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Tnik TRAF2 and NCK interacting kinase [ Mus musculus (house mouse) ]

Gene ID: 665113, updated on 13-Jan-2025

Summary

Official Symbol
Tnikprovided by MGI
Official Full Name
TRAF2 and NCK interacting kinaseprovided by MGI
Primary source
MGI:MGI:1916264
See related
Ensembl:ENSMUSG00000027692 AllianceGenome:MGI:1916264
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1500031A17Rik; 4831440I19Rik; C530008O15Rik; C630040K21Rik
Summary
Predicted to enable protein serine/threonine kinase activity. Involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane. Is active in glutamatergic synapse. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 54. Orthologous to human TNIK (TRAF2 and NCK interacting kinase). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in frontal lobe adult (RPKM 7.4), cortex adult (RPKM 5.7) and 18 other tissues See more
Orthologs
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Genomic context

See Tnik in Genome Data Viewer
Location:
3 A3; 3 11.92 cM
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (28317362..28724734)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (28261901..28670585)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_07254 Neighboring gene phospholipase D1 Neighboring gene STARR-seq mESC enhancer starr_07256 Neighboring gene STARR-seq mESC enhancer starr_07258 Neighboring gene STARR-seq mESC enhancer starr_07259 Neighboring gene predicted gene, 42196 Neighboring gene predicted gene, 54170 Neighboring gene STARR-seq mESC enhancer starr_07260 Neighboring gene microRNA 466q Neighboring gene VISTA enhancer mm492 Neighboring gene STARR-seq mESC enhancer starr_07263 Neighboring gene STARR-seq mESC enhancer starr_07264 Neighboring gene STARR-seq mESC enhancer starr_07265 Neighboring gene RIKEN cDNA 1700112D23 gene Neighboring gene predicted gene, 52603 Neighboring gene solute carrier family 2 (facilitated glucose transporter), member 2 Neighboring gene predicted pseudogene 6505

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (3) 
  • Targeted (6)  1 citation

Interactions

General gene information

Clone Names

  • KIAA0551, MGC189819, MGC189859

Gene Ontology Provided by MGI

Items 1 - 25 of 27
Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity  
enables AMP-activated protein kinase activity  
enables ATP binding  
enables DNA-dependent protein kinase activity  
enables Rho-dependent protein serine/threonine kinase activity  
enables eukaryotic translation initiation factor 2alpha kinase activity  
enables histone H2AS1 kinase activity  
enables histone H2AS121 kinase activity  
enables histone H2AT120 kinase activity  
enables histone H2AXS139 kinase activity  
enables histone H2BS14 kinase activity  
enables histone H2BS36 kinase activity  
enables histone H3S10 kinase activity  
enables histone H3S28 kinase activity  
enables histone H3S57 kinase activity  
enables histone H3T11 kinase activity  
enables histone H3T3 kinase activity  
enables histone H3T45 kinase activity  
enables histone H3T6 kinase activity  
enables histone H4S1 kinase activity  
enables protein binding PubMed 
enables protein kinase activity  
enables protein serine kinase activity  
enables protein serine/threonine kinase activity  
enables protein serine/threonine kinase activity  
enables protein serine/threonine kinase activity  
enables ribosomal protein S6 kinase activity  
Items 1 - 25 of 27
Process Evidence Code Pubs
involved_in MAPK cascade  
involved_in Wnt signaling pathway  
involved_in actin cytoskeleton organization  
involved_in actin cytoskeleton organization  
involved_in chromatin remodeling  
involved_in cytoskeleton organization  
involved_in intracellular signal transduction  
involved_in intracellular signal transduction  
involved_in microvillus assembly  
involved_in nervous system development  
involved_in neuron projection morphogenesis  
involved_in positive regulation of JNK cascade  
involved_in positive regulation of JNK cascade  
involved_in positive regulation of dendrite morphogenesis  
involved_in positive regulation of protein phosphorylation  
involved_in protein autophosphorylation  
involved_in protein autophosphorylation  
involved_in protein localization to plasma membrane  
involved_in protein phosphorylation  
involved_in protein phosphorylation  
involved_in regulation of MAPK cascade  
involved_in regulation of dendrite morphogenesis  
involved_in regulation of dendrite morphogenesis  
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane PubMed 
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane  
is_active_in cytoplasm  
located_in cytoplasm  
located_in cytoplasm  
located_in cytoskeleton  
located_in cytoskeleton  
located_in cytosol  
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse  
located_in nucleoplasm  
located_in nucleus  
located_in nucleus  
located_in perinuclear region of cytoplasm PubMed 
is_active_in postsynaptic density, intracellular component  
is_active_in presynapse  
located_in recycling endosome PubMed 

General protein information

Preferred Names
traf2 and NCK-interacting protein kinase
NP_001156479.1
NP_001156480.1
NP_001156481.1
NP_081186.1
XP_006535580.1
XP_006535581.1
XP_006535582.1
XP_006535583.1
XP_006535584.1
XP_011248006.1
XP_011248007.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163007.1NP_001156479.1  traf2 and NCK-interacting protein kinase isoform 2

    See identical proteins and their annotated locations for NP_001156479.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal, in-frame coding exon compared to variant 1, resulting in a shorter isoform (2) missing an 8 aa protein segment compared to isoform 1.
    Source sequence(s)
    BC050868, CK620825
    Consensus CDS
    CCDS50878.1
    UniProtKB/TrEMBL
    B2RXX2, B9EKN8
    Related
    ENSMUSP00000124876.3, ENSMUST00000159680.9
    Conserved Domains (2) summary
    smart00036
    Location:10341332
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06637
    Location:18313
    STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase
  2. NM_001163008.1NP_001156480.1  traf2 and NCK-interacting protein kinase isoform 3

    See identical proteins and their annotated locations for NP_001156480.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two internal, in-frame coding exons compared to variant 1, resulting in a shorter isoform (3) missing two protein segments compared to isoform 1.
    Source sequence(s)
    BC050868
    Consensus CDS
    CCDS50879.1
    UniProtKB/Swiss-Prot
    P83510
    UniProtKB/TrEMBL
    B2RXX2
    Related
    ENSMUSP00000124681.3, ENSMUST00000159236.9
    Conserved Domains (3) summary
    smart00036
    Location:10051303
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06637
    Location:18313
    STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase
  3. NM_001163009.1NP_001156481.1  traf2 and NCK-interacting protein kinase isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an internal, in-frame coding exon, and differs at the 3' end compared to variant 1, resulting in a longer isoform (4) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC121268, AI115107, BC050868, CF531435, CK620825
    UniProtKB/TrEMBL
    B2RY17
    Related
    ENSMUST00000162037.9
    Conserved Domains (3) summary
    smart00036
    Location:10341326
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06637
    Location:18313
    STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase
  4. NM_026910.1NP_081186.1  traf2 and NCK-interacting protein kinase isoform 1

    See identical proteins and their annotated locations for NP_081186.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    BC050868, CD348964, CK620825
    Consensus CDS
    CCDS50877.1
    UniProtKB/TrEMBL
    B2RQ80, B2RXX2
    Related
    ENSMUSP00000125081.3, ENSMUST00000160307.9
    Conserved Domains (3) summary
    smart00036
    Location:10421340
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06637
    Location:18313
    STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    28317362..28724734
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535519.4XP_006535582.1  traf2 and NCK-interacting protein kinase isoform X3

    UniProtKB/TrEMBL
    B2RXX2
    Conserved Domains (2) summary
    smart00036
    Location:10451343
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06637
    Location:18313
    STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase
  2. XM_006535517.4XP_006535580.1  traf2 and NCK-interacting protein kinase isoform X1

    UniProtKB/TrEMBL
    B2RY17
    Conserved Domains (2) summary
    smart00036
    Location:10451337
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06637
    Location:18313
    STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase
  3. XM_006535518.4XP_006535581.1  traf2 and NCK-interacting protein kinase isoform X2

    UniProtKB/TrEMBL
    B2RY17
    Conserved Domains (2) summary
    smart00036
    Location:10421334
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06637
    Location:18313
    STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase
  4. XM_006535521.4XP_006535584.1  traf2 and NCK-interacting protein kinase isoform X5

    UniProtKB/TrEMBL
    B2RXX2, E9PUL9
    Related
    ENSMUSP00000124011.2, ENSMUST00000160518.8
    Conserved Domains (2) summary
    smart00036
    Location:10131311
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06637
    Location:18313
    STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase
  5. XM_006535520.4XP_006535583.1  traf2 and NCK-interacting protein kinase isoform X4

    UniProtKB/TrEMBL
    B2RY17
    Conserved Domains (2) summary
    smart00036
    Location:10161308
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06637
    Location:18313
    STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase
  6. XM_011249704.4XP_011248006.1  traf2 and NCK-interacting protein kinase isoform X6

    UniProtKB/TrEMBL
    B2RY17
    Conserved Domains (2) summary
    smart00036
    Location:9901282
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:1258
    PKc_like; Protein Kinases, catalytic domain
  7. XM_011249705.4XP_011248007.1  traf2 and NCK-interacting protein kinase isoform X7

    UniProtKB/TrEMBL
    B2RY17
    Conserved Domains (2) summary
    smart00036
    Location:9611253
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:1258
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_004941378.1 RNA Sequence

    Related
    ENSMUST00000160934.8
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