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Zbtb7a zinc finger and BTB domain containing 7a [ Mus musculus (house mouse) ]

Gene ID: 16969, updated on 4-Jan-2025

Summary

Official Symbol
Zbtb7aprovided by MGI
Official Full Name
zinc finger and BTB domain containing 7aprovided by MGI
Primary source
MGI:MGI:1335091
See related
Ensembl:ENSMUSG00000035011 AllianceGenome:MGI:1335091
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lrf; FBI-1; Zbtb7; Pokemon; 9030619K07Rik; 9130006G12Rik
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and histone acetyltransferase binding activity. Involved in several processes, including double-strand break repair via classical nonhomologous end joining; hemopoiesis; and regulation of DNA-templated transcription. Part of DNA-dependent protein kinase complex. Colocalizes with site of double-strand break. Is expressed in several structures, including branchial arch; central nervous system; early conceptus; genitourinary system; and limb bud. Orthologous to human ZBTB7A (zinc finger and BTB domain containing 7A). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in colon adult (RPKM 50.1), adrenal adult (RPKM 36.3) and 23 other tissues See more
Orthologs
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Genomic context

See Zbtb7a in Genome Data Viewer
Location:
10 C1; 10 39.72 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80971113..80988056)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (81135225..81152222)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene microRNA 5615-1 Neighboring gene microRNA 5615-2 Neighboring gene mitogen-activated protein kinase kinase 2 Neighboring gene STARR-positive B cell enhancer ABC_E463 Neighboring gene STARR-positive B cell enhancer ABC_E8349 Neighboring gene STARR-seq mESC enhancer starr_27318 Neighboring gene protein inhibitor of activated STAT 4 Neighboring gene STARR-positive B cell enhancer ABC_E901 Neighboring gene STARR-positive B cell enhancer ABC_E8866 Neighboring gene STARR-positive B cell enhancer ABC_E3901 Neighboring gene STARR-positive B cell enhancer ABC_E5157 Neighboring gene STARR-positive B cell enhancer ABC_E2329 Neighboring gene small nucleolar RNA, C/D box 37 Neighboring gene eukaryotic translation elongation factor 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding PubMed 
enables DNA-binding transcription factor activity PubMed 
enables DNA-binding transcription factor activity PubMed 
enables DNA-binding transcription factor activity  
enables DNA-binding transcription factor activity, RNA polymerase II-specific  
enables DNA-binding transcription factor binding  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
enables SMAD binding  
enables SMAD binding  
enables histone acetyltransferase binding PubMed 
enables metal ion binding  
enables nuclear androgen receptor binding  
enables nuclear androgen receptor binding  
enables protein binding PubMed 
enables sequence-specific DNA binding PubMed 
enables sequence-specific double-stranded DNA binding  
enables transcription corepressor binding  
enables transcription corepressor binding  
Items 1 - 25 of 38
Process Evidence Code Pubs
involved_in B cell differentiation PubMed 
involved_in DNA-templated transcription PubMed 
involved_in cartilage development PubMed 
involved_in chromatin organization PubMed 
involved_in chromatin remodeling  
involved_in chromatin remodeling  
involved_in double-strand break repair via classical nonhomologous end joining PubMed 
involved_in erythrocyte maturation PubMed 
involved_in erythrocyte maturation  
involved_in fat cell differentiation  
involved_in fat cell differentiation  
involved_in negative regulation of DNA-templated transcription PubMed 
involved_in negative regulation of DNA-templated transcription  
involved_in negative regulation of Notch signaling pathway PubMed 
involved_in negative regulation of androgen receptor signaling pathway  
involved_in negative regulation of androgen receptor signaling pathway  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II PubMed 
involved_in negative regulation of transcription by RNA polymerase II PubMed 
involved_in negative regulation of transcription by RNA polymerase II  
involved_in negative regulation of transcription by RNA polymerase II  
involved_in negative regulation of transforming growth factor beta receptor signaling pathway  
involved_in negative regulation of transforming growth factor beta receptor signaling pathway  
involved_in positive regulation of NF-kappaB transcription factor activity  
involved_in positive regulation of NF-kappaB transcription factor activity  
involved_in protein localization to nucleus  
involved_in protein localization to nucleus  
involved_in regulation of DNA-binding transcription factor activity PubMed 
involved_in regulation of DNA-templated transcription  
involved_in regulation of alternative mRNA splicing, via spliceosome  
involved_in regulation of alternative mRNA splicing, via spliceosome  
involved_in regulation of apoptotic process  
involved_in regulation of apoptotic process  
involved_in regulation of glycolytic process  
involved_in regulation of glycolytic process  
involved_in regulation of osteoclast differentiation  
involved_in regulation of transcription by RNA polymerase II  
involved_in regulation of transcription regulatory region DNA binding  
involved_in regulation of transcription regulatory region DNA binding  
Items 1 - 25 of 38
Component Evidence Code Pubs
part_of DNA-dependent protein kinase complex PubMed 
located_in cytoplasm  
located_in cytoplasm  
is_active_in nucleus  
located_in nucleus  
located_in nucleus  
located_in nucleus PubMed 
colocalizes_with site of double-strand break PubMed 

General protein information

Preferred Names
zinc finger and BTB domain-containing protein 7A
Names
POK erythroid myeloid ontogenic factor
POZ and Krueppel erythroid myeloid ontogenic factor
leukemia/lymphoma related factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001404861.1NP_001391790.1  zinc finger and BTB domain-containing protein 7A

    Status: VALIDATED

    Source sequence(s)
    AC155932
    UniProtKB/Swiss-Prot
    B2RRP7, B7ZNL6, O88939, Q3U372, Q9CRJ0
    UniProtKB/TrEMBL
    B7ZWA9
  2. NM_001404862.1NP_001391791.1  zinc finger and BTB domain-containing protein 7A

    Status: VALIDATED

    Source sequence(s)
    AC155932
    UniProtKB/Swiss-Prot
    B2RRP7, B7ZNL6, O88939, Q3U372, Q9CRJ0
    UniProtKB/TrEMBL
    B7ZWA9
  3. NM_001404863.1NP_001391792.1  zinc finger and BTB domain-containing protein 7A

    Status: VALIDATED

    Source sequence(s)
    AC155932
    UniProtKB/Swiss-Prot
    B2RRP7, B7ZNL6, O88939, Q3U372, Q9CRJ0
    UniProtKB/TrEMBL
    B7ZWA9
    Related
    ENSMUSP00000113612.2, ENSMUST00000119606.8
  4. NM_001404864.1NP_001391793.1  zinc finger and BTB domain-containing protein 7A

    Status: VALIDATED

    Source sequence(s)
    AC155932
    UniProtKB/Swiss-Prot
    B2RRP7, B7ZNL6, O88939, Q3U372, Q9CRJ0
    UniProtKB/TrEMBL
    B7ZWA9
  5. NM_001404865.1NP_001391794.1  zinc finger and BTB domain-containing protein 7A

    Status: VALIDATED

    Source sequence(s)
    AC155932
    UniProtKB/Swiss-Prot
    B2RRP7, B7ZNL6, O88939, Q3U372, Q9CRJ0
    UniProtKB/TrEMBL
    B7ZWA9
  6. NM_001404866.1NP_001391795.1  zinc finger and BTB domain-containing protein 7A

    Status: VALIDATED

    Source sequence(s)
    AC155932
    UniProtKB/Swiss-Prot
    B2RRP7, B7ZNL6, O88939, Q3U372, Q9CRJ0
    UniProtKB/TrEMBL
    B7ZWA9
  7. NM_001404867.1NP_001391796.1  zinc finger and BTB domain-containing protein 7A

    Status: VALIDATED

    Source sequence(s)
    AC155932
    UniProtKB/Swiss-Prot
    B2RRP7, B7ZNL6, O88939, Q3U372, Q9CRJ0
    UniProtKB/TrEMBL
    B7ZWA9
    Related
    ENSMUSP00000113428.2, ENSMUST00000117956.2
  8. NM_010731.4NP_034861.3  zinc finger and BTB domain-containing protein 7A

    See identical proteins and their annotated locations for NP_034861.3

    Status: VALIDATED

    Source sequence(s)
    AC155932
    Consensus CDS
    CCDS35991.1
    UniProtKB/Swiss-Prot
    B2RRP7, B7ZNL6, O88939, Q3U372, Q9CRJ0
    UniProtKB/TrEMBL
    B7ZWA9
    Related
    ENSMUSP00000047333.9, ENSMUST00000048128.15
    Conserved Domains (3) summary
    sd00017
    Location:406426
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18326
    Location:9128
    BTB_POZ_ZBTB7A; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A)
    pfam13465
    Location:419443
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    80971113..80988056
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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