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Cenpc1 centromere protein C1 [ Mus musculus (house mouse) ]

Gene ID: 12617, updated on 4-Jan-2025

Summary

Official Symbol
Cenpc1provided by MGI
Official Full Name
centromere protein C1provided by MGI
Primary source
MGI:MGI:99700
See related
Ensembl:ENSMUSG00000029253 AllianceGenome:MGI:99700
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cenpc; CENP-C
Summary
This gene encodes a centromeric protein component of a nucleosome-associated complex that plays a central role in kinetochore protein assembly, mitotic progression and chromosome segregation. The human ortholog encodes a protein with DNA-binding activity, that associates constitutively to kinetochores throughout the cell cycle, as part of a prekinetochore complex, together with centromeric protein-A and centromeric protein-B. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Expression
Broad expression in CNS E11.5 (RPKM 7.5), CNS E14 (RPKM 5.7) and 24 other tissues See more
Orthologs
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Genomic context

See Cenpc1 in Genome Data Viewer
Location:
5 E1; 5 43.56 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (86159877..86214325, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (86012018..86065962, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35251 Neighboring gene STARR-seq mESC enhancer starr_13541 Neighboring gene predicted gene, 24626 Neighboring gene STARR-seq mESC enhancer starr_13543 Neighboring gene STARR-positive B cell enhancer ABC_E1055 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:86498237-86498420 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:86500459-86500642 Neighboring gene STARR-positive B cell enhancer ABC_E3586 Neighboring gene predicted gene 2287 Neighboring gene predicted gene, 24524 Neighboring gene signal transducing adaptor family member 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables centromeric DNA binding  
enables centromeric DNA binding  
enables identical protein binding  
enables identical protein binding  
enables protein binding PubMed 
Process Evidence Code Pubs
involved_in attachment of mitotic spindle microtubules to kinetochore  
involved_in cell division  
involved_in chromosome segregation  
involved_in chromosome segregation  
involved_in chromosome segregation PubMed 
involved_in kinetochore assembly  
involved_in kinetochore assembly  
involved_in kinetochore assembly  
involved_in mitotic cell cycle  
involved_in mitotic cell cycle  
involved_in spindle attachment to meiosis I kinetochore  
Component Evidence Code Pubs
located_in condensed chromosome, centromeric region PubMed 
located_in condensed chromosome, centromeric region  
part_of inner kinetochore  
located_in kinetochore  
located_in kinetochore  
located_in midbody  
located_in midbody  
located_in nuclear body  
located_in nuclear body  
located_in nucleoplasm  
located_in nucleus PubMed 
located_in pericentric heterochromatin PubMed 
located_in pericentric heterochromatin  
located_in pericentric heterochromatin  

General protein information

Preferred Names
centromere protein C
Names
centromere autoantigen C1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001345902.1NP_001332831.1  centromere protein C isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC101846, AC107634, AK143566, BC150700, BY718033
    UniProtKB/Swiss-Prot
    P49452
    UniProtKB/TrEMBL
    Q3UPF6
  2. NM_001345903.1NP_001332832.1  centromere protein C isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and the 5' coding region and uses a downstream start codon compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC101846, AC107634, AK143566, BC150700, BY718033
    UniProtKB/Swiss-Prot
    P49452
    UniProtKB/TrEMBL
    Q3UPF6
  3. NM_001345904.1NP_001332833.1  centromere protein C isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and the 5' coding region and uses a downstream start codon compared to variant 1. The resulting isoform (4) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC101846, AC107634, AK143566, BC150700, BY718033
    UniProtKB/Swiss-Prot
    P49452
    UniProtKB/TrEMBL
    Q3UPF6
    Conserved Domains (2) summary
    pfam15620
    Location:2255
    CENP-C_mid; Centromere assembly component CENP-C middle DNMT3B-binding region
    cl21464
    Location:555639
    cupin_like; Conserved domain found in cupin and related proteins
  4. NM_001421563.1NP_001408492.1  centromere protein C isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC101846, AC107634
  5. NM_001421564.1NP_001408493.1  centromere protein C isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC101846, AC107634
  6. NM_007683.4NP_031709.2  centromere protein C isoform 2

    See identical proteins and their annotated locations for NP_031709.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC101846, AC107634, AK143566, BC150700, BY718033
    Consensus CDS
    CCDS39123.1
    UniProtKB/Swiss-Prot
    B9EK81, P49452
    Related
    ENSMUSP00000031170.9, ENSMUST00000031170.10
    Conserved Domains (3) summary
    pfam15620
    Location:266519
    CENP-C_mid; Centromere assembly component CENP-C middle DNMT3B-binding region
    pfam15622
    Location:7261
    CENP_C_N; Kinetochore assembly subunit CENP-C N-terminal
    cl21464
    Location:819903
    cupin_like; Conserved domain found in cupin and related proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    86159877..86214325 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254095.2XP_030109955.1  centromere protein C isoform X1

    Conserved Domains (3) summary
    pfam15620
    Location:355608
    CENP-C_mid; Centromere assembly component CENP-C middle DNMT3B-binding region
    pfam15622
    Location:110350
    CENP_C_N; Kinetochore assembly subunit CENP-C N-terminal
    cl21464
    Location:889973
    cupin_like; Conserved domain found in cupin and related proteins
  2. XM_017320638.3XP_017176127.1  centromere protein C isoform X5

    Conserved Domains (2) summary
    pfam15620
    Location:2255
    CENP-C_mid; Centromere assembly component CENP-C middle DNMT3B-binding region
    cl21464
    Location:555639
    cupin_like; Conserved domain found in cupin and related proteins
  3. XM_030254096.2XP_030109956.1  centromere protein C isoform X2

    Conserved Domains (3) summary
    pfam15620
    Location:355608
    CENP-C_mid; Centromere assembly component CENP-C middle DNMT3B-binding region
    pfam15622
    Location:110350
    CENP_C_N; Kinetochore assembly subunit CENP-C N-terminal
    cl21464
    Location:908942
    cupin_like; Conserved domain found in cupin and related proteins
  4. XM_017320636.3XP_017176125.1  centromere protein C isoform X3

    Conserved Domains (3) summary
    pfam15620
    Location:266519
    CENP-C_mid; Centromere assembly component CENP-C middle DNMT3B-binding region
    pfam15622
    Location:7261
    CENP_C_N; Kinetochore assembly subunit CENP-C N-terminal
    cl21464
    Location:819853
    cupin_like; Conserved domain found in cupin and related proteins
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