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Epilepsy with generalized tonic-clonic seizures

MedGen UID:
4987
•Concept ID:
C0014549
•
Disease or Syndrome
Synonym: Tonic-clonic epilepsy
 
Monarch Initiative: MONDO:0005754

Definition

Epilepsy characterized by generalized tonic-clonic seizures. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Epilepsy with generalized tonic-clonic seizures

Professional guidelines

PubMed

ILAE definition of the Idiopathic Generalized Epilepsy Syndromes: Position statement by the ILAE Task Force on Nosology and Definitions.
Hirsch E, French J, Scheffer IE, Bogacz A, Alsaadi T, Sperling MR, Abdulla F, Zuberi SM, Trinka E, Specchio N, Somerville E, Samia P, Riney K, Nabbout R, Jain S, Wilmshurst JM, Auvin S, Wiebe S, Perucca E, Moshé SL, Tinuper P, Wirrell EC
Epilepsia 2022 Jun;63(6):1475-1499. Epub 2022 May 3 doi: 10.1111/epi.17236. PMID: 35503716
Evidence-based anti-seizure monotherapy in newly diagnosed epilepsy: A new approach.
Compagno Strandberg M, Söderberg-Löfdal K, Kimland E, Dahlin M, Källén K
Acta Neurol Scand 2020 Oct;142(4):323-332. Epub 2020 Jul 17 doi: 10.1111/ane.13312. PMID: 32627842
Multi-gene panel testing in Korean patients with common genetic generalized epilepsy syndromes.
Lee CG, Lee J, Lee M
PLoS One 2018;13(6):e0199321. Epub 2018 Jun 20 doi: 10.1371/journal.pone.0199321. PMID: 29924869Free PMC Article

Recent clinical studies

Etiology

Oligoepilepsy and lifelong seizure susceptibility in epilepsy with generalized tonic-clonic seizures alone: Experience at an adult tertiary center.
Peña-Ceballos J, Moloney PB, Kilbride RD, Naggar HE, Widdess-Walsh P, Delanty N
Epilepsy Res 2024 May;202:107362. Epub 2024 Apr 19 doi: 10.1016/j.eplepsyres.2024.107362. PMID: 38652996
How to diagnose and classify idiopathic (genetic) generalized epilepsies.
Elmali AD, Auvin S, Bast T, Rubboli G, Koutroumanidis M
Epileptic Disord 2020 Aug 1;22(4):399-420. doi: 10.1684/epd.2020.1192. PMID: 32782228
Peripapillary retinal nerve fibre layer thinning in genetic generalized epilepsy.
González de la Aleja J, Guerrero-Molina M, Saíz-Díaz RA, López-Muñoz F, Raga-Martínez I, Hernández-Gallego J, Navarrete-Chamorro P, Povedano-Montero FJ
Seizure 2019 Oct;71:201-206. Epub 2019 Aug 1 doi: 10.1016/j.seizure.2019.07.022. PMID: 31386963
Long-term outcome in adolescent-onset generalized genetic epilepsies.
Vorderwülbecke BJ, Kowski AB, Kirschbaum A, Merkle H, Senf P, Janz D, Holtkamp M
Epilepsia 2017 Jul;58(7):1244-1250. Epub 2017 May 2 doi: 10.1111/epi.13761. PMID: 28464258
Valproate in adolescents with photosensitive epilepsy with generalized tonic-clonic seizures only.
Verrotti A, Grosso S, D'Egidio C, Parisi P, Spalice A, Pavone P, Capovilla G, Agostinelli S
Eur J Paediatr Neurol 2014 Jan;18(1):13-8. Epub 2013 Jul 26 doi: 10.1016/j.ejpn.2013.06.006. PMID: 23891468

Diagnosis

Recurrence rates and risk factors for seizure recurrence following antiseizure medication withdrawal in adolescent patients with genetic generalized epilepsy.
Komatsubara T, Kobayashi Y, Hiraiwa A, Magara S, Hojo M, Ono T, Okazaki K, Fukuda M, Tohyama J
Epilepsia Open 2022 Jun;7(2):332-343. Epub 2022 Apr 28 doi: 10.1002/epi4.12603. PMID: 35445562Free PMC Article
How to diagnose and classify idiopathic (genetic) generalized epilepsies.
Elmali AD, Auvin S, Bast T, Rubboli G, Koutroumanidis M
Epileptic Disord 2020 Aug 1;22(4):399-420. doi: 10.1684/epd.2020.1192. PMID: 32782228
Long-term outcome in adolescent-onset generalized genetic epilepsies.
Vorderwülbecke BJ, Kowski AB, Kirschbaum A, Merkle H, Senf P, Janz D, Holtkamp M
Epilepsia 2017 Jul;58(7):1244-1250. Epub 2017 May 2 doi: 10.1111/epi.13761. PMID: 28464258
Valproate in adolescents with photosensitive epilepsy with generalized tonic-clonic seizures only.
Verrotti A, Grosso S, D'Egidio C, Parisi P, Spalice A, Pavone P, Capovilla G, Agostinelli S
Eur J Paediatr Neurol 2014 Jan;18(1):13-8. Epub 2013 Jul 26 doi: 10.1016/j.ejpn.2013.06.006. PMID: 23891468

Therapy

Oligoepilepsy and lifelong seizure susceptibility in epilepsy with generalized tonic-clonic seizures alone: Experience at an adult tertiary center.
Peña-Ceballos J, Moloney PB, Kilbride RD, Naggar HE, Widdess-Walsh P, Delanty N
Epilepsy Res 2024 May;202:107362. Epub 2024 Apr 19 doi: 10.1016/j.eplepsyres.2024.107362. PMID: 38652996
Recurrence rates and risk factors for seizure recurrence following antiseizure medication withdrawal in adolescent patients with genetic generalized epilepsy.
Komatsubara T, Kobayashi Y, Hiraiwa A, Magara S, Hojo M, Ono T, Okazaki K, Fukuda M, Tohyama J
Epilepsia Open 2022 Jun;7(2):332-343. Epub 2022 Apr 28 doi: 10.1002/epi4.12603. PMID: 35445562Free PMC Article
Long-term outcome in adolescent-onset generalized genetic epilepsies.
Vorderwülbecke BJ, Kowski AB, Kirschbaum A, Merkle H, Senf P, Janz D, Holtkamp M
Epilepsia 2017 Jul;58(7):1244-1250. Epub 2017 May 2 doi: 10.1111/epi.13761. PMID: 28464258

Prognosis

Oligoepilepsy and lifelong seizure susceptibility in epilepsy with generalized tonic-clonic seizures alone: Experience at an adult tertiary center.
Peña-Ceballos J, Moloney PB, Kilbride RD, Naggar HE, Widdess-Walsh P, Delanty N
Epilepsy Res 2024 May;202:107362. Epub 2024 Apr 19 doi: 10.1016/j.eplepsyres.2024.107362. PMID: 38652996
Recurrence rates and risk factors for seizure recurrence following antiseizure medication withdrawal in adolescent patients with genetic generalized epilepsy.
Komatsubara T, Kobayashi Y, Hiraiwa A, Magara S, Hojo M, Ono T, Okazaki K, Fukuda M, Tohyama J
Epilepsia Open 2022 Jun;7(2):332-343. Epub 2022 Apr 28 doi: 10.1002/epi4.12603. PMID: 35445562Free PMC Article
Long-term outcome in adolescent-onset generalized genetic epilepsies.
Vorderwülbecke BJ, Kowski AB, Kirschbaum A, Merkle H, Senf P, Janz D, Holtkamp M
Epilepsia 2017 Jul;58(7):1244-1250. Epub 2017 May 2 doi: 10.1111/epi.13761. PMID: 28464258

Clinical prediction guides

Recurrence rates and risk factors for seizure recurrence following antiseizure medication withdrawal in adolescent patients with genetic generalized epilepsy.
Komatsubara T, Kobayashi Y, Hiraiwa A, Magara S, Hojo M, Ono T, Okazaki K, Fukuda M, Tohyama J
Epilepsia Open 2022 Jun;7(2):332-343. Epub 2022 Apr 28 doi: 10.1002/epi4.12603. PMID: 35445562Free PMC Article
Peripapillary retinal nerve fibre layer thinning in genetic generalized epilepsy.
González de la Aleja J, Guerrero-Molina M, Saíz-Díaz RA, López-Muñoz F, Raga-Martínez I, Hernández-Gallego J, Navarrete-Chamorro P, Povedano-Montero FJ
Seizure 2019 Oct;71:201-206. Epub 2019 Aug 1 doi: 10.1016/j.seizure.2019.07.022. PMID: 31386963

Supplemental Content

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