolk sac tumor of the endometrium: a case report and review of the literatures.
Lu T, Qi L, Ma Y, Lu G, Zhang X, Liu P
Arch Gynecol Obstet 2019 Nov;300(5):1177-1187. Epub 2019 Sep 23 doi: 10.1007/s00404-019-05309-3. PMID: 31549219
Melanoma of the lower genital tract: Prognostic factors and treatment modalities.
Gadducci A, Carinelli S, Guerrieri ME, Aletti GD
Gynecol Oncol 2018 Jul;150(1):180-189. Epub 2018 May 1 doi: 10.1016/j.ygyno.2018.04.562. PMID: 29728261

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