LOCUS NM_002977 9719 bp mRNA linear PRI 13-DEC-2024
DEFINITION Homo sapiens sodium voltage-gated channel alpha subunit 9 (SCN9A),
transcript variant 1, mRNA.
ACCESSION NM_002977
VERSION NM_002977.4
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (bases 1 to 9719)
AUTHORS Kim,J.S., Meeker,S., Ru,F., Tran,M., Zabka,T.S., Hackos,D. and
Undem,B.J.
TITLE Role of NaV1.7 in postganglionic sympathetic nerve function in
human and guinea-pig arteries
JOURNAL J Physiol 602 (14), 3505-3518 (2024)
PUBMED 38743485
REMARK GeneRIF: Role of NaV1.7 in postganglionic sympathetic nerve
function in human and guinea-pig arteries.
REFERENCE 2 (bases 1 to 9719)
AUTHORS Noguchi,A., Tezuka,T., Okuda,H., Kobayashi,H., Harada,K.H.,
Yoshida,T., Akioka,S., Wada,K., Takeya,A., Kabata-Murasawa,R.,
Kondo,D., Ishikawa,K., Asano,T., Fujiwara,M., Hishikawa,N.,
Mizukami,T., Hitomi,T., Youssefian,S., Nagai,Y., Tanaka,M., Eto,K.,
Shiraishi,H., Amaya,F., Koizumi,A. and Takahashi,T.
TITLE Genetic Analysis of SCN11A, SCN10A, and SCN9A in Familial Episodic
Pain Syndrome (FEPS) in Japan and Proposal of Clinical Diagnostic
Criteria
JOURNAL Int J Mol Sci 25 (13), 6832 (2024)
PUBMED 38999942
REMARK GeneRIF: Genetic Analysis of SCN11A, SCN10A, and SCN9A in Familial
Episodic Pain Syndrome (FEPS) in Japan and Proposal of Clinical
Diagnostic Criteria.
Publication Status: Online-Only
REFERENCE 3 (bases 1 to 9719)
AUTHORS Waheed,S., Ramzan,K., Ahmad,S., Khan,M.S., Wajid,M., Ullah,H.,
Umar,A., Iqbal,R., Ullah,R. and Bari,A.
TITLE Identification and In-Silico study of non-synonymous functional
SNPs in the human SCN9A gene
JOURNAL PLoS One 19 (2), e0297367 (2024)
PUBMED 38394191
REMARK GeneRIF: Identification and In-Silico study of non-synonymous
functional SNPs in the human SCN9A gene.
Erratum:[PLoS One. 2024 Mar 26;19(3):e0301489. doi:
10.1371/journal.pone.0301489. PMID: 38530842]
Publication Status: Online-Only
REFERENCE 4 (bases 1 to 9719)
AUTHORS Cox,J.J., Reimann,F., Nicholas,A.K., Thornton,G., Roberts,E.,
Springell,K., Karbani,G., Jafri,H., Mannan,J., Raashid,Y.,
Al-Gazali,L., Hamamy,H., Valente,E.M., Gorman,S., Williams,R.,
McHale,D.P., Wood,J.N., Gribble,F.M. and Woods,C.G.
TITLE An SCN9A channelopathy causes congenital inability to experience
pain
JOURNAL Nature 444 (7121), 894-898 (2006)
PUBMED 17167479
REMARK GeneRIF: data suggest that SCN9A is an essential and non-redundant
requirement for nociception in humans
GeneRIF: An SCN9A channelopathy causes congenital inability to
experience pain
REFERENCE 5 (bases 1 to 9719)
AUTHORS Plummer,N.W. and Meisler,M.H.
TITLE Evolution and diversity of mammalian sodium channel genes
JOURNAL Genomics 57 (2), 323-331 (1999)
PUBMED 10198179
REMARK Review article
REFERENCE 6 (bases 1 to 9719)
AUTHORS Sangameswaran,L., Fish,L.M., Koch,B.D., Rabert,D.K., Delgado,S.G.,
Ilnicka,M., Jakeman,L.B., Novakovic,S., Wong,K., Sze,P.,
Tzoumaka,E., Stewart,G.R., Herman,R.C., Chan,H., Eglen,R.M. and
Hunter,J.C.
TITLE A novel tetrodotoxin-sensitive, voltage-gated sodium channel
expressed in rat and human dorsal root ganglia
JOURNAL J Biol Chem 272 (23), 14805-14809 (1997)
PUBMED 9169448
REFERENCE 7 (bases 1 to 9719)
AUTHORS Klugbauer,N., Lacinova,L., Flockerzi,V. and Hofmann,F.
TITLE Structure and functional expression of a new member of the
tetrodotoxin-sensitive voltage-activated sodium channel family from
human neuroendocrine cells
JOURNAL EMBO J 14 (6), 1084-1090 (1995)
PUBMED 7720699
REFERENCE 8 (bases 1 to 9719)
AUTHORS Schon,K.R., Parker,A.P.J. and Woods,C.G.
TITLE Congenital Insensitivity to Pain Overview
JOURNAL (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
Amemiya A (Eds.);
GENEREVIEWS(R);
(1993)
PUBMED 29419974
REFERENCE 9 (bases 1 to 9719)
AUTHORS Kurth,I.
TITLE Hereditary Sensory and Autonomic Neuropathy Type II
JOURNAL (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
Amemiya A (Eds.);
GENEREVIEWS(R);
(1993)
PUBMED 21089229
REFERENCE 10 (bases 1 to 9719)
AUTHORS Hisama,F.M., Dib-Hajj,S.D. and Waxman,S.G.
TITLE SCN9A Neuropathic Pain Syndromes
JOURNAL (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
Amemiya A (Eds.);
GENEREVIEWS(R);
(1993)
PUBMED 20301342
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AC074101.5, AC108146.3 and
AC107082.3.
On Dec 15, 2023 this sequence version replaced NM_002977.3.
Summary: This gene encodes a voltage-gated sodium channel which
plays a significant role in nociception signaling. Mutations in
this gene have been associated with primary erythermalgia,
channelopathy-associated insensitivity to pain, and paroxysmal
extreme pain disorder. [provided by RefSeq, Aug 2009].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
CDS exon combination :: DQ857292.1, X82835.1 [ECO:0000331]
RNAseq introns :: mixed sample support SAMEA1965299,
SAMEA1966682 [ECO:0006172]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-248 AC074101.5 41540-41787 c
249-556 AC108146.3 67152-67459 c
557-675 AC108146.3 62609-62727 c
676-765 AC108146.3 62163-62252 c
766-894 AC108146.3 61445-61573 c
895-986 AC108146.3 59891-59982 c
987-1199 AC108146.3 58743-58955 c
1200-1263 AC108146.3 50252-50315 c
1264-1405 AC108146.3 48884-49025 c
1406-1612 AC108146.3 44090-44296 c
1613-1900 AC108146.3 41989-42276 c
1901-2239 AC108146.3 40139-40477 c
2240-2369 AC108146.3 37332-37461 c
2370-2608 AC108146.3 36010-36248 c
2609-2782 AC108146.3 33793-33966 c
2783-3139 AC108146.3 32636-32992 c
3140-3616 AC108146.3 28052-28528 c
3617-3737 AC108146.3 7418-7538 c
3738-3892 AC107082.3 109099-109253 c
3893-4066 AC107082.3 104691-104864 c
4067-4189 AC107082.3 99937-100059 c
4190-4471 AC107082.3 95288-95569 c
4472-4525 AC107082.3 94267-94320 c
4526-4663 AC107082.3 93164-93301 c
4664-4768 AC107082.3 70957-71061 c
4769-5039 AC107082.3 70552-70822 c
5040-9719 AC107082.3 61782-66461 c
FEATURES Location/Qualifiers
source 1..9719
/organism="Homo sapiens"
/mol_type="mRNA"
/db_xref="taxon:9606"
/chromosome="2"
/map="2q24.3"
gene 1..9719
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/note="sodium voltage-gated channel alpha subunit 9"
/db_xref="GeneID:6335"
/db_xref="HGNC:HGNC:10597"
/db_xref="MIM:603415"
exon 1..248
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/inference="alignment:Splign:2.1.0"
exon 249..556
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/inference="alignment:Splign:2.1.0"
misc_feature 278..280
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/note="upstream in-frame stop codon"
CDS 299..6232
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/note="isoform 1 is encoded by transcript variant 1;
sodium channel, voltage-gated, type IX, alpha polypeptide;
sodium channel protein type 9 subunit alpha; sodium
channel, voltage-gated, type IX, alpha subunit;
voltage-gated sodium channel alpha subunit Nav1.7; hNE-Na;
peripheral sodium channel 1; neuroendocrine sodium
channel; sodium channel protein type IX subunit alpha;
voltage-gated sodium channel subunit alpha Nav1.7"
/codon_start=1
/product="sodium channel protein type 9 subunit alpha
isoform 1"
/protein_id="NP_002968.2"
/db_xref="CCDS:CCDS46441.1"
/db_xref="GeneID:6335"
/db_xref="HGNC:HGNC:10597"
/db_xref="MIM:603415"
/translation="MAMLPPPGPQSFVHFTKQSLALIEQRIAERKSKEPKEEKKDDDE
EAPKPSSDLEAGKQLPFIYGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNA
TPALYMLSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFT
GIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRV
LRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCF
RNSLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIG
RNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFY
LINLILAVVAMAYEEQNQANIEEAKQKELEFQQMLDRLKKEQEEAEAIAAAAAEYTSI
RRSRIMGLSESSSETSKLSSKSAKERRNRRKKKNQKKLSSGEEKGDAEKLSKSESEDS
IRRKSFHLGVEGHRRAHEKRLSTPNQSPLSIRGSLFSARRSSRTSLFSFKGRGRDIGS
ETEFADDEHSIFGDNESRRGSLFVPHRPQERRSSNISQASRSPPMLPVNGKMHSAVDC
NGVVSLVDGRSALMLPNGQLLPEGTTNQIHKKRRCSSYLLSEDMLNDPNLRQRAMSRA
SILTNTVEELEESRQKCPPWWYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAIT
ICIVLNTLFMAMEHHPMTEEFKNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWN
IFDSLIVTLSLVELFLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALG
NLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLC
GEWIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVLNLFLALLLSSFSSDNLTAIEEDP
DANNLQIAVTRIKKGINYVKQTLREFILKAFSKKPKISREIRQAEDLNTKKENYISNH
TLAEMSKGHNFLKEKDKISGFGSSVDKHLMEDSDGQSFIHNPSLTVTVPIAPGESDLE
NMNAEELSSDSDSEYSKVRLNRSSSSECSTVDNPLPGEGEEAEAEPMNSDEPEACFTD
GCVWRFSCCQVNIESGKGKIWWNIRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIY
IERKKTIKIILEYADKIFTYIFILEMLLKWIAYGYKTYFTNAWCWLDFLIVDVSLVTL
VANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIF
WLIFSIMGVNLFAGKFYECINTTDGSRFPASQVPNRSECFALMNVSQNVRWKNLKVNF
DNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFF
TLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKIQ
GCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGECV
LKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLARIGRIL
RLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEDGINDMF
NFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGI
FYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQ
FIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGES
GEMDSLRSQMEERFMSANPSKVSYEPITTTLKRKQEDVSATVIQRAYRRYRLRQNVKN
ISSIYIKDGDRDDDLLNKKDMAFDNVNENSSPEKTDATSSTTSPPSYDSVTKPDKEKY
EQDRTEKEDKGKDSKESKK"
misc_feature 374..463
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 632..1528
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
Region: I. /evidence=ECO:0000305"
misc_feature 674..733
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
transmembrane region"
misc_feature 749..814
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
transmembrane region"
misc_feature 854..910
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
transmembrane region"
misc_feature 923..925
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q15858.3); glycosylation site"
misc_feature 929..979
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
transmembrane region"
misc_feature 1022..1099
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
transmembrane region"
misc_feature 1145..1147
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000269|PubMed:30765606,
ECO:0007744|PDB:6J8G, ECO:0007744|PDB:6J8H,
ECO:0007744|PDB:6J8I, ECO:0007744|PDB:6J8J; propagated
from UniProtKB/Swiss-Prot (Q15858.3); glycosylation site"
misc_feature 1427..1504
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
transmembrane region"
misc_feature 1679..1927
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 1991..2131
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 2441..3232
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
Region: II. /evidence=ECO:0000305"
misc_feature 2501..2551
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
transmembrane region"
misc_feature 2579..2653
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
transmembrane region"
misc_feature 2681..2731
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
transmembrane region"
misc_feature 2729..2731
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/note="Is directly targeted by the spider protoxin-II.
/evidence=ECO:0000269|PubMed:30661758; propagated from
UniProtKB/Swiss-Prot (Q15858.3); other site"
misc_feature 2744..2746
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/note="Is directly targeted by the spider protoxin-II.
/evidence=ECO:0000269|PubMed:30661758; propagated from
UniProtKB/Swiss-Prot (Q15858.3); other site"
misc_feature 2759..2809
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
transmembrane region"
misc_feature 2861..2929
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
transmembrane region"
misc_feature 3086..3166
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
transmembrane region"
misc_feature 3569..3709
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 3803..4729
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
Region: III. /evidence=ECO:0000305"
misc_feature 3827..3901
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
transmembrane region"
misc_feature 3938..4015
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
transmembrane region"
misc_feature 4022..4099
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
transmembrane region"
misc_feature 4127..4177
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
transmembrane region"
misc_feature 4217..4291
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
transmembrane region"
misc_feature 4319..4321
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000269|PubMed:30765606,
ECO:0007744|PDB:6J8G, ECO:0007744|PDB:6J8H,
ECO:0007744|PDB:6J8I, ECO:0007744|PDB:6J8J; propagated
from UniProtKB/Swiss-Prot (Q15858.3); glycosylation site"
misc_feature 4361..4363
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000269|PubMed:30765606,
ECO:0007744|PDB:6J8G, ECO:0007744|PDB:6J8H,
ECO:0007744|PDB:6J8I, ECO:0007744|PDB:6J8J; propagated
from UniProtKB/Swiss-Prot (Q15858.3); glycosylation site"
misc_feature 4388..4390
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000269|PubMed:30765606,
ECO:0007744|PDB:6J8G, ECO:0007744|PDB:6J8H,
ECO:0007744|PDB:6J8I, ECO:0007744|PDB:6J8J; propagated
from UniProtKB/Swiss-Prot (Q15858.3); glycosylation site"
misc_feature 4559..4636
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
transmembrane region"
misc_feature 4733..4735
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/note="Phosphoserine, by PKC.
/evidence=ECO:0000269|PubMed:25240195; propagated from
UniProtKB/Swiss-Prot (Q15858.3); phosphorylation site"
misc_feature 4754..5650
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
Region: IV. /evidence=ECO:0000305"
misc_feature 4808..4867
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
transmembrane region"
misc_feature 4901..4966
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
transmembrane region"
misc_feature 4994..5059
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
transmembrane region"
misc_feature 5087..5146
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
transmembrane region"
misc_feature 5186..5254
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
transmembrane region"
misc_feature 5465..5542
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
transmembrane region"
misc_feature 6065..6229
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
exon 557..675
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/inference="alignment:Splign:2.1.0"
exon 676..765
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/inference="alignment:Splign:2.1.0"
exon 766..894
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/inference="alignment:Splign:2.1.0"
exon 895..986
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/inference="alignment:Splign:2.1.0"
exon 987..1199
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/inference="alignment:Splign:2.1.0"
exon 1200..1263
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/inference="alignment:Splign:2.1.0"
exon 1264..1405
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/inference="alignment:Splign:2.1.0"
exon 1406..1612
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/inference="alignment:Splign:2.1.0"
exon 1613..1900
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/inference="alignment:Splign:2.1.0"
exon 1901..2239
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/inference="alignment:Splign:2.1.0"
exon 2240..2369
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/inference="alignment:Splign:2.1.0"
exon 2370..2608
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/inference="alignment:Splign:2.1.0"
exon 2609..2782
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/inference="alignment:Splign:2.1.0"
exon 2783..3139
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/inference="alignment:Splign:2.1.0"
exon 3140..3616
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/inference="alignment:Splign:2.1.0"
exon 3617..3737
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/inference="alignment:Splign:2.1.0"
exon 3738..3892
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/inference="alignment:Splign:2.1.0"
exon 3893..4066
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/inference="alignment:Splign:2.1.0"
exon 4067..4189
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/inference="alignment:Splign:2.1.0"
exon 4190..4471
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/inference="alignment:Splign:2.1.0"
exon 4472..4525
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/inference="alignment:Splign:2.1.0"
exon 4526..4663
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/inference="alignment:Splign:2.1.0"
exon 4664..4768
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/inference="alignment:Splign:2.1.0"
exon 4769..5039
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/inference="alignment:Splign:2.1.0"
exon 5040..9719
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/inference="alignment:Splign:2.1.0"
regulatory 6496..6501
/regulatory_class="polyA_signal_sequence"
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/note="hexamer: AATAAA"
polyA_site 6521
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/note="major polyA site"
regulatory 9697..9702
/regulatory_class="polyA_signal_sequence"
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/note="hexamer: AATAAA"
polyA_site 9719
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/note="major polyA site"
ORIGIN
1 agtctgcttg caggcggtcg ccagcgctcc agcggcggct gtcggctttc caattccgcc
61 agctcggctg aggctgggct agcctgggtg ccagtggctg ctagcggcag gcgtcccctg
121 agcaacagga gcccagagaa aaagaagcag ccctgagaga gcgccgggga aggagaggcc
181 cgcgccctct cctggagcca gattctgcag gtgcactggg tggggatgat cggcgggcta
241 ggttgcaagc ctcttatgtg aggagctgaa gaggaattaa aatatacagg atgaaaagat
301 ggcaatgttg cctcccccag gacctcagag ctttgtccat ttcacaaaac agtctcttgc
361 cctcattgaa caacgcattg ctgaaagaaa atcaaaggaa cccaaagaag aaaagaaaga
421 tgatgatgaa gaagccccaa agccaagcag tgacttggaa gctggcaaac agctgccctt
481 catctatggg gacattcctc ccggcatggt gtcagagccc ctggaggact tggaccccta
541 ctatgcagac aaaaagactt tcatagtatt gaacaaaggg aaaacaatct tccgtttcaa
601 tgccacacct gctttatata tgctttctcc tttcagtcct ctaagaagaa tatctattaa
661 gattttagta cactccttat tcagcatgct catcatgtgc actattctga caaactgcat
721 atttatgacc atgaataacc caccggactg gaccaaaaat gtcgagtaca cttttactgg
781 aatatatact tttgaatcac ttgtaaaaat ccttgcaaga ggcttctgtg taggagaatt
841 cacttttctt cgtgacccgt ggaactggct ggattttgtc gtcattgttt ttgcgtattt
901 aacagaattt gtaaacctag gcaatgtttc agctcttcga actttcagag tattgagagc
961 tttgaaaact atttctgtaa tcccaggcct gaagacaatt gtaggggctt tgatccagtc
1021 agtgaagaag ctttctgatg tcatgatcct gactgtgttc tgtctgagtg tgtttgcact
1081 aattggacta cagctgttca tgggaaacct gaagcataaa tgttttcgaa attcacttga
1141 aaataatgaa acattagaaa gcataatgaa taccctagag agtgaagaag actttagaaa
1201 atatttttat tacttggaag gatccaaaga tgctctcctt tgtggtttca gcacagattc
1261 aggtcagtgt ccagaggggt acacctgtgt gaaaattggc agaaaccctg attatggcta
1321 cacgagcttt gacactttca gctgggcctt cttagccttg tttaggctaa tgacccaaga
1381 ttactgggaa aacctttacc aacagacgct gcgtgctgct ggcaaaacct acatgatctt
1441 ctttgtcgta gtgattttcc tgggctcctt ttatctaata aacttgatcc tggctgtggt
1501 tgccatggca tatgaagaac agaaccaggc aaacattgaa gaagctaaac agaaagaatt
1561 agaatttcaa cagatgttag accgtcttaa aaaagagcaa gaagaagctg aggcaattgc
1621 agcggcagcg gctgaatata caagtattag gagaagcaga attatgggcc tctcagagag
1681 ttcttctgaa acatccaaac tgagctctaa aagtgctaaa gaaagaagaa acagaagaaa
1741 gaaaaagaat caaaagaagc tctccagtgg agaggaaaag ggagatgctg agaaattgtc
1801 gaaatcagaa tcagaggaca gcatcagaag aaaaagtttc caccttggtg tcgaagggca
1861 taggcgagca catgaaaaga ggttgtctac ccccaatcag tcaccactca gcattcgtgg
1921 ctccttgttt tctgcaaggc gaagcagcag aacaagtctt tttagtttca aaggcagagg
1981 aagagatata ggatctgaga ctgaatttgc cgatgatgag cacagcattt ttggagacaa
2041 tgagagcaga aggggctcac tgtttgtgcc ccacagaccc caggagcgac gcagcagtaa
2101 catcagccaa gccagtaggt ccccaccaat gctgccggtg aacgggaaaa tgcacagtgc
2161 tgtggactgc aacggtgtgg tctccctggt tgatggacgc tcagccctca tgctccccaa
2221 tggacagctt ctgccagagg gcacgaccaa tcaaatacac aagaaaaggc gttgtagttc
2281 ctatctcctt tcagaggata tgctgaatga tcccaacctc agacagagag caatgagtag
2341 agcaagcata ttaacaaaca ctgtggaaga acttgaagag tccagacaaa aatgtccacc
2401 ttggtggtac agatttgcac acaaattctt gatctggaat tgctctccat attggataaa
2461 attcaaaaag tgtatctatt ttattgtaat ggatcctttt gtagatcttg caattaccat
2521 ttgcatagtt ttaaacacat tatttatggc tatggaacac cacccaatga ctgaggaatt
2581 caaaaatgta cttgctatag gaaatttggt ctttactgga atctttgcag ctgaaatggt
2641 attaaaactg attgccatgg atccatatga gtatttccaa gtaggctgga atatttttga
2701 cagccttatt gtgactttaa gtttagtgga gctctttcta gcagatgtgg aaggattgtc
2761 agttctgcga tcattcagac tgctccgagt cttcaagttg gcaaaatcct ggccaacatt
2821 gaacatgctg attaagatca ttggtaactc agtaggggct ctaggtaacc tcaccttagt
2881 gttggccatc atcgtcttca tttttgctgt ggtcggcatg cagctctttg gtaagagcta
2941 caaagaatgt gtctgcaaga tcaatgatga ctgtacgctc ccacggtggc acatgaacga
3001 cttcttccac tccttcctga ttgtgttccg cgtgctgtgt ggagagtgga tagagaccat
3061 gtgggactgt atggaggtcg ctggtcaagc tatgtgcctt attgtttaca tgatggtcat
3121 ggtcattgga aacctggtgg tcctaaacct atttctggcc ttattattga gctcatttag
3181 ttcagacaat cttacagcaa ttgaagaaga ccctgatgca aacaacctcc agattgcagt
3241 gactagaatt aaaaagggaa taaattatgt gaaacaaacc ttacgtgaat ttattctaaa
3301 agcattttcc aaaaagccaa agatttccag ggagataaga caagcagaag atctgaatac
3361 taagaaggaa aactatattt ctaaccatac acttgctgaa atgagcaaag gtcacaattt
3421 cctcaaggaa aaagataaaa tcagtggttt tggaagcagc gtggacaaac acttgatgga
3481 agacagtgat ggtcaatcat ttattcacaa tcccagcctc acagtgacag tgccaattgc
3541 acctggggaa tccgatttgg aaaatatgaa tgctgaggaa cttagcagtg attcggatag
3601 tgaatacagc aaagtgagat taaaccggtc aagctcctca gagtgcagca cagttgataa
3661 ccctttgcct ggagaaggag aagaagcaga ggctgaacct atgaattccg atgagccaga
3721 ggcctgtttc acagatggtt gtgtatggag gttctcatgc tgccaagtta acatagagtc
3781 agggaaagga aaaatctggt ggaacatcag gaaaacctgc tacaagattg ttgaacacag
3841 ttggtttgaa agcttcattg tcctcatgat cctgctcagc agtggtgccc tggcttttga
3901 agatatttat attgaaagga aaaagaccat taagattatc ctggagtatg cagacaagat
3961 cttcacttac atcttcattc tggaaatgct tctaaaatgg atagcatatg gttataaaac
4021 atatttcacc aatgcctggt gttggctgga tttcctaatt gttgatgttt ctttggttac
4081 tttagtggca aacactcttg gctactcaga tcttggcccc attaaatccc ttcggacact
4141 gagagcttta agacctctaa gagccttatc tagatttgaa ggaatgaggg tcgttgtgaa
4201 tgcactcata ggagcaattc cttccatcat gaatgtgcta cttgtgtgtc ttatattctg
4261 gctgatattc agcatcatgg gagtaaattt gtttgctggc aagttctatg agtgtattaa
4321 caccacagat gggtcacggt ttcctgcaag tcaagttcca aatcgttccg aatgttttgc
4381 ccttatgaat gttagtcaaa atgtgcgatg gaaaaacctg aaagtgaact ttgataatgt
4441 cggacttggt tacctatctc tgcttcaagt tgcaactttt aagggatgga cgattattat
4501 gtatgcagca gtggattctg ttaatgtaga caagcagccc aaatatgaat atagcctcta
4561 catgtatatt tattttgtcg tctttatcat ctttgggtca ttcttcactt tgaacttgtt
4621 cattggtgtc atcatagata atttcaacca acagaaaaag aagcttggag gtcaagacat
4681 ctttatgaca gaagaacaga agaaatacta taatgcaatg aaaaagctgg ggtccaagaa
4741 gccacaaaag ccaattcctc gaccagggaa caaaatccaa ggatgtatat ttgacctagt
4801 gacaaatcaa gcctttgata ttagtatcat ggttcttatc tgtctcaaca tggtaaccat
4861 gatggtagaa aaggagggtc aaagtcaaca tatgactgaa gttttatatt ggataaatgt
4921 ggtttttata atccttttca ctggagaatg tgtgctaaaa ctgatctccc tcagacacta
4981 ctacttcact gtaggatgga atatttttga ttttgtggtt gtgattatct ccattgtagg
5041 tatgtttcta gctgatttga ttgaaacgta ttttgtgtcc cctaccctgt tccgagtgat
5101 ccgtcttgcc aggattggcc gaatcctacg tctagtcaaa ggagcaaagg ggatccgcac
5161 gctgctcttt gctttgatga tgtcccttcc tgcgttgttt aacatcggcc tcctgctctt
5221 cctggtcatg ttcatctacg ccatctttgg aatgtccaac tttgcctatg ttaaaaagga
5281 agatggaatt aatgacatgt tcaattttga gacctttggc aacagtatga tttgcctgtt
5341 ccaaattaca acctctgctg gctgggatgg attgctagca cctattctta acagtaagcc
5401 acccgactgt gacccaaaaa aagttcatcc tggaagttca gttgaaggag actgtggtaa
5461 cccatctgtt ggaatattct actttgttag ttatatcatc atatccttcc tggttgtggt
5521 gaacatgtac attgcagtca tactggagaa ttttagtgtt gccactgaag aaagtactga
5581 acctctgagt gaggatgact ttgagatgtt ctatgaggtt tgggagaagt ttgatcccga
5641 tgcgacccag tttatagagt tctctaaact ctctgatttt gcagctgccc tggatcctcc
5701 tcttctcata gcaaaaccca acaaagtcca gctcattgcc atggatctgc ccatggttag
5761 tggtgaccgg atccattgtc ttgacatctt atttgctttt acaaagcgtg ttttgggtga
5821 gagtggggag atggattctc ttcgttcaca gatggaagaa aggttcatgt ctgcaaatcc
5881 ttccaaagtg tcctatgaac ccatcacaac cacactaaaa cggaaacaag aggatgtgtc
5941 tgctactgtc attcagcgtg cttatagacg ttaccgctta aggcaaaatg tcaaaaatat
6001 atcaagtata tacataaaag atggagacag agatgatgat ttactcaata aaaaagatat
6061 ggcttttgat aatgttaatg agaactcaag tccagaaaaa acagatgcca cttcatccac
6121 cacctctcca ccttcatatg atagtgtaac aaagccagac aaagagaaat atgaacaaga
6181 cagaacagaa aaggaagaca aagggaaaga cagcaaggaa agcaaaaaat agagcttcat
6241 ttttgatata ttgtttacag cctgtgaaag tgatttattt gtgttaataa aactcttttg
6301 aggaagtcta tgccaaaatc ctttttatca aaatattctc gaaggcagtg cagtcactaa
6361 ctctgatttc ctaagaaagg tgggcagcat tagcagatgg ttatttttgc actgatgatt
6421 ctttaagaat cgtaagagaa ctctgtagga attattgatt atagcataca aaagtgattc
6481 agttttttgg tttttaataa atcagaagac catgtagaaa acttttacat ctgccttgtc
6541 atcttttcac aggattgtaa ttagtcttgt ttcccatgta aataaacaac acacgcatac
6601 agaaaaatct attatttatc tattatttgg aaatcaacaa aagtatttgc cttggctttg
6661 caatgaaatg cttgatagaa gtaatggaca ttagttatga atgtttagtt aaaatgcatt
6721 attagggagc ttgacttttt atcaatgtac agaggttatt ctatattttg aggtgcttaa
6781 atttattcta cattgcatca gaaccaattt atatgtgcct ataaaatgcc atgggattaa
6841 aaatatatgt aggctattca tttctacaaa tgtttttcat tcatcttgac tcacatgcca
6901 acaaggataa gacttacctt tagagtattg tgtttcatag cctttcttct ttcatatccc
6961 tttttgttca tagaataacc acagaacttg aaaaattatt ctaagtacat attacactcc
7021 tcaaaaaaaa caaagataac tgagaaaaaa gttattgaca gaagttctat ttgctattat
7081 ttacatagcc taacatttga ctgtgctgcc caaaatactg ataatagtct cttaaactct
7141 tttgtcaaat tttcctgctt tcttatgcag tattgtttag tcatcctttc gctgtaagca
7201 aagttgatga aatccttcct gatatgcagt tagttgtttg accacggtac atacttgagc
7261 agataataac ttgggcacag tatttattgc atcacttgta tacaatcccg tgtttggcaa
7321 gctttcaaat catgtaatat gacagacttt acacagatat gtgtttagta tgaataaaaa
7381 agcattgaaa tagggattct tgccaacttg ctctcttgcc accaacttac tttcctaaat
7441 tatggaagta atcttttttg gatatacttc aatgtataca atgaggaaga tgtcaccttc
7501 tccttaaaat tctatgatgt gaaatatatt ttgcctcaat caacacagta ccatgggctt
7561 ctaatttatc aagcacatat tcattttgca ttagctgtag acatctagtt ttttgaaaac
7621 acctattaat agtaatttga aaagaaataa ccataatgct ttttttcgtg agtttatttc
7681 aggaatatga gatctttctt ctataaagtt attcatgcac aggcaaaaat tgagctacac
7741 aggtagaatg tagttttact tagaagattt ttgtgggagg ttttgaagca aatatataaa
7801 acaactttca ctaatttgct ttccatattt aaaaaataat aaattacatt tatataataa
7861 atgtttaaag cacatatttt ttgttgttct ggcaatttaa aaagaaagag gatttaaacg
7921 tacctataga aacaaagatt tatggttaaa gaatgagatc agaagtctag aatgttttta
7981 aattgtgata tattttacaa catccgttat tactttgaga catttgtcct aatctacgta
8041 taaaactcaa tctagggcta aagattcttt ataccatctt aggttcattc atcttaggct
8101 atttgaacca ctttttaatt taatatgaaa gacaccatgc agtgttttcc gagactacat
8161 agatcatttt atcacatacc taccaagcct gttggaaata ggttttgata atttaagtag
8221 ggacctatac aaaatatatt acatttatca gatttttaaa tacattcaat taagaattta
8281 acatcacctt aaatttgaat tcaatctacc gttatttcaa actcacaaat ataactgcat
8341 tatgaatact tacataatgt agtaagacaa gatgtttgac aggttcgtgt gtaattttct
8401 attaatgttt ttacattgcc ttgtttttat gtaaaataaa aaatatgggc aactggtttg
8461 ttaacaacac aatttcttct tagcatttca aaaatatata taaagttgtt ctttttccta
8521 tttcatgaac tatgtttttt tttaaaataa catggttaag ttttatatat atttacgttt
8581 gtttcaggaa tgtctacttg tgacttttta tcaattaaaa ataatatttg gaagaaagag
8641 cttattaagt ataagcttga agtaaaatta gacctctctt tccatgtaga ttactgtttg
8701 tactgatggt ttcacccttc agaaggcact gtcatattaa tatttaaatt ttataatcgc
8761 tgaacttatt acacccaaca atacagaaag gcagttacac tgaagaactt aacttagaat
8821 aaaatggaag caaacaggtt ttctaaaaac ttttttaagt gaccaggtct cgctctgtca
8881 cccaggctag agtgcaatgg catgatcata gctctctgca gcctcaactc tgggctcaag
8941 caaccctcct gcctcagcct cccaagtagc taagactaca ggtacatgcc accatgcctg
9001 gctaatattt aaatttttgt agataagggg tcttgctatg ttgcccaggc tagtctcaaa
9061 ctcctggctt caagtgttcc tactgtcatg acctgccaac atgctggggt tacaggcatg
9121 agccaccatg ccccaaacag gtttgaacac aaatctttcg gatgaaaatt agagaaccta
9181 attttagctt tttgatagtt acctagtttg caaaagattt gggtgacttg tgagctgttt
9241 ttaaatgctg attgttgaac atcacaaccc aaaatactta gcatgatttt atagagtttt
9301 gatagcttta ttaaaaagag tgaaaataaa atgcatatgt aaataaagca gttctaaata
9361 gctatttcag agaaatgtta atagaagtgc tgaaagaagg gccaactaaa ttaggatggc
9421 cagggaattg gcctgggttt aggacctatg tatgaaggcc accaattttt taaaaatatc
9481 tgtggtttat tatgttatta tcttcttgag gaaaacaatc aagaattgct tcatgaaaat
9541 aaataaatag ccatgaatat cataaagctg tttacatagg attctttaca aatttcatag
9601 atctatgaat gctcaaaatg tttgagtttg ccataaatta tattgtagtt atattgtagt
9661 tatacttgag actgacacat tgtaatataa tctaagaata aaagttatac aaaataaaa
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