LOCUS NP_055158 228 aa linear PRI 28-OCT-2024
DEFINITION claudin-15 [Homo sapiens].
ACCESSION NP_055158
VERSION NP_055158.1
DBSOURCE REFSEQ: accession NM_014343.3
KEYWORDS RefSeq; MANE Select.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 228)
AUTHORS Rajagopal,N. and Nangia,S.
TITLE Unique structural features of claudin-5 and claudin-15 lead to
functionally distinct tight junction strand architecture
JOURNAL Ann N Y Acad Sci 1517 (1), 225-233 (2022)
PUBMED 36114674
REMARK GeneRIF: Unique structural features of claudin-5 and claudin-15
lead to functionally distinct tight junction strand architecture.
REFERENCE 2 (residues 1 to 228)
AUTHORS Hempel,C., Rosenthal,R., Fromm,A., Krug,S.M., Fromm,M., Gunzel,D.
and Piontek,J.
TITLE Tight junction channels claudin-10b and claudin-15: Functional
mapping of pore-lining residues
JOURNAL Ann N Y Acad Sci 1515 (1), 129-142 (2022)
PUBMED 35650657
REMARK GeneRIF: Tight junction channels claudin-10b and claudin-15:
Functional mapping of pore-lining residues.
REFERENCE 3 (residues 1 to 228)
AUTHORS Gonschior,H., Schmied,C., Van der Veen,R.E., Eichhorst,J.,
Himmerkus,N., Piontek,J., Gunzel,D., Bleich,M., Furuse,M.,
Haucke,V. and Lehmann,M.
TITLE Nanoscale segregation of channel and barrier claudins enables
paracellular ion flux
JOURNAL Nat Commun 13 (1), 4985 (2022)
PUBMED 36008380
REMARK Publication Status: Online-Only
REFERENCE 4 (residues 1 to 228)
AUTHORS Watanabe,M., Higashi,T., Ozeki,K., Higashi,A.Y., Sugimoto,K.,
Mine,H., Takagi,H., Ozaki,Y., Muto,S., Okabe,N., Matsumura,Y.,
Hasegawa,T., Shio,Y., Suzuki,H. and Chiba,H.
TITLE CLDN15 is a novel diagnostic marker for malignant pleural
mesothelioma
JOURNAL Sci Rep 11 (1), 12554 (2021)
PUBMED 34131154
REMARK GeneRIF: CLDN15 is a novel diagnostic marker for malignant pleural
mesothelioma.
Publication Status: Online-Only
REFERENCE 5 (residues 1 to 228)
AUTHORS Ong,M.L.D.M., Yeruva,S., Sailer,A., Nilsen,S.P. and Turner,J.R.
TITLE Differential regulation of claudin-2 and claudin-15 expression in
children and adults with malabsorptive disease
JOURNAL Lab Invest 100 (3), 483-490 (2020)
PUBMED 31605016
REMARK GeneRIF: Differential regulation of claudin-2 and claudin-15
expression in children and adults with malabsorptive disease.
REFERENCE 6 (residues 1 to 228)
AUTHORS Kiuchi-Saishin,Y., Gotoh,S., Furuse,M., Takasuga,A., Tano,Y. and
Tsukita,S.
TITLE Differential expression patterns of claudins, tight junction
membrane proteins, in mouse nephron segments
JOURNAL J Am Soc Nephrol 13 (4), 875-886 (2002)
PUBMED 11912246
REFERENCE 7 (residues 1 to 228)
AUTHORS Tsukita,S., Furuse,M. and Itoh,M.
TITLE Multifunctional strands in tight junctions
JOURNAL Nat Rev Mol Cell Biol 2 (4), 285-293 (2001)
PUBMED 11283726
REMARK Review article
REFERENCE 8 (residues 1 to 228)
AUTHORS Heiskala,M., Peterson,P.A. and Yang,Y.
TITLE The roles of claudin superfamily proteins in paracellular transport
JOURNAL Traffic 2 (2), 93-98 (2001)
PUBMED 11247307
REMARK Review article
REFERENCE 9 (residues 1 to 228)
AUTHORS Yi,X., Wang,Y. and Yu,F.S.
TITLE Corneal epithelial tight junctions and their response to
lipopolysaccharide challenge
JOURNAL Invest Ophthalmol Vis Sci 41 (13), 4093-4100 (2000)
PUBMED 11095601
REFERENCE 10 (residues 1 to 228)
AUTHORS Kniesel,U. and Wolburg,H.
TITLE Tight junctions of the blood-brain barrier
JOURNAL Cell Mol Neurobiol 20 (1), 57-76 (2000)
PUBMED 10690502
REMARK Review article
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AJ245738.1 and AK056103.1.
Summary: This gene encodes a member of the claudin family. Claudins
are integral membrane proteins and components of tight junction
strands. Tight junction strands serve as a physical barrier to
prevent solutes and water from passing freely through the
paracellular space between epithelial or endothelial cell sheets,
and also play critical roles in maintaining cell polarity and
signal transductions. Alternatively spliced transcript variants
encoding the same protein have been found for this gene. [provided
by RefSeq, Jun 2010].
Transcript Variant: This variant (2) has a shorter and alternate 5'
UTR, as compared to variant 1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: ERR279859.229.1, DRR138528.254063.1
[ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA2153946, SAMEA2159764
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
MANE Ensembl match :: ENST00000308344.10/ ENSP00000308870.5
RefSeq Select criteria :: based on conservation, expression,
longest protein
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..228
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="7"
/map="7q22.1"
Protein 1..228
/product="claudin-15"
/calculated_mol_wt=24225
Site 2..24
/site_type="transmembrane region"
/note="propagated from UniProtKB/Swiss-Prot (P56746.1)"
Region 3..177
/region_name="PMP22_Claudin"
/note="PMP-22/EMP/MP20/Claudin family; cl21598"
/db_xref="CDD:473919"
Site 55
/site_type="other"
/note="Important for Na(+)-selective paracellular ion
transport. /evidence=ECO:0000269|PubMed:12055082,
ECO:0000269|PubMed:35650657; propagated from
UniProtKB/Swiss-Prot (P56746.1)"
Site 64
/site_type="other"
/note="Important for Na(+)-selective paracellular ion
transport. /evidence=ECO:0000269|PubMed:12055082,
ECO:0000269|PubMed:35650657; propagated from
UniProtKB/Swiss-Prot (P56746.1)"
Site 68
/site_type="other"
/note="Important for the formation of tight-junction
strand-like structures. /evidence=ECO:0000250; propagated
from UniProtKB/Swiss-Prot (P56746.1)"
Site 75..99
/site_type="transmembrane region"
/note="propagated from UniProtKB/Swiss-Prot (P56746.1)"
Site 111
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:19690332; propagated from
UniProtKB/Swiss-Prot (P56746.1)"
Site 116..140
/site_type="transmembrane region"
/note="propagated from UniProtKB/Swiss-Prot (P56746.1)"
Region 146..147
/region_name="Important for the formation of
tight-junction strand-like structures.
/evidence=ECO:0000250"
/note="propagated from UniProtKB/Swiss-Prot (P56746.1)"
Site 160..182
/site_type="transmembrane region"
/note="propagated from UniProtKB/Swiss-Prot (P56746.1)"
Region 208..228
/region_name="Disordered.
/evidence=ECO:0000256|SAM:MobiDB-lite"
/note="propagated from UniProtKB/Swiss-Prot (P56746.1)"
Site 211
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:D3ZQJ0; propagated from
UniProtKB/Swiss-Prot (P56746.1)"
Site 218
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q9Z0S5; propagated from
UniProtKB/Swiss-Prot (P56746.1)"
CDS 1..228
/gene="CLDN15"
/coded_by="NM_014343.3:222..908"
/db_xref="CCDS:CCDS5717.1"
/db_xref="GeneID:24146"
/db_xref="HGNC:HGNC:2036"
/db_xref="MIM:615778"
ORIGIN
1 msmavetfgf fmatvgllml gvtlpnsywr vstvhgnvit tntifenlwf scatdslgvy
61 ncwefpsmla lsgyiqacra lmitaillgf lglllgiagl rctnigglel srkaklaata
121 galhilagic gmvaiswyaf nitrdffdpl ypgtkyelgp alylgwsasl isilgglclc
181 sacccgsded paasarrpyq apvsvmpvat sdqegdssfg kygrnayv
//