U.S. flag

An official website of the United States government

GNAS GNAS complex locus [ Homo sapiens (human) ]

Gene ID: 2778, updated on 27-Dec-2024

Summary

Official Symbol
GNASprovided by HGNC
Official Full Name
GNAS complex locusprovided by HGNC
Primary source
HGNC:HGNC:4392
See related
Ensembl:ENSG00000087460 MIM:139320; AllianceGenome:HGNC:4392
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AHO; GSA; GSP; POH; GPSA; NESP; SCG6; SgVI; GNAS1; PITA3; AIMAH1; C20orf45
Summary
This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. [provided by RefSeq, Aug 2012]
Expression
Ubiquitous expression in thyroid (RPKM 405.2), brain (RPKM 137.2) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See GNAS in Genome Data Viewer
Location:
20q13.32
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (58839748..58911192)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (60622888..60694319)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (57414803..57486247)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene GNAS antisense RNA 1 Neighboring gene microRNA 296 Neighboring gene microRNA 298 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18178 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:57429646-57430522 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:57430523-57431398 Neighboring gene uncharacterized LOC101927932 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18179 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13080 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13082 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13081 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13083 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13084 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr20:57470438-57471032 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:57471033-57471626 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:57474225-57474776 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18180 Neighboring gene uncharacterized LOC107985382 Neighboring gene small integral membrane protein 30-like Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr20:57540701-57541253 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:57556569-57557069 Neighboring gene negative elongation factor complex member C/D

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2021-01-12)

ClinGen Genome Curation Page
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated 2021-01-12)

ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
EBI GWAS Catalog
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
EBI GWAS Catalog
Genome-wide association study of theta band event-related oscillations identifies serotonin receptor gene HTR7 influencing risk of alcohol dependence.
EBI GWAS Catalog
Genomic association analysis of common variants influencing antihypertensive response to hydrochlorothiazide.
EBI GWAS Catalog
Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.
EBI GWAS Catalog

Pathways from PubChem

Interactions

General gene information

Clone Names

  • MGC33735

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables D1 dopamine receptor binding  
enables D1 dopamine receptor binding PubMed 
enables G protein activity PubMed 
enables G protein activity  
enables G-protein beta/gamma-subunit complex binding  
enables G-protein beta/gamma-subunit complex binding  
enables GTP binding  
enables GTPase activity  
enables GTPase activity PubMed 
enables adenylate cyclase activator activity  
enables adenylate cyclase activator activity  
enables adenylate cyclase regulator activity PubMed 
enables beta-2 adrenergic receptor binding  
enables corticotropin-releasing hormone receptor 1 binding  
enables insulin-like growth factor receptor binding  
enables ionotropic glutamate receptor binding  
enables metal ion binding  
enables mu-type opioid receptor binding  
enables protein binding PubMed 
Items 1 - 25 of 34
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway  
involved_in activation of adenylate cyclase activity PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway PubMed 
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway PubMed 
involved_in adenylate cyclase-activating dopamine receptor signaling pathway  
involved_in adenylate cyclase-activating dopamine receptor signaling pathway  
involved_in adenylate cyclase-activating serotonin receptor signaling pathway PubMed 
involved_in bone development PubMed 
involved_in bone development PubMed 
involved_in cellular response to catecholamine stimulus  
involved_in cellular response to glucagon stimulus  
involved_in cellular response to prostaglandin E stimulus  
involved_in cognition PubMed 
involved_in cognition PubMed 
involved_in developmental growth PubMed 
involved_in developmental growth PubMed 
involved_in female pregnancy PubMed 
involved_in hair follicle placode formation PubMed 
involved_in hair follicle placode formation PubMed 
involved_in intracellular transport PubMed 
involved_in negative regulation of inflammatory response to antigenic stimulus  
involved_in negative regulation of multicellular organism growth  
involved_in platelet aggregation PubMed 
involved_in platelet aggregation PubMed 
involved_in positive regulation of cold-induced thermogenesis PubMed 
involved_in protein secretion PubMed 
involved_in regulation of insulin secretion  
involved_in regulation of signal transduction PubMed 
involved_in renal water homeostasis  
involved_in response to parathyroid hormone PubMed 
involved_in response to prostaglandin E PubMed 
involved_in sensory perception of chemical stimulus  
involved_in sensory perception of smell PubMed 
Items 1 - 25 of 34
Component Evidence Code Pubs
located_in apical plasma membrane  
is_active_in cytoplasm  
located_in cytoplasm PubMed 
located_in cytosol PubMed 
located_in cytosol  
located_in extracellular exosome PubMed 
located_in extracellular region  
part_of heterotrimeric G-protein complex  
part_of heterotrimeric G-protein complex  
part_of heterotrimeric G-protein complex PubMed 
located_in membrane PubMed 
located_in membrane PubMed 
located_in membrane  
located_in nucleus PubMed 
located_in perinuclear region of cytoplasm PubMed 
located_in plasma membrane  
located_in plasma membrane PubMed 
located_in ruffle  
located_in trans-Golgi network membrane PubMed 
located_in transport vesicle  

General protein information

Preferred Names
protein ALEX; protein GNAS; protein SCG6 (secretogranin VI)
Names
G protein subunit alpha S
adenylate cyclase-stimulating G alpha protein
alternative gene product encoded by XL-exon
extra large alphas protein
guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1
guanine nucleotide regulatory protein
secretogranin VI

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016194.2 RefSeqGene

    Range
    5009..76453
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000516.7NP_000507.1  protein GNAS isoform GNASL

    See identical proteins and their annotated locations for NP_000507.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is biallelically expressed and encodes guanine nucleotide binding protein alpha s long (GNASL), also known as alpha-S2, a form of the G-protein alpha subunit.
    Source sequence(s)
    AF105253, AF493897, BC008855, BU857975
    Consensus CDS
    CCDS13472.1
    UniProtKB/Swiss-Prot
    A6NI00, E1P5G5, P04895, P63092, Q12927, Q14433, Q32P26, Q5JWD2, Q5JWD4, Q5JWD5, Q6NR75, Q6NXS0, Q8TBC0, Q96H70
    UniProtKB/TrEMBL
    A0A0S2Z3H8, Q5FWY2
    Related
    ENSP00000360126.3, ENST00000371085.8
    Conserved Domains (1) summary
    cd00066
    Location:41388
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
  2. NM_001077488.5NP_001070956.1  protein GNAS isoform f

    See identical proteins and their annotated locations for NP_001070956.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) is biallelically expressed and uses an alternate in frame splice site, compared to variant 1. It encodes isoform f which has an additional amino acid in the internal region compared to isoform GNASL.
    Source sequence(s)
    AF105253, AF493897, BC008855, BC089157, M14631
    Consensus CDS
    CCDS46623.1
    UniProtKB/TrEMBL
    Q5FWY2
    Related
    ENSP00000346328.7, ENST00000354359.12
    Conserved Domains (1) summary
    cd00066
    Location:41389
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
  3. NM_001077489.4NP_001070957.1  protein GNAS isoform g

    See identical proteins and their annotated locations for NP_001070957.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) is biallelically expressed and lacks an alternate in-frame coding exon, compared to variant 1. It encodes isoform g, which lacks an internal segment, compared to isoform GNASL.
    Source sequence(s)
    AF105253, AF493897, BC066923, BC089157
    Consensus CDS
    CCDS42892.1
    UniProtKB/TrEMBL
    Q5FWY2
    Related
    ENSP00000265620.7, ENST00000265620.11
    Conserved Domains (1) summary
    cd00066
    Location:41373
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
  4. NM_001077490.3NP_001070958.1  protein ALEX isoform Alex

    See identical proteins and their annotated locations for NP_001070958.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as GNASXL), is paternally expressed and includes an alternate 5' exon, compared to variant 1. This variant includes two overlapping ORFs encoding XLas and Alex, respectively. This RefSeq represents Alex (also known as alexX), which has no similarity to other proteins encoded by this gene. It interacts with XLas, and their interaction is essential for G-protein signaling in neuroendocrine cells.
    Source sequence(s)
    AL132655, BQ029639, X04408
    UniProtKB/Swiss-Prot
    A2A2S4, P84996
    UniProtKB/TrEMBL
    A0A8I5F5B5
    Conserved Domains (1) summary
    PHA03247
    Location:125345
    PHA03247; large tegument protein UL36; Provisional
  5. NM_001309840.2NP_001296769.1  protein ALEX isoform h

    See identical proteins and their annotated locations for NP_001296769.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) is paternally expressed, contains an alternate 5' terminal exon (A/B or Exon 1A) and uses a downstream start codon, compared to variant 1. Variants 9 and 11 encode the same isoform h (described in PMID:21713996), which has a shorter N-terminus, compared to isoform GNASL.
    Source sequence(s)
    AL537118, CN403086, X04408, X56009
    Consensus CDS
    CCDS93068.1
    UniProtKB/TrEMBL
    A0A590UJ22, A0A590UJ58, A0A590UJI6, A0A590UJQ2, A0A590UJY8, A0A9K3Y787, B0AZR9, Q5FWY2, S4R3E3, S4R3V9
    Related
    ENSP00000499660.1, ENST00000477931.5
    Conserved Domains (1) summary
    cd00066
    Location:1329
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
  6. NM_001309842.2NP_001296771.1  protein ALEX isoform i

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) contains an alternate 3' exon structure, compared to variant 1. It encodes isoform i, which has a shorter and distinct C-terminus, compared to isoform GNASL.
    Source sequence(s)
    AA948160, BC089157, BF800576, BF879848, CB530031, DB483472
    Consensus CDS
    CCDS82633.1
    UniProtKB/TrEMBL
    A2A2R6, Q5JWD1
    Related
    ENSP00000360122.1, ENST00000371081.5
    Conserved Domains (1) summary
    smart00275
    Location:2071
    G_alpha; G protein alpha subunit
  7. NM_001309861.2NP_001296790.1  protein ALEX isoform h

    See identical proteins and their annotated locations for NP_001296790.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) contains an alternate 5' terminal exon, compared to variant 1. Variants 9 and 11 encode the same isoform h (described in PMID:21713996), which has a shorter N-terminus, compared to isoform GNASL.
    Source sequence(s)
    AF105253, AK315874, CN273438
    Consensus CDS
    CCDS93068.1
    UniProtKB/TrEMBL
    A0A590UJ22, A0A590UJ58, A0A590UJI6, A0A590UJQ2, A0A590UJY8, A0A9K3Y787, B0AZR9, Q5FWY2, S4R3E3, S4R3V9
    Related
    ENSP00000499673.2, ENST00000472183.6
    Conserved Domains (1) summary
    cd00066
    Location:1329
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
  8. NM_001309883.1NP_001296812.1  protein ALEX isoform Alex

    See identical proteins and their annotated locations for NP_001296812.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) contains an alternate 5' exon structure compared to variant 1. It encodes the protein Alex (also known as alexX), which has no similarity to other proteins encoded by this gene. It interacts with XLas, and their interaction is essential for G-protein signaling in neuroendocrine cells. Variants 2 and 12 encode the same protein (Alex).
    Source sequence(s)
    AA948160, AJ224867, AL132655, BF800576, BF879848
    UniProtKB/Swiss-Prot
    A2A2S4, P84996
    UniProtKB/TrEMBL
    A0A8I5F5B5
    Related
    ENSP00000302237.4, ENST00000306120.4
    Conserved Domains (1) summary
    PHA03247
    Location:125345
    PHA03247; large tegument protein UL36; Provisional
  9. NM_001410912.1NP_001397841.1  protein ALEX isoform j

    Status: REVIEWED

    Source sequence(s)
    AL109840, AL121917, AL132655
    Consensus CDS
    CCDS93063.1
    UniProtKB/TrEMBL
    A0A0A0MR13, Q5FWY2
    Related
    ENSP00000304472.12, ENST00000306090.12
  10. NM_001410913.1NP_001397842.1  protein ALEX isoform k

    Status: REVIEWED

    Source sequence(s)
    AL109840, AL121917, AL132655
    Consensus CDS
    CCDS93066.1
    UniProtKB/TrEMBL
    Q5JWE9
    Related
    ENSP00000265621.6, ENST00000349036.9
  11. NM_016592.5NP_057676.1  protein SCG6 (secretogranin VI) isoform SCG6

    See identical proteins and their annotated locations for NP_057676.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) is maternally expressed and encodes secretogranin VI (SCG6, also known as NESP55), which localizes to large secretory vesicles of endocrine cells and neurons. Its coding region is within the 5'-most exon and does not overlap the coding regions used by other transcripts; thus SCG6 has no similarity to isoforms of the G-protein alpha subunit. This variant has an antisense transcript, GNAS-AS1.
    Source sequence(s)
    AF105253, AL132655, BC008855, BC036081
    Consensus CDS
    CCDS13471.1
    UniProtKB/Swiss-Prot
    B2RB88, E1P5G2, O95417, O95467
    Related
    ENSP00000360115.3, ENST00000371075.7
    Conserved Domains (1) summary
    pfam06390
    Location:1245
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
  12. NM_080425.4NP_536350.2  protein GNAS isoform XLas

    See identical proteins and their annotated locations for NP_536350.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as GNASXL) is paternally expressed and includes an alternate 5' exon, compared to variant 1. This variant includes two overlapping open reading frames encoding isoforms XLas and Alex, respectively. This RefSeq represents isoform XLas (also known as alpha sXXL), which is a neuroendocrine-specific G-protein alpha subunit. The encoded isoform has a distinct and longer N-terminus, compared to isoform GNASL. Variants 2 and 12 both encode the same isoform (Alex).
    Source sequence(s)
    AL132655, BQ029639, CN295544, X04408
    Consensus CDS
    CCDS46622.1
    UniProtKB/Swiss-Prot
    A2A2S3, E1P5G3, O75684, O75685, Q5JW67, Q5JWF1, Q5JWF2, Q9NY42
    Related
    ENSP00000360141.3, ENST00000371100.9
    Conserved Domains (2) summary
    cd00066
    Location:6841031
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
    smart00275
    Location:6631034
    G_alpha; G protein alpha subunit
  13. NM_080426.4NP_536351.1  protein GNAS isoform GNASS

    See identical proteins and their annotated locations for NP_536351.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) is biallelically expressed. It lacks an internal exon and uses an alternate splice site, compared to variant 1. It encodes isoform GNASS, also known as alpha-S1, which differs in an internal region and has identical N- and C-termini, compared to isoform GNASL.
    Source sequence(s)
    AF105253, AF493897, BC089157
    Consensus CDS
    CCDS46624.1
    UniProtKB/TrEMBL
    A0A0S2Z3S5, Q5FWY2
    Related
    ENSP00000360136.3, ENST00000371095.7
    Conserved Domains (1) summary
    cd00066
    Location:41374
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

RNA

  1. NR_132272.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13) contains alternate 5' and 3' terminal exons, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AA948160, AL121917, BF800576, BF879848, HY141824
  2. NR_132273.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) contains alternate 5' and 3' terminal exons, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AA948160, AL121917, AV751821, BF800576, BF879848, BM894355
    Related
    ENST00000464960.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    58839748..58911192
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047440113.1XP_047296069.1  protein ALEX isoform X3

    UniProtKB/TrEMBL
    Q5FWY2
  2. XM_017027815.2XP_016883304.1  protein ALEX isoform X4

    UniProtKB/TrEMBL
    Q5FWY2
    Conserved Domains (1) summary
    cd00066
    Location:5341
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
  3. XM_047440114.1XP_047296070.1  protein GNAS isoform X5

    UniProtKB/TrEMBL
    A0A590UJB7, A0A590UJQ9, A0A590UJR6, Q5FWY2
    Related
    ENSP00000499353.2, ENST00000663479.2
  4. XM_047440122.1XP_047296078.1  protein GNAS isoform X8

    UniProtKB/TrEMBL
    A0A590UJF0, A0A590UJG5, A0A590UKA4, Q5FWY2
    Related
    ENSP00000499794.2, ENST00000482112.6
  5. XM_017027812.3XP_016883301.1  protein GNAS isoform X1

    UniProtKB/TrEMBL
    A0A7I2V5R6
    Related
    ENSP00000504675.2, ENST00000676826.2
  6. XM_017027813.3XP_016883302.1  protein ALEX isoform X2

    UniProtKB/Swiss-Prot
    Q5JWF2
    Related
    ENSP00000360143.4, ENST00000371102.8
  7. XM_047440121.1XP_047296077.1  protein GNAS isoform X8

    UniProtKB/TrEMBL
    A0A590UJF0, A0A590UJG5, A0A590UKA4, Q5FWY2
  8. XM_047440125.1XP_047296081.1  protein GNAS isoform X5

    UniProtKB/TrEMBL
    A0A590UJB7, A0A590UJQ9, A0A590UJR6, Q5FWY2
    Related
    ENSP00000499552.2, ENST00000470512.6
  9. XM_047440118.1XP_047296074.1  protein GNAS isoform X7

    UniProtKB/TrEMBL
    A0A590UJA5, A0A590UJB0, A0A590UJJ0, A0A590UK28, A0A590UKA1, A0A590UKA9, A0A590UKB4, Q5FWY2
    Related
    ENSP00000499762.2, ENST00000478585.6
  10. XM_017027817.2XP_016883306.1  protein GNAS isoform X8

    UniProtKB/TrEMBL
    A0A590UJF0, A0A590UJG5, A0A590UKA4, Q5FWY2
    Related
    ENSP00000499392.1, ENST00000480975.5
    Conserved Domains (1) summary
    cd00066
    Location:1314
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
  11. XM_047440117.1XP_047296073.1  protein GNAS isoform X5

    UniProtKB/TrEMBL
    A0A590UJB7, A0A590UJQ9, A0A590UJR6, Q5FWY2
  12. XM_024451875.2XP_024307643.1  protein GNAS isoform X6

    UniProtKB/TrEMBL
    A0A590UJ22, A0A590UJ58, A0A590UJI6, A0A590UJQ2, A0A590UJY8, A0A9K3Y787, B0AZR9, Q5FWY2, S4R3E3, S4R3V9
    Related
    ENSP00000474219.2, ENST00000604005.6
    Conserved Domains (1) summary
    cd00066
    Location:1329
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
  13. XM_047440120.1XP_047296076.1  protein GNAS isoform X7

    UniProtKB/TrEMBL
    A0A590UJA5, A0A590UJB0, A0A590UJJ0, A0A590UK28, A0A590UKA1, A0A590UKA9, A0A590UKB4, Q5FWY2
  14. XM_017027819.2XP_016883308.1  protein GNAS isoform X8

    UniProtKB/TrEMBL
    A0A590UJF0, A0A590UJG5, A0A590UKA4, Q5FWY2
    Conserved Domains (1) summary
    cd00066
    Location:1314
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
  15. XM_047440116.1XP_047296072.1  protein GNAS isoform X5

    UniProtKB/TrEMBL
    A0A590UJB7, A0A590UJQ9, A0A590UJR6, Q5FWY2
  16. XM_047440123.1XP_047296079.1  protein GNAS isoform X8

    UniProtKB/TrEMBL
    A0A590UJF0, A0A590UJG5, A0A590UKA4, Q5FWY2
  17. XM_047440115.1XP_047296071.1  protein GNAS isoform X5

    UniProtKB/TrEMBL
    A0A590UJB7, A0A590UJQ9, A0A590UJR6, Q5FWY2
  18. XM_024451873.2XP_024307641.1  protein GNAS isoform X6

    UniProtKB/TrEMBL
    A0A590UJ22, A0A590UJ58, A0A590UJI6, A0A590UJQ2, A0A590UJY8, A0A9K3Y787, B0AZR9, Q5FWY2, S4R3E3, S4R3V9
    Related
    ENSP00000499435.2, ENST00000488652.6
    Conserved Domains (1) summary
    cd00066
    Location:1329
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
  19. XM_047440119.1XP_047296075.1  protein GNAS isoform X7

    UniProtKB/TrEMBL
    A0A590UJA5, A0A590UJB0, A0A590UJJ0, A0A590UK28, A0A590UKA1, A0A590UKA9, A0A590UKB4, Q5FWY2
    Related
    ENSP00000499443.2, ENST00000492907.6
  20. XM_017027818.3XP_016883307.1  protein GNAS isoform X8

    UniProtKB/TrEMBL
    A0A590UJF0, A0A590UJG5, A0A590UKA4, Q5FWY2
    Related
    ENSP00000499409.2, ENST00000476935.6
    Conserved Domains (1) summary
    cd00066
    Location:1314
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
  21. XM_017027820.1XP_016883309.1  protein GNAS isoform X9

    UniProtKB/TrEMBL
    Q5FWY2
    Conserved Domains (1) summary
    cd00066
    Location:11314
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
  22. XM_047440124.1XP_047296080.1  protein GNAS isoform X9

    UniProtKB/TrEMBL
    Q5FWY2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    60622888..60694319
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054323370.1XP_054179345.1  protein ALEX isoform X3

    UniProtKB/TrEMBL
    Q5FWY2
  2. XM_054323371.1XP_054179346.1  protein ALEX isoform X4

    UniProtKB/TrEMBL
    Q5FWY2
  3. XM_054323372.1XP_054179347.1  protein GNAS isoform X5

    UniProtKB/TrEMBL
    A0A590UJB7, A0A590UJQ9, A0A590UJR6, Q5FWY2
  4. XM_054323378.1XP_054179353.1  protein GNAS isoform X8

    UniProtKB/TrEMBL
    A0A590UJF0, A0A590UJG5, A0A590UKA4, Q5FWY2
  5. XM_054323365.1XP_054179340.1  protein GNAS isoform X1

    UniProtKB/TrEMBL
    A0A7I2V5R6
  6. XM_054323366.1XP_054179341.1  protein ALEX isoform X2

  7. XM_054323367.1XP_054179342.1  protein GNAS isoform X5

    UniProtKB/TrEMBL
    A0A590UJB7, A0A590UJQ9, A0A590UJR6, Q5FWY2
  8. XM_054323368.1XP_054179343.1  protein GNAS isoform X7

    UniProtKB/TrEMBL
    A0A590UJA5, A0A590UJB0, A0A590UJJ0, A0A590UK28, A0A590UKA1, A0A590UKA9, A0A590UKB4, Q5FWY2
  9. XM_054323369.1XP_054179344.1  protein GNAS isoform X8

    UniProtKB/TrEMBL
    A0A590UJF0, A0A590UJG5, A0A590UKA4, Q5FWY2
  10. XM_054323373.1XP_054179348.1  protein GNAS isoform X5

    UniProtKB/TrEMBL
    A0A590UJB7, A0A590UJQ9, A0A590UJR6, Q5FWY2
  11. XM_054323374.1XP_054179349.1  protein GNAS isoform X6

    UniProtKB/TrEMBL
    A0A590UJ22, A0A590UJ58, A0A590UJI6, A0A590UJQ2, A0A590UJY8, A0A9K3Y787, B0AZR9, Q5FWY2, S4R3E3, S4R3V9
  12. XM_054323375.1XP_054179350.1  protein GNAS isoform X7

    UniProtKB/TrEMBL
    A0A590UJA5, A0A590UJB0, A0A590UJJ0, A0A590UK28, A0A590UKA1, A0A590UKA9, A0A590UKB4, Q5FWY2
  13. XM_054323376.1XP_054179351.1  protein GNAS isoform X8

    UniProtKB/TrEMBL
    A0A590UJF0, A0A590UJG5, A0A590UKA4, Q5FWY2
  14. XM_054323377.1XP_054179352.1  protein GNAS isoform X9

    UniProtKB/TrEMBL
    Q5FWY2
External link. Please review our privacy policy.