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Hibernoma

MedGen UID:: 61456
•Concept ID:: C0205822
•: Neoplastic Process

Synonym:	Hibernomas
SNOMED CT:	Hibernoma (77027006); Fetal fat cell lipoma (77027006); Brown fat tumor (77027006); Hibernoma (404064001); Granular cell lipoma (404064001)

Monarch Initiative:	MONDO:0021168

Definition

A rare benign slow growing adipose tissue tumor, characterized by the presence of polygonal brown fat cells with multivacuolated and/or granular cytoplasm. The tumor is usually painless and is most often seen in young adults. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVHibernoma

Neoplasm
- Neoplasm by Special Category
  - Benign neoplasm
    - Benign connective and soft tissue neoplasm
      - Benign lipomatous neoplasm
        Lipoma
        Hibernoma
        Bone Hibernoma
        Central nervous system hibernoma

Professional guidelines

PubMed

Comparative pathophysiology, toxicology, and human cancer risk assessment of pharmaceutical-induced hibernoma.

Radi Z, Bartholomew P, Elwell M, Vogel WM
Toxicol Appl Pharmacol 2013 Dec 15;273(3):456-63. Epub 2013 Oct 18 doi: 10.1016/j.taap.2013.10.011. PMID: 24141031

Deep-seated huge hibernoma of soft tissue: a rare differential diagnosis of atypical lipomatous tumor/well differentiated liposarcoma.

Vassos N, Lell M, Hohenberger W, Croner RS, Agaimy A
Int J Clin Exp Pathol 2013;6(10):2178-84. Epub 2013 Sep 15 PMID: 24133596 Free PMC Article

Rhabdomyoma of the head and neck: morphology and differential diagnosis.

Hansen T, Katenkamp D
Virchows Arch 2005 Nov;447(5):849-54. Epub 2005 Aug 18 doi: 10.1007/s00428-005-0038-8. PMID: 16133368

See all (4)

Recent clinical studies

Etiology

Comparative pathophysiology, toxicology, and human cancer risk assessment of pharmaceutical-induced hibernoma.

Radi Z, Bartholomew P, Elwell M, Vogel WM
Toxicol Appl Pharmacol 2013 Dec 15;273(3):456-63. Epub 2013 Oct 18 doi: 10.1016/j.taap.2013.10.011. PMID: 24141031

Fat-containing salivary gland tumors: a review.

Agaimy A
Head Neck Pathol 2013 Jul;7 Suppl 1(Suppl 1):S90-6. Epub 2013 Jul 3 doi: 10.1007/s12105-013-0459-7. PMID: 23821211 Free PMC Article

Subpleural hibernoma.

Ugalde PA, Guilbault F, Vaillancourt R, Couture C
Ann Thorac Surg 2007 Oct;84(4):1376-8. doi: 10.1016/j.athoracsur.2007.05.044. PMID: 17889004

Hibernoma of the neck.

Carinci F, Carls FP, Pelucchi S, Grandi E, Hassanipour A, Pastore A
J Craniofac Surg 2001 May;12(3):284-6. doi: 10.1097/00001665-200105000-00015. PMID: 11358103

Lipomatous tumors.

Weiss SW
Monogr Pathol 1996;38:207-39. PMID: 8744279

See all (36)

Diagnosis

Lipomatoses.

Dupuis H, Lemaitre M, Jannin A, Douillard C, Espiard S, Vantyghem MC
Ann Endocrinol (Paris) 2024 Jun;85(3):231-247. Epub 2024 Jun 12 doi: 10.1016/j.ando.2024.05.003. PMID: 38871514

Mammary Hibernoma: A Rare Entity.

Riley MP, Karamchandani DM
Arch Pathol Lab Med 2015 Dec;139(12):1565-7. doi: 10.5858/arpa.2014-0318-RS. PMID: 26619029

Hibernoma.

Klevos G, Jose J, Pretell-Mazzini J, Conway S
Am J Orthop (Belle Mead NJ) 2015 Jun;44(6):284-7. PMID: 26046999

Hibernoma.

Alves GR, Antunes MS, Bellenzier L, Haygert CJ
QJM 2013 Aug;106(8):773. Epub 2012 Aug 26 doi: 10.1093/qjmed/hcs157. PMID: 22927539

Lipomatous tumors.

Weiss SW
Monogr Pathol 1996;38:207-39. PMID: 8744279

See all (190)

Therapy

Histopathological Changes in Liver and Heart Tissue Associated with Experimental Ultraviolet Radiation A and B Exposure on Wistar Albino Rats.

Keskin S, Acikgoz E, Ertürk FY, Ragbetli MC, Ozkol H
Photochem Photobiol 2023 Jan;99(1):132-136. Epub 2022 Jun 28 doi: 10.1111/php.13664. PMID: 35702999

Hibernoma as an incidental finding in the 18F-FDG PET/CT of a patient with melanoma.

Marcoval J, Sabaté-Llobera A, Bermejo J, Fornons-Servent R
Melanoma Res 2020 Aug;30(4):420-422. doi: 10.1097/CMR.0000000000000530. PMID: 30358644

Propranolol 18F-FDG PET/CT: A Noninvasive Approach for Differential Diagnosis of Hibernoma and Liposarcoma.

Ciappuccini R, Bardet S, Aide N
Clin Nucl Med 2017 Nov;42(11):879-880. doi: 10.1097/RLU.0000000000001830. PMID: 28902737

Sonographic findings of hibernoma. A report of two cases.

Hardes J, Scheil-Bertram S, Hartwig E, Gebert C, Gosheger G, Schulte M
J Clin Ultrasound 2005 Jul-Aug;33(6):298-301. doi: 10.1002/jcu.20126. PMID: 16134158

Epidural hibernoma as a complication of corticosteroid treatment. Case report.

Perling LH, Laurent JP, Cheek WR
J Neurosurg 1988 Oct;69(4):613-6. doi: 10.3171/jns.1988.69.4.0613. PMID: 3047343

See all (5)

Prognosis

Retroperitoneal hibernoma resected via laparoscopic surgery.

Sujino H, Kasahara K, Tanigawa M, Enomoto M, Udo R, Tago T, Okazaki N, Mazaki J, Ishizaki T, Nagao T, Katsumata K, Tsuchida A, Nagakawa Y
Asian J Endosc Surg 2023 Jul;16(3):528-532. Epub 2023 Jan 2 doi: 10.1111/ases.13160. PMID: 36592950

Mammary Hibernoma: A Rare Entity.

Riley MP, Karamchandani DM
Arch Pathol Lab Med 2015 Dec;139(12):1565-7. doi: 10.5858/arpa.2014-0318-RS. PMID: 26619029

Subpleural hibernoma.

Ugalde PA, Guilbault F, Vaillancourt R, Couture C
Ann Thorac Surg 2007 Oct;84(4):1376-8. doi: 10.1016/j.athoracsur.2007.05.044. PMID: 17889004

Hibernoma of the neck.

Carinci F, Carls FP, Pelucchi S, Grandi E, Hassanipour A, Pastore A
J Craniofac Surg 2001 May;12(3):284-6. doi: 10.1097/00001665-200105000-00015. PMID: 11358103

Lipomatous tumors.

Weiss SW
Monogr Pathol 1996;38:207-39. PMID: 8744279

See all (27)

Clinical prediction guides

Cutaneous lesions and other non-endocrine manifestations of Multiple Endocrine Neoplasia type 1 syndrome.

Pierotti L, Pardi E, Dinoi E, Piaggi P, Borsari S, Della Valentina S, Sardella C, Michelucci A, Caligo MA, Bogazzi F, Marcocci C, Cetani F
Front Endocrinol (Lausanne) 2023;14:1191040. Epub 2023 Jul 7 doi: 10.3389/fendo.2023.1191040. PMID: 37484956 Free PMC Article

Intraosseous hibernoma: clinicopathologic and imaging analysis of 18 cases.

Gangahar CN, Dehner CA, Wang DP, Amini B, Hillen T, O'Conor C, Jennings SN, Byrnes K, Montgomery EA, Czerniak BA, Bridge JA, Schroeder MC, Jennings JW, Wang WL, Chrisinger JSA
Histopathology 2023 Jul;83(1):40-48. Epub 2023 Apr 26 doi: 10.1111/his.14928. PMID: 37099409

Liposarcoma With Hibernoma-like Histology: A Clinicopathologic Study of 16 Cases.

Kojima N, Komiyama M, Shinoda Y, Watanabe SI, Yatabe Y, Kawai A, Yoshida A
Am J Surg Pathol 2022 Oct 1;46(10):1319-1328. Epub 2022 Apr 27 doi: 10.1097/PAS.0000000000001911. PMID: 35475774

Comparative pathophysiology, toxicology, and human cancer risk assessment of pharmaceutical-induced hibernoma.

Radi Z, Bartholomew P, Elwell M, Vogel WM
Toxicol Appl Pharmacol 2013 Dec 15;273(3):456-63. Epub 2013 Oct 18 doi: 10.1016/j.taap.2013.10.011. PMID: 24141031

Hibernoma: ultrastructural observations.

Fleishman JS, Schwartz RA
J Surg Oncol 1983 Aug;23(4):285-9. doi: 10.1002/jso.2930230414. PMID: 6876806

See all (32)

Recent systematic reviews

Brachial plexus neuropathy by hibernoma compression: An unusual presentation of peripheral non-neural sheath nerve tumor and a systematic review of literature.

Sousa LHA, Chaves JPG, Marques RAM, Silva LLG
Neurol India 2019 Mar-Apr;67(2):481-484. doi: 10.4103/0028-3886.258049. PMID: 31085864

See all (1)

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Hibernoma

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

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