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Epilepsy

MedGen UID:
4506
Concept ID:
C0014544
Disease or Syndrome
Synonyms: Seizure disorder; Seizure Disorders
SNOMED CT: Epilepsy (84757009); Seizure disorder (128613002)
 
Monarch Initiative: MONDO:0005027

Definition

A disease of the brain characterized by an enduring predisposition to generate epileptic seizures. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEpilepsy

Professional guidelines

PubMed

Pressler RM, Abend NS, Auvin S, Boylan G, Brigo F, Cilio MR, De Vries LS, Elia M, Espeche A, Hahn CD, Inder T, Jette N, Kakooza-Mwesige A, Mader S, Mizrahi EM, Moshé SL, Nagarajan L, Noyman I, Nunes ML, Samia P, Shany E, Shellhaas RA, Subota A, Triki CC, Tsuchida T, Vinayan KP, Wilmshurst JM, Yozawitz EG, Hartmann H
Epilepsia 2023 Oct;64(10):2550-2570. Epub 2023 Sep 1 doi: 10.1111/epi.17745. PMID: 37655702
Zuberi SM, Wirrell E, Yozawitz E, Wilmshurst JM, Specchio N, Riney K, Pressler R, Auvin S, Samia P, Hirsch E, Galicchio S, Triki C, Snead OC, Wiebe S, Cross JH, Tinuper P, Scheffer IE, Perucca E, Moshé SL, Nabbout R
Epilepsia 2022 Jun;63(6):1349-1397. Epub 2022 May 3 doi: 10.1111/epi.17239. PMID: 35503712
Uy CE, Binks S, Irani SR
Pract Neurol 2021 Oct;21(5):412-423. Epub 2021 Jun 9 doi: 10.1136/practneurol-2020-002567. PMID: 34108243Free PMC Article

Curated

UK NICE Guideline NG217, Epilepsies in children, young people and adults, 2022

Recent clinical studies

Etiology

Perucca P, Bahlo M, Berkovic SF
Annu Rev Genomics Hum Genet 2020 Aug 31;21:205-230. Epub 2020 Apr 27 doi: 10.1146/annurev-genom-120219-074937. PMID: 32339036
Beghi E
Neuroepidemiology 2020;54(2):185-191. Epub 2019 Dec 18 doi: 10.1159/000503831. PMID: 31852003
Scheffer IE, Berkovic S, Capovilla G, Connolly MB, French J, Guilhoto L, Hirsch E, Jain S, Mathern GW, Moshé SL, Nordli DR, Perucca E, Tomson T, Wiebe S, Zhang YH, Zuberi SM
Epilepsia 2017 Apr;58(4):512-521. Epub 2017 Mar 8 doi: 10.1111/epi.13709. PMID: 28276062Free PMC Article
Beghi E, Giussani G, Sander JW
Epileptic Disord 2015 Sep;17(3):243-53. doi: 10.1684/epd.2015.0751. PMID: 26234761
Shorvon SD
Epilepsia 2011 Jun;52(6):1052-7. Epub 2011 Mar 30 doi: 10.1111/j.1528-1167.2011.03041.x. PMID: 21449936

Diagnosis

Katyayan A, Diaz-Medina G
Neurol Clin 2021 Aug;39(3):779-795. doi: 10.1016/j.ncl.2021.04.002. PMID: 34215386
Beghi E
Neuroepidemiology 2020;54(2):185-191. Epub 2019 Dec 18 doi: 10.1159/000503831. PMID: 31852003
Sharma P, Hussain A, Greenwood R
F1000Res 2019;8 Epub 2019 Feb 6 doi: 10.12688/f1000research.16494.1. PMID: 30800292Free PMC Article
Nat Rev Dis Primers 2018 May 3;4:18025. doi: 10.1038/nrdp.2018.25. PMID: 29722353
Baxendale S
Pract Neurol 2018 Feb;18(1):43-48. Epub 2018 Jan 11 doi: 10.1136/practneurol-2017-001827. PMID: 29326240

Therapy

Perucca E, White HS, Bialer M
CNS Drugs 2023 Sep;37(9):781-795. Epub 2023 Aug 21 doi: 10.1007/s40263-023-01025-4. PMID: 37603261Free PMC Article
Goldenholz DM, Goldenholz SR
Int Rev Neurobiol 2020;153:231-266. Epub 2020 Jun 9 doi: 10.1016/bs.irn.2020.03.033. PMID: 32563290
Billakota S, Devinsky O, Marsh E
Curr Opin Neurol 2019 Apr;32(2):220-226. doi: 10.1097/WCO.0000000000000660. PMID: 30676535
Gloss D, Vickrey B
Cochrane Database Syst Rev 2014 Mar 5;2014(3):CD009270. doi: 10.1002/14651858.CD009270.pub3. PMID: 24595491Free PMC Article
Engel J Jr, Pitkänen A, Loeb JA, Dudek FE, Bertram EH 3rd, Cole AJ, Moshé SL, Wiebe S, Jensen FE, Mody I, Nehlig A, Vezzani A
Epilepsia 2013 Aug;54 Suppl 4(0 4):61-9. doi: 10.1111/epi.12299. PMID: 23909854Free PMC Article

Prognosis

GBD 2016 Neurology Collaborators
Lancet Neurol 2019 May;18(5):459-480. Epub 2019 Mar 14 doi: 10.1016/S1474-4422(18)30499-X. PMID: 30879893Free PMC Article
Kalilani L, Sun X, Pelgrims B, Noack-Rink M, Villanueva V
Epilepsia 2018 Dec;59(12):2179-2193. Epub 2018 Nov 13 doi: 10.1111/epi.14596. PMID: 30426482
Narayan B, Nelson-Piercy C
Clin Med (Lond) 2017 Jun;17(3):251-257. doi: 10.7861/clinmedicine.17-3-251. PMID: 28572227Free PMC Article
Fiest KM, Sauro KM, Wiebe S, Patten SB, Kwon CS, Dykeman J, Pringsheim T, Lorenzetti DL, Jetté N
Neurology 2017 Jan 17;88(3):296-303. Epub 2016 Dec 16 doi: 10.1212/WNL.0000000000003509. PMID: 27986877Free PMC Article
Abramovici S, Bagić A
Handb Clin Neurol 2016;138:159-71. doi: 10.1016/B978-0-12-802973-2.00010-0. PMID: 27637958

Clinical prediction guides

Dhakar MB, Sheikh ZB, Desai M, Desai RA, Sternberg EJ, Popescu C, Baron-Lee J, Rampal N, Hirsch LJ, Gilmore EJ, Maciel CB
J Clin Neurophysiol 2023 Sep 1;40(6):553-561. Epub 2022 Feb 3 doi: 10.1097/WNP.0000000000000919. PMID: 35239553
Baud MO, Proix T, Rao VR, Schindler K
Curr Opin Neurol 2020 Apr;33(2):163-172. doi: 10.1097/WCO.0000000000000798. PMID: 32049738
Meisel C, Loddenkemper T
Neuropharmacology 2020 Aug 1;172:107898. Epub 2019 Dec 5 doi: 10.1016/j.neuropharm.2019.107898. PMID: 31839204
Iasemidis LD
Neurosurg Clin N Am 2011 Oct;22(4):489-506, vi. doi: 10.1016/j.nec.2011.07.004. PMID: 21939848Free PMC Article
Sierra M, Berrios GE
Psychiatry Res 2000 Mar 6;93(2):153-64. doi: 10.1016/s0165-1781(00)00100-1. PMID: 10725532

Recent systematic reviews

Zhang MW, Liang XY, Wang J, Gao LD, Liao HJ, He YH, Yi YH, He N, Liao WP; China Epilepsy Gene 1.0 Project
Seizure 2024 Mar;116:4-13. Epub 2023 Sep 23 doi: 10.1016/j.seizure.2023.09.021. PMID: 37777370
Haneef Z, Skrehot HC
Epilepsia 2023 Apr;64(4):811-820. Epub 2023 Feb 16 doi: 10.1111/epi.17524. PMID: 36727550
Lehner J, Frueh JS, Datta AN
Sleep Med Rev 2022 Oct;65:101689. Epub 2022 Aug 17 doi: 10.1016/j.smrv.2022.101689. PMID: 36037570
Jafarpour S, Hirsch LJ, Gaínza-Lein M, Kellinghaus C, Detyniecki K
Seizure 2019 May;68:9-15. Epub 2018 May 21 doi: 10.1016/j.seizure.2018.05.013. PMID: 29871784
Fiest KM, Sauro KM, Wiebe S, Patten SB, Kwon CS, Dykeman J, Pringsheim T, Lorenzetti DL, Jetté N
Neurology 2017 Jan 17;88(3):296-303. Epub 2016 Dec 16 doi: 10.1212/WNL.0000000000003509. PMID: 27986877Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2022
      UK NICE Guideline NG217, Epilepsies in children, young people and adults, 2022

    Consumer resources

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