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Dissociation

MedGen UID:
88527
Concept ID:
C0086168
Mental or Behavioral Dysfunction
Synonyms: Dissociation - mental defense mechanism; Dissociative reaction
SNOMED CT: Dissociation - mental defense mechanism (286669009)
 
HPO: HP:0032940

Definition

Disruption or detachment of certain aspects of one's normal psychological functioning typically involves a disconnection or separation from thoughts, feelings, sensations, memories, or one's sense of identity or reality. [from HPO]

Professional guidelines

PubMed

Burback L, Brémault-Phillips S, Nijdam MJ, McFarlane A, Vermetten E
Curr Neuropharmacol 2024;22(4):557-635. doi: 10.2174/1570159X21666230428091433. PMID: 37132142Free PMC Article
Nikayin S, Murphy E, Krystal JH, Wilkinson ST
Expert Opin Drug Saf 2022 Jun;21(6):777-787. Epub 2022 Apr 19 doi: 10.1080/14740338.2022.2066651. PMID: 35416105
Lipsky BA, Byren I, Hoey CT
Clin Infect Dis 2010 Jun 15;50(12):1641-52. doi: 10.1086/652861. PMID: 20459324

Recent clinical studies

Etiology

Krüger C
J Trauma Dissociation 2020 Jan-Feb;21(1):1-13. doi: 10.1080/15299732.2020.1675134. PMID: 31891334
Loewenstein RJ
Dialogues Clin Neurosci 2018 Sep;20(3):229-242. doi: 10.31887/DCNS.2018.20.3/rloewenstein. PMID: 30581293Free PMC Article
Choi KR, Seng JS, Briggs EC, Munro-Kramer ML, Graham-Bermann SA, Lee RC, Ford JD
J Am Acad Child Adolesc Psychiatry 2017 Dec;56(12):1062-1072. Epub 2017 Oct 4 doi: 10.1016/j.jaac.2017.09.425. PMID: 29173740Free PMC Article
Ford JD, Gómez JM
J Trauma Dissociation 2015;16(3):225-31. doi: 10.1080/15299732.2015.989648. PMID: 25760316
Spiegel D, Loewenstein RJ, Lewis-Fernández R, Sar V, Simeon D, Vermetten E, Cardeña E, Dell PF
Depress Anxiety 2011 Sep;28(9):824-52. doi: 10.1002/da.20874. PMID: 21910187

Diagnosis

Lynn SJ, Polizzi C, Merckelbach H, Chiu CD, Maxwell R, van Heugten D, Lilienfeld SO
Annu Rev Clin Psychol 2022 May 9;18:259-289. Epub 2022 Feb 28 doi: 10.1146/annurev-clinpsy-081219-102424. PMID: 35226824
van Minnen A, Tibben M
J Behav Ther Exp Psychiatry 2021 Sep;72:101655. Epub 2021 Apr 2 doi: 10.1016/j.jbtep.2021.101655. PMID: 33848810
Lyssenko L, Schmahl C, Bockhacker L, Vonderlin R, Bohus M, Kleindienst N
Am J Psychiatry 2018 Jan 1;175(1):37-46. Epub 2017 Sep 26 doi: 10.1176/appi.ajp.2017.17010025. PMID: 28946763
Choi KR, Seng JS, Briggs EC, Munro-Kramer ML, Graham-Bermann SA, Lee RC, Ford JD
J Am Acad Child Adolesc Psychiatry 2017 Dec;56(12):1062-1072. Epub 2017 Oct 4 doi: 10.1016/j.jaac.2017.09.425. PMID: 29173740Free PMC Article
Flanagin BA, Leslie MP
Orthop Clin North Am 2013 Jan;44(1):1-7. doi: 10.1016/j.ocl.2012.09.002. PMID: 23174321

Therapy

Anand A, Mathew SJ, Sanacora G, Murrough JW, Goes FS, Altinay M, Aloysi AS, Asghar-Ali AA, Barnett BS, Chang LC, Collins KA, Costi S, Iqbal S, Jha MK, Krishnan K, Malone DA, Nikayin S, Nissen SE, Ostroff RB, Reti IM, Wilkinson ST, Wolski K, Hu B
N Engl J Med 2023 Jun 22;388(25):2315-2325. Epub 2023 May 24 doi: 10.1056/NEJMoa2302399. PMID: 37224232
Lima TM, Visacri MB, Aguiar PM
Eur J Clin Pharmacol 2022 Mar;78(3):311-338. Epub 2021 Oct 27 doi: 10.1007/s00228-021-03216-8. PMID: 34705064
Mitchell JM, Bogenschutz M, Lilienstein A, Harrison C, Kleiman S, Parker-Guilbert K, Ot'alora G M, Garas W, Paleos C, Gorman I, Nicholas C, Mithoefer M, Carlin S, Poulter B, Mithoefer A, Quevedo S, Wells G, Klaire SS, van der Kolk B, Tzarfaty K, Amiaz R, Worthy R, Shannon S, Woolley JD, Marta C, Gelfand Y, Hapke E, Amar S, Wallach Y, Brown R, Hamilton S, Wang JB, Coker A, Matthews R, de Boer A, Yazar-Klosinski B, Emerson A, Doblin R
Nat Med 2021 Jun;27(6):1025-1033. Epub 2021 May 10 doi: 10.1038/s41591-021-01336-3. PMID: 33972795Free PMC Article
Daly EJ, Trivedi MH, Janik A, Li H, Zhang Y, Li X, Lane R, Lim P, Duca AR, Hough D, Thase ME, Zajecka J, Winokur A, Divacka I, Fagiolini A, Cubala WJ, Bitter I, Blier P, Shelton RC, Molero P, Manji H, Drevets WC, Singh JB
JAMA Psychiatry 2019 Sep 1;76(9):893-903. doi: 10.1001/jamapsychiatry.2019.1189. PMID: 31166571Free PMC Article
Popova V, Daly EJ, Trivedi M, Cooper K, Lane R, Lim P, Mazzucco C, Hough D, Thase ME, Shelton RC, Molero P, Vieta E, Bajbouj M, Manji H, Drevets WC, Singh JB
Am J Psychiatry 2019 Jun 1;176(6):428-438. Epub 2019 May 21 doi: 10.1176/appi.ajp.2019.19020172. PMID: 31109201

Prognosis

Payne J, Garlitski AC, Weinstock J, Homoud M, Madias C, Estes NAM
J Interv Card Electrophysiol 2018 Aug;52(3):323-334. Epub 2018 Aug 13 doi: 10.1007/s10840-018-0412-5. PMID: 30105429
Ye F, Hatahet M, Youniss MA, Toklu HZ, Mazza JJ, Yale S
WMJ 2018 Jun;117(2):73-78. PMID: 30048576
Zaman MJ, Philipson P, Chen R, Farag A, Shipley M, Marmot MG, Timmis AD, Hemingway H
Heart 2013 May;99(10):729-36. Epub 2013 Feb 13 doi: 10.1136/heartjnl-2012-302925. PMID: 23406688Free PMC Article
Brand BL
J Trauma Dissociation 2012;13(4):387-96. doi: 10.1080/15299732.2012.672550. PMID: 22651673
Rennie JM
Eur J Pediatr 1997 Feb;156(2):83-7. doi: 10.1007/s004310050559. PMID: 9039506

Clinical prediction guides

Chung BY, Hensel S, Schmidinger I, Bekrater-Bodmann R, Flor H
Eur J Pain 2020 Aug;24(7):1257-1268. Epub 2020 Apr 15 doi: 10.1002/ejp.1567. PMID: 32232961
Vonderlin R, Kleindienst N, Alpers GW, Bohus M, Lyssenko L, Schmahl C
Psychol Med 2018 Nov;48(15):2467-2476. Epub 2018 Apr 10 doi: 10.1017/S0033291718000740. PMID: 29631646
Lyssenko L, Schmahl C, Bockhacker L, Vonderlin R, Bohus M, Kleindienst N
Am J Psychiatry 2018 Jan 1;175(1):37-46. Epub 2017 Sep 26 doi: 10.1176/appi.ajp.2017.17010025. PMID: 28946763
Ozer EJ, Best SR, Lipsey TL, Weiss DS
Psychol Bull 2003 Jan;129(1):52-73. doi: 10.1037/0033-2909.129.1.52. PMID: 12555794
Sierra M, Berrios GE
Psychiatry Res 2000 Mar 6;93(2):153-64. doi: 10.1016/s0165-1781(00)00100-1. PMID: 10725532

Recent systematic reviews

Nelson Z, Aslan AT, Beahm NP, Blyth M, Cappiello M, Casaus D, Dominguez F, Egbert S, Hanretty A, Khadem T, Olney K, Abdul-Azim A, Aggrey G, Anderson DT, Barosa M, Bosco M, Chahine EB, Chowdhury S, Christensen A, de Lima Corvino D, Fitzpatrick M, Fleece M, Footer B, Fox E, Ghanem B, Hamilton F, Hayes J, Jegorovic B, Jent P, Jimenez-Juarez RN, Joseph A, Kang M, Kludjian G, Kurz S, Lee RA, Lee TC, Li T, Maraolo AE, Maximos M, McDonald EG, Mehta D, Moore WJ, Nguyen CT, Papan C, Ravindra A, Spellberg B, Taylor R, Thumann A, Tong SYC, Veve M, Wilson J, Yassin A, Zafonte V, Mena Lora AJ
JAMA Netw Open 2024 Nov 4;7(11):e2444495. doi: 10.1001/jamanetworkopen.2024.44495. PMID: 39495518
Wang S, Zheng S, Zhang X, Ma R, Feng S, Song M, Zhu H, Jia H
J Trauma Dissociation 2024 Jan-Feb;25(1):6-29. Epub 2023 Jul 11 doi: 10.1080/15299732.2023.2231920. PMID: 37431255
Hanin C, Arnulf I, Maranci JB, Lecendreux M, Levinson DF, Cohen D, Laurent-Levinson C
Acta Psychiatr Scand 2021 Jul;144(1):28-41. Epub 2021 May 5 doi: 10.1111/acps.13300. PMID: 33779983Free PMC Article
Finsterer J, Iglseder S, Wanschitz J, Topakian R, Löscher WN, Grisold W
Acta Neurol Scand 2019 Feb;139(2):92-105. Epub 2018 Oct 23 doi: 10.1111/ane.13035. PMID: 30295933
Bisson JI
BMJ Clin Evid 2010 Feb 3;2010 PMID: 21718580Free PMC Article

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