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Metabolic dysfunction-associated steatotic liver disease

MedGen UID:
96033
Concept ID:
C0400966
Disease or Syndrome
Synonyms: Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis (NASH)
SNOMED CT: Non-alcoholic fatty liver (197315008); NAFL - non-alcoholic fatty liver (197315008); NAFLD - nonalcoholic fatty liver disease (1231824009); Nonalcoholic fatty liver disease (1231824009); Non-alcoholic fatty liver disease (1231824009)
 
Monarch Initiative: MONDO:0013209
Orphanet: ORPHA33271

Definition

Nonalcoholic fatty liver disease (NAFLD) is the presence of hepatic steatosis with or without inflammation and fibrosis that is not caused by alcohol. NAFLD is subdivided into nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH). [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetabolic dysfunction-associated steatotic liver disease

Professional guidelines

PubMed

European Association for the Study of the Liver (EASL); European Association for the Study of Diabetes (EASD); European Association for the Study of Obesity (EASO)
J Hepatol 2024 Sep;81(3):492-542. Epub 2024 Jun 7 doi: 10.1016/j.jhep.2024.04.031. PMID: 38851997
Rinella ME, Lazarus JV, Ratziu V, Francque SM, Sanyal AJ, Kanwal F, Romero D, Abdelmalek MF, Anstee QM, Arab JP, Arrese M, Bataller R, Beuers U, Boursier J, Bugianesi E, Byrne CD, Castro Narro GE, Chowdhury A, Cortez-Pinto H, Cryer DR, Cusi K, El-Kassas M, Klein S, Eskridge W, Fan J, Gawrieh S, Guy CD, Harrison SA, Kim SU, Koot BG, Korenjak M, Kowdley KV, Lacaille F, Loomba R, Mitchell-Thain R, Morgan TR, Powell EE, Roden M, Romero-Gómez M, Silva M, Singh SP, Sookoian SC, Spearman CW, Tiniakos D, Valenti L, Vos MB, Wong VW, Xanthakos S, Yilmaz Y, Younossi Z, Hobbs A, Villota-Rivas M, Newsome PN; NAFLD Nomenclature consensus group
J Hepatol 2023 Dec;79(6):1542-1556. Epub 2023 Jun 24 doi: 10.1016/j.jhep.2023.06.003. PMID: 37364790
Rinella ME, Lazarus JV, Ratziu V, Francque SM, Sanyal AJ, Kanwal F, Romero D, Abdelmalek MF, Anstee QM, Arab JP, Arrese M, Bataller R, Beuers U, Boursier J, Bugianesi E, Byrne CD, Castro Narro GE, Chowdhury A, Cortez-Pinto H, Cryer DR, Cusi K, El-Kassas M, Klein S, Eskridge W, Fan J, Gawrieh S, Guy CD, Harrison SA, Kim SU, Koot BG, Korenjak M, Kowdley KV, Lacaille F, Loomba R, Mitchell-Thain R, Morgan TR, Powell EE, Roden M, Romero-Gómez M, Silva M, Singh SP, Sookoian SC, Spearman CW, Tiniakos D, Valenti L, Vos MB, Wong VW, Xanthakos S, Yilmaz Y, Younossi Z, Hobbs A, Villota-Rivas M, Newsome PN; NAFLD Nomenclature consensus group
Hepatology 2023 Dec 1;78(6):1966-1986. Epub 2023 Jun 24 doi: 10.1097/HEP.0000000000000520. PMID: 37363821Free PMC Article

Curated

UK NICE Diagnostics Guidance DG50, MRI-based technologies for assessing non-alcoholic fatty liver disease, 2023

Recent clinical studies

Etiology

European Association for the Study of the Liver (EASL); European Association for the Study of Diabetes (EASD); European Association for the Study of Obesity (EASO)
J Hepatol 2024 Sep;81(3):492-542. Epub 2024 Jun 7 doi: 10.1016/j.jhep.2024.04.031. PMID: 38851997
Lekakis V, Papatheodoridis GV
Eur J Intern Med 2024 Apr;122:3-10. Epub 2023 Nov 7 doi: 10.1016/j.ejim.2023.11.005. PMID: 37940495
Yanai H, Adachi H, Hakoshima M, Iida S, Katsuyama H
Int J Mol Sci 2023 Oct 23;24(20) doi: 10.3390/ijms242015473. PMID: 37895151Free PMC Article
Hutchison AL, Tavaglione F, Romeo S, Charlton M
J Hepatol 2023 Dec;79(6):1524-1541. Epub 2023 Sep 18 doi: 10.1016/j.jhep.2023.08.030. PMID: 37730124
Rinella ME, Lazarus JV, Ratziu V, Francque SM, Sanyal AJ, Kanwal F, Romero D, Abdelmalek MF, Anstee QM, Arab JP, Arrese M, Bataller R, Beuers U, Boursier J, Bugianesi E, Byrne CD, Castro Narro GE, Chowdhury A, Cortez-Pinto H, Cryer DR, Cusi K, El-Kassas M, Klein S, Eskridge W, Fan J, Gawrieh S, Guy CD, Harrison SA, Kim SU, Koot BG, Korenjak M, Kowdley KV, Lacaille F, Loomba R, Mitchell-Thain R, Morgan TR, Powell EE, Roden M, Romero-Gómez M, Silva M, Singh SP, Sookoian SC, Spearman CW, Tiniakos D, Valenti L, Vos MB, Wong VW, Xanthakos S, Yilmaz Y, Younossi Z, Hobbs A, Villota-Rivas M, Newsome PN; NAFLD Nomenclature consensus group
J Hepatol 2023 Dec;79(6):1542-1556. Epub 2023 Jun 24 doi: 10.1016/j.jhep.2023.06.003. PMID: 37364790

Diagnosis

Israelsen M, Francque S, Tsochatzis EA, Krag A
Lancet 2024 Nov 2;404(10464):1761-1778. doi: 10.1016/S0140-6736(24)01811-7. PMID: 39488409
European Association for the Study of the Liver (EASL); European Association for the Study of Diabetes (EASD); European Association for the Study of Obesity (EASO)
J Hepatol 2024 Sep;81(3):492-542. Epub 2024 Jun 7 doi: 10.1016/j.jhep.2024.04.031. PMID: 38851997
Singal AG, Kanwal F, Llovet JM
Nat Rev Clin Oncol 2023 Dec;20(12):864-884. Epub 2023 Oct 26 doi: 10.1038/s41571-023-00825-3. PMID: 37884736
Rinella ME, Lazarus JV, Ratziu V, Francque SM, Sanyal AJ, Kanwal F, Romero D, Abdelmalek MF, Anstee QM, Arab JP, Arrese M, Bataller R, Beuers U, Boursier J, Bugianesi E, Byrne CD, Castro Narro GE, Chowdhury A, Cortez-Pinto H, Cryer DR, Cusi K, El-Kassas M, Klein S, Eskridge W, Fan J, Gawrieh S, Guy CD, Harrison SA, Kim SU, Koot BG, Korenjak M, Kowdley KV, Lacaille F, Loomba R, Mitchell-Thain R, Morgan TR, Powell EE, Roden M, Romero-Gómez M, Silva M, Singh SP, Sookoian SC, Spearman CW, Tiniakos D, Valenti L, Vos MB, Wong VW, Xanthakos S, Yilmaz Y, Younossi Z, Hobbs A, Villota-Rivas M, Newsome PN; NAFLD Nomenclature consensus group
J Hepatol 2023 Dec;79(6):1542-1556. Epub 2023 Jun 24 doi: 10.1016/j.jhep.2023.06.003. PMID: 37364790
Rinella ME, Lazarus JV, Ratziu V, Francque SM, Sanyal AJ, Kanwal F, Romero D, Abdelmalek MF, Anstee QM, Arab JP, Arrese M, Bataller R, Beuers U, Boursier J, Bugianesi E, Byrne CD, Castro Narro GE, Chowdhury A, Cortez-Pinto H, Cryer DR, Cusi K, El-Kassas M, Klein S, Eskridge W, Fan J, Gawrieh S, Guy CD, Harrison SA, Kim SU, Koot BG, Korenjak M, Kowdley KV, Lacaille F, Loomba R, Mitchell-Thain R, Morgan TR, Powell EE, Roden M, Romero-Gómez M, Silva M, Singh SP, Sookoian SC, Spearman CW, Tiniakos D, Valenti L, Vos MB, Wong VW, Xanthakos S, Yilmaz Y, Younossi Z, Hobbs A, Villota-Rivas M, Newsome PN; NAFLD Nomenclature consensus group
Hepatology 2023 Dec 1;78(6):1966-1986. Epub 2023 Jun 24 doi: 10.1097/HEP.0000000000000520. PMID: 37363821Free PMC Article

Therapy

Loomba R, Hartman ML, Lawitz EJ, Vuppalanchi R, Boursier J, Bugianesi E, Yoneda M, Behling C, Cummings OW, Tang Y, Brouwers B, Robins DA, Nikooie A, Bunck MC, Haupt A, Sanyal AJ; SYNERGY-NASH Investigators
N Engl J Med 2024 Jul 25;391(4):299-310. Epub 2024 Jun 8 doi: 10.1056/NEJMoa2401943. PMID: 38856224
Brouwers B, Rao G, Tang Y, Rodríguez Á, Glass LC, Hartman ML
Diabetes Res Clin Pract 2024 May;211:111675. Epub 2024 Apr 16 doi: 10.1016/j.diabres.2024.111675. PMID: 38636848
Simon TG, Wilechansky RM, Stoyanova S, Grossman A, Dichtel LE, Lauer GM, Miller KK, Hoshida Y, Corey KE, Loomba R, Chung RT, Chan AT
JAMA 2024 Mar 19;331(11):920-929. doi: 10.1001/jama.2024.1215. PMID: 38502074Free PMC Article
Zeng J, Fan JG, Francque SM
United European Gastroenterol J 2024 Mar;12(2):177-186. Epub 2024 Jan 9 doi: 10.1002/ueg2.12525. PMID: 38193865Free PMC Article
Yanai H, Adachi H, Hakoshima M, Iida S, Katsuyama H
Int J Mol Sci 2023 Oct 23;24(20) doi: 10.3390/ijms242015473. PMID: 37895151Free PMC Article

Prognosis

European Association for the Study of the Liver (EASL); European Association for the Study of Diabetes (EASD); European Association for the Study of Obesity (EASO)
J Hepatol 2024 Sep;81(3):492-542. Epub 2024 Jun 7 doi: 10.1016/j.jhep.2024.04.031. PMID: 38851997
Simon TG, Wilechansky RM, Stoyanova S, Grossman A, Dichtel LE, Lauer GM, Miller KK, Hoshida Y, Corey KE, Loomba R, Chung RT, Chan AT
JAMA 2024 Mar 19;331(11):920-929. doi: 10.1001/jama.2024.1215. PMID: 38502074Free PMC Article
Miao L, Targher G, Byrne CD, Cao YY, Zheng MH
Trends Endocrinol Metab 2024 Aug;35(8):697-707. Epub 2024 Feb 29 doi: 10.1016/j.tem.2024.02.007. PMID: 38429161
Lekakis V, Papatheodoridis GV
Eur J Intern Med 2024 Apr;122:3-10. Epub 2023 Nov 7 doi: 10.1016/j.ejim.2023.11.005. PMID: 37940495
Yanai H, Adachi H, Hakoshima M, Iida S, Katsuyama H
Int J Mol Sci 2023 Oct 23;24(20) doi: 10.3390/ijms242015473. PMID: 37895151Free PMC Article

Clinical prediction guides

Israelsen M, Francque S, Tsochatzis EA, Krag A
Lancet 2024 Nov 2;404(10464):1761-1778. doi: 10.1016/S0140-6736(24)01811-7. PMID: 39488409
European Association for the Study of the Liver (EASL); European Association for the Study of Diabetes (EASD); European Association for the Study of Obesity (EASO)
J Hepatol 2024 Sep;81(3):492-542. Epub 2024 Jun 7 doi: 10.1016/j.jhep.2024.04.031. PMID: 38851997
Lin H, Lee HW, Yip TC, Tsochatzis E, Petta S, Bugianesi E, Yoneda M, Zheng MH, Hagström H, Boursier J, Calleja JL, Goh GB, Chan WK, Gallego-Durán R, Sanyal AJ, de Lédinghen V, Newsome PN, Fan JG, Castéra L, Lai M, Harrison SA, Fournier-Poizat C, Wong GL, Pennisi G, Armandi A, Nakajima A, Liu WY, Shang Y, de Saint-Loup M, Llop E, Teh KK, Lara-Romero C, Asgharpour A, Mahgoub S, Chan MS, Canivet CM, Romero-Gomez M, Kim SU, Wong VW; VCTE-Prognosis Study Group
JAMA 2024 Apr 16;331(15):1287-1297. doi: 10.1001/jama.2024.1447. PMID: 38512249Free PMC Article
Bilson J, Mantovani A, Byrne CD, Targher G
Diabetes Metab 2024 Jan;50(1):101506. Epub 2023 Dec 21 doi: 10.1016/j.diabet.2023.101506. PMID: 38141808
Lekakis V, Papatheodoridis GV
Eur J Intern Med 2024 Apr;122:3-10. Epub 2023 Nov 7 doi: 10.1016/j.ejim.2023.11.005. PMID: 37940495

Recent systematic reviews

Dutta D, Kamrul-Hasan ABM, Mondal E, Nagendra L, Joshi A, Bhattacharya S
Endocr Pract 2024 Jul;30(7):631-638. Epub 2024 May 1 doi: 10.1016/j.eprac.2024.04.016. PMID: 38697306
Wongtrakul W, Charatcharoenwitthaya N, Charatcharoenwitthaya P
Eur J Gastroenterol Hepatol 2024 Apr 1;36(4):351-358. Epub 2024 Feb 23 doi: 10.1097/MEG.0000000000002719. PMID: 38407898
Abuelazm MT, Mohamed I, Naeem A, Khlidj Y, Tanashat M, Katamesh BE, Abusuilik H, Altobaishat O, Abdelnabi M, Abdelazeem B
Eur J Gastroenterol Hepatol 2024 Apr 1;36(4):371-381. Epub 2024 Feb 23 doi: 10.1097/MEG.0000000000002715. PMID: 38407890
Jamalinia M, Zare F, Noorizadeh K, Bagheri Lankarani K
Aliment Pharmacol Ther 2024 Feb;59(4):445-458. Epub 2024 Jan 7 doi: 10.1111/apt.17869. PMID: 38186044
Lai J, Luo L, Zhou T, Feng X, Ye J, Zhong B
Biomolecules 2023 Sep 6;13(9) doi: 10.3390/biom13091356. PMID: 37759756Free PMC Article

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    Clinical resources

    Practice guidelines

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    Curated

    • NICE, 2023
      UK NICE Diagnostics Guidance DG50, MRI-based technologies for assessing non-alcoholic fatty liver disease, 2023

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