bZIP transcription factor E4bp4 deficiency effect on lineage-depleted bone marrow cells
Summary:
Analysis of wild-type and E4bp4-knockout lineage-depleted bone marrow which is enriched for hematopoietic progenitor cells. Transcription factor E4bp4 (Nfil3) is essential for natural killer (NK) cell development. Results provide insight into downstream targets of E4bp4 in early NK development.
Male V, Nisoli I, Kostrzewski T, Allan DS et al. The transcription factor E4bp4/Nfil3 controls commitment to the NK lineage and directly regulates Eomes and Id2 expression. J Exp Med 2014 Apr 7;211(4):635-42. PMID: 24663216
