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R12E2.11 Orotate phosphoribosyltransferase [ Caenorhabditis elegans ]

Gene ID: 172008, updated on 9-Dec-2024

Summary

Official Symbol
R12E2.11
Official Full Name
Orotate phosphoribosyltransferase
Primary source
WormBase:WBGene00020036
Locus tag
CELE_R12E2.11
See related
AllianceGenome:WB:WBGene00020036
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables orotate phosphoribosyltransferase activity. Involved in UMP biosynthetic process. Is expressed in body wall musculature; intestine; spermatheca; and vulval muscle. Human ortholog(s) of this gene implicated in orotic aciduria and purine-pyrimidine metabolic disorder. Orthologous to human UMPS (uridine monophosphate synthetase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See R12E2.11 in Genome Data Viewer
Location:
chromosome: I
Exon count:
3
Sequence:
Chromosome: I; NC_003279.8 (4172438..4173624, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Inactive protein-tyrosine phosphatase egg-5 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Small ribosomal subunit protein bS6m Neighboring gene MPN domain-containing protein Neighboring gene ncRNA

Interactions

General gene information

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in 'de novo' UMP biosynthetic process  
involved_in UMP biosynthetic process  
involved_in UMP biosynthetic process PubMed 
involved_in UMP salvage  
involved_in pyrimidine nucleobase biosynthetic process  
involved_in pyrimidine nucleotide biosynthetic process  

General protein information

Preferred Names
Orotate phosphoribosyltransferase
NP_491317.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    4172438..4173624 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058916.6NP_491317.1  Orotate phosphoribosyltransferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491317.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O61790
    Conserved Domains (1) summary
    COG0461
    Location:32221
    PyrE; Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]
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