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Rpl4 ribosomal protein L4 [ Mus musculus (house mouse) ]

Gene ID: 67891, updated on 9-Dec-2024

Summary

Official Symbol
Rpl4provided by MGI
Official Full Name
ribosomal protein L4provided by MGI
Primary source
MGI:MGI:1915141
See related
Ensembl:ENSMUSG00000032399 AllianceGenome:MGI:1915141
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2010004J23Rik
Summary
A structural constituent of ribosome. Predicted to be involved in positive regulation of axon extension. Located in cytoplasm. Part of cytosolic large ribosomal subunit. Is expressed in 8-cell stage embryo. Orthologous to human RPL4 (ribosomal protein L4). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in liver E14 (RPKM 606.0), CNS E11.5 (RPKM 541.9) and 28 other tissues See more
Orthologs
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Genomic context

See Rpl4 in Genome Data Viewer
Location:
9 C; 9 34.54 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (64080159..64085805)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (64173387..64178562)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39360 Neighboring gene lactase-like Neighboring gene zwilch kinetochore protein Neighboring gene STARR-seq mESC enhancer starr_24420 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:64027060-64027169 Neighboring gene STARR-seq mESC enhancer starr_24421 Neighboring gene small nucleolar RNA, C/D box 16A Neighboring gene predicted gene, 23344 Neighboring gene predicted gene, 22571 Neighboring gene predicted gene, 23136 Neighboring gene predicted gene, 22455 Neighboring gene small nuclear RNA activating complex, polypeptide 5 Neighboring gene STARR-seq mESC enhancer starr_24422 Neighboring gene mitogen-activated protein kinase kinase 1 Neighboring gene STARR-seq mESC enhancer starr_24424 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:64075662-64075771 Neighboring gene ubiquitin carboxyl-terminal esterase L4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 5S rRNA binding  
enables RNA binding  
enables protein binding PubMed 
enables structural constituent of ribosome  
enables structural constituent of ribosome PubMed 
enables structural constituent of ribosome  
Component Evidence Code Pubs
located_in A band  
located_in cytoplasm PubMed 
located_in cytosol  
part_of cytosolic large ribosomal subunit  
part_of cytosolic large ribosomal subunit PubMed 
part_of cytosolic large ribosomal subunit PubMed 
part_of cytosolic large ribosomal subunit  
located_in cytosolic ribosome  
part_of large ribosomal subunit  
located_in nucleus  
located_in nucleus  
is_active_in postsynapse PubMed 
is_active_in postsynaptic density  
is_active_in presynapse PubMed 
part_of ribonucleoprotein complex PubMed 
is_active_in ribosome PubMed 
located_in rough endoplasmic reticulum  
located_in rough endoplasmic reticulum  

General protein information

Preferred Names
large ribosomal subunit protein uL4
Names
60S ribosomal protein L4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024212.5NP_077174.1  large ribosomal subunit protein uL4

    See identical proteins and their annotated locations for NP_077174.1

    Status: VALIDATED

    Source sequence(s)
    AC160118
    Consensus CDS
    CCDS40667.1
    UniProtKB/Swiss-Prot
    Q9CY08, Q9D8E6
    UniProtKB/TrEMBL
    Q564E8
    Related
    ENSMUSP00000034966.8, ENSMUST00000034966.9
    Conserved Domains (1) summary
    PTZ00428
    Location:2352
    PTZ00428; 60S ribosomal protein L4; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    64080159..64085805
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155218.1XP_036011111.1  large ribosomal subunit protein uL4 isoform X1

    UniProtKB/Swiss-Prot
    Q9CY08, Q9D8E6
    UniProtKB/TrEMBL
    Q564E8
    Conserved Domains (1) summary
    PTZ00428
    Location:2352
    PTZ00428; 60S ribosomal protein L4; Provisional
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