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    Ccn1 cellular communication network factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 16007, updated on 4-Jan-2025

    Summary

    Official Symbol
    Ccn1provided by MGI
    Official Full Name
    cellular communication network factor 1provided by MGI
    Primary source
    MGI:MGI:88613
    See related
    Ensembl:ENSMUSG00000028195 AllianceGenome:MGI:88613
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cyr61; Igfbp10
    Summary
    Enables extracellular matrix binding activity and integrin binding activity. Acts upstream of or within several processes, including circulatory system development; positive regulation of hydrolase activity; and regulation of apoptotic process. Located in collagen-containing extracellular matrix. Is expressed in several structures, including brain; embryo mesenchyme; extraembryonic component; heart; and sensory organ. Used to study atrial heart septal defect 1 and atrioventricular septal defect. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human CCN1 (cellular communication network factor 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in lung adult (RPKM 41.5), limb E14.5 (RPKM 37.8) and 26 other tissues See more
    Orthologs
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    Genomic context

    See Ccn1 in Genome Data Viewer
    Location:
    3 H2; 3 70.18 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (145352726..145355740, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (145646971..145649985, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene zinc finger, HIT type 6 Neighboring gene STARR-seq mESC enhancer starr_09198 Neighboring gene predicted gene, 40164 Neighboring gene predicted gene, 17501 Neighboring gene STARR-seq mESC enhancer starr_09202 Neighboring gene STARR-seq mESC enhancer starr_09203 Neighboring gene STARR-seq mESC enhancer starr_09204 Neighboring gene STARR-seq mESC enhancer starr_09205 Neighboring gene dimethylarginine dimethylaminohydrolase 1 Neighboring gene ribosomal protein L36A, pseudogene 2 Neighboring gene predicted gene, 35187

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables extracellular matrix binding PubMed 
    enables growth factor binding  
    enables heparin binding  
    enables heparin binding  
    enables integrin binding  
    enables integrin binding PubMed 
    Items 1 - 25 of 55
    Process Evidence Code Pubs
    acts_upstream_of apoptotic process PubMed 
    acts_upstream_of_or_within apoptotic process involved in heart morphogenesis PubMed 
    acts_upstream_of_or_within atrial septum morphogenesis PubMed 
    acts_upstream_of_or_within atrioventricular valve morphogenesis PubMed 
    involved_in cell adhesion  
    acts_upstream_of_or_within cell adhesion PubMed 
    involved_in cell adhesion  
    acts_upstream_of_or_within cell-cell adhesion PubMed 
    involved_in chemotaxis  
    involved_in chemotaxis  
    acts_upstream_of chondroblast differentiation PubMed 
    acts_upstream_of_or_within chondroblast differentiation PubMed 
    acts_upstream_of_or_within chorio-allantoic fusion PubMed 
    acts_upstream_of_or_within extracellular matrix organization PubMed 
    acts_upstream_of_or_within intussusceptive angiogenesis PubMed 
    acts_upstream_of_or_within labyrinthine layer blood vessel development PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic process PubMed 
    acts_upstream_of_or_within osteoblast differentiation PubMed 
    involved_in positive regulation of BMP signaling pathway  
    involved_in positive regulation of BMP signaling pathway  
    acts_upstream_of_or_within positive regulation of apoptotic process PubMed 
    involved_in positive regulation of bone mineralization  
    involved_in positive regulation of bone mineralization  
    acts_upstream_of_or_within positive regulation of cartilage development PubMed 
    involved_in positive regulation of cell differentiation  
    acts_upstream_of_or_within positive regulation of cell differentiation PubMed 
    involved_in positive regulation of cell migration  
    acts_upstream_of_or_within positive regulation of cell migration PubMed 
    involved_in positive regulation of cell migration  
    acts_upstream_of_or_within positive regulation of cell-substrate adhesion PubMed 
    acts_upstream_of_or_within positive regulation of ceramide biosynthetic process PubMed 
    involved_in positive regulation of chemokine (C-X-C motif) ligand 2 production  
    acts_upstream_of_or_within positive regulation of cysteine-type endopeptidase activity PubMed 
    involved_in positive regulation of interleukin-1 beta production  
    involved_in positive regulation of interleukin-17 production  
    involved_in positive regulation of interleukin-6 production  
    involved_in positive regulation of osteoblast differentiation  
    involved_in positive regulation of osteoblast differentiation  
    involved_in positive regulation of osteoblast proliferation  
    involved_in positive regulation of osteoblast proliferation  
    acts_upstream_of_or_within positive regulation of phospholipase activity PubMed 
    involved_in positive regulation of protein kinase activity  
    involved_in positive regulation of protein phosphorylation  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of tumor necrosis factor (ligand) superfamily member 11 production  
    involved_in positive regulation of tumor necrosis factor production  
    acts_upstream_of_or_within reactive oxygen species metabolic process PubMed 
    involved_in regulation of ERK1 and ERK2 cascade  
    involved_in regulation of ERK1 and ERK2 cascade  
    involved_in signal transduction  
    involved_in signal transduction  
    acts_upstream_of_or_within ventricular septum development PubMed 
    involved_in wound healing, spreading of cells  
    involved_in wound healing, spreading of cells  
    Items 1 - 25 of 55
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix PubMed 
    located_in cytosol  
    is_active_in extracellular matrix  
    located_in extracellular region  
    is_active_in extracellular space  
    located_in membrane  

    General protein information

    Preferred Names
    CCN family member 1
    Names
    3CH61
    IBP-10
    IGF-binding protein 10
    IGFBP-10
    cysteine rich protein 61
    cysteine-rich angiogenic inducer 61
    insulin-like growth factor-binding protein 10
    intermediate early
    protein CYR61

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010516.2NP_034646.1  CCN family member 1 precursor

      See identical proteins and their annotated locations for NP_034646.1

      Status: VALIDATED

      Source sequence(s)
      AC136729, AK159452
      Consensus CDS
      CCDS17895.1
      UniProtKB/Swiss-Prot
      P18406
      UniProtKB/TrEMBL
      Q3TX21
      Related
      ENSMUSP00000029846.4, ENSMUST00000029846.5
      Conserved Domains (4) summary
      smart00209
      Location:230270
      TSP1; Thrombospondin type 1 repeats
      smart00214
      Location:100159
      VWC; von Willebrand factor (vWF) type C domain
      pfam00007
      Location:291373
      Cys_knot; Cystine-knot domain
      pfam00219
      Location:2678
      IGFBP; Insulin-like growth factor binding protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      145352726..145355740 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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