LOCUS CAB32_DROME 310 aa linear INV 27-NOV-2024
DEFINITION RecName: Full=Calbindin-32.
ACCESSION P41044
VERSION P41044.1
DBSOURCE UniProtKB: locus CAB32_DROME, accession P41044;
class: standard.
extra accessions:Q9V7W4
created: Feb 1, 1995.
sequence updated: Feb 1, 1995.
annotation updated: Nov 27, 2024.
xrefs: X68566.1, CAA48566.1, S59242.1, AAA15214.1, S59190.1,
S59191.1, AE013599.5, AAF57925.1, AY058340.1, AAL13569.1, S37695,
NP_001286511.1, NP_476838.1
xrefs (non-sequence databases): AlphaFoldDB:P41044, SMR:P41044,
BioGRID:62607, STRING:7227.FBpp0086204, PaxDb:7227-FBpp0086204,
DNASU:36905, EnsemblMetazoa:FBtr0087056,
EnsemblMetazoa:FBpp0086204, EnsemblMetazoa:FBgn0004580,
EnsemblMetazoa:FBtr0340072, EnsemblMetazoa:FBpp0309078,
GeneID:36905, KEGG:dme:Dmel_CG6702, AGR:FB:FBgn0004580, CTD:36905,
FlyBase:FBgn0004580, VEuPathDB:VectorBase:FBgn0004580,
eggNOG:KOG0027, GeneTree:ENSGT00950000183108,
HOGENOM:CLU_054826_1_0_1, InParanoid:P41044, OMA:IVLCNEP,
OrthoDB:3218718at2759, PhylomeDB:P41044, BioGRID-ORCS:36905,
GenomeRNAi:36905, PRO:PR:P41044, Proteomes:UP000000803,
Bgee:FBgn0004580, ExpressionAtlas:P41044, GO:0005829, GO:0030425,
GO:0005634, GO:0045202, GO:0043195, GO:0061175, GO:0097467,
GO:0005509, GO:1900271, GO:0099509, CDD:cd16179,
FunFam:1.10.238.10:FF:000054, FunFam:1.10.238.10:FF:000262,
FunFam:1.10.238.10:FF:000304, Gene3D:1.10.238.10,
InterPro:IPR051001, InterPro:IPR011992, InterPro:IPR018247,
InterPro:IPR002048, InterPro:IPR035799, PANTHER:PTHR19972,
PANTHER:PTHR19972:SF10, Pfam:PF00036, Pfam:PF13499, SMART:SM00054,
SUPFAM:SSF47473, PROSITE:PS00018, PROSITE:PS50222
KEYWORDS Calcium; Metal-binding; Reference proteome; Repeat.
SOURCE Drosophila melanogaster (fruit fly)
ORGANISM Drosophila melanogaster
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE 1 (residues 1 to 310)
AUTHORS Reifegerste,R., Grimm,S., Albert,S., Lipski,N., Heimbeck,G.,
Hofbauer,A., Pflugfelder,G.O., Quack,D., Reichmuth,C., Schug,B.,
Zinsmaier,K.E., Buchner,S. and Buchner,E.
TITLE An invertebrate calcium-binding protein of the calbindin subfamily:
protein structure, genomic organization, and expression pattern of
the calbindin-32 gene of Drosophila
JOURNAL J Neurosci 13 (5), 2186-2198 (1993)
PUBMED 8478695
REMARK NUCLEOTIDE SEQUENCE [MRNA].;
STRAIN=Berlin; TISSUE=Brain
REFERENCE 2 (residues 1 to 310)
AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
TITLE The genome sequence of Drosophila melanogaster
JOURNAL Science 287 (5461), 2185-2195 (2000)
PUBMED 10731132
REMARK NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].;
STRAIN=Berkeley
REFERENCE 3 (residues 1 to 310)
AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
Rubin,G.M. and Lewis,S.E.
TITLE Annotation of the Drosophila melanogaster euchromatic genome: a
systematic review
JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002)
PUBMED 12537572
REMARK GENOME REANNOTATION.;
STRAIN=Berkeley
REFERENCE 4 (residues 1 to 310)
AUTHORS Stapleton,M., Carlson,J., Brokstein,P., Yu,C., Champe,M.,
George,R., Guarin,H., Kronmiller,B., Pacleb,J., Park,S., Wan,K.,
Rubin,G.M. and Celniker,S.E.
TITLE A Drosophila full-length cDNA resource
JOURNAL Genome Biol 3 (12), RESEARCH0080 (2002)
PUBMED 12537569
REMARK NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].;
STRAIN=Berkeley; TISSUE=Head
COMMENT On Mar 15, 2005 this sequence version replaced gi:481058.
[TISSUE SPECIFICITY] Expressed in a large number of neuron of the
brain and the thoracic ganglion as well as in two small muscles of
the thorax.
[SIMILARITY] Belongs to the calbindin family. {ECO:0000305}.
FEATURES Location/Qualifiers
source 1..310
/organism="Drosophila melanogaster"
/db_xref="taxon:7227"
gene 1..310
/gene="Cbp53E"
/locus_tag="CG6702"
/gene_synonym="cbn"
Protein 1..310
/product="Calbindin-32"
/UniProtKB_evidence="Evidence at transcript level"
Region 1..310
/region_name="Mature chain"
/note="Calbindin-32. /id=PRO_0000073477."
Region 35..70
/region_name="Domain"
/note="EF-hand 1.
/evidence=ECO:0000255|PROSITE-ProRule:PRU00448."
Region 40..301
/region_name="EFh_HEF_CBN"
/note="EF-hand, calcium binding motif, found in Drosophila
melanogaster calbindin-32 (CBN) and similar proteins;
cd16179"
/db_xref="CDD:320079"
Region 40..68
/region_name="EF-hand motif"
/note="EF-hand motif [structural motif]"
/db_xref="CDD:320079"
Site order(48,50,52,59,98,100,102,109,144,146,148,155,190,192,
194,201,237,239,241,248)
/site_type="other"
/note="putative Ca binding site [ion binding]"
/db_xref="CDD:320079"
Region 84..120
/region_name="Domain"
/note="EF-hand 2.
/evidence=ECO:0000255|PROSITE-ProRule:PRU00448."
Region 89..118
/region_name="EF-hand motif"
/note="EF-hand motif [structural motif]"
/db_xref="CDD:320079"
Region 131..166
/region_name="Domain"
/note="EF-hand 3.
/evidence=ECO:0000255|PROSITE-ProRule:PRU00448."
Region 135..164
/region_name="EF-hand motif"
/note="EF-hand motif [structural motif]"
/db_xref="CDD:320079"
Region 177..212
/region_name="Domain"
/note="EF-hand 4.
/evidence=ECO:0000255|PROSITE-ProRule:PRU00448."
Region 181..210
/region_name="EF-hand motif"
/note="EF-hand motif [structural motif]"
/db_xref="CDD:320079"
Region 224..259
/region_name="Domain"
/note="EF-hand 5.
/evidence=ECO:0000255|PROSITE-ProRule:PRU00448."
Region 228..257
/region_name="EF-hand motif"
/note="EF-hand motif [structural motif]"
/db_xref="CDD:320079"
Region 273..301
/region_name="EF-hand motif"
/note="EF-hand motif [structural motif]"
/db_xref="CDD:320079"
Region 283..304
/region_name="Domain"
/note="EF-hand 6.
/evidence=ECO:0000255|PROSITE-ProRule:PRU00448."
ORIGIN
1 mdsaaaaaak rvqiekahnf mrqyrdpesr elkklsanqf mdvwahydkd gngyiegtel
61 dgflrefvss anatdispea vtdtmleelk scfmeayddn qdgkidirel aqllpmeenf
121 lllfrfdnpl essvefmkiw reydtdnsgy ieadelknfl rdllkeakki ndvsedklie
181 ytdtmlqvfd ankdgrlqls emakllpvke nflcrqvfkg atkltkedie kvfslydrdn
241 sgtieneelk gflkdllelv kkddydaqdl aafeetimrg vgtdkhgkis rkeltmillt
301 lakispddee
//