U.S. flag

An official website of the United States government

Stb5p [Saccharomyces cerevisiae S288C]

NCBI Reference Sequence: NP_012048.3

Identical Proteins FASTA Graphics 

LOCUS       NP_012048                743 aa            linear   PLN 17-DEC-2024
DEFINITION  Stb5p [Saccharomyces cerevisiae S288C].
ACCESSION   NP_012048
VERSION     NP_012048.3
DBLINK      BioProject: PRJNA128
DBSOURCE    REFSEQ: accession NM_001179309.3
KEYWORDS    RefSeq.
SOURCE      Saccharomyces cerevisiae S288C
  ORGANISM  Saccharomyces cerevisiae S288C
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
            Saccharomyces.
REFERENCE   1  (residues 1 to 743)
  AUTHORS   Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
            Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
            Weng,S. and Cherry,J.M.
  TITLE     New data and collaborations at the Saccharomyces Genome Database:
            updated reference genome, alleles, and the Alliance of Genome
            Resources
  JOURNAL   Genetics 220 (4) (2022)
   PUBMED   34897464
REFERENCE   2  (residues 1 to 743)
  AUTHORS   Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
            Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
            Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
            Oliver,S.G.
  TITLE     Life with 6000 genes
  JOURNAL   Science 274 (5287), 546 (1996)
   PUBMED   8849441
REFERENCE   3  (residues 1 to 743)
  AUTHORS   Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J.,
            Du,Z., Favello,A., Fulton,L., Gattung,S. et al.
  TITLE     Complete nucleotide sequence of Saccharomyces cerevisiae chromosome
            VIII
  JOURNAL   Science 265 (5181), 2077-2082 (1994)
   PUBMED   8091229
REFERENCE   4  (residues 1 to 743)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (17-DEC-2024) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (residues 1 to 743)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (04-MAY-2012) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Protein update by submitter
REFERENCE   6  (residues 1 to 743)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (31-MAR-2011) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
  REMARK    Sequence update by submitter
REFERENCE   7  (residues 1 to 743)
  CONSRTM   Saccharomyces Genome Database
  TITLE     Direct Submission
  JOURNAL   Submitted (11-DEC-2009) Department of Genetics, Stanford
            University, Stanford, CA 94305-5120, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by SGD. The reference
            sequence is identical to DAA06871.
            
            On Jul 30, 2012 this sequence version replaced NP_012048.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: SGD
            Annotation Status   :: Full Annotation
            Annotation Version  :: R64-4-1
            URL                 :: http://www.yeastgenome.org/
            ##Genome-Annotation-Data-END##
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..743
                     /organism="Saccharomyces cerevisiae S288C"
                     /strain="S288C"
                     /db_xref="taxon:559292"
                     /chromosome="VIII"
     Protein         1..743
                     /product="Stb5p"
                     /calculated_mol_wt=83343
     Region          20..58
                     /region_name="Zn_clus"
                     /note="Fungal Zn(2)-Cys(6) binuclear cluster domain;
                     pfam00172"
                     /db_xref="CDD:395120"
     Site            order(21,26..29,31,34,44)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238023"
     Site            order(22,25,32,39,42,49)
                     /site_type="other"
                     /note="Zn2+ binding site [ion binding]"
                     /db_xref="CDD:238023"
     Region          293..699
                     /region_name="fungal_TF_MHR"
                     /note="fungal transcription factor regulatory middle
                     homology region; cd12148"
                     /db_xref="CDD:213391"
     CDS             1..743
                     /gene="STB5"
                     /locus_tag="YHR178W"
                     /coded_by="NM_001179309.3:1..2232"
                     /experiment="EXISTENCE:curator inference:GO:0005634
                     nucleus [PMID:11943786]"
                     /experiment="EXISTENCE:direct assay:GO:0003700 DNA-binding
                     transcription factor activity [PMID:11943786]"
                     /experiment="EXISTENCE:direct assay:GO:0006368
                     transcription elongation by RNA polymerase II
                     [PMID:11943786]"
                     /experiment="EXISTENCE:direct assay:GO:0043565
                     sequence-specific DNA binding [PMID:19111667]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0003700
                     DNA-binding transcription factor activity [PMID:11943786]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0006357
                     regulation of transcription by RNA polymerase II
                     [PMID:16914749]"
                     /experiment="EXISTENCE:mutant phenotype:GO:0034599
                     cellular response to oxidative stress [PMID:16914749]"
                     /note="Transcription factor; regulates multidrug
                     resistance and the oxidative stress response; forms a
                     heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger
                     domain that interacts with a pleiotropic drug resistance
                     element in vitro; negative regulator of autophagy,
                     modulating the transcription of genes involved in NADPH
                     production and the pentose phosphate pathway; Stb5p
                     expression is reduced during nitrogen starvation and
                     autophagy induction, while STB5 mRNA levels are
                     significantly increased"
                     /db_xref="GeneID:856583"
                     /db_xref="SGD:S000001221"
ORIGIN      
        1 mdgpnfahqg grsqrttely scarcrklkk kcgkqiptca ncdkngahcs ypgraprrtk
       61 keladamlrg eyvpvkrnkk vgksplstks mpnsssplsa ngaitpgfsp yenddahkmk
      121 qlkpsdpinl vmgaspnsse gvsslisvlt slndnsnpss hlssnensmi psrslpasvq
      181 qssttssfgg yntpspliss hvpanaqavp lqnnnrntsn gdngsnvnhd nnngstntpq
      241 lsltpyanns apngkfdsvp vdassiefet msccfkggrt tswvredgsf ksidrslldr
      301 fiaayfkhnh rlfpmidkia flndaatitd ferlydnkny pdsfvfkvym imaigcttlq
      361 ragmvsqdee clsehlafla mkkfrsviil qdietvrcll llgiysffep kgssswtisg
      421 iimrltiglg lnreltakkl ksmsaleaea ryrvfwsayc ferlvctslg risgiddedi
      481 tvplpralyv derddlemtk lmislrkmgg riykqvhsvs agrqkltieq kqeiisglrk
      541 eldeiysres errklkksqm dqverennst tnvisfhsse iwlamrysql qillyrpsal
      601 mpkppidsls tlgefclqaw khtytlykkr llplnwitlf rtlticntil yclcqwsidl
      661 ieskieiqqc veilrhfger wifamrcadv fqnisntild islshgkvpn mdqltrelfg
      721 asdsyqdild ennvdvswvd klv
//
1..743
/gene="STB5"
/locus_tag="YHR178W"
/coded_by="NM_001179309.3:1..2232"
/experiment="EXISTENCE:curator inference:GO:0005634
nucleus [PMID:11943786]"
/experiment="EXISTENCE:direct assay:GO:0003700 DNA-binding
transcription factor activity [PMID:11943786]"
/experiment="EXISTENCE:direct assay:GO:0006368
transcription elongation by RNA polymerase II
[PMID:11943786]"
/experiment="EXISTENCE:direct assay:GO:0043565
sequence-specific DNA binding [PMID:19111667]"
/experiment="EXISTENCE:mutant phenotype:GO:0003700
DNA-binding transcription factor activity [PMID:11943786]"
/experiment="EXISTENCE:mutant phenotype:GO:0006357
regulation of transcription by RNA polymerase II
[PMID:16914749]"
/experiment="EXISTENCE:mutant phenotype:GO:0034599
cellular response to oxidative stress [PMID:16914749]"
/note="Transcription factor; regulates multidrug
resistance and the oxidative stress response; forms a
heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger
domain that interacts with a pleiotropic drug resistance
element in vitro; negative regulator of autophagy,
modulating the transcription of genes involved in NADPH
production and the pentose phosphate pathway; Stb5p
expression is reduced during nitrogen starvation and
autophagy induction, while STB5 mRNA levels are
significantly increased"
/db_xref="GeneID:856583"
/db_xref="SGD:S000001221"
Feature NP_012048 : 1 segment
Display: FASTA GenBank Help
Details

Supplemental Content

Change region shown

Customize view

Reference sequence information

  • RefSeq mRNA
    See reference mRNA sequence for the STB5 gene (NM_001179309.3).

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
External link. Please review our privacy policy.