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Rattus norvegicus TRPM8 channel associated factor 2C (Tcaf2c), mRNA

NCBI Reference Sequence: NM_001431991.1

FASTA Graphics 

LOCUS       NM_001431991            4440 bp    mRNA    linear   ROD 27-JUL-2024
DEFINITION  Rattus norvegicus TRPM8 channel associated factor 2C (Tcaf2c),
            mRNA.
ACCESSION   NM_001431991 XM_063286945
VERSION     NM_001431991.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4440)
  AUTHORS   Gkika,D., Lemonnier,L., Shapovalov,G., Gordienko,D., Poux,C.,
            Bernardini,M., Bokhobza,A., Bidaux,G., Degerny,C., Verreman,K.,
            Guarmit,B., Benahmed,M., de Launoit,Y., Bindels,R.J., Fiorio Pla,A.
            and Prevarskaya,N.
  TITLE     TRP channel-associated factors are a novel protein family that
            regulates TRPM8 trafficking and activity
  JOURNAL   J Cell Biol 208 (1), 89-107 (2015)
   PUBMED   25559186
REFERENCE   2  (bases 1 to 4440)
  AUTHORS   Nagamachi,A., Matsui,H., Asou,H., Ozaki,Y., Aki,D., Kanai,A.,
            Takubo,K., Suda,T., Nakamura,T., Wolff,L., Honda,H. and Inaba,T.
  TITLE     Haploinsufficiency of SAMD9L, an endosome fusion facilitator,
            causes myeloid malignancies in mice mimicking human diseases with
            monosomy 7
  JOURNAL   Cancer Cell 24 (3), 305-317 (2013)
   PUBMED   24029230
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Jul 24, 2024 this sequence version replaced XM_063286945.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.381002.1,
                                           SRR26643295.18094.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-209               JAXUCZ010000004.1  72542915-72543123   c
            210-846             JAXUCZ010000004.1  72540759-72541395   c
            847-1841            JAXUCZ010000004.1  72526159-72527153   c
            1842-1939           JAXUCZ010000004.1  72525768-72525865   c
            1940-2153           JAXUCZ010000004.1  72524609-72524822   c
            2154-2393           JAXUCZ010000004.1  72523997-72524236   c
            2394-2731           JAXUCZ010000004.1  72522825-72523162   c
            2732-4440           JAXUCZ010000004.1  72520327-72522035   c
FEATURES             Location/Qualifiers
     source          1..4440
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q24"
     gene            1..4440
                     /gene="Tcaf2c"
                     /gene_synonym="Fam115c; Fam139a; Tcaf2"
                     /note="TRPM8 channel associated factor 2C"
                     /db_xref="GeneID:100912416"
                     /db_xref="RGD:1591778"
     exon            1..209
                     /gene="Tcaf2c"
                     /gene_synonym="Fam115c; Fam139a; Tcaf2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    107..109
                     /gene="Tcaf2c"
                     /gene_synonym="Fam115c; Fam139a; Tcaf2"
                     /note="upstream in-frame stop codon"
     exon            210..846
                     /gene="Tcaf2c"
                     /gene_synonym="Fam115c; Fam139a; Tcaf2"
                     /inference="alignment:Splign:2.1.0"
     CDS             224..2983
                     /gene="Tcaf2c"
                     /gene_synonym="Fam115c; Fam139a; Tcaf2"
                     /note="protein FAM115C-like; family with sequence
                     similarity 115, member C; TRPM8 channel-associated factor
                     2; family with sequence similarity 139, member A"
                     /codon_start=1
                     /product="TRPM8 channel associated factor 2C"
                     /protein_id="NP_001418920.1"
                     /db_xref="GeneID:100912416"
                     /db_xref="RGD:1591778"
                     /translation="MATTPDAAFEALMNGVTSWDLPKEFTPSELLLIGEAAFPVMVND
                     KGQVLIAASFYGQGRLVVLSHEGYLLHAGLAPFLLNAVSWLCPSPEAPIAVHSSLASL
                     VNILRDSGVNALVQPEPGEALGVFCIDAYNDTLTEKLVQFVKHGGGLLIGGQACNWAS
                     QQGSDKVLFSFPGNQVTSVAGVYFTDVYGGINRFKVSKKVPKIPLHIRCWEELRRDQE
                     QLLDGISMLDIRTGGVPSQLLVHGSLAFPVGLDNSFLSCFLAAARYGCGRVVLAAHEA
                     MLCAPKMEPFLLNAIRWLSRDQGKTIGVNKSLKNLNSLLLKHGVKCSLESHLTSDMGV
                     YCCVAYSDQDAKKIQEFVAEGGGLLIGGQSWWWASQNQGSSALRSFPGNVVLNPFGLS
                     ILPQTISPGCFPVLPIDIRNYHFRRALSEFQAMVNHKGGNLEKKYFGKLGVDGAGFLQ
                     IPAKGVPAYISVHRILRKMLRQAGLPAVSKNNPVSSQSCEAALLCLATELAHSGTDCS
                     QIAHNHGTQTCSSDLCSSEHPITVEINGTNTGDSDVWMSTGLYLLEGQSTEISLSEPA
                     ASAGLKVQIGCHTDNLSHARQLFRAPVVTYQCCMDRTQRSVSCLWGGLLYIIVPKGCQ
                     LGPVSVTITKAVPAPYYKLGKTSLEEWKSCMQKNLGPWGELATDSVILTVPTESLKNL
                     EDPAPLLQLWDEIMKAVAKLAAQPFPFERPERIVTDVQISNGWMHSGYPIMCHVESVQ
                     ELVSLADIRSKGLWGPIHELGHNQQRSGWEFRPHTTEATCNLWSVYVHETVLGIPRAQ
                     AHPQLKPEEREKRIKEHLQKGAPLSDWKVWTALETYLQLQEVFGWEPFMNLFAEYQCI
                     VHIPKDNESKMNLWLKLFSEKVQKNLVPFFEAWGWPIQKPVAEALACFPSWQDHPLKM
                     YIGME"
     exon            847..1841
                     /gene="Tcaf2c"
                     /gene_synonym="Fam115c; Fam139a; Tcaf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..1939
                     /gene="Tcaf2c"
                     /gene_synonym="Fam115c; Fam139a; Tcaf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..2153
                     /gene="Tcaf2c"
                     /gene_synonym="Fam115c; Fam139a; Tcaf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2154..2393
                     /gene="Tcaf2c"
                     /gene_synonym="Fam115c; Fam139a; Tcaf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2394..2731
                     /gene="Tcaf2c"
                     /gene_synonym="Fam115c; Fam139a; Tcaf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2732..4440
                     /gene="Tcaf2c"
                     /gene_synonym="Fam115c; Fam139a; Tcaf2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaggccccg ccccaggaag acccttattc aaacagcgct ccgctcctcg gcagatacgg
       61 tctgccagca gcaaccacaa aagtctggtc cctgtttctc ccagtgtagg gctgggtgtc
      121 cgagcacttg ggccacgtgg ggaggaaacc cttaaagttc cagaaggcta ctggacgcca
      181 ttccggacag tcagtgaatc ttctcgcagc aattggcaga accatggcaa caactcctga
      241 tgctgctttt gaggccctca tgaatggagt gaccagctgg gatctcccta aagaattcac
      301 tcccagtgaa ctccttctta ttggagaggc agccttccca gtgatggtga acgacaaggg
      361 ccaggtgctc attgctgcct ctttctatgg ccaaggccgc ctggtggtcc tatcccatga
      421 gggctacctg ctgcatgctg gcttggctcc atttcttctc aatgcagtga gctggctctg
      481 cccctccccg gaggctccca ttgcagtgca ttcttccttg gcatccttag ttaacatcct
      541 cagggactct ggggtaaacg cactggttca gcctgagcct ggagaggctc tgggagtttt
      601 ttgcattgat gcctacaatg acaccttgac cgagaagcta gttcagtttg tgaagcatgg
      661 tgggggcttg ctcattggag gccaggcctg caattgggcc agtcaacagg ggagtgacaa
      721 agtgctgttc agtttccctg ggaaccaggt gacaagtgtg gctggagtgt acttcactga
      781 tgtctatggg ggtataaacc ggttcaaggt ctctaagaag gtacccaaga tccccctcca
      841 tatcaggtgt tgggaggagc tcaggcgtga ccaggagcag cttctggatg ggatctctat
      901 gttggacatc aggactgggg gtgtcccctc acagctgttg gtacatgggt ccctggcctt
      961 ccctgtgggc cttgataact ccttccttag ctgcttccta gcagctgccc gctatggttg
     1021 tggtcgggtg gtgttggctg cacacgaggc catgctctgt gctcctaaaa tggaaccctt
     1081 tttgctcaat gctatacgtt ggttgtccag agaccaggga aagactattg gggtgaacaa
     1141 aagtctcaag aatctgaatt ccctattgtt gaagcatgga gtgaagtgca gcctggagtc
     1201 ccatttgacc agtgatatgg gtgtctactg ctgtgtagct tatagtgacc aggatgccaa
     1261 gaaaatacag gagtttgtag cagagggtgg ggggttgctc attggtggtc agtcctggtg
     1321 gtgggcttcc cagaaccaag gcagctctgc attgcgtagt ttccctggga atgtcgtcct
     1381 caatcccttt ggcctcagca ttttgcctca gaccatcagc ccaggctgtt tccctgtcct
     1441 tcctatagac ataaggaact accattttcg aagggctctt tctgagttcc aggctatggt
     1501 gaaccacaag ggtgggaact tggaaaagaa gtattttgga aaattgggag tagatggagc
     1561 aggctttctt cagattcctg caaagggagt tcctgcttat atatctgtgc accggatcct
     1621 gaggaagatg ctacgtcagg caggcctccc tgctgtgagc aagaataacc cggtgtccag
     1681 tcagtcctgt gaggctgcac tgctctgtct agccacagag ctggcacatt ctgggactga
     1741 ttgctcccag atagctcata accatggcac tcagacctgc tcctctgatc tctgctcctc
     1801 agaacatccc attacagtgg agatcaatgg aaccaacaca ggtgacagtg atgtctggat
     1861 gagtactggg ctctacctcc tggaaggaca aagcacagag atttctctct ctgaacctgc
     1921 tgcctcggct ggcctgaagg tgcagatcgg atgtcacact gataatctca gtcatgccag
     1981 acagctgttc cgagcccctg tggtaacgta tcagtgctgt atggacagaa cccaacggtc
     2041 agtctcctgc ctctggggtg gtctcctgta catcattgtg cccaaaggct gtcaacttgg
     2101 ccctgtatct gtcaccatca caaaggcagt gcctgcccca tactacaagc taggtaagac
     2161 atcactggag gagtggaaga gctgcatgca gaagaacctg gggccctggg gagagttggc
     2221 cacagacagt gtcatcctga cagtgccaac cgaaagcctg aagaatctgg aagatccagc
     2281 tcctctgctc caactctggg atgagattat gaaggctgtg gccaagctgg cagcccagcc
     2341 cttccctttt gaaaggcctg agagaattgt cactgatgtt cagatatcaa atggctggat
     2401 gcattcagga taccccatca tgtgccatgt ggaatctgtg caagaactag tcagtttggc
     2461 agacataaga agtaagggcc tatggggacc catccatgag ctgggccaca atcagcaacg
     2521 cagtggttgg gagttccgcc cacataccac cgaggccacc tgcaatctct ggtcagtcta
     2581 tgttcatgag acagtcctgg ggattcccag agctcaggcc caccctcaac tgaaacctga
     2641 agaaagagag aagaggatca aagaacacct tcagaaggga gcacccctga gtgactggaa
     2701 ggtttggaca gcactggaga catatctgca gctccaggag gtctttgggt gggagccatt
     2761 catgaacctc tttgctgaat accaatgcat tgttcacatc cccaaagaca atgagagcaa
     2821 gatgaactta tggctgaagt tgttctctga gaaagtgcag aagaacctgg ttcctttctt
     2881 tgaagcctgg ggctggccta tccagaagcc agtggctgaa gccctggcct gctttccttc
     2941 ctggcaggat caccccttga agatgtacat tgggatggag tagtaggggc tgtggagaca
     3001 gttggggtgg gagaggtcat tgggtagggg aaatgggtgg gataaggaag gaccacagta
     3061 ctagcttcac tgtggtctag cttgagacac tcactgctta actatttttc tctactgttt
     3121 gattttcaaa tatattttgg gcggttttaa atatcattcc atgctttctt gcaaaaacta
     3181 cttgtgatag tgaacctagt gaatgttcct ttccacatcc catcagcata tcccaaactc
     3241 agggactttt tcctctgata ctacttgtat cccttggcag cttcttggca catgaaaagc
     3301 actaaaaaaa tacttgctat atgaaagaac actaaagtgt tgtgacatag aaggaacagt
     3361 cagtgcatgg tcctaagact gtgtacagca ttttctctga gttactggga taatcttcca
     3421 ccagttaata tctccttatc gtacaggaga aaatagcatg gatattaaac aacttctgca
     3481 gtcaagactg agaagagaaa gtgtcaaatt tcacagatgt ccataagggt gataaactgt
     3541 ggatcttatc ctcaacggat tgagaatgtt aacaaaactt tgcccaaaag atacatgaaa
     3601 gtttattgac ctttacttgc tttcctgtgt tcattattga aatgtgacaa aataccaaat
     3661 tggatctcta aatgttttgg taattaatct tctctttacg ttgccagaca ttcatttgtc
     3721 ttggaaggaa cctggccttg ggaaaaaaat ttaaaccaag gaaattcatt ttccaaactg
     3781 gtgatcatct tcattgtgat gggagggaga ggtgagtaga cagataatgc tggaattggg
     3841 gggttaccta agagatcaga ccaaatccta accttgtgca caccacctct ctggaggatc
     3901 tggagccctg tggggttttc ttctcattcc tgaaaagaga tcctggctct gcctctcgtt
     3961 tttatgctct tggttatctg tgactgcaat acccacagat tatgcttgtg tacataaaaa
     4021 caagactttt ttctgctcaa aattttatag ttctgtgttt agaaatctta tttaggaaaa
     4081 aaatattgaa gagtattaag ctcagtcaaa gtctcagcat aagtggggta gggatcagga
     4141 agtcccatcc ctagttggag atctgttggg atgactgctg ggaggagagt cagctttcgt
     4201 cagatatgtg gtccctgaga ggctacccat gctgtacacc tgcacttagc gctacatata
     4261 ggcagcgcta agggattcag tgagctgtaa aagaaagcac atgagtttag gtggaaatag
     4321 atatgtagga ctaggagatg aatgagaagg acatgcatta tggttttgat aaaagcacct
     4381 tatatccatg tatggaattt tcaacgaata aaaatgaata aaaagctata tgtaaatcca
//
224..2983
/gene="Tcaf2c"
/gene_synonym="Fam115c; Fam139a; Tcaf2"
/note="protein FAM115C-like; family with sequence
similarity 115, member C; TRPM8 channel-associated factor
2; family with sequence similarity 139, member A"
/codon_start=1
/product="TRPM8 channel associated factor 2C"
/protein_id="NP_001418920.1"
/db_xref="GeneID:100912416"
/db_xref="RGD:1591778"
/translation="MATTPDAAFEALMNGVTSWDLPKEFTPSELLLIGEAAFPVMVND
KGQVLIAASFYGQGRLVVLSHEGYLLHAGLAPFLLNAVSWLCPSPEAPIAVHSSLASL
VNILRDSGVNALVQPEPGEALGVFCIDAYNDTLTEKLVQFVKHGGGLLIGGQACNWAS
QQGSDKVLFSFPGNQVTSVAGVYFTDVYGGINRFKVSKKVPKIPLHIRCWEELRRDQE
QLLDGISMLDIRTGGVPSQLLVHGSLAFPVGLDNSFLSCFLAAARYGCGRVVLAAHEA
MLCAPKMEPFLLNAIRWLSRDQGKTIGVNKSLKNLNSLLLKHGVKCSLESHLTSDMGV
YCCVAYSDQDAKKIQEFVAEGGGLLIGGQSWWWASQNQGSSALRSFPGNVVLNPFGLS
ILPQTISPGCFPVLPIDIRNYHFRRALSEFQAMVNHKGGNLEKKYFGKLGVDGAGFLQ
IPAKGVPAYISVHRILRKMLRQAGLPAVSKNNPVSSQSCEAALLCLATELAHSGTDCS
QIAHNHGTQTCSSDLCSSEHPITVEINGTNTGDSDVWMSTGLYLLEGQSTEISLSEPA
ASAGLKVQIGCHTDNLSHARQLFRAPVVTYQCCMDRTQRSVSCLWGGLLYIIVPKGCQ
LGPVSVTITKAVPAPYYKLGKTSLEEWKSCMQKNLGPWGELATDSVILTVPTESLKNL
EDPAPLLQLWDEIMKAVAKLAAQPFPFERPERIVTDVQISNGWMHSGYPIMCHVESVQ
ELVSLADIRSKGLWGPIHELGHNQQRSGWEFRPHTTEATCNLWSVYVHETVLGIPRAQ
AHPQLKPEEREKRIKEHLQKGAPLSDWKVWTALETYLQLQEVFGWEPFMNLFAEYQCI
VHIPKDNESKMNLWLKLFSEKVQKNLVPFFEAWGWPIQKPVAEALACFPSWQDHPLKM
YIGME"
Feature NM_001431991 : 1 segment
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