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    Bcl2 B cell leukemia/lymphoma 2 [ Mus musculus (house mouse) ]

    Gene ID: 12043, updated on 5-Jan-2025

    Summary

    Official Symbol
    Bcl2provided by MGI
    Official Full Name
    B cell leukemia/lymphoma 2provided by MGI
    Primary source
    MGI:MGI:88138
    See related
    Ensembl:ENSMUSG00000057329 AllianceGenome:MGI:88138
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bcl-2; C430015F12Rik; D630044D05Rik; D830018M01Rik
    Summary
    This gene encodes a member of the B cell lymphoma 2 protein family. Members of this family regulate cell death in multiple cell types and can have either proapoptotic or antiapoptotic activities. The protein encoded by this gene inhibits mitochondrial-mediated apoptosis. This protein is an integral outer mitochondrial membrane protein that functions as part of signaling pathway that controls mitochondrial permeability in response to apoptotic stimuli. This protein may also play a role in neuron cell survival and autophagy. Abnormal expression and chromosomal translocations of this gene are associated with cancer progression in numerous tissues. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
    Expression
    Ubiquitous expression in spleen adult (RPKM 4.5), limb E14.5 (RPKM 2.8) and 23 other tissues See more
    Orthologs
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    Genomic context

    See Bcl2 in Genome Data Viewer
    Location:
    1 E2.1; 1 49.76 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (106465906..106642020, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (106538176..106714290, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_01857 Neighboring gene predicted gene 6651 Neighboring gene STARR-seq mESC enhancer starr_01858 Neighboring gene predicted gene, 41928 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:108445776-108445929 Neighboring gene STARR-positive B cell enhancer ABC_E3295 Neighboring gene STARR-seq mESC enhancer starr_01859 Neighboring gene STARR-positive B cell enhancer ABC_E1227 Neighboring gene microRNA 3473f Neighboring gene STARR-positive B cell enhancer mm9_chr1:108466183-108466484 Neighboring gene STARR-positive B cell enhancer mm9_chr1:108516642-108516943 Neighboring gene STARR-seq mESC enhancer starr_01860 Neighboring gene predicted gene, 37053 Neighboring gene STARR-positive B cell enhancer ABC_E4341 Neighboring gene 3-ketodihydrosphingosine reductase Neighboring gene STARR-positive B cell enhancer ABC_E3296 Neighboring gene vacuolar protein sorting 4B Neighboring gene predicted gene, 53577

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (1) 
    • Targeted (9)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 26
    Function Evidence Code Pubs
    enables BH domain binding  
    enables BH3 domain binding  
    enables BH3 domain binding  
    enables DNA-binding transcription factor binding  
    enables DNA-binding transcription factor binding  
    enables channel activity  
    enables channel activity  
    enables channel activity  
    enables channel inhibitor activity  
    enables channel inhibitor activity  
    enables identical protein binding  
    enables identical protein binding  
    enables molecular adaptor activity PubMed 
    enables molecular adaptor activity  
    enables protease binding  
    enables protease binding  
    enables protein binding PubMed 
    enables protein heterodimerization activity  
    enables protein heterodimerization activity  
    enables protein phosphatase 2A binding PubMed 
    enables protein phosphatase binding PubMed 
    enables protein-containing complex binding  
    enables sequence-specific DNA binding  
    enables transcription factor binding PubMed 
    enables ubiquitin protein ligase binding  
    enables ubiquitin protein ligase binding  
    Items 1 - 25 of 26
    Items 1 - 25 of 215
    Process Evidence Code Pubs
    acts_upstream_of B cell apoptotic process PubMed 
    acts_upstream_of_or_within B cell apoptotic process PubMed 
    acts_upstream_of_or_within B cell differentiation PubMed 
    acts_upstream_of_or_within B cell homeostasis PubMed 
    acts_upstream_of_or_within B cell lineage commitment PubMed 
    acts_upstream_of_or_within B cell proliferation PubMed 
    involved_in B cell receptor signaling pathway  
    involved_in B cell receptor signaling pathway  
    acts_upstream_of_or_within CD8-positive, alpha-beta T cell lineage commitment PubMed 
    involved_in DNA damage response  
    acts_upstream_of G1/S transition of mitotic cell cycle PubMed 
    acts_upstream_of T cell apoptotic process PubMed 
    acts_upstream_of_or_within T cell apoptotic process PubMed 
    acts_upstream_of_or_within T cell differentiation PubMed 
    acts_upstream_of_or_within T cell differentiation PubMed 
    acts_upstream_of_or_within T cell differentiation in thymus PubMed 
    acts_upstream_of_or_within T cell homeostasis PubMed 
    acts_upstream_of_or_within T cell homeostasis PubMed 
    acts_upstream_of_or_within T cell lineage commitment PubMed 
    acts_upstream_of_or_within actin filament organization PubMed 
    acts_upstream_of_or_within animal organ morphogenesis PubMed 
    acts_upstream_of_or_within apoptotic mitochondrial changes PubMed 
    acts_upstream_of apoptotic process PubMed 
    acts_upstream_of_or_within apoptotic process PubMed 
    involved_in autophagy  
    acts_upstream_of_or_within axon regeneration PubMed 
    acts_upstream_of_or_within axonogenesis PubMed 
    acts_upstream_of_or_within behavioral fear response PubMed 
    acts_upstream_of_or_within branching involved in ureteric bud morphogenesis PubMed 
    acts_upstream_of_or_within branching involved in ureteric bud morphogenesis PubMed 
    acts_upstream_of calcium ion transport into cytosol PubMed 
    acts_upstream_of cell growth PubMed 
    acts_upstream_of cell migration PubMed 
    acts_upstream_of_or_within cell morphogenesis PubMed 
    acts_upstream_of_or_within cell morphogenesis PubMed 
    acts_upstream_of_or_within cell population proliferation PubMed 
    acts_upstream_of_or_within cell-cell adhesion PubMed 
    acts_upstream_of_or_within cellular response to glucose starvation PubMed 
    acts_upstream_of_or_within cellular response to hypoxia PubMed 
    acts_upstream_of_or_within cochlear nucleus development PubMed 
    involved_in defense response to virus  
    involved_in defense response to virus  
    acts_upstream_of dendritic cell apoptotic process PubMed 
    acts_upstream_of_or_within developmental growth PubMed 
    acts_upstream_of_or_within developmental pigmentation PubMed 
    acts_upstream_of_or_within developmental pigmentation PubMed 
    acts_upstream_of developmental pigmentation PubMed 
    acts_upstream_of_or_within digestive tract morphogenesis PubMed 
    acts_upstream_of_or_within ear development PubMed 
    acts_upstream_of_or_within ear development PubMed 
    acts_upstream_of_or_within endoplasmic reticulum calcium ion homeostasis PubMed 
    acts_upstream_of epithelial cell apoptotic process PubMed 
    acts_upstream_of establishment of localization in cell PubMed 
    involved_in extrinsic apoptotic signaling pathway in absence of ligand  
    acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand PubMed 
    acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors PubMed 
    acts_upstream_of_or_within focal adhesion assembly PubMed 
    acts_upstream_of_or_within gland morphogenesis PubMed 
    acts_upstream_of_or_within glomerulus development PubMed 
    involved_in hair follicle morphogenesis PubMed 
    acts_upstream_of_or_within hematopoietic stem cell differentiation PubMed 
    acts_upstream_of_or_within hemopoiesis PubMed 
    acts_upstream_of_or_within homeostasis of number of cells within a tissue PubMed 
    acts_upstream_of_or_within immune system development PubMed 
    acts_upstream_of_or_within intracellular calcium ion homeostasis PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage  
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage PubMed 
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress PubMed 
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to oxidative stress PubMed 
    acts_upstream_of_or_within kidney development PubMed 
    acts_upstream_of_or_within kidney development PubMed 
    acts_upstream_of_or_within leukocyte homeostasis PubMed 
    acts_upstream_of lymphocyte apoptotic process PubMed 
    acts_upstream_of_or_within lymphocyte apoptotic process PubMed 
    acts_upstream_of_or_within lymphocyte homeostasis PubMed 
    acts_upstream_of_or_within lymphocyte homeostasis PubMed 
    acts_upstream_of_or_within lymphoid progenitor cell differentiation PubMed 
    acts_upstream_of_or_within male gonad development PubMed 
    acts_upstream_of_or_within melanin metabolic process PubMed 
    acts_upstream_of_or_within melanocyte differentiation PubMed 
    acts_upstream_of melanocyte differentiation PubMed 
    acts_upstream_of_or_within melanocyte differentiation PubMed 
    acts_upstream_of_or_within mesenchymal cell development PubMed 
    acts_upstream_of_or_within metanephros development PubMed 
    acts_upstream_of mitotic cell cycle PubMed 
    acts_upstream_of motor neuron apoptotic process PubMed 
    acts_upstream_of myeloid cell apoptotic process PubMed 
    acts_upstream_of_or_within negative regulation of B cell apoptotic process PubMed 
    acts_upstream_of_or_within negative regulation of G1/S transition of mitotic cell cycle PubMed 
    acts_upstream_of_or_within negative regulation of G1/S transition of mitotic cell cycle PubMed 
    acts_upstream_of_or_within negative regulation of T cell apoptotic process PubMed 
    involved_in negative regulation of anoikis  
    involved_in negative regulation of anoikis  
    acts_upstream_of_or_within negative regulation of apoptotic process PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic process PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic process PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic process PubMed 
    involved_in negative regulation of apoptotic process  
    acts_upstream_of_or_within negative regulation of apoptotic process PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic signaling pathway PubMed 
    involved_in negative regulation of apoptotic signaling pathway  
    involved_in negative regulation of autophagy PubMed 
    involved_in negative regulation of autophagy  
    involved_in negative regulation of autophagy  
    acts_upstream_of_or_within negative regulation of calcium ion transport into cytosol PubMed 
    involved_in negative regulation of cardiac muscle cell apoptotic process  
    acts_upstream_of_or_within negative regulation of cell growth PubMed 
    acts_upstream_of_or_within negative regulation of cell migration PubMed 
    acts_upstream_of_or_within negative regulation of cell population proliferation PubMed 
    involved_in negative regulation of cellular pH reduction  
    involved_in negative regulation of cellular pH reduction  
    acts_upstream_of_or_within negative regulation of dendritic cell apoptotic process PubMed 
    acts_upstream_of_or_within negative regulation of epithelial cell apoptotic process PubMed 
    acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  
    involved_in negative regulation of intrinsic apoptotic signaling pathway  
    involved_in negative regulation of intrinsic apoptotic signaling pathway  
    acts_upstream_of_or_within negative regulation of lymphocyte apoptotic process PubMed 
    acts_upstream_of_or_within negative regulation of mitotic cell cycle PubMed 
    acts_upstream_of_or_within negative regulation of motor neuron apoptotic process PubMed 
    acts_upstream_of_or_within negative regulation of myeloid cell apoptotic process PubMed 
    acts_upstream_of_or_within negative regulation of neuron apoptotic process PubMed 
    acts_upstream_of_or_within negative regulation of neuron apoptotic process PubMed 
    acts_upstream_of_or_within negative regulation of neuron apoptotic process PubMed 
    acts_upstream_of_or_within negative regulation of ossification PubMed 
    acts_upstream_of_or_within negative regulation of osteoblast proliferation PubMed 
    acts_upstream_of_or_within negative regulation of retinal cell programmed cell death PubMed 
    acts_upstream_of neuron apoptotic process PubMed 
    acts_upstream_of_or_within neuron apoptotic process PubMed 
    acts_upstream_of neuron apoptotic process PubMed 
    acts_upstream_of_or_within neuron apoptotic process PubMed 
    acts_upstream_of neuron maturation PubMed 
    acts_upstream_of_or_within oocyte development PubMed 
    acts_upstream_of_or_within organ growth PubMed 
    acts_upstream_of_or_within ossification PubMed 
    acts_upstream_of osteoblast proliferation PubMed 
    acts_upstream_of_or_within ovarian follicle development PubMed 
    acts_upstream_of_or_within peptidyl-serine phosphorylation PubMed 
    acts_upstream_of peptidyl-serine phosphorylation PubMed 
    acts_upstream_of_or_within peptidyl-threonine phosphorylation PubMed 
    acts_upstream_of_or_within pigment granule organization PubMed 
    involved_in pigmentation PubMed 
    involved_in positive regulation of B cell proliferation  
    involved_in positive regulation of B cell proliferation  
    involved_in positive regulation of apoptotic process  
    acts_upstream_of_or_within positive regulation of catalytic activity PubMed 
    acts_upstream_of_or_within positive regulation of cell growth PubMed 
    involved_in positive regulation of cell population proliferation PubMed 
    acts_upstream_of_or_within positive regulation of cell population proliferation PubMed 
    involved_in positive regulation of cell population proliferation  
    acts_upstream_of_or_within positive regulation of developmental pigmentation PubMed 
    acts_upstream_of_or_within positive regulation of developmental pigmentation PubMed 
    acts_upstream_of_or_within positive regulation of melanocyte differentiation PubMed 
    acts_upstream_of_or_within positive regulation of multicellular organism growth PubMed 
    acts_upstream_of_or_within positive regulation of neuron maturation PubMed 
    acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation PubMed 
    acts_upstream_of_or_within positive regulation of skeletal muscle fiber development PubMed 
    acts_upstream_of_or_within positive regulation of smooth muscle cell migration PubMed 
    acts_upstream_of_or_within post-embryonic development PubMed 
    acts_upstream_of_or_within post-embryonic development PubMed 
    acts_upstream_of_or_within post-embryonic development PubMed 
    acts_upstream_of_or_within protein dephosphorylation PubMed 
    acts_upstream_of_or_within protein polyubiquitination PubMed 
    acts_upstream_of_or_within reactive oxygen species metabolic process PubMed 
    acts_upstream_of_or_within regulation of apoptotic process PubMed 
    involved_in regulation of autophagy PubMed 
    acts_upstream_of_or_within regulation of calcium ion transport PubMed 
    acts_upstream_of_or_within regulation of catalytic activity PubMed 
    acts_upstream_of_or_within regulation of cell cycle PubMed 
    acts_upstream_of_or_within regulation of cell-matrix adhesion PubMed 
    acts_upstream_of_or_within regulation of developmental pigmentation PubMed 
    acts_upstream_of_or_within regulation of gene expression PubMed 
    acts_upstream_of_or_within regulation of glycoprotein biosynthetic process PubMed 
    acts_upstream_of_or_within regulation of growth PubMed 
    involved_in regulation of mitochondrial membrane permeability PubMed 
    involved_in regulation of mitochondrial membrane potential PubMed 
    acts_upstream_of_or_within regulation of nitrogen utilization PubMed 
    acts_upstream_of_or_within regulation of programmed cell death PubMed 
    acts_upstream_of_or_within regulation of protein localization PubMed 
    acts_upstream_of_or_within regulation of protein stability PubMed 
    involved_in regulation of transmembrane transporter activity  
    involved_in regulation of viral genome replication PubMed 
    involved_in release of cytochrome c from mitochondria  
    involved_in release of cytochrome c from mitochondria PubMed 
    acts_upstream_of_or_within renal system process PubMed 
    acts_upstream_of_or_within response to UV-B PubMed 
    acts_upstream_of_or_within response to acid chemical PubMed 
    acts_upstream_of_or_within response to cytokine PubMed 
    acts_upstream_of_or_within response to cytokine PubMed 
    involved_in response to ethanol  
    acts_upstream_of_or_within response to gamma radiation PubMed 
    acts_upstream_of_or_within response to glucocorticoid PubMed 
    acts_upstream_of_or_within response to glucocorticoid PubMed 
    acts_upstream_of_or_within response to hydrogen peroxide PubMed 
    involved_in response to iron ion  
    involved_in response to iron ion  
    acts_upstream_of_or_within response to ischemia PubMed 
    involved_in response to nicotine  
    involved_in response to nicotine  
    acts_upstream_of_or_within response to oxidative stress PubMed 
    acts_upstream_of_or_within response to steroid hormone PubMed 
    acts_upstream_of_or_within response to toxic substance PubMed 
    acts_upstream_of_or_within response to toxic substance PubMed 
    involved_in response to toxic substance  
    acts_upstream_of_or_within response to xenobiotic stimulus PubMed 
    acts_upstream_of_or_within response to xenobiotic stimulus PubMed 
    involved_in response to xenobiotic stimulus  
    acts_upstream_of retinal cell programmed cell death PubMed 
    acts_upstream_of skeletal muscle fiber development PubMed 
    acts_upstream_of smooth muscle cell migration PubMed 
    acts_upstream_of_or_within spleen development PubMed 
    acts_upstream_of_or_within spleen development PubMed 
    acts_upstream_of_or_within stem cell development PubMed 
    acts_upstream_of_or_within thymus development PubMed 
    acts_upstream_of_or_within thymus development PubMed 
    acts_upstream_of_or_within ureteric bud development PubMed 
    Items 1 - 25 of 215
    Items 1 - 20 of 32
    Component Evidence Code Pubs
    part_of BAD-BCL-2 complex  
    part_of BAD-BCL-2 complex  
    is_active_in cytoplasm PubMed 
    located_in cytoplasm PubMed 
    located_in cytoplasm PubMed 
    located_in cytosol PubMed 
    located_in endoplasmic reticulum PubMed 
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum membrane PubMed 
    is_active_in endoplasmic reticulum membrane  
    is_active_in endoplasmic reticulum membrane  
    located_in intracellular anatomical structure PubMed 
    located_in membrane PubMed 
    located_in membrane PubMed 
    located_in mitochondrial crista  
    located_in mitochondrial membrane PubMed 
    is_active_in mitochondrial outer membrane  
    is_active_in mitochondrial outer membrane  
    located_in mitochondrial outer membrane  
    is_active_in mitochondrial outer membrane  
    located_in mitochondrion PubMed 
    located_in mitochondrion PubMed 
    located_in mitochondrion PubMed 
    located_in myelin sheath PubMed 
    located_in nuclear membrane PubMed 
    located_in nuclear membrane  
    located_in nucleus PubMed 
    located_in nucleus PubMed 
    located_in perinuclear region of cytoplasm  
    part_of pore complex  
    part_of pore complex  
    part_of protein-containing complex  
    Items 1 - 20 of 32

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009741.5NP_033871.2  apoptosis regulator Bcl-2 isoform 1

      See identical proteins and their annotated locations for NP_033871.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
      Source sequence(s)
      AC122842, AC162916, BC095964
      Consensus CDS
      CCDS15209.1
      UniProtKB/Swiss-Prot
      P10417, P10418, Q4VBF6
      UniProtKB/TrEMBL
      Q8BQK4
      Related
      ENSMUSP00000108371.2, ENSMUST00000112751.2
      Conserved Domains (3) summary
      smart00265
      Location:733
      BH4; BH4 Bcl-2 homology region 4
      cd06845
      Location:81198
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
      TIGR00865
      Location:11236
      bcl-2; apoptosis regulator
    2. NM_177410.3NP_803129.2  apoptosis regulator Bcl-2 isoform 2

      See identical proteins and their annotated locations for NP_803129.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' coding region and UTR compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC122842, AK049473, BC068988, BY118935
      Consensus CDS
      CCDS78667.1
      UniProtKB/TrEMBL
      Q6NTH7, Q8BQK4
      Related
      ENSMUSP00000139856.2, ENSMUST00000189999.2
      Conserved Domains (3) summary
      smart00265
      Location:733
      BH4; BH4 Bcl-2 homology region 4
      cd06845
      Location:81196
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
      TIGR00865
      Location:11196
      bcl-2; apoptosis regulator

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      106465906..106642020 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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