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CBY1 chibby 1, beta catenin antagonist [ Homo sapiens (human) ]

Gene ID: 25776, updated on 4-Jan-2025

Summary

Official Symbol
CBY1provided by HGNC
Official Full Name
chibby 1, beta catenin antagonistprovided by HGNC
Primary source
HGNC:HGNC:1307
See related
Ensembl:ENSG00000100211 MIM:607757; AllianceGenome:HGNC:1307
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CBY; arb1; PGEA1; C22orf2; Chibby1; PIGEA14; PIGEA-14; HS508I15A
Summary
Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in prostate (RPKM 16.6), adrenal (RPKM 16.3) and 25 other tissues See more
Orthologs
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Genomic context

See CBY1 in Genome Data Viewer
Location:
22q13.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (38656638..38673850)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (39126822..39144043)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (39052643..39069855)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein S29 pseudogene 31 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19014 Neighboring gene family with sequence similarity 227 member A Neighboring gene MPRA-validated peak4492 silencer Neighboring gene MPRA-validated peak4493 silencer Neighboring gene TOMM22 divergent transcript Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr22:39077750-39078949 Neighboring gene translocase of outer mitochondrial membrane 22

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables beta-catenin binding PubMed 
enables beta-catenin binding PubMed 
enables identical protein binding PubMed 
enables protein binding PubMed 
enables protein homodimerization activity PubMed 
Component Evidence Code Pubs
located_in centriole PubMed 
located_in ciliary basal body  
located_in cytosol  
located_in nuclear speck  
located_in nucleoplasm  
is_active_in nucleus  
located_in nucleus PubMed 
located_in trans-Golgi network PubMed 

General protein information

Preferred Names
protein chibby homolog 1
Names
ARPP-binding protein
PKD2 interactor, Golgi and endoplasmic reticulum-associated 1
chibby CTNNB1-mediated transcription inhibitor
chibby family member 1, beta catenin antagonist
chibby homolog 1
coiled-coil protein PIGEA-14
cytosolic leucine-rich protein
polycystin-2 interactor, Golgi- and endoplasmic reticulum-associated protein, 14 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047138.1 RefSeqGene

    Range
    4986..22198
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001002880.4NP_001002880.3  protein chibby homolog 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL021707, AU099418, BC016139, CD626926
    Consensus CDS
    CCDS13974.1
    UniProtKB/Swiss-Prot
    B2R4S2, Q66GT6, Q9UIK9, Q9Y3M2
    UniProtKB/TrEMBL
    B0QY54
    Related
    ENSP00000380026.2, ENST00000396811.6
    Conserved Domains (1) summary
    pfam14645
    Location:1114
    Chibby; Chibby family
  2. NM_015373.4NP_056188.1  protein chibby homolog 1

    See identical proteins and their annotated locations for NP_056188.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL021707, AL136686, BC016139, CD702742
    Consensus CDS
    CCDS13974.1
    UniProtKB/Swiss-Prot
    B2R4S2, Q66GT6, Q9UIK9, Q9Y3M2
    UniProtKB/TrEMBL
    B0QY54
    Related
    ENSP00000216029.3, ENST00000216029.8
    Conserved Domains (1) summary
    pfam14645
    Location:1114
    Chibby; Chibby family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    38656638..38673850
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    39126822..39144043
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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