LOCUS MCES_MOUSE 465 aa linear ROD 27-NOV-2024
DEFINITION RecName: Full=mRNA cap guanine-N(7) methyltransferase; AltName:
Full=RG7MT1; AltName: Full=mRNA (guanine-N(7))-methyltransferase;
AltName: Full=mRNA cap methyltransferase.
ACCESSION Q9D0L8
VERSION Q9D0L8.1
DBSOURCE UniProtKB: locus MCES_MOUSE, accession Q9D0L8;
class: standard.
extra accessions:Q3V3U9,Q6ZQC6,Q9D5F1
created: Sep 5, 2006.
sequence updated: Jun 1, 2001.
annotation updated: Nov 27, 2024.
xrefs: AK129130.1, BAC97940.1, AK011300.1, BAB27527.1, AK015403.1,
BAB29834.1, AK031780.1, BAE43278.1, BC021794.1, AAH21794.1,
AK082331.1, BAC38469.1, NP_001164424.1, NP_080716.1,
XP_006526256.1, XP_006526257.1, XP_006526259.1, XP_006526260.1,
XP_011245293.1
xrefs (non-sequence databases): CCDS:CCDS37852.1, CCDS:CCDS50314.1,
AlphaFoldDB:Q9D0L8, SMR:Q9D0L8, BioGRID:212521, IntAct:Q9D0L8,
STRING:10090.ENSMUSP00000009679, GlyGen:Q9D0L8, iPTMnet:Q9D0L8,
PhosphoSitePlus:Q9D0L8, SwissPalm:Q9D0L8, jPOST:Q9D0L8,
PaxDb:10090-ENSMUSP00000009679, PeptideAtlas:Q9D0L8,
ProteomicsDB:252743, ProteomicsDB:252744, ProteomicsDB:252745,
Pumba:Q9D0L8, Antibodypedia:21962, DNASU:67897,
Ensembl:ENSMUST00000009679.11, Ensembl:ENSMUSP00000009679.5,
Ensembl:ENSMUSG00000009535.14, Ensembl:ENSMUST00000025427.14,
Ensembl:ENSMUSP00000025427.8, GeneID:67897, KEGG:mmu:67897,
UCSC:uc008fnj.2, UCSC:uc012bem.1, AGR:MGI:1915147, CTD:8731,
MGI:1915147, VEuPathDB:HostDB:ENSMUSG00000009535, eggNOG:KOG1975,
GeneTree:ENSGT00390000002368, HOGENOM:CLU_020346_0_1_1,
InParanoid:Q9D0L8, OMA:SHYNTLQ, OrthoDB:167537at2759,
PhylomeDB:Q9D0L8, TreeFam:TF314347, Reactome:R-MMU-72086,
Reactome:R-MMU-77075, BioGRID-ORCS:67897, ChiTaRS:Rnmt,
PRO:PR:Q9D0L8, Proteomes:UP000000589, RNAct:Q9D0L8,
Bgee:ENSMUSG00000009535, ExpressionAtlas:Q9D0L8, GO:0001650,
GO:0160130, GO:0031533, GO:0005654, GO:0005634, GO:0043235,
GO:0004482, GO:0003723, GO:0006370, GO:1990830, CDD:cd02440,
Gene3D:3.40.50.150, InterPro:IPR004971, InterPro:IPR016899,
InterPro:IPR039753, InterPro:IPR029063, PANTHER:PTHR12189:SF2,
PANTHER:PTHR12189, Pfam:PF03291, PIRSF:PIRSF028762,
SUPFAM:SSF53335, PROSITE:PS51562
KEYWORDS Alternative splicing; Methyltransferase; mRNA capping; mRNA
processing; Nucleus; Phosphoprotein; Reference proteome;
RNA-binding; S-adenosyl-L-methionine; Transferase.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (residues 1 to 465)
AUTHORS Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
Saga,Y., Nagase,T., Ohara,O. and Koga,H.
TITLE Prediction of the coding sequences of mouse homologues of KIAA
gene: III. the complete nucleotide sequences of 500 mouse
KIAA-homologous cDNAs identified by screening of terminal sequences
of cDNA clones randomly sampled from size-fractionated libraries
JOURNAL DNA Res 10 (4), 167-180 (2003)
PUBMED 14621295
REMARK NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).;
TISSUE=Brain
REFERENCE 2 (residues 1 to 465)
AUTHORS Carninci,P., Kasukawa,T., Katayama,S., Gough,J., Frith,M.C.,
Maeda,N., Oyama,R., Ravasi,T., Lenhard,B., Wells,C., Kodzius,R.,
Shimokawa,K., Bajic,V.B., Brenner,S.E., Batalov,S., Forrest,A.R.,
Zavolan,M., Davis,M.J., Wilming,L.G., Aidinis,V., Allen,J.E.,
Ambesi-Impiombato,A., Apweiler,R., Aturaliya,R.N., Bailey,T.L.,
Bansal,M., Baxter,L., Beisel,K.W., Bersano,T., Bono,H., Chalk,A.M.,
Chiu,K.P., Choudhary,V., Christoffels,A., Clutterbuck,D.R.,
Crowe,M.L., Dalla,E., Dalrymple,B.P., de Bono,B., Della Gatta,G.,
di Bernardo,D., Down,T., Engstrom,P., Fagiolini,M., Faulkner,G.,
Fletcher,C.F., Fukushima,T., Furuno,M., Futaki,S., Gariboldi,M.,
Georgii-Hemming,P., Gingeras,T.R., Gojobori,T., Green,R.E.,
Gustincich,S., Harbers,M., Hayashi,Y., Hensch,T.K., Hirokawa,N.,
Hill,D., Huminiecki,L., Iacono,M., Ikeo,K., Iwama,A., Ishikawa,T.,
Jakt,M., Kanapin,A., Katoh,M., Kawasawa,Y., Kelso,J., Kitamura,H.,
Kitano,H., Kollias,G., Krishnan,S.P., Kruger,A., Kummerfeld,S.K.,
Kurochkin,I.V., Lareau,L.F., Lazarevic,D., Lipovich,L., Liu,J.,
Liuni,S., McWilliam,S., Madan Babu,M., Madera,M., Marchionni,L.,
Matsuda,H., Matsuzawa,S., Miki,H., Mignone,F., Miyake,S.,
Morris,K., Mottagui-Tabar,S., Mulder,N., Nakano,N., Nakauchi,H.,
Ng,P., Nilsson,R., Nishiguchi,S., Nishikawa,S., Nori,F., Ohara,O.,
Okazaki,Y., Orlando,V., Pang,K.C., Pavan,W.J., Pavesi,G.,
Pesole,G., Petrovsky,N., Piazza,S., Reed,J., Reid,J.F., Ring,B.Z.,
Ringwald,M., Rost,B., Ruan,Y., Salzberg,S.L., Sandelin,A.,
Schneider,C., Schonbach,C., Sekiguchi,K., Semple,C.A., Seno,S.,
Sessa,L., Sheng,Y., Shibata,Y., Shimada,H., Shimada,K., Silva,D.,
Sinclair,B., Sperling,S., Stupka,E., Sugiura,K., Sultana,R.,
Takenaka,Y., Taki,K., Tammoja,K., Tan,S.L., Tang,S., Taylor,M.S.,
Tegner,J., Teichmann,S.A., Ueda,H.R., van Nimwegen,E., Verardo,R.,
Wei,C.L., Yagi,K., Yamanishi,H., Zabarovsky,E., Zhu,S., Zimmer,A.,
Hide,W., Bult,C., Grimmond,S.M., Teasdale,R.D., Liu,E.T.,
Brusic,V., Quackenbush,J., Wahlestedt,C., Mattick,J.S., Hume,D.A.,
Kai,C., Sasaki,D., Tomaru,Y., Fukuda,S., Kanamori-Katayama,M.,
Suzuki,M., Aoki,J., Arakawa,T., Iida,J., Imamura,K., Itoh,M.,
Kato,T., Kawaji,H., Kawagashira,N., Kawashima,T., Kojima,M.,
Kondo,S., Konno,H., Nakano,K., Ninomiya,N., Nishio,T., Okada,M.,
Plessy,C., Shibata,K., Shiraki,T., Suzuki,S., Tagami,M., Waki,K.,
Watahiki,A., Okamura-Oho,Y., Suzuki,H., Kawai,J. and Hayashizaki,Y.
CONSRTM FANTOM Consortium; RIKEN Genome Exploration Research Group and
Genome Science Group (Genome Network Project Core Group)
TITLE The transcriptional landscape of the mammalian genome
JOURNAL Science 309 (5740), 1559-1563 (2005)
PUBMED 16141072
REMARK NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).;
STRAIN=C57BL/6J; TISSUE=Cerebellum, Head, and Testis
Erratum:[Science. 2006 Mar 24;311(5768):1713]
REFERENCE 3 (residues 1 to 465)
AUTHORS Gerhard,D.S., Wagner,L., Feingold,E.A., Shenmen,C.M., Grouse,L.H.,
Schuler,G., Klein,S.L., Old,S., Rasooly,R., Good,P., Guyer,M.,
Peck,A.M., Derge,J.G., Lipman,D., Collins,F.S., Jang,W., Sherry,S.,
Feolo,M., Misquitta,L., Lee,E., Rotmistrovsky,K., Greenhut,S.F.,
Schaefer,C.F., Buetow,K., Bonner,T.I., Haussler,D., Kent,J.,
Kiekhaus,M., Furey,T., Brent,M., Prange,C., Schreiber,K.,
Shapiro,N., Bhat,N.K., Hopkins,R.F., Hsie,F., Driscoll,T.,
Soares,M.B., Casavant,T.L., Scheetz,T.E., Brown-stein,M.J.,
Usdin,T.B., Toshiyuki,S., Carninci,P., Piao,Y., Dudekula,D.B.,
Ko,M.S., Kawakami,K., Suzuki,Y., Sugano,S., Gruber,C.E.,
Smith,M.R., Simmons,B., Moore,T., Waterman,R., Johnson,S.L.,
Ruan,Y., Wei,C.L., Mathavan,S., Gunaratne,P.H., Wu,J., Garcia,A.M.,
Hulyk,S.W., Fuh,E., Yuan,Y., Sneed,A., Kowis,C., Hodgson,A.,
Muzny,D.M., McPherson,J., Gibbs,R.A., Fahey,J., Helton,E.,
Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M.,
Madari,A., Young,A.C., Wetherby,K.D., Granite,S.J., Kwong,P.N.,
Brinkley,C.P., Pearson,R.L., Bouffard,G.G., Blakesly,R.W.,
Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J.,
Myers,R.M., Butterfield,Y.S., Griffith,M., Griffith,O.L.,
Krzywinski,M.I., Liao,N., Morin,R., Palmquist,D., Petrescu,A.S.,
Skalska,U., Smailus,D.E., Stott,J.M., Schnerch,A., Schein,J.E.,
Jones,S.J., Holt,R.A., Baross,A., Marra,M.A., Clifton,S.,
Makowski,K.A., Bosak,S. and Malek,J.
CONSRTM MGC Project Team
TITLE The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC)
JOURNAL Genome Res 14 (10B), 2121-2127 (2004)
PUBMED 15489334
REMARK NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).;
STRAIN=FVB/N; TISSUE=Colon
Erratum:[Genome Res. 2006 Jun;16(6):804. Morrin, Ryan [corrected to
Morin, Ryan]]
REFERENCE 4 (residues 1 to 465)
AUTHORS Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
TITLE Phosphoproteomic analysis of the developing mouse brain
JOURNAL Mol Cell Proteomics 3 (11), 1093-1101 (2004)
PUBMED 15345747
REMARK PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-11 AND SER-15, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].;
TISSUE=Embryonic brain
REFERENCE 5 (residues 1 to 465)
AUTHORS Villen,J., Beausoleil,S.A., Gerber,S.A. and Gygi,S.P.
TITLE Large-scale phosphorylation analysis of mouse liver
JOURNAL Proc Natl Acad Sci U S A 104 (5), 1488-1493 (2007)
PUBMED 17242355
REMARK PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].;
TISSUE=Liver
REFERENCE 6 (residues 1 to 465)
AUTHORS Trost,M., English,L., Lemieux,S., Courcelles,M., Desjardins,M. and
Thibault,P.
TITLE The phagosomal proteome in interferon-gamma-activated macrophages
JOURNAL Immunity 30 (1), 143-154 (2009)
PUBMED 19144319
REMARK PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-100, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
REFERENCE 7 (residues 1 to 465)
AUTHORS Sweet,S.M., Bailey,C.M., Cunningham,D.L., Heath,J.K. and
Cooper,H.J.
TITLE Large scale localization of protein phosphorylation by use of
electron capture dissociation mass spectrometry
JOURNAL Mol Cell Proteomics 8 (5), 904-912 (2009)
PUBMED 19131326
REMARK PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].;
TISSUE=Embryonic fibroblast
REFERENCE 8 (residues 1 to 465)
AUTHORS Huttlin,E.L., Jedrychowski,M.P., Elias,J.E., Goswami,T., Rad,R.,
Beausoleil,S.A., Villen,J., Haas,W., Sowa,M.E. and Gygi,S.P.
TITLE A tissue-specific atlas of mouse protein phosphorylation and
expression
JOURNAL Cell 143 (7), 1174-1189 (2010)
PUBMED 21183079
REMARK PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-11; SER-15; SER-64
AND SER-100, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
ANALYSIS].;
TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung,
Pancreas, Spleen, and Testis
COMMENT On or before Sep 7, 2006 this sequence version replaced
gi:81893726, gi:81881427.
[FUNCTION] Catalytic subunit of the mRNA-capping methyltransferase
RNMT:RAMAC complex that methylates the N7 position of the added
guanosine to the 5'-cap structure of mRNAs. Binds RNA containing
5'-terminal GpppC. {ECO:0000250|UniProtKB:O43148}.
[CATALYTIC ACTIVITY] Reaction=a 5'-end
(5'-triphosphoguanosine)-ribonucleoside in mRNA +
S-adenosyl-L-methionine = a 5'-end (N(7)-methyl
5'-triphosphoguanosine)-ribonucleoside in mRNA +
S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:67008,
Rhea:RHEA-COMP:17166, Rhea:RHEA-COMP:17167, ChEBI:CHEBI:57856,
ChEBI:CHEBI:59789, ChEBI:CHEBI:156461, ChEBI:CHEBI:167617;
EC=2.1.1.56; Evidence={ECO:0000250|UniProtKB:O43148,
ECO:0000255|PROSITE-ProRule:PRU00895}.
ACTIVITY REGULATION: Methyltransferase activity is activated by
RAMAC. {ECO:0000250|UniProtKB:O43148}.
[SUBUNIT] Interacts with importin alpha, leading to stimulate both
RNA-binding and methyltransferase activity. Interaction with
importin alpha and beta is required for its nuclear localization,
importin beta dissociating in response to RanGTP, allowing
RNMT-importin alpha to bind RNA substrates. Interacts with
elongating form of polymerase II and RNGTT. Interacts with RAMAC,
this interaction significantly enhances RNA-binding and cap
methyltransferase activity. {ECO:0000250|UniProtKB:O43148}.
[SUBCELLULAR LOCATION] Nucleus {ECO:0000250|UniProtKB:O43148}.
[ALTERNATIVE PRODUCTS] Event=Alternative splicing; Named
isoforms=3; Name=1; IsoId=Q9D0L8-1; Sequence=Displayed; Name=2;
IsoId=Q9D0L8-2; Sequence=VSP_020243; Name=3; IsoId=Q9D0L8-3;
Sequence=VSP_020242.
[SIMILARITY] Belongs to the class I-like SAM-binding
methyltransferase superfamily. mRNA cap 0 methyltransferase family.
{ECO:0000255|PROSITE-ProRule:PRU00895}.
[SEQUENCE CAUTION] Sequence=BAC97940.1; Type=Erroneous initiation;
Evidence={ECO:0000305}.
FEATURES Location/Qualifiers
source 1..465
/organism="Mus musculus"
/db_xref="taxon:10090"
gene 1..465
/gene="Rnmt"
/gene_synonym="Kiaa0398"
Protein 1..465
/product="mRNA cap guanine-N(7) methyltransferase"
/EC_number="2.1.1.56"
/note="RG7MT1; mRNA (guanine-N(7))-methyltransferase; mRNA
cap methyltransferase"
/UniProtKB_evidence="Evidence at protein level"
Region 1..465
/region_name="Mature chain"
/note="mRNA cap guanine-N(7) methyltransferase.
/id=PRO_0000248323."
Region 1..132
/region_name="Region of interest in the sequence"
/note="Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite."
Site 11
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:15345747,
ECO:0007744|PubMed:21183079."
Site 15
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:15345747,
ECO:0007744|PubMed:17242355, ECO:0007744|PubMed:19131326,
ECO:0007744|PubMed:21183079."
Region 32
/region_name="Conflict"
/note="E -> K (in Ref. 2; BAB29834).
/evidence=ECO:0000305."
Region 53
/region_name="Conflict"
/note="L -> H (in Ref. 2; BAE43278).
/evidence=ECO:0000305."
Site 64
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:21183079."
Region 65..129
/region_name="Compositionally biased region"
/note="Basic and acidic residues.
/evidence=ECO:0000256|SAM:MobiDB-lite."
Site 100
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0007744|PubMed:19144319,
ECO:0007744|PubMed:21183079."
Site 105
/site_type="phosphorylation"
/note="Phosphoserine.
/evidence=ECO:0000250|UniProtKB:Q5U2U7."
Region 113..115
/region_name="Short sequence motif of biological interest"
/note="Nuclear localization signal.
/evidence=ECO:0000250."
Region 125..464
/region_name="Pox_MCEL"
/note="mRNA capping enzyme; pfam03291"
/db_xref="CDD:281307"
Region 156..464
/region_name="Domain"
/note="mRNA cap 0 methyltransferase.
/evidence=ECO:0000255|PROSITE-ProRule:PRU00895."
Site order(193..199,216..217,249..251,273)
/site_type="other"
/note="S-adenosylmethionine binding site [chemical
binding]"
/db_xref="CDD:100107"
Site 197
/site_type="other"
/note="mRNA cap binding.
/evidence=ECO:0000255|PROSITE-ProRule:PRU00895."
Site 203
/site_type="other"
/note="mRNA cap binding.
/evidence=ECO:0000255|PROSITE-ProRule:PRU00895."
Site 228
/site_type="other"
/note="mRNA cap binding.
/evidence=ECO:0000255|PROSITE-ProRule:PRU00895."
Site 277
/site_type="other"
/note="mRNA cap binding.
/evidence=ECO:0000255|PROSITE-ProRule:PRU00895."
Region 315..369
/region_name="Splicing variant"
/note="Missing (in isoform 3).
/evidence=ECO:0000303|PubMed:16141072. /id=VSP_020242."
Site 359
/site_type="other"
/note="mRNA cap binding.
/evidence=ECO:0000255|PROSITE-ProRule:PRU00895."
Region 370..465
/region_name="Splicing variant"
/note="Missing (in isoform 2).
/evidence=ECO:0000303|PubMed:16141072. /id=VSP_020243."
Site 456
/site_type="other"
/note="mRNA cap binding.
/evidence=ECO:0000255|PROSITE-ProRule:PRU00895."
ORIGIN
1 megsakasva sdpesppggn epaaasgqrl pentppcqqv dqpkmqkefg edlveqnssy
61 vqdspskkrk ldveiileek hseddggsak rsklergdvs edepslgrln qtkrklqpqd
121 devpqklqkl eeghssavaa hynelqevgl akrsqsrify lrnfnnwiks iligeilekv
181 rqrktrditv ldlgcgkggd llkwrkgris rlvcadiadi smkqcqqrye dmrcrrdneh
241 ifsaefitad cskellvekf rdpemyfdvc scqfachysf esqvqadtml rnacgrlnpg
301 gyfigttpns felirrleas etesfgneiy tvkfqkkgny plfgckydfn legvvdvpef
361 lvyfplltem akkynmkliy kktflefyee kiknnenkml lkrmqaleqy pahensklas
421 ekvgdythaa eylkksqvrl plgtlsksew eatsiylvfa fekqq
//