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Homo sapiens METH1 protein (METH1) mRNA, complete cds

GenBank: AF060152.1

FASTA Graphics 

LOCUS       AF060152                3430 bp    mRNA    linear   PRI 17-OCT-2005
DEFINITION  Homo sapiens METH1 protein (METH1) mRNA, complete cds.
ACCESSION   AF060152
VERSION     AF060152.1
KEYWORDS    .
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3430)
  AUTHORS   Vazquez,F., Hastings,G., Ortega,M.A., Lane,T.F., Oikemus,S.,
            Lombardo,M. and Iruela-Arispe,M.L.
  TITLE     METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a
            new family of proteins with angio-inhibitory activity
  JOURNAL   J. Biol. Chem. 274 (33), 23349-23357 (1999)
   PUBMED   10438512
REFERENCE   2  (bases 1 to 3430)
  AUTHORS   Lee,N.V., Rodriguez-Manzaneque,J.C., Thai,S.N., Twal,W.O.,
            Luque,A., Lyons,K.M., Argraves,W.S. and Iruela-Arispe,M.L.
  TITLE     Fibulin-1 acts as a cofactor for the matrix metalloprotease
            ADAMTS-1
  JOURNAL   J. Biol. Chem. 280 (41), 34796-34804 (2005)
   PUBMED   16061471
REFERENCE   3  (bases 1 to 3430)
  AUTHORS   Vazquez,F., Hastings,G., Ortega,M.-A., Lane,T.F., Lombardo,M.,
            Oikemus,S. and Iruela-Arispe,M.L.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-APR-1998) Pathology, Beth Israel Deaconess Medical
            Center, 99, Brookline Avenue, Boston, MA 02214, USA
FEATURES             Location/Qualifiers
     source          1..3430
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
     gene            1..3430
                     /gene="METH1"
     CDS             238..3090
                     /gene="METH1"
                     /note="extracellular protein with metalloprotease and TSP
                     domains"
                     /codon_start=1
                     /product="METH1 protein"
                     /protein_id="AAD48080.1"
                     /translation="MGNAERAPGSRSFGPVPTLLLLAAALLAVSDALGRPSEEDEELV
                     VPELERAPGHGTTRLRLHAFDQQLDLELRPDSSFLAPGFTLQNVGRKSGSETPLPETD
                     LAHCFYSGTVNGDPSSAAALSLCEGVRGAFYLLGEAYFIQPLPAASERLATAAPGEKP
                     PAPLQFHLLRRNRQGDVGGTCGVVDDEPRPTGKAETEDEDEGTEGEDEGPQWSPQDPA
                     LQGVGQPTGTGSIRKKRFVSSHRYVETMLVADQSMAEFHGSGLKHYLLTLFSVAARLY
                     KHPSIRNSVSLVVVKILVIHDEQKGPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYD
                     TAILFTRQDLCGSQTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNM
                     PHDDAKQCASLNGVNQDSHMMASMLSNLDHSQPWSPCSAYMITSFLDNGHGECLMDKP
                     QNPIQLPGDLPGTSYDANRQCQFTFGEDSKHCPDAASTCSTLWCTGTSGGVLVCQTKH
                     FPWADGTSCGEGKWCINGKCVNKTDRKHFDTPFHGSWGMWGPWGDCSRTCGGGVQYTM
                     RECDNPVPKNGGKYCEGKRVRYRSCNLEDCPDNNGKTFREEQCEAHNEFSKASFGSGP
                     AVEWIPKYAGVSPKDRCKLICQAKGIGYFFVLQPKVVDGTPCSPDSTSVCVQGQCVKA
                     GCDRIIDSKKKFDKCGVCGGNGSTCKKISGSVTSAKPGYHDIITIPTGATNIEVKQRN
                     QRGSRNNGSFLAIKAADGTYILNGDYTLSTLEQDIMYKGVVLRYSGSSAALERIRSFS
                     PLKEPLTIQVLTVGNALRPKIKYTYFVKKKKESFNAIPTFSAWVIEEWGECSKSCELG
                     WQRRLVECRDINGQPASECAKEVKPASTRPCADHPCPQWQLGEWSSCSKTCGKGYKKR
                     SLKCLSHDGGVLSHESCDPLKKPKHFIDFCTMAECS"
ORIGIN      
        1 tgcagcgcct cctcttagtg actccgggag cttcggctgt agccggctct gcgcgccctt
       61 ccaacgaata atagaaattg ttaattttaa caatccagag caggccaacg aggctttgct
      121 ctcccgaccc gaactaaagc tccctcgctc cgtgcgctgc tacgagcggt gtctcctggg
      181 gctccaatgc agcgagctgt gcccgagggg ttcggaaggc gcaagctggg cagcgacatg
      241 gggaacgcgg agcgggctcc ggggtctcgg agctttgggc ccgtacccac gctgctgctg
      301 ctcgccgcgg cgctactggc cgtgtcggac gcactcgggc gcccctccga ggaggacgag
      361 gagctagtgg tgccggagct ggagcgcgcc ccgggacacg ggaccacgcg cctccgcctg
      421 cacgcctttg accagcagct ggatctggag ctgcggcccg acagcagctt tttggcgccc
      481 ggcttcacgc tccagaacgt ggggcgcaaa tccgggtccg agacgccgct tccggaaacc
      541 gacctggcgc actgcttcta ctccggcacc gtgaatggcg atcccagctc ggctgccgcc
      601 ctcagcctct gcgagggcgt gcgcggcgcc ttctacctgc tgggggaggc gtatttcatc
      661 cagccgctgc ccgccgccag cgagcgcctc gccaccgccg ccccagggga gaagccgccg
      721 gcaccactac agttccacct cctgcggcgg aatcggcagg gcgacgtagg cggcacgtgc
      781 ggggtcgtgg acgacgagcc ccggccgact gggaaagcgg agaccgaaga cgaggacgaa
      841 gggactgagg gcgaggacga agggcctcag tggtcgccgc aggacccggc actgcaaggc
      901 gtaggacagc ccacaggaac tggaagcata agaaagaagc gatttgtgtc cagtcaccgc
      961 tatgtggaaa ccatgcttgt ggcagaccag tcgatggcag aattccacgg cagtggtcta
     1021 aagcattacc ttctcacgtt gttttcggtg gcagccagat tgtacaaaca ccccagcatt
     1081 cgtaattcag ttagcctggt ggtggtgaag atcttggtca tccacgatga acagaagggg
     1141 ccggaagtga cctccaatgc tgccctcact ctgcggaact tttgcaactg gcagaagcag
     1201 cacaacccac ccagtgaccg ggatgcagag cactatgaca cagcaattct tttcaccaga
     1261 caggacttgt gtgggtccca gacatgtgat actcttggga tggctgatgt tggaactgtg
     1321 tgtgatccga gcagaagctg ctccgtcata gaagatgatg gtttacaagc tgccttcacc
     1381 acagcccatg aattaggcca cgtgtttaac atgccacatg atgatgcaaa gcagtgtgcc
     1441 agccttaatg gtgtgaacca ggattcccac atgatggcgt caatgctttc caacctggac
     1501 cacagccagc cttggtctcc ttgcagtgcc tacatgatta catcatttct ggataatggt
     1561 catggggaat gtttgatgga caagcctcag aatcccatac agctcccagg cgatctccct
     1621 ggcacctcgt acgatgccaa ccggcagtgc cagtttacat ttggggagga ctccaaacac
     1681 tgccctgatg cagccagcac atgtagcacc ttgtggtgta ccggcacctc tggtggggtg
     1741 ctggtgtgtc aaaccaaaca cttcccgtgg gcggatggca ccagctgtgg agaagggaaa
     1801 tggtgtatca acggcaagtg tgtgaacaaa accgacagaa agcattttga tacgcctttt
     1861 catggaagct ggggaatgtg ggggccttgg ggagactgtt cgagaacgtg cggtggagga
     1921 gtccagtaca cgatgaggga atgtgacaac ccagtcccaa agaatggagg gaagtactgt
     1981 gaaggcaaac gagtgcgcta cagatcctgt aaccttgagg actgtccaga caataatgga
     2041 aaaaccttta gagaggaaca atgtgaagca cacaacgagt tttcaaaagc ttcctttggg
     2101 agtgggcctg cggtggaatg gattcccaag tacgctggcg tctcaccaaa ggacaggtgc
     2161 aagctcatct gccaagccaa aggcattggc tacttcttcg ttttgcagcc caaggttgta
     2221 gatggtactc catgtagccc agattccacc tctgtctgtg tgcaaggaca gtgtgtaaaa
     2281 gctggttgtg atcgcatcat agactccaaa aagaagtttg ataaatgtgg tgtttgcggg
     2341 ggaaatggat ctacttgtaa aaaaatatca ggatcagtta ctagtgcaaa acctggatat
     2401 catgatatca tcacaattcc aactggagcc accaacatcg aagtgaaaca gcggaaccag
     2461 aggggatcca ggaacaatgg cagctttctt gccatcaaag ctgctgatgg cacatatatt
     2521 cttaatggtg actacacttt gtccacctta gagcaagaca ttatgtacaa aggtgttgtc
     2581 ttgaggtaca gcggctcctc tgcggcattg gaaagaattc gcagctttag ccctctcaaa
     2641 gagcccttga ccatccaggt tcttactgtg ggcaatgccc ttcgacctaa aattaaatac
     2701 acctacttcg taaagaagaa gaaggaatct ttcaatgcta tccccacttt ttcagcatgg
     2761 gtcattgaag agtggggcga atgttctaag tcatgtgaat tgggttggca gagaagactg
     2821 gtagaatgcc gagacattaa tggacagcct gcttccgagt gtgcaaagga agtgaagcca
     2881 gccagcacca gaccttgtgc agaccatccc tgcccccagt ggcagctggg ggagtggtca
     2941 tcatgttcta agacctgtgg gaagggttac aaaaaaagaa gcttgaagtg tctgtcccat
     3001 gatggagggg tgttatctca tgagagctgt gatcctttaa agaaacctaa acatttcata
     3061 gacttttgca caatggcaga atgcagttaa gtggtttaag tggtgttagc tttgaggcaa
     3121 ggcaaagtga ggaagggctg gtgcagggaa agcaagaagg ctggagggat ccagcgtatc
     3181 ttgccagtaa ccagtgaggt gtatcagtaa ggtgggatta tgggggtaga tagaaaagga
     3241 gttgaatcat cagagtaaac tgccagttgc aaatttgata ggatagttag tgaggattat
     3301 taacctctga gcagtgatat agcataataa anccccgggc attattatta ttatttcttt
     3361 tgttacatct attacaagtt tagaaaaaac aaagcaattg tcaaaaaaaa aaaaaaaaaa
     3421 aaaaaaaaaa
//
238..3090
/gene="METH1"
/note="extracellular protein with metalloprotease and TSP
domains"
/codon_start=1
/product="METH1 protein"
/protein_id="AAD48080.1"
/translation="MGNAERAPGSRSFGPVPTLLLLAAALLAVSDALGRPSEEDEELV
VPELERAPGHGTTRLRLHAFDQQLDLELRPDSSFLAPGFTLQNVGRKSGSETPLPETD
LAHCFYSGTVNGDPSSAAALSLCEGVRGAFYLLGEAYFIQPLPAASERLATAAPGEKP
PAPLQFHLLRRNRQGDVGGTCGVVDDEPRPTGKAETEDEDEGTEGEDEGPQWSPQDPA
LQGVGQPTGTGSIRKKRFVSSHRYVETMLVADQSMAEFHGSGLKHYLLTLFSVAARLY
KHPSIRNSVSLVVVKILVIHDEQKGPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYD
TAILFTRQDLCGSQTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNM
PHDDAKQCASLNGVNQDSHMMASMLSNLDHSQPWSPCSAYMITSFLDNGHGECLMDKP
QNPIQLPGDLPGTSYDANRQCQFTFGEDSKHCPDAASTCSTLWCTGTSGGVLVCQTKH
FPWADGTSCGEGKWCINGKCVNKTDRKHFDTPFHGSWGMWGPWGDCSRTCGGGVQYTM
RECDNPVPKNGGKYCEGKRVRYRSCNLEDCPDNNGKTFREEQCEAHNEFSKASFGSGP
AVEWIPKYAGVSPKDRCKLICQAKGIGYFFVLQPKVVDGTPCSPDSTSVCVQGQCVKA
GCDRIIDSKKKFDKCGVCGGNGSTCKKISGSVTSAKPGYHDIITIPTGATNIEVKQRN
QRGSRNNGSFLAIKAADGTYILNGDYTLSTLEQDIMYKGVVLRYSGSSAALERIRSFS
PLKEPLTIQVLTVGNALRPKIKYTYFVKKKKESFNAIPTFSAWVIEEWGECSKSCELG
WQRRLVECRDINGQPASECAKEVKPASTRPCADHPCPQWQLGEWSSCSKTCGKGYKKR
SLKCLSHDGGVLSHESCDPLKKPKHFIDFCTMAECS"
Feature AF060152 : 1 segment
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Supplemental Content

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Reference sequence information

  • RefSeq mRNA
    See reference mRNA sequence for the ADAMTS1 gene (NM_006988.5).

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