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INTS4 integrator complex subunit 4 [ Homo sapiens (human) ]

Gene ID: 92105, updated on 4-Jan-2025

Summary

Official Symbol
INTS4provided by HGNC
Official Full Name
integrator complex subunit 4provided by HGNC
Primary source
HGNC:HGNC:25048
See related
Ensembl:ENSG00000149262 MIM:611348; AllianceGenome:HGNC:25048
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
INT4; MST093
Summary
INTS4 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in lymph node (RPKM 4.0), appendix (RPKM 3.5) and 25 other tissues See more
Orthologs
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Genomic context

See INTS4 in Genome Data Viewer
Location:
11q14.1
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (77874362..77994668, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (77807588..77927912, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (77589766..77705714, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene remodeling and spacing factor 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:77530149-77531122 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:77531123-77532095 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3803 Neighboring gene ribosomal protein S20 pseudogene 27 Neighboring gene adipogenesis associated Mth938 domain containing Neighboring gene ribosomal protein L21 pseudogene 95 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:77643873-77644620 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:77644621-77645367 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5312 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3804 Neighboring gene MPRA-validated peak1367 silencer Neighboring gene NDUFC2-KCTD14 readthrough Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:77727696-77728196 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:77733111-77733678 Neighboring gene uncharacterized LOC124902723 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:77733679-77734248 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:77734249-77734816 Neighboring gene Sharpr-MPRA regulatory region 11011 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:77741282-77741794 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3805 Neighboring gene Sharpr-MPRA regulatory region 10650 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:77750634-77751590 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3807 Neighboring gene potassium channel tetramerization domain containing 14 Neighboring gene NADH:ubiquinone oxidoreductase subunit C2 Neighboring gene thyroid hormone responsive

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Pathways from PubChem

Interactions

General gene information

Clone Names

  • MGC16733

Gene Ontology Provided by GOA

Component Evidence Code Pubs
part_of integrator complex  
part_of integrator complex PubMed 
part_of integrator complex PubMed 
located_in nucleolus  
located_in nucleoplasm  
is_active_in nucleus PubMed 
located_in nucleus PubMed 
located_in nucleus PubMed 

General protein information

Preferred Names
integrator complex subunit 4
Names
MSTP093

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033547.4NP_291025.3  integrator complex subunit 4

    See identical proteins and their annotated locations for NP_291025.3

    Status: VALIDATED

    Source sequence(s)
    BC009859, BC009995, BC015664
    Consensus CDS
    CCDS31644.1
    UniProtKB/Swiss-Prot
    Q2YD62, Q6PJG4, Q7Z4E7, Q96G32, Q96GA1, Q96HW7, Q9BRC0
    UniProtKB/TrEMBL
    A8K4A1
    Related
    ENSP00000434466.1, ENST00000534064.6
    Conserved Domains (3) summary
    COG1413
    Location:51256
    HEAT; HEAT repeat [General function prediction only]
    sd00044
    Location:199221
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:379460
    Adaptin_N; Adaptin N terminal region

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    77874362..77994668 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018560.3XP_016874049.1  integrator complex subunit 4 isoform X1

    UniProtKB/TrEMBL
    A0A8Q3SHL8, A0A8Q3WKC7
    Related
    ENSP00000511686.1, ENST00000695096.1
  2. XM_047427873.1XP_047283829.1  integrator complex subunit 4 isoform X3

    UniProtKB/TrEMBL
    A0A8C8UVZ7, A0A8Q3SHR8
    Related
    ENSP00000441084.2, ENST00000535943.2
  3. XM_047427872.1XP_047283828.1  integrator complex subunit 4 isoform X2

    UniProtKB/TrEMBL
    A0A8Q3SHR8, A0A8Q3SHT4
    Related
    ENSP00000511692.1, ENST00000695101.1
  4. XM_011545353.4XP_011543655.1  integrator complex subunit 4 isoform X4

    UniProtKB/TrEMBL
    A0A8Q3WKB5, A0A8Q3WKW5
    Related
    ENSP00000511696.1, ENST00000695105.1
    Conserved Domains (3) summary
    COG1413
    Location:51256
    HEAT; HEAT repeat [General function prediction only]
    pfam12755
    Location:198255
    Vac14_Fab1_bd; Vacuolar 14 Fab1-binding region
    sd00044
    Location:199221
    HEAT; HEAT repeat [structural motif]

RNA

  1. XR_002957208.2 RNA Sequence

  2. XR_001748036.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    77807588..77927912 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054370508.1XP_054226483.1  integrator complex subunit 4 isoform X1

    UniProtKB/TrEMBL
    A0A8Q3SHL8, A0A8Q3WKC7
  2. XM_054370510.1XP_054226485.1  integrator complex subunit 4 isoform X3

    UniProtKB/TrEMBL
    A0A8C8UVZ7, A0A8Q3SHR8
  3. XM_054370509.1XP_054226484.1  integrator complex subunit 4 isoform X2

    UniProtKB/TrEMBL
    A0A8Q3SHR8, A0A8Q3SHT4
  4. XM_054370511.1XP_054226486.1  integrator complex subunit 4 isoform X4

    UniProtKB/TrEMBL
    A0A8Q3WKB5, A0A8Q3WKW5

RNA

  1. XR_008488495.1 RNA Sequence

  2. XR_008488494.1 RNA Sequence

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