Extracellular matrix protein cysteine rich 61 (CCN1) effect on LN229 glioma cells
Summary:
Analysis of LN229 glioma cells with doxycycline-inducible expression of Cyr61 (CCN1), induced for 24h with doxycycline. CCN1 expression may reduce efficacy of oncolytic HSV-1 brain cancer therapy. Results provide insight into CCN1-mediated oncolytic HSV-1 inhibition.
GPL570:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Citation:
Haseley A, Boone S, Wojton J, Yu L et al. Extracellular matrix protein CCN1 limits oncolytic efficacy in glioma. Cancer Res 2012 Mar 15;72(6):1353-62. PMID: 22282654
