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Homo sapiens sodium voltage-gated channel alpha subunit 9 (SCN9A), transcript variant 1, mRNA

NCBI Reference Sequence: NM_002977.4

FASTA Graphics 

LOCUS       NM_002977               9719 bp    mRNA    linear   PRI 13-DEC-2024
DEFINITION  Homo sapiens sodium voltage-gated channel alpha subunit 9 (SCN9A),
            transcript variant 1, mRNA.
ACCESSION   NM_002977
VERSION     NM_002977.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9719)
  AUTHORS   Kim,J.S., Meeker,S., Ru,F., Tran,M., Zabka,T.S., Hackos,D. and
            Undem,B.J.
  TITLE     Role of NaV1.7 in postganglionic sympathetic nerve function in
            human and guinea-pig arteries
  JOURNAL   J Physiol 602 (14), 3505-3518 (2024)
   PUBMED   38743485
  REMARK    GeneRIF: Role of NaV1.7 in postganglionic sympathetic nerve
            function in human and guinea-pig arteries.
REFERENCE   2  (bases 1 to 9719)
  AUTHORS   Noguchi,A., Tezuka,T., Okuda,H., Kobayashi,H., Harada,K.H.,
            Yoshida,T., Akioka,S., Wada,K., Takeya,A., Kabata-Murasawa,R.,
            Kondo,D., Ishikawa,K., Asano,T., Fujiwara,M., Hishikawa,N.,
            Mizukami,T., Hitomi,T., Youssefian,S., Nagai,Y., Tanaka,M., Eto,K.,
            Shiraishi,H., Amaya,F., Koizumi,A. and Takahashi,T.
  TITLE     Genetic Analysis of SCN11A, SCN10A, and SCN9A in Familial Episodic
            Pain Syndrome (FEPS) in Japan and Proposal of Clinical Diagnostic
            Criteria
  JOURNAL   Int J Mol Sci 25 (13), 6832 (2024)
   PUBMED   38999942
  REMARK    GeneRIF: Genetic Analysis of SCN11A, SCN10A, and SCN9A in Familial
            Episodic Pain Syndrome (FEPS) in Japan and Proposal of Clinical
            Diagnostic Criteria.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9719)
  AUTHORS   Waheed,S., Ramzan,K., Ahmad,S., Khan,M.S., Wajid,M., Ullah,H.,
            Umar,A., Iqbal,R., Ullah,R. and Bari,A.
  TITLE     Identification and In-Silico study of non-synonymous functional
            SNPs in the human SCN9A gene
  JOURNAL   PLoS One 19 (2), e0297367 (2024)
   PUBMED   38394191
  REMARK    GeneRIF: Identification and In-Silico study of non-synonymous
            functional SNPs in the human SCN9A gene.
            Erratum:[PLoS One. 2024 Mar 26;19(3):e0301489. doi:
            10.1371/journal.pone.0301489. PMID: 38530842]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9719)
  AUTHORS   Cox,J.J., Reimann,F., Nicholas,A.K., Thornton,G., Roberts,E.,
            Springell,K., Karbani,G., Jafri,H., Mannan,J., Raashid,Y.,
            Al-Gazali,L., Hamamy,H., Valente,E.M., Gorman,S., Williams,R.,
            McHale,D.P., Wood,J.N., Gribble,F.M. and Woods,C.G.
  TITLE     An SCN9A channelopathy causes congenital inability to experience
            pain
  JOURNAL   Nature 444 (7121), 894-898 (2006)
   PUBMED   17167479
  REMARK    GeneRIF: data suggest that SCN9A is an essential and non-redundant
            requirement for nociception in humans
            GeneRIF: An SCN9A channelopathy causes congenital inability to
            experience pain
REFERENCE   5  (bases 1 to 9719)
  AUTHORS   Plummer,N.W. and Meisler,M.H.
  TITLE     Evolution and diversity of mammalian sodium channel genes
  JOURNAL   Genomics 57 (2), 323-331 (1999)
   PUBMED   10198179
  REMARK    Review article
REFERENCE   6  (bases 1 to 9719)
  AUTHORS   Sangameswaran,L., Fish,L.M., Koch,B.D., Rabert,D.K., Delgado,S.G.,
            Ilnicka,M., Jakeman,L.B., Novakovic,S., Wong,K., Sze,P.,
            Tzoumaka,E., Stewart,G.R., Herman,R.C., Chan,H., Eglen,R.M. and
            Hunter,J.C.
  TITLE     A novel tetrodotoxin-sensitive, voltage-gated sodium channel
            expressed in rat and human dorsal root ganglia
  JOURNAL   J Biol Chem 272 (23), 14805-14809 (1997)
   PUBMED   9169448
REFERENCE   7  (bases 1 to 9719)
  AUTHORS   Klugbauer,N., Lacinova,L., Flockerzi,V. and Hofmann,F.
  TITLE     Structure and functional expression of a new member of the
            tetrodotoxin-sensitive voltage-activated sodium channel family from
            human neuroendocrine cells
  JOURNAL   EMBO J 14 (6), 1084-1090 (1995)
   PUBMED   7720699
REFERENCE   8  (bases 1 to 9719)
  AUTHORS   Schon,K.R., Parker,A.P.J. and Woods,C.G.
  TITLE     Congenital Insensitivity to Pain Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   29419974
REFERENCE   9  (bases 1 to 9719)
  AUTHORS   Kurth,I.
  TITLE     Hereditary Sensory and Autonomic Neuropathy Type II
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   21089229
REFERENCE   10 (bases 1 to 9719)
  AUTHORS   Hisama,F.M., Dib-Hajj,S.D. and Waxman,S.G.
  TITLE     SCN9A Neuropathic Pain Syndromes
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301342
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC074101.5, AC108146.3 and
            AC107082.3.
            
            On Dec 15, 2023 this sequence version replaced NM_002977.3.
            
            Summary: This gene encodes a voltage-gated sodium channel which
            plays a significant role in nociception signaling. Mutations in
            this gene have been associated with primary erythermalgia,
            channelopathy-associated insensitivity to pain, and paroxysmal
            extreme pain disorder. [provided by RefSeq, Aug 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: DQ857292.1, X82835.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA1965299,
                                    SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-248               AC074101.5         41540-41787         c
            249-556             AC108146.3         67152-67459         c
            557-675             AC108146.3         62609-62727         c
            676-765             AC108146.3         62163-62252         c
            766-894             AC108146.3         61445-61573         c
            895-986             AC108146.3         59891-59982         c
            987-1199            AC108146.3         58743-58955         c
            1200-1263           AC108146.3         50252-50315         c
            1264-1405           AC108146.3         48884-49025         c
            1406-1612           AC108146.3         44090-44296         c
            1613-1900           AC108146.3         41989-42276         c
            1901-2239           AC108146.3         40139-40477         c
            2240-2369           AC108146.3         37332-37461         c
            2370-2608           AC108146.3         36010-36248         c
            2609-2782           AC108146.3         33793-33966         c
            2783-3139           AC108146.3         32636-32992         c
            3140-3616           AC108146.3         28052-28528         c
            3617-3737           AC108146.3         7418-7538           c
            3738-3892           AC107082.3         109099-109253       c
            3893-4066           AC107082.3         104691-104864       c
            4067-4189           AC107082.3         99937-100059        c
            4190-4471           AC107082.3         95288-95569         c
            4472-4525           AC107082.3         94267-94320         c
            4526-4663           AC107082.3         93164-93301         c
            4664-4768           AC107082.3         70957-71061         c
            4769-5039           AC107082.3         70552-70822         c
            5040-9719           AC107082.3         61782-66461         c
FEATURES             Location/Qualifiers
     source          1..9719
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q24.3"
     gene            1..9719
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /note="sodium voltage-gated channel alpha subunit 9"
                     /db_xref="GeneID:6335"
                     /db_xref="HGNC:HGNC:10597"
                     /db_xref="MIM:603415"
     exon            1..248
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /inference="alignment:Splign:2.1.0"
     exon            249..556
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    278..280
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /note="upstream in-frame stop codon"
     CDS             299..6232
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     sodium channel, voltage-gated, type IX, alpha polypeptide;
                     sodium channel protein type 9 subunit alpha; sodium
                     channel, voltage-gated, type IX, alpha subunit;
                     voltage-gated sodium channel alpha subunit Nav1.7; hNE-Na;
                     peripheral sodium channel 1; neuroendocrine sodium
                     channel; sodium channel protein type IX subunit alpha;
                     voltage-gated sodium channel subunit alpha Nav1.7"
                     /codon_start=1
                     /product="sodium channel protein type 9 subunit alpha
                     isoform 1"
                     /protein_id="NP_002968.2"
                     /db_xref="CCDS:CCDS46441.1"
                     /db_xref="GeneID:6335"
                     /db_xref="HGNC:HGNC:10597"
                     /db_xref="MIM:603415"
                     /translation="MAMLPPPGPQSFVHFTKQSLALIEQRIAERKSKEPKEEKKDDDE
                     EAPKPSSDLEAGKQLPFIYGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNA
                     TPALYMLSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFT
                     GIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRV
                     LRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCF
                     RNSLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIG
                     RNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFY
                     LINLILAVVAMAYEEQNQANIEEAKQKELEFQQMLDRLKKEQEEAEAIAAAAAEYTSI
                     RRSRIMGLSESSSETSKLSSKSAKERRNRRKKKNQKKLSSGEEKGDAEKLSKSESEDS
                     IRRKSFHLGVEGHRRAHEKRLSTPNQSPLSIRGSLFSARRSSRTSLFSFKGRGRDIGS
                     ETEFADDEHSIFGDNESRRGSLFVPHRPQERRSSNISQASRSPPMLPVNGKMHSAVDC
                     NGVVSLVDGRSALMLPNGQLLPEGTTNQIHKKRRCSSYLLSEDMLNDPNLRQRAMSRA
                     SILTNTVEELEESRQKCPPWWYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAIT
                     ICIVLNTLFMAMEHHPMTEEFKNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWN
                     IFDSLIVTLSLVELFLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALG
                     NLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLC
                     GEWIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVLNLFLALLLSSFSSDNLTAIEEDP
                     DANNLQIAVTRIKKGINYVKQTLREFILKAFSKKPKISREIRQAEDLNTKKENYISNH
                     TLAEMSKGHNFLKEKDKISGFGSSVDKHLMEDSDGQSFIHNPSLTVTVPIAPGESDLE
                     NMNAEELSSDSDSEYSKVRLNRSSSSECSTVDNPLPGEGEEAEAEPMNSDEPEACFTD
                     GCVWRFSCCQVNIESGKGKIWWNIRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIY
                     IERKKTIKIILEYADKIFTYIFILEMLLKWIAYGYKTYFTNAWCWLDFLIVDVSLVTL
                     VANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIF
                     WLIFSIMGVNLFAGKFYECINTTDGSRFPASQVPNRSECFALMNVSQNVRWKNLKVNF
                     DNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFF
                     TLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKIQ
                     GCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGECV
                     LKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLARIGRIL
                     RLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEDGINDMF
                     NFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGI
                     FYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQ
                     FIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGES
                     GEMDSLRSQMEERFMSANPSKVSYEPITTTLKRKQEDVSATVIQRAYRRYRLRQNVKN
                     ISSIYIKDGDRDDDLLNKKDMAFDNVNENSSPEKTDATSSTTSPPSYDSVTKPDKEKY
                     EQDRTEKEDKGKDSKESKK"
     misc_feature    374..463
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    632..1528
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
                     Region: I. /evidence=ECO:0000305"
     misc_feature    674..733
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
                     transmembrane region"
     misc_feature    749..814
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
                     transmembrane region"
     misc_feature    854..910
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
                     transmembrane region"
     misc_feature    923..925
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q15858.3); glycosylation site"
     misc_feature    929..979
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
                     transmembrane region"
     misc_feature    1022..1099
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
                     transmembrane region"
     misc_feature    1145..1147
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:30765606,
                     ECO:0007744|PDB:6J8G, ECO:0007744|PDB:6J8H,
                     ECO:0007744|PDB:6J8I, ECO:0007744|PDB:6J8J; propagated
                     from UniProtKB/Swiss-Prot (Q15858.3); glycosylation site"
     misc_feature    1427..1504
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
                     transmembrane region"
     misc_feature    1679..1927
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1991..2131
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    2441..3232
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
                     Region: II. /evidence=ECO:0000305"
     misc_feature    2501..2551
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
                     transmembrane region"
     misc_feature    2579..2653
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
                     transmembrane region"
     misc_feature    2681..2731
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
                     transmembrane region"
     misc_feature    2729..2731
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /note="Is directly targeted by the spider protoxin-II.
                     /evidence=ECO:0000269|PubMed:30661758; propagated from
                     UniProtKB/Swiss-Prot (Q15858.3); other site"
     misc_feature    2744..2746
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /note="Is directly targeted by the spider protoxin-II.
                     /evidence=ECO:0000269|PubMed:30661758; propagated from
                     UniProtKB/Swiss-Prot (Q15858.3); other site"
     misc_feature    2759..2809
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
                     transmembrane region"
     misc_feature    2861..2929
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
                     transmembrane region"
     misc_feature    3086..3166
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
                     transmembrane region"
     misc_feature    3569..3709
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    3803..4729
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
                     Region: III. /evidence=ECO:0000305"
     misc_feature    3827..3901
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
                     transmembrane region"
     misc_feature    3938..4015
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
                     transmembrane region"
     misc_feature    4022..4099
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
                     transmembrane region"
     misc_feature    4127..4177
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
                     transmembrane region"
     misc_feature    4217..4291
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
                     transmembrane region"
     misc_feature    4319..4321
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:30765606,
                     ECO:0007744|PDB:6J8G, ECO:0007744|PDB:6J8H,
                     ECO:0007744|PDB:6J8I, ECO:0007744|PDB:6J8J; propagated
                     from UniProtKB/Swiss-Prot (Q15858.3); glycosylation site"
     misc_feature    4361..4363
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:30765606,
                     ECO:0007744|PDB:6J8G, ECO:0007744|PDB:6J8H,
                     ECO:0007744|PDB:6J8I, ECO:0007744|PDB:6J8J; propagated
                     from UniProtKB/Swiss-Prot (Q15858.3); glycosylation site"
     misc_feature    4388..4390
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:30765606,
                     ECO:0007744|PDB:6J8G, ECO:0007744|PDB:6J8H,
                     ECO:0007744|PDB:6J8I, ECO:0007744|PDB:6J8J; propagated
                     from UniProtKB/Swiss-Prot (Q15858.3); glycosylation site"
     misc_feature    4559..4636
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
                     transmembrane region"
     misc_feature    4733..4735
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /note="Phosphoserine, by PKC.
                     /evidence=ECO:0000269|PubMed:25240195; propagated from
                     UniProtKB/Swiss-Prot (Q15858.3); phosphorylation site"
     misc_feature    4754..5650
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
                     Region: IV. /evidence=ECO:0000305"
     misc_feature    4808..4867
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
                     transmembrane region"
     misc_feature    4901..4966
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
                     transmembrane region"
     misc_feature    4994..5059
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
                     transmembrane region"
     misc_feature    5087..5146
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
                     transmembrane region"
     misc_feature    5186..5254
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
                     transmembrane region"
     misc_feature    5465..5542
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
                     transmembrane region"
     misc_feature    6065..6229
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /note="propagated from UniProtKB/Swiss-Prot (Q15858.3);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            557..675
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /inference="alignment:Splign:2.1.0"
     exon            676..765
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /inference="alignment:Splign:2.1.0"
     exon            766..894
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /inference="alignment:Splign:2.1.0"
     exon            895..986
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1199
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1263
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1405
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1612
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1900
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..2239
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /inference="alignment:Splign:2.1.0"
     exon            2240..2369
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /inference="alignment:Splign:2.1.0"
     exon            2370..2608
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /inference="alignment:Splign:2.1.0"
     exon            2609..2782
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /inference="alignment:Splign:2.1.0"
     exon            2783..3139
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /inference="alignment:Splign:2.1.0"
     exon            3140..3616
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /inference="alignment:Splign:2.1.0"
     exon            3617..3737
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /inference="alignment:Splign:2.1.0"
     exon            3738..3892
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /inference="alignment:Splign:2.1.0"
     exon            3893..4066
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /inference="alignment:Splign:2.1.0"
     exon            4067..4189
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /inference="alignment:Splign:2.1.0"
     exon            4190..4471
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /inference="alignment:Splign:2.1.0"
     exon            4472..4525
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /inference="alignment:Splign:2.1.0"
     exon            4526..4663
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /inference="alignment:Splign:2.1.0"
     exon            4664..4768
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /inference="alignment:Splign:2.1.0"
     exon            4769..5039
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /inference="alignment:Splign:2.1.0"
     exon            5040..9719
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6496..6501
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /note="hexamer: AATAAA"
     polyA_site      6521
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /note="major polyA site"
     regulatory      9697..9702
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /note="hexamer: AATAAA"
     polyA_site      9719
                     /gene="SCN9A"
                     /gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
                     NENA; PN1; SFNP"
                     /note="major polyA site"
ORIGIN      
        1 agtctgcttg caggcggtcg ccagcgctcc agcggcggct gtcggctttc caattccgcc
       61 agctcggctg aggctgggct agcctgggtg ccagtggctg ctagcggcag gcgtcccctg
      121 agcaacagga gcccagagaa aaagaagcag ccctgagaga gcgccgggga aggagaggcc
      181 cgcgccctct cctggagcca gattctgcag gtgcactggg tggggatgat cggcgggcta
      241 ggttgcaagc ctcttatgtg aggagctgaa gaggaattaa aatatacagg atgaaaagat
      301 ggcaatgttg cctcccccag gacctcagag ctttgtccat ttcacaaaac agtctcttgc
      361 cctcattgaa caacgcattg ctgaaagaaa atcaaaggaa cccaaagaag aaaagaaaga
      421 tgatgatgaa gaagccccaa agccaagcag tgacttggaa gctggcaaac agctgccctt
      481 catctatggg gacattcctc ccggcatggt gtcagagccc ctggaggact tggaccccta
      541 ctatgcagac aaaaagactt tcatagtatt gaacaaaggg aaaacaatct tccgtttcaa
      601 tgccacacct gctttatata tgctttctcc tttcagtcct ctaagaagaa tatctattaa
      661 gattttagta cactccttat tcagcatgct catcatgtgc actattctga caaactgcat
      721 atttatgacc atgaataacc caccggactg gaccaaaaat gtcgagtaca cttttactgg
      781 aatatatact tttgaatcac ttgtaaaaat ccttgcaaga ggcttctgtg taggagaatt
      841 cacttttctt cgtgacccgt ggaactggct ggattttgtc gtcattgttt ttgcgtattt
      901 aacagaattt gtaaacctag gcaatgtttc agctcttcga actttcagag tattgagagc
      961 tttgaaaact atttctgtaa tcccaggcct gaagacaatt gtaggggctt tgatccagtc
     1021 agtgaagaag ctttctgatg tcatgatcct gactgtgttc tgtctgagtg tgtttgcact
     1081 aattggacta cagctgttca tgggaaacct gaagcataaa tgttttcgaa attcacttga
     1141 aaataatgaa acattagaaa gcataatgaa taccctagag agtgaagaag actttagaaa
     1201 atatttttat tacttggaag gatccaaaga tgctctcctt tgtggtttca gcacagattc
     1261 aggtcagtgt ccagaggggt acacctgtgt gaaaattggc agaaaccctg attatggcta
     1321 cacgagcttt gacactttca gctgggcctt cttagccttg tttaggctaa tgacccaaga
     1381 ttactgggaa aacctttacc aacagacgct gcgtgctgct ggcaaaacct acatgatctt
     1441 ctttgtcgta gtgattttcc tgggctcctt ttatctaata aacttgatcc tggctgtggt
     1501 tgccatggca tatgaagaac agaaccaggc aaacattgaa gaagctaaac agaaagaatt
     1561 agaatttcaa cagatgttag accgtcttaa aaaagagcaa gaagaagctg aggcaattgc
     1621 agcggcagcg gctgaatata caagtattag gagaagcaga attatgggcc tctcagagag
     1681 ttcttctgaa acatccaaac tgagctctaa aagtgctaaa gaaagaagaa acagaagaaa
     1741 gaaaaagaat caaaagaagc tctccagtgg agaggaaaag ggagatgctg agaaattgtc
     1801 gaaatcagaa tcagaggaca gcatcagaag aaaaagtttc caccttggtg tcgaagggca
     1861 taggcgagca catgaaaaga ggttgtctac ccccaatcag tcaccactca gcattcgtgg
     1921 ctccttgttt tctgcaaggc gaagcagcag aacaagtctt tttagtttca aaggcagagg
     1981 aagagatata ggatctgaga ctgaatttgc cgatgatgag cacagcattt ttggagacaa
     2041 tgagagcaga aggggctcac tgtttgtgcc ccacagaccc caggagcgac gcagcagtaa
     2101 catcagccaa gccagtaggt ccccaccaat gctgccggtg aacgggaaaa tgcacagtgc
     2161 tgtggactgc aacggtgtgg tctccctggt tgatggacgc tcagccctca tgctccccaa
     2221 tggacagctt ctgccagagg gcacgaccaa tcaaatacac aagaaaaggc gttgtagttc
     2281 ctatctcctt tcagaggata tgctgaatga tcccaacctc agacagagag caatgagtag
     2341 agcaagcata ttaacaaaca ctgtggaaga acttgaagag tccagacaaa aatgtccacc
     2401 ttggtggtac agatttgcac acaaattctt gatctggaat tgctctccat attggataaa
     2461 attcaaaaag tgtatctatt ttattgtaat ggatcctttt gtagatcttg caattaccat
     2521 ttgcatagtt ttaaacacat tatttatggc tatggaacac cacccaatga ctgaggaatt
     2581 caaaaatgta cttgctatag gaaatttggt ctttactgga atctttgcag ctgaaatggt
     2641 attaaaactg attgccatgg atccatatga gtatttccaa gtaggctgga atatttttga
     2701 cagccttatt gtgactttaa gtttagtgga gctctttcta gcagatgtgg aaggattgtc
     2761 agttctgcga tcattcagac tgctccgagt cttcaagttg gcaaaatcct ggccaacatt
     2821 gaacatgctg attaagatca ttggtaactc agtaggggct ctaggtaacc tcaccttagt
     2881 gttggccatc atcgtcttca tttttgctgt ggtcggcatg cagctctttg gtaagagcta
     2941 caaagaatgt gtctgcaaga tcaatgatga ctgtacgctc ccacggtggc acatgaacga
     3001 cttcttccac tccttcctga ttgtgttccg cgtgctgtgt ggagagtgga tagagaccat
     3061 gtgggactgt atggaggtcg ctggtcaagc tatgtgcctt attgtttaca tgatggtcat
     3121 ggtcattgga aacctggtgg tcctaaacct atttctggcc ttattattga gctcatttag
     3181 ttcagacaat cttacagcaa ttgaagaaga ccctgatgca aacaacctcc agattgcagt
     3241 gactagaatt aaaaagggaa taaattatgt gaaacaaacc ttacgtgaat ttattctaaa
     3301 agcattttcc aaaaagccaa agatttccag ggagataaga caagcagaag atctgaatac
     3361 taagaaggaa aactatattt ctaaccatac acttgctgaa atgagcaaag gtcacaattt
     3421 cctcaaggaa aaagataaaa tcagtggttt tggaagcagc gtggacaaac acttgatgga
     3481 agacagtgat ggtcaatcat ttattcacaa tcccagcctc acagtgacag tgccaattgc
     3541 acctggggaa tccgatttgg aaaatatgaa tgctgaggaa cttagcagtg attcggatag
     3601 tgaatacagc aaagtgagat taaaccggtc aagctcctca gagtgcagca cagttgataa
     3661 ccctttgcct ggagaaggag aagaagcaga ggctgaacct atgaattccg atgagccaga
     3721 ggcctgtttc acagatggtt gtgtatggag gttctcatgc tgccaagtta acatagagtc
     3781 agggaaagga aaaatctggt ggaacatcag gaaaacctgc tacaagattg ttgaacacag
     3841 ttggtttgaa agcttcattg tcctcatgat cctgctcagc agtggtgccc tggcttttga
     3901 agatatttat attgaaagga aaaagaccat taagattatc ctggagtatg cagacaagat
     3961 cttcacttac atcttcattc tggaaatgct tctaaaatgg atagcatatg gttataaaac
     4021 atatttcacc aatgcctggt gttggctgga tttcctaatt gttgatgttt ctttggttac
     4081 tttagtggca aacactcttg gctactcaga tcttggcccc attaaatccc ttcggacact
     4141 gagagcttta agacctctaa gagccttatc tagatttgaa ggaatgaggg tcgttgtgaa
     4201 tgcactcata ggagcaattc cttccatcat gaatgtgcta cttgtgtgtc ttatattctg
     4261 gctgatattc agcatcatgg gagtaaattt gtttgctggc aagttctatg agtgtattaa
     4321 caccacagat gggtcacggt ttcctgcaag tcaagttcca aatcgttccg aatgttttgc
     4381 ccttatgaat gttagtcaaa atgtgcgatg gaaaaacctg aaagtgaact ttgataatgt
     4441 cggacttggt tacctatctc tgcttcaagt tgcaactttt aagggatgga cgattattat
     4501 gtatgcagca gtggattctg ttaatgtaga caagcagccc aaatatgaat atagcctcta
     4561 catgtatatt tattttgtcg tctttatcat ctttgggtca ttcttcactt tgaacttgtt
     4621 cattggtgtc atcatagata atttcaacca acagaaaaag aagcttggag gtcaagacat
     4681 ctttatgaca gaagaacaga agaaatacta taatgcaatg aaaaagctgg ggtccaagaa
     4741 gccacaaaag ccaattcctc gaccagggaa caaaatccaa ggatgtatat ttgacctagt
     4801 gacaaatcaa gcctttgata ttagtatcat ggttcttatc tgtctcaaca tggtaaccat
     4861 gatggtagaa aaggagggtc aaagtcaaca tatgactgaa gttttatatt ggataaatgt
     4921 ggtttttata atccttttca ctggagaatg tgtgctaaaa ctgatctccc tcagacacta
     4981 ctacttcact gtaggatgga atatttttga ttttgtggtt gtgattatct ccattgtagg
     5041 tatgtttcta gctgatttga ttgaaacgta ttttgtgtcc cctaccctgt tccgagtgat
     5101 ccgtcttgcc aggattggcc gaatcctacg tctagtcaaa ggagcaaagg ggatccgcac
     5161 gctgctcttt gctttgatga tgtcccttcc tgcgttgttt aacatcggcc tcctgctctt
     5221 cctggtcatg ttcatctacg ccatctttgg aatgtccaac tttgcctatg ttaaaaagga
     5281 agatggaatt aatgacatgt tcaattttga gacctttggc aacagtatga tttgcctgtt
     5341 ccaaattaca acctctgctg gctgggatgg attgctagca cctattctta acagtaagcc
     5401 acccgactgt gacccaaaaa aagttcatcc tggaagttca gttgaaggag actgtggtaa
     5461 cccatctgtt ggaatattct actttgttag ttatatcatc atatccttcc tggttgtggt
     5521 gaacatgtac attgcagtca tactggagaa ttttagtgtt gccactgaag aaagtactga
     5581 acctctgagt gaggatgact ttgagatgtt ctatgaggtt tgggagaagt ttgatcccga
     5641 tgcgacccag tttatagagt tctctaaact ctctgatttt gcagctgccc tggatcctcc
     5701 tcttctcata gcaaaaccca acaaagtcca gctcattgcc atggatctgc ccatggttag
     5761 tggtgaccgg atccattgtc ttgacatctt atttgctttt acaaagcgtg ttttgggtga
     5821 gagtggggag atggattctc ttcgttcaca gatggaagaa aggttcatgt ctgcaaatcc
     5881 ttccaaagtg tcctatgaac ccatcacaac cacactaaaa cggaaacaag aggatgtgtc
     5941 tgctactgtc attcagcgtg cttatagacg ttaccgctta aggcaaaatg tcaaaaatat
     6001 atcaagtata tacataaaag atggagacag agatgatgat ttactcaata aaaaagatat
     6061 ggcttttgat aatgttaatg agaactcaag tccagaaaaa acagatgcca cttcatccac
     6121 cacctctcca ccttcatatg atagtgtaac aaagccagac aaagagaaat atgaacaaga
     6181 cagaacagaa aaggaagaca aagggaaaga cagcaaggaa agcaaaaaat agagcttcat
     6241 ttttgatata ttgtttacag cctgtgaaag tgatttattt gtgttaataa aactcttttg
     6301 aggaagtcta tgccaaaatc ctttttatca aaatattctc gaaggcagtg cagtcactaa
     6361 ctctgatttc ctaagaaagg tgggcagcat tagcagatgg ttatttttgc actgatgatt
     6421 ctttaagaat cgtaagagaa ctctgtagga attattgatt atagcataca aaagtgattc
     6481 agttttttgg tttttaataa atcagaagac catgtagaaa acttttacat ctgccttgtc
     6541 atcttttcac aggattgtaa ttagtcttgt ttcccatgta aataaacaac acacgcatac
     6601 agaaaaatct attatttatc tattatttgg aaatcaacaa aagtatttgc cttggctttg
     6661 caatgaaatg cttgatagaa gtaatggaca ttagttatga atgtttagtt aaaatgcatt
     6721 attagggagc ttgacttttt atcaatgtac agaggttatt ctatattttg aggtgcttaa
     6781 atttattcta cattgcatca gaaccaattt atatgtgcct ataaaatgcc atgggattaa
     6841 aaatatatgt aggctattca tttctacaaa tgtttttcat tcatcttgac tcacatgcca
     6901 acaaggataa gacttacctt tagagtattg tgtttcatag cctttcttct ttcatatccc
     6961 tttttgttca tagaataacc acagaacttg aaaaattatt ctaagtacat attacactcc
     7021 tcaaaaaaaa caaagataac tgagaaaaaa gttattgaca gaagttctat ttgctattat
     7081 ttacatagcc taacatttga ctgtgctgcc caaaatactg ataatagtct cttaaactct
     7141 tttgtcaaat tttcctgctt tcttatgcag tattgtttag tcatcctttc gctgtaagca
     7201 aagttgatga aatccttcct gatatgcagt tagttgtttg accacggtac atacttgagc
     7261 agataataac ttgggcacag tatttattgc atcacttgta tacaatcccg tgtttggcaa
     7321 gctttcaaat catgtaatat gacagacttt acacagatat gtgtttagta tgaataaaaa
     7381 agcattgaaa tagggattct tgccaacttg ctctcttgcc accaacttac tttcctaaat
     7441 tatggaagta atcttttttg gatatacttc aatgtataca atgaggaaga tgtcaccttc
     7501 tccttaaaat tctatgatgt gaaatatatt ttgcctcaat caacacagta ccatgggctt
     7561 ctaatttatc aagcacatat tcattttgca ttagctgtag acatctagtt ttttgaaaac
     7621 acctattaat agtaatttga aaagaaataa ccataatgct ttttttcgtg agtttatttc
     7681 aggaatatga gatctttctt ctataaagtt attcatgcac aggcaaaaat tgagctacac
     7741 aggtagaatg tagttttact tagaagattt ttgtgggagg ttttgaagca aatatataaa
     7801 acaactttca ctaatttgct ttccatattt aaaaaataat aaattacatt tatataataa
     7861 atgtttaaag cacatatttt ttgttgttct ggcaatttaa aaagaaagag gatttaaacg
     7921 tacctataga aacaaagatt tatggttaaa gaatgagatc agaagtctag aatgttttta
     7981 aattgtgata tattttacaa catccgttat tactttgaga catttgtcct aatctacgta
     8041 taaaactcaa tctagggcta aagattcttt ataccatctt aggttcattc atcttaggct
     8101 atttgaacca ctttttaatt taatatgaaa gacaccatgc agtgttttcc gagactacat
     8161 agatcatttt atcacatacc taccaagcct gttggaaata ggttttgata atttaagtag
     8221 ggacctatac aaaatatatt acatttatca gatttttaaa tacattcaat taagaattta
     8281 acatcacctt aaatttgaat tcaatctacc gttatttcaa actcacaaat ataactgcat
     8341 tatgaatact tacataatgt agtaagacaa gatgtttgac aggttcgtgt gtaattttct
     8401 attaatgttt ttacattgcc ttgtttttat gtaaaataaa aaatatgggc aactggtttg
     8461 ttaacaacac aatttcttct tagcatttca aaaatatata taaagttgtt ctttttccta
     8521 tttcatgaac tatgtttttt tttaaaataa catggttaag ttttatatat atttacgttt
     8581 gtttcaggaa tgtctacttg tgacttttta tcaattaaaa ataatatttg gaagaaagag
     8641 cttattaagt ataagcttga agtaaaatta gacctctctt tccatgtaga ttactgtttg
     8701 tactgatggt ttcacccttc agaaggcact gtcatattaa tatttaaatt ttataatcgc
     8761 tgaacttatt acacccaaca atacagaaag gcagttacac tgaagaactt aacttagaat
     8821 aaaatggaag caaacaggtt ttctaaaaac ttttttaagt gaccaggtct cgctctgtca
     8881 cccaggctag agtgcaatgg catgatcata gctctctgca gcctcaactc tgggctcaag
     8941 caaccctcct gcctcagcct cccaagtagc taagactaca ggtacatgcc accatgcctg
     9001 gctaatattt aaatttttgt agataagggg tcttgctatg ttgcccaggc tagtctcaaa
     9061 ctcctggctt caagtgttcc tactgtcatg acctgccaac atgctggggt tacaggcatg
     9121 agccaccatg ccccaaacag gtttgaacac aaatctttcg gatgaaaatt agagaaccta
     9181 attttagctt tttgatagtt acctagtttg caaaagattt gggtgacttg tgagctgttt
     9241 ttaaatgctg attgttgaac atcacaaccc aaaatactta gcatgatttt atagagtttt
     9301 gatagcttta ttaaaaagag tgaaaataaa atgcatatgt aaataaagca gttctaaata
     9361 gctatttcag agaaatgtta atagaagtgc tgaaagaagg gccaactaaa ttaggatggc
     9421 cagggaattg gcctgggttt aggacctatg tatgaaggcc accaattttt taaaaatatc
     9481 tgtggtttat tatgttatta tcttcttgag gaaaacaatc aagaattgct tcatgaaaat
     9541 aaataaatag ccatgaatat cataaagctg tttacatagg attctttaca aatttcatag
     9601 atctatgaat gctcaaaatg tttgagtttg ccataaatta tattgtagtt atattgtagt
     9661 tatacttgag actgacacat tgtaatataa tctaagaata aaagttatac aaaataaaa
//
299..6232
/gene="SCN9A"
/gene_synonym="ETHA; FEB3B; GEFSP7; HSAN2D; Nav1.7; NE-NA;
NENA; PN1; SFNP"
/note="isoform 1 is encoded by transcript variant 1;
sodium channel, voltage-gated, type IX, alpha polypeptide;
sodium channel protein type 9 subunit alpha; sodium
channel, voltage-gated, type IX, alpha subunit;
voltage-gated sodium channel alpha subunit Nav1.7; hNE-Na;
peripheral sodium channel 1; neuroendocrine sodium
channel; sodium channel protein type IX subunit alpha;
voltage-gated sodium channel subunit alpha Nav1.7"
/codon_start=1
/product="sodium channel protein type 9 subunit alpha
isoform 1"
/protein_id="NP_002968.2"
/db_xref="CCDS:CCDS46441.1"
/db_xref="GeneID:6335"
/db_xref="HGNC:HGNC:10597"
/db_xref="MIM:603415"
/translation="MAMLPPPGPQSFVHFTKQSLALIEQRIAERKSKEPKEEKKDDDE
EAPKPSSDLEAGKQLPFIYGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNA
TPALYMLSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFT
GIYTFESLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRV
LRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCF
RNSLENNETLESIMNTLESEEDFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIG
RNPDYGYTSFDTFSWAFLALFRLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFY
LINLILAVVAMAYEEQNQANIEEAKQKELEFQQMLDRLKKEQEEAEAIAAAAAEYTSI
RRSRIMGLSESSSETSKLSSKSAKERRNRRKKKNQKKLSSGEEKGDAEKLSKSESEDS
IRRKSFHLGVEGHRRAHEKRLSTPNQSPLSIRGSLFSARRSSRTSLFSFKGRGRDIGS
ETEFADDEHSIFGDNESRRGSLFVPHRPQERRSSNISQASRSPPMLPVNGKMHSAVDC
NGVVSLVDGRSALMLPNGQLLPEGTTNQIHKKRRCSSYLLSEDMLNDPNLRQRAMSRA
SILTNTVEELEESRQKCPPWWYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAIT
ICIVLNTLFMAMEHHPMTEEFKNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWN
IFDSLIVTLSLVELFLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALG
NLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLC
GEWIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVLNLFLALLLSSFSSDNLTAIEEDP
DANNLQIAVTRIKKGINYVKQTLREFILKAFSKKPKISREIRQAEDLNTKKENYISNH
TLAEMSKGHNFLKEKDKISGFGSSVDKHLMEDSDGQSFIHNPSLTVTVPIAPGESDLE
NMNAEELSSDSDSEYSKVRLNRSSSSECSTVDNPLPGEGEEAEAEPMNSDEPEACFTD
GCVWRFSCCQVNIESGKGKIWWNIRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIY
IERKKTIKIILEYADKIFTYIFILEMLLKWIAYGYKTYFTNAWCWLDFLIVDVSLVTL
VANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIF
WLIFSIMGVNLFAGKFYECINTTDGSRFPASQVPNRSECFALMNVSQNVRWKNLKVNF
DNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFF
TLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKIQ
GCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGECV
LKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLARIGRIL
RLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEDGINDMF
NFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGI
FYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQ
FIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGES
GEMDSLRSQMEERFMSANPSKVSYEPITTTLKRKQEDVSATVIQRAYRRYRLRQNVKN
ISSIYIKDGDRDDDLLNKKDMAFDNVNENSSPEKTDATSSTTSPPSYDSVTKPDKEKY
EQDRTEKEDKGKDSKESKK"
Feature NM_002977 : 1 segment
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