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Heparin-induced thrombocytopenia(HIT)

MedGen UID:
124423
•Concept ID:
C0272285
•
Disease or Syndrome
Synonym: HIT
SNOMED CT: Heparin-induced thrombocytopenia (73397007); Heparin induced thrombocytopenia (73397007)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
HPO: HP:0011874
Monarch Initiative: MONDO:0018048
Orphanet: ORPHA3325

Definition

Low platelet count following administration of unfractionated or (less commonly) low-molecular weight heparin. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHeparin-induced thrombocytopenia
Follow this link to review classifications for Heparin-induced thrombocytopenia in Orphanet.

Professional guidelines

PubMed

Heparin-induced Thrombocytopenia: Perioperative Diagnosis and Management.
Koster A, Nagler M, Erdoes G, Levy JH
Anesthesiology 2022 Feb 1;136(2):336-344. doi: 10.1097/ALN.0000000000004090. PMID: 34910815
Diagnosis and management of heparin-induced thrombocytopenia.
Gruel Y, De Maistre E, Pouplard C, Mullier F, Susen S, Roullet S, Blais N, Le Gal G, Vincentelli A, Lasne D, Lecompte T, Albaladejo P, Godier A; Members of the French Working Group on Perioperative Haemostasis Groupe d’intérêt en hémostase périopératoire GIHP
Anaesth Crit Care Pain Med 2020 Apr;39(2):291-310. Epub 2020 Apr 13 doi: 10.1016/j.accpm.2020.03.012. PMID: 32299756
Heparin-induced thrombocytopenia (HIT): Review of incidence, diagnosis, and management.
Hogan M, Berger JS
Vasc Med 2020 Apr;25(2):160-173. Epub 2020 Mar 20 doi: 10.1177/1358863X19898253. PMID: 32195628

Recent clinical studies

Etiology

Thrombocytopenia: Evaluation and Management.
Gauer RL, Whitaker DJ
Am Fam Physician 2022 Sep;106(3):288-298. PMID: 36126009
Heparin-induced thrombocytopenia (HIT): Review of incidence, diagnosis, and management.
Hogan M, Berger JS
Vasc Med 2020 Apr;25(2):160-173. Epub 2020 Mar 20 doi: 10.1177/1358863X19898253. PMID: 32195628
Heparin-induced thrombocytopenia (HIT).
Evans NS, Gomes M
Vasc Med 2017 Aug;22(4):353-355. Epub 2017 Jun 13 doi: 10.1177/1358863X17714340. PMID: 28606001
Heparin-Induced Thrombocytopenia.
Frazer CA
J Infus Nurs 2017 Mar/Apr;40(2):98-100. doi: 10.1097/NAN.0000000000000215. PMID: 28248809
Heparin-induced thrombocytopenia.
Lovecchio F
Clin Toxicol (Phila) 2014 Jul;52(6):579-83. Epub 2014 May 20 doi: 10.3109/15563650.2014.917181. PMID: 24844576

Diagnosis

Heparin-induced thrombocytopenia: pathophysiology, diagnosis and treatment.
Hvas AM, Favaloro EJ, Hellfritzsch M
Expert Rev Hematol 2021 Apr;14(4):335-346. Epub 2021 Mar 30 doi: 10.1080/17474086.2021.1905512. PMID: 33736552
Heparin-induced thrombocytopenia (HIT): Review of incidence, diagnosis, and management.
Hogan M, Berger JS
Vasc Med 2020 Apr;25(2):160-173. Epub 2020 Mar 20 doi: 10.1177/1358863X19898253. PMID: 32195628
Heparin-induced thrombocytopenia (HIT).
Evans NS, Gomes M
Vasc Med 2017 Aug;22(4):353-355. Epub 2017 Jun 13 doi: 10.1177/1358863X17714340. PMID: 28606001
Heparin induced thrombocytopenia.
Linkins LA
BMJ 2015 Jan 8;350:g7566. doi: 10.1136/bmj.g7566. PMID: 25569604
Heparin-induced thrombocytopenia.
Meyer JP
BJU Int 2007 Apr;99(4):728-30. doi: 10.1111/j.1464-410X.2006.06781.x. PMID: 17378837

Therapy

Heparin-induced thrombocytopenia.
Jevtic SD, Morris AM, Warkentin TE, Pai M
CMAJ 2021 May 17;193(20):E736. Epub 2021 Apr 27 doi: 10.1503/cmaj.210637. PMID: 33906965Free PMC Article
Heparin-induced thrombocytopenia: pathophysiology, diagnosis and treatment.
Hvas AM, Favaloro EJ, Hellfritzsch M
Expert Rev Hematol 2021 Apr;14(4):335-346. Epub 2021 Mar 30 doi: 10.1080/17474086.2021.1905512. PMID: 33736552
Heparin-induced thrombocytopenia (HIT): Review of incidence, diagnosis, and management.
Hogan M, Berger JS
Vasc Med 2020 Apr;25(2):160-173. Epub 2020 Mar 20 doi: 10.1177/1358863X19898253. PMID: 32195628
Heparin-Induced Thrombocytopenia.
Frazer CA
J Infus Nurs 2017 Mar/Apr;40(2):98-100. doi: 10.1097/NAN.0000000000000215. PMID: 28248809
Heparin-induced thrombocytopenia.
Lovecchio F
Clin Toxicol (Phila) 2014 Jul;52(6):579-83. Epub 2014 May 20 doi: 10.3109/15563650.2014.917181. PMID: 24844576

Prognosis

Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination.
Greinacher A, Thiele T, Warkentin TE, Weisser K, Kyrle PA, Eichinger S
N Engl J Med 2021 Jun 3;384(22):2092-2101. Epub 2021 Apr 9 doi: 10.1056/NEJMoa2104840. PMID: 33835769Free PMC Article
Heparin-induced thrombocytopenia (HIT): Review of incidence, diagnosis, and management.
Hogan M, Berger JS
Vasc Med 2020 Apr;25(2):160-173. Epub 2020 Mar 20 doi: 10.1177/1358863X19898253. PMID: 32195628
Heparin-induced thrombocytopenia (HIT).
Evans NS, Gomes M
Vasc Med 2017 Aug;22(4):353-355. Epub 2017 Jun 13 doi: 10.1177/1358863X17714340. PMID: 28606001
Heparin-induced thrombocytopenia.
Greinacher A
J Thromb Haemost 2009 Jul;7 Suppl 1:9-12. doi: 10.1111/j.1538-7836.2009.03385.x. PMID: 19630757
Heparin induced thrombocytopenia.
Dryjski M, Dryjski H
Eur J Vasc Endovasc Surg 1996 Apr;11(3):260-9. doi: 10.1016/s1078-5884(96)80072-4. PMID: 8601236

Clinical prediction guides

Heparin-induced thrombocytopenia: pathophysiology, diagnosis and treatment.
Hvas AM, Favaloro EJ, Hellfritzsch M
Expert Rev Hematol 2021 Apr;14(4):335-346. Epub 2021 Mar 30 doi: 10.1080/17474086.2021.1905512. PMID: 33736552
Pathogenesis of heparin-induced thrombocytopenia.
Arepally GM, Cines DB
Transl Res 2020 Nov;225:131-140. Epub 2020 May 15 doi: 10.1016/j.trsl.2020.04.014. PMID: 32417430Free PMC Article
Heparin-induced thrombocytopenia (HIT): Review of incidence, diagnosis, and management.
Hogan M, Berger JS
Vasc Med 2020 Apr;25(2):160-173. Epub 2020 Mar 20 doi: 10.1177/1358863X19898253. PMID: 32195628
Drug-associated thrombocytopenia.
Bakchoul T, Marini I
Hematology Am Soc Hematol Educ Program 2018 Nov 30;2018(1):576-583. doi: 10.1182/asheducation-2018.1.576. PMID: 30504360Free PMC Article
American Society of Hematology 2018 guidelines for management of venous thromboembolism: heparin-induced thrombocytopenia.
Cuker A, Arepally GM, Chong BH, Cines DB, Greinacher A, Gruel Y, Linkins LA, Rodner SB, Selleng S, Warkentin TE, Wex A, Mustafa RA, Morgan RL, Santesso N
Blood Adv 2018 Nov 27;2(22):3360-3392. doi: 10.1182/bloodadvances.2018024489. PMID: 30482768Free PMC Article

Recent systematic reviews

COVID-19 Vaccine-Related Thrombosis: A Systematic Review and Exploratory Analysis.
Bilotta C, Perrone G, Adelfio V, Spatola GF, Uzzo ML, Argo A, Zerbo S
Front Immunol 2021;12:729251. Epub 2021 Nov 29 doi: 10.3389/fimmu.2021.729251. PMID: 34912330Free PMC Article
Comparative effectiveness and safety of anticoagulants for the treatment of heparin-induced thrombocytopenia.
Nilius H, Kaufmann J, Cuker A, Nagler M
Am J Hematol 2021 Jul 1;96(7):805-815. Epub 2021 May 3 doi: 10.1002/ajh.26194. PMID: 33857342Free PMC Article
Management of heparin-induced thrombocytopenia: systematic reviews and meta-analyses.
Morgan RL, Ashoorion V, Cuker A, Begum H, Ross S, Martinez N, Chong BH, Linkins LA, Warkentin TE, Wiercioch W, Nieuwlaat R, Schünemann H, Santesso N
Blood Adv 2020 Oct 27;4(20):5184-5193. doi: 10.1182/bloodadvances.2020002963. PMID: 33095876Free PMC Article
Aspirin or heparin or both for improving pregnancy outcomes in women with persistent antiphospholipid antibodies and recurrent pregnancy loss.
Hamulyák EN, Scheres LJ, Marijnen MC, Goddijn M, Middeldorp S
Cochrane Database Syst Rev 2020 May 2;5(5):CD012852. doi: 10.1002/14651858.CD012852.pub2. PMID: 32358837Free PMC Article
Normal saline versus heparin for patency of central venous catheters in adult patients - a systematic review and meta-analysis.
Zhong L, Wang HL, Xu B, Yuan Y, Wang X, Zhang YY, Ji L, Pan ZM, Hu ZS
Crit Care 2017 Jan 8;21(1):5. doi: 10.1186/s13054-016-1585-x. PMID: 28063456Free PMC Article

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