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Lipc lipase, hepatic [ Mus musculus (house mouse) ]

Gene ID: 15450, updated on 4-Jan-2025

Summary

Official Symbol
Lipcprovided by MGI
Official Full Name
lipase, hepaticprovided by MGI
Primary source
MGI:MGI:96216
See related
Ensembl:ENSMUSG00000032207 AllianceGenome:MGI:96216
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HL; Hpl
Summary
Enables lipase activity. Acts upstream of or within cholesterol homeostasis; cholesterol metabolic process; and cholesterol transport. Located in extracellular space. Is expressed in chondrocranium; femur; liver; liver lobe; and spleen. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; familial combined hyperlipidemia; glucose metabolism disease (multiple); obesity; and peripheral vascular disease. Orthologous to human LIPC (lipase C, hepatic type). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in liver adult (RPKM 48.1), liver E18 (RPKM 35.8) and 3 other tissues See more
Orthologs
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Genomic context

See Lipc in Genome Data Viewer
Location:
9 D; 9 39.57 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (70705410..70859503, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (70798128..70952221, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene MINDY lysine 48 deubiquitinase 2 Neighboring gene STARR-positive B cell enhancer ABC_E2903 Neighboring gene predicted gene, 31872 Neighboring gene a disintegrin and metallopeptidase domain 10 Neighboring gene cytochrome c, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_24559 Neighboring gene STARR-seq mESC enhancer starr_24560 Neighboring gene VISTA enhancer mm190 Neighboring gene ribosomal RNA processing 7 homolog A pseudogene Neighboring gene STARR-seq mESC enhancer starr_24562 Neighboring gene STARR-seq mESC enhancer starr_24564 Neighboring gene predicted gene, 32017 Neighboring gene predicted gene, 46118 Neighboring gene predicted gene, 32074

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acetylesterase activity  
enables acyltransferase activity  
enables apolipoprotein binding  
enables apolipoprotein binding  
enables chylomicron binding  
enables heparan sulfate proteoglycan binding  
enables heparin binding  
enables heparin binding  
enables identical protein binding  
enables lipase activity PubMed 
enables lipid binding  
enables lipoprotein lipase activity  
enables low-density lipoprotein particle binding  
enables lysophospholipase activity  
enables lysophospholipase activity  
enables monoacylglycerol lipase activity  
enables phosphatidylserine 1-acylhydrolase activity  
enables phospholipase A1 activity  
enables phospholipase A1 activity  
enables phospholipase A1 activity  
enables triacylglycerol lipase activity  
enables triacylglycerol lipase activity  
Items 1 - 25 of 33
Process Evidence Code Pubs
involved_in cholesterol homeostasis  
acts_upstream_of_or_within cholesterol homeostasis PubMed 
involved_in cholesterol homeostasis  
acts_upstream_of_or_within cholesterol metabolic process PubMed 
acts_upstream_of_or_within cholesterol transport PubMed 
involved_in chylomicron remnant clearance  
involved_in chylomicron remodeling  
involved_in fatty acid biosynthetic process  
involved_in fatty acid biosynthetic process  
involved_in fatty acid biosynthetic process  
involved_in fatty acid metabolic process  
involved_in glycerophospholipid catabolic process  
involved_in heparan sulfate proteoglycan biosynthetic process  
involved_in high-density lipoprotein particle remodeling  
involved_in high-density lipoprotein particle remodeling  
involved_in high-density lipoprotein particle remodeling  
involved_in low-density lipoprotein particle clearance  
involved_in low-density lipoprotein particle remodeling  
involved_in low-density lipoprotein particle remodeling  
involved_in neutral lipid catabolic process  
involved_in phosphatidic acid metabolic process  
involved_in phosphatidylcholine metabolic process  
involved_in phosphatidylethanolamine metabolic process  
involved_in phosphatidylserine metabolic process  
involved_in regulation of plasma lipoprotein particle levels  
involved_in triglyceride catabolic process  
involved_in triglyceride catabolic process  
involved_in triglyceride catabolic process  
involved_in triglyceride homeostasis  
involved_in triglyceride homeostasis  
involved_in triglyceride metabolic process  
involved_in very-low-density lipoprotein particle remodeling  
involved_in very-low-density lipoprotein particle remodeling  
Items 1 - 25 of 33
Component Evidence Code Pubs
located_in cell surface  
located_in early endosome  
is_active_in extracellular space  
located_in extracellular space PubMed 
located_in extracellular space  
part_of high-density lipoprotein particle  
located_in late endosome  
located_in microvillus  

General protein information

Preferred Names
hepatic triacylglycerol lipase
Names
hepatic lipase
lipase member C
lysophospholipase
phospholipase A1
NP_001311401.1
NP_001311402.1
NP_001398716.1
NP_001398717.1
NP_001398718.1
NP_032306.2
XP_006510880.1
XP_006510881.1
XP_036010505.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324472.1NP_001311401.1  hepatic triacylglycerol lipase isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    BC021841, BY337256
    Consensus CDS
    CCDS23324.1
    UniProtKB/Swiss-Prot
    P27656, Q8VC44
    Conserved Domains (2) summary
    cd01758
    Location:353488
    PLAT_LPL; PLAT/ LH2 domain present in lipoprotein lipase (LPL). LPL is a key enzyme in catabolism of plasma lipoprotein triglycerides (TGs) and has therefeore has a profound influence on triglyceride and high-density lipoprotein (HDL) cholesterol levels in the ...
    pfam00151
    Location:18350
    Lipase
  2. NM_001324473.1NP_001311402.1  hepatic triacylglycerol lipase isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks a portion of the 5' coding region, compared to variant 1. Variant 3 is predicted to encode a protein (isoform 2) which lacks the signal peptide that is present in isoform 1.
    Source sequence(s)
    BC021841, BY337256
    Consensus CDS
    CCDS90617.1
    UniProtKB/TrEMBL
    Q3TYU0
    Related
    ENSMUSP00000149185.2, ENSMUST00000216798.2
    Conserved Domains (3) summary
    cd00707
    Location:1261
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
    cd01758
    Location:268403
    PLAT_LPL; PLAT/ LH2 domain present in lipoprotein lipase (LPL). LPL is a key enzyme in catabolism of plasma lipoprotein triglycerides (TGs) and has therefeore has a profound influence on triglyceride and high-density lipoprotein (HDL) cholesterol levels in the ...
    pfam00151
    Location:1265
    Lipase; Lipase
  3. NM_001411787.1NP_001398716.1  hepatic triacylglycerol lipase isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC137843, CT025701
    UniProtKB/Swiss-Prot
    P27656, Q8VC44
  4. NM_001411788.1NP_001398717.1  hepatic triacylglycerol lipase isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC137843, CT025701
  5. NM_001411789.1NP_001398718.1  hepatic triacylglycerol lipase isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC137843, CT025701
  6. NM_008280.2NP_032306.2  hepatic triacylglycerol lipase isoform 1 precursor

    See identical proteins and their annotated locations for NP_032306.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    BC021841
    Consensus CDS
    CCDS23324.1
    UniProtKB/Swiss-Prot
    P27656, Q8VC44
    Related
    ENSMUSP00000034731.9, ENSMUST00000034731.10
    Conserved Domains (2) summary
    cd01758
    Location:353488
    PLAT_LPL; PLAT/ LH2 domain present in lipoprotein lipase (LPL). LPL is a key enzyme in catabolism of plasma lipoprotein triglycerides (TGs) and has therefeore has a profound influence on triglyceride and high-density lipoprotein (HDL) cholesterol levels in the ...
    pfam00151
    Location:18350
    Lipase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    70705410..70859503 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154612.1XP_036010505.1  hepatic triacylglycerol lipase isoform X3

    Conserved Domains (2) summary
    cd01758
    Location:284419
    PLAT_LPL; PLAT/ LH2 domain present in lipoprotein lipase (LPL). LPL is a key enzyme in catabolism of plasma lipoprotein triglycerides (TGs) and has therefeore has a profound influence on triglyceride and high-density lipoprotein (HDL) cholesterol levels in the ...
    pfam00151
    Location:1281
    Lipase
  2. XM_006510817.3XP_006510880.1  hepatic triacylglycerol lipase isoform X3

    Conserved Domains (2) summary
    cd01758
    Location:284419
    PLAT_LPL; PLAT/ LH2 domain present in lipoprotein lipase (LPL). LPL is a key enzyme in catabolism of plasma lipoprotein triglycerides (TGs) and has therefeore has a profound influence on triglyceride and high-density lipoprotein (HDL) cholesterol levels in the ...
    pfam00151
    Location:1281
    Lipase
  3. XM_006510818.4XP_006510881.1  hepatic triacylglycerol lipase isoform X4

    Conserved Domains (1) summary
    pfam00151
    Location:18366
    Lipase
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