LOCUS NP_012048 743 aa linear PLN 17-DEC-2024
DEFINITION Stb5p [Saccharomyces cerevisiae S288C].
ACCESSION NP_012048
VERSION NP_012048.3
DBLINK BioProject: PRJNA128
DBSOURCE REFSEQ: accession NM_001179309.3
KEYWORDS RefSeq.
SOURCE Saccharomyces cerevisiae S288C
ORGANISM Saccharomyces cerevisiae S288C
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
Saccharomyces.
REFERENCE 1 (residues 1 to 743)
AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M.,
Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S.,
Weng,S. and Cherry,J.M.
TITLE New data and collaborations at the Saccharomyces Genome Database:
updated reference genome, alleles, and the Alliance of Genome
Resources
JOURNAL Genetics 220 (4) (2022)
PUBMED 34897464
REFERENCE 2 (residues 1 to 743)
AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B.,
Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M.,
Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and
Oliver,S.G.
TITLE Life with 6000 genes
JOURNAL Science 274 (5287), 546 (1996)
PUBMED 8849441
REFERENCE 3 (residues 1 to 743)
AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J.,
Du,Z., Favello,A., Fulton,L., Gattung,S. et al.
TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome
VIII
JOURNAL Science 265 (5181), 2077-2082 (1994)
PUBMED 8091229
REFERENCE 4 (residues 1 to 743)
CONSRTM NCBI Genome Project
TITLE Direct Submission
JOURNAL Submitted (17-DEC-2024) National Center for Biotechnology
Information, NIH, Bethesda, MD 20894, USA
REFERENCE 5 (residues 1 to 743)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Protein update by submitter
REFERENCE 6 (residues 1 to 743)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
REMARK Sequence update by submitter
REFERENCE 7 (residues 1 to 743)
CONSRTM Saccharomyces Genome Database
TITLE Direct Submission
JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford
University, Stanford, CA 94305-5120, USA
COMMENT REVIEWED REFSEQ: This record has been curated by SGD. The reference
sequence is identical to DAA06871.
On Jul 30, 2012 this sequence version replaced NP_012048.2.
##Genome-Annotation-Data-START##
Annotation Provider :: SGD
Annotation Status :: Full Annotation
Annotation Version :: R64-4-1
URL :: http://www.yeastgenome.org/
##Genome-Annotation-Data-END##
Method: conceptual translation.
FEATURES Location/Qualifiers
source 1..743
/organism="Saccharomyces cerevisiae S288C"
/strain="S288C"
/db_xref="taxon:559292"
/chromosome="VIII"
Protein 1..743
/product="Stb5p"
/calculated_mol_wt=83343
Region 20..58
/region_name="Zn_clus"
/note="Fungal Zn(2)-Cys(6) binuclear cluster domain;
pfam00172"
/db_xref="CDD:395120"
Site order(21,26..29,31,34,44)
/site_type="DNA binding"
/note="DNA binding site [nucleotide binding]"
/db_xref="CDD:238023"
Site order(22,25,32,39,42,49)
/site_type="other"
/note="Zn2+ binding site [ion binding]"
/db_xref="CDD:238023"
Region 293..699
/region_name="fungal_TF_MHR"
/note="fungal transcription factor regulatory middle
homology region; cd12148"
/db_xref="CDD:213391"
CDS 1..743
/gene="STB5"
/locus_tag="YHR178W"
/coded_by="NM_001179309.3:1..2232"
/experiment="EXISTENCE:curator inference:GO:0005634
nucleus [PMID:11943786]"
/experiment="EXISTENCE:direct assay:GO:0003700 DNA-binding
transcription factor activity [PMID:11943786]"
/experiment="EXISTENCE:direct assay:GO:0006368
transcription elongation by RNA polymerase II
[PMID:11943786]"
/experiment="EXISTENCE:direct assay:GO:0043565
sequence-specific DNA binding [PMID:19111667]"
/experiment="EXISTENCE:mutant phenotype:GO:0003700
DNA-binding transcription factor activity [PMID:11943786]"
/experiment="EXISTENCE:mutant phenotype:GO:0006357
regulation of transcription by RNA polymerase II
[PMID:16914749]"
/experiment="EXISTENCE:mutant phenotype:GO:0034599
cellular response to oxidative stress [PMID:16914749]"
/note="Transcription factor; regulates multidrug
resistance and the oxidative stress response; forms a
heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger
domain that interacts with a pleiotropic drug resistance
element in vitro; negative regulator of autophagy,
modulating the transcription of genes involved in NADPH
production and the pentose phosphate pathway; Stb5p
expression is reduced during nitrogen starvation and
autophagy induction, while STB5 mRNA levels are
significantly increased"
/db_xref="GeneID:856583"
/db_xref="SGD:S000001221"
ORIGIN
1 mdgpnfahqg grsqrttely scarcrklkk kcgkqiptca ncdkngahcs ypgraprrtk
61 keladamlrg eyvpvkrnkk vgksplstks mpnsssplsa ngaitpgfsp yenddahkmk
121 qlkpsdpinl vmgaspnsse gvsslisvlt slndnsnpss hlssnensmi psrslpasvq
181 qssttssfgg yntpspliss hvpanaqavp lqnnnrntsn gdngsnvnhd nnngstntpq
241 lsltpyanns apngkfdsvp vdassiefet msccfkggrt tswvredgsf ksidrslldr
301 fiaayfkhnh rlfpmidkia flndaatitd ferlydnkny pdsfvfkvym imaigcttlq
361 ragmvsqdee clsehlafla mkkfrsviil qdietvrcll llgiysffep kgssswtisg
421 iimrltiglg lnreltakkl ksmsaleaea ryrvfwsayc ferlvctslg risgiddedi
481 tvplpralyv derddlemtk lmislrkmgg riykqvhsvs agrqkltieq kqeiisglrk
541 eldeiysres errklkksqm dqverennst tnvisfhsse iwlamrysql qillyrpsal
601 mpkppidsls tlgefclqaw khtytlykkr llplnwitlf rtlticntil yclcqwsidl
661 ieskieiqqc veilrhfger wifamrcadv fqnisntild islshgkvpn mdqltrelfg
721 asdsyqdild ennvdvswvd klv
//