NUTF2 nuclear transport factor 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: NUTF2provided by HGNC
Official Full Name: nuclear transport factor 2provided by HGNC
Primary source: HGNC:HGNC:13722
See related: Ensembl:ENSG00000102898 MIM:605813; AllianceGenome:HGNC:13722
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NTF2; PP15; NTF-2
Summary: This gene encodes a cytosolic factor that facilitates protein transport into the nucleus. The encoded protein is required for nuclear import of the small Ras-like GTPase, Ran which is involved in numerous cellular processes. This protein also interacts with the nuclear pore complex glycoprotein p62. [provided by RefSeq, Apr 2016]
Expression: Ubiquitous expression in placenta (RPKM 14.8), testis (RPKM 14.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 16q22.1

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (67846933..67872567)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (73642707..73668340)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (67880836..67906470)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DNA-Origami NanoTrap for Studying the Selective Barriers Formed by Phenylalanine-Glycine-Rich Nucleoporins.
Title: DNA-Origami NanoTrap for Studying the Selective Barriers Formed by Phenylalanine-Glycine-Rich Nucleoporins.
Nuclear Transport Factor 2 (NTF2) suppresses WM983B metastatic melanoma by modifying cell migration, metastasis, and gene expression.
Title: Nuclear Transport Factor 2 (NTF2) suppresses WM983B metastatic melanoma by modifying cell migration, metastasis, and gene expression.
These results showed that BLM enters the nucleus via the importin beta1, RanGDP and NTF2 dependent pathway, demonstrating for the first time the nuclear trafficking mechanism of a DNA helicase.
Title: Characterization of the nuclear import pathway for BLM protein.
Binding of Ran to NTF2 is required for NTF2 to inhibit nuclear expansion and import of large cargo molecules.
Title: Nuclear size is sensitive to NTF2 protein levels in a manner dependent on Ran binding.
Nucleocytoplasmic translocation of NTF2 is regulated in mammalian cells.
Title: Nuclear-cytoplasmic trafficking of NTF2, the nuclear import receptor for the RanGTPase, is subjected to regulation.
Data suggest actin accumulation in senescent cells is due to the failure of RanGTP restoration with ATP deficiency and NTF2 accumulation, resulting in decreased actin export via Exp6 inactivation.
Title: Reduction of exportin 6 activity leads to actin accumulation via failure of RanGTP restoration and NTF2 sequestration in the nuclei of senescent cells.
NTF2 is a potential mediator of retinal vasculature integrity.
Title: Overexpression of nuclear transport factor 2 may protect against diabetic retinopathy.
Results report that NTF2 and Ran control nuclear import of the filamentous actin capping protein CapG.
Title: A new role for nuclear transport factor 2 and Ran: nuclear import of CapG.
A nuclear pore binding site was studied on a mutated NTF2 protein.
Title: Computational and biochemical identification of a nuclear pore complex binding site on the nuclear transport carrier NTF2.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci. EBI GWAS Catalog EBI GWAS CatalogPubMed
Common variants at 30 loci contribute to polygenic dyslipidemia. EBI GWAS Catalog EBI GWAS CatalogPubMed
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
integrase	gag-pol	NTF2 is enriched at the nuclear envelope and interacts with NUP153, When added in excess to the import assay, NUP153C inhibited the nuclear import of IN.	PubMed
matrix	gag	NTF2 coordinates the activity of Ran by binding Ran-GDP into a complex with nucleoporin-docked karyopherins during nuclear import of HIV-1 Matrix	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-153756 (e-PCR)
- UniSTS:177920

SHGC-31645 (e-PCR)
- UniSTS:37153

NUTF2_9060 (e-PCR)
- UniSTS:468096

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear import signal receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IDA Inferred from Direct Assay more info	PubMed
enables small GTPase binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of nuclear pore	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in protein export from nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to nuclear pore	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
located_in nuclear inner membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear outer membrane	IEA Inferred from Electronic Annotation more info
part_of nuclear pore central transport channel	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: nuclear transport factor 2

Names: placental protein 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001322038.2 → NP_001308967.1 nuclear transport factor 2

Status: REVIEWED

Source sequence(s)

AC040162

Consensus CDS

CCDS10848.1

UniProtKB/Swiss-Prot

B2R4G7, P13662, P61970, Q6IB67

UniProtKB/TrEMBL

H3BRV9

Related

ENSP00000515103.1, ENST00000700613.1

Conserved Domains (1) summary

cd00780
Location:7 → 122

NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
NM_001322039.2 → NP_001308968.1 nuclear transport factor 2

Status: REVIEWED

Source sequence(s)

AC040162, BP216441

Consensus CDS

CCDS10848.1

UniProtKB/Swiss-Prot

B2R4G7, P13662, P61970, Q6IB67

UniProtKB/TrEMBL

H3BRV9

Related

ENSP00000456428.1, ENST00000567105.5

Conserved Domains (1) summary

cd00780
Location:7 → 122

NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
NM_001322040.2 → NP_001308969.1 nuclear transport factor 2

Status: REVIEWED

Source sequence(s)

BX647782, HY123109, X07315

Consensus CDS

CCDS10848.1

UniProtKB/Swiss-Prot

B2R4G7, P13662, P61970, Q6IB67

UniProtKB/TrEMBL

H3BRV9

Related

ENSP00000457989.1, ENST00000569436.7

Conserved Domains (1) summary

cd00780
Location:7 → 122

NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
NM_001322041.2 → NP_001308970.1 nuclear transport factor 2

Status: REVIEWED

Source sequence(s)

AC040162, BX394845

Consensus CDS

CCDS10848.1

UniProtKB/Swiss-Prot

B2R4G7, P13662, P61970, Q6IB67

UniProtKB/TrEMBL

H3BRV9

Related

ENSP00000457022.1, ENST00000568396.2

Conserved Domains (1) summary

cd00780
Location:7 → 122

NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
NM_005796.3 → NP_005787.1 nuclear transport factor 2

See identical proteins and their annotated locations for NP_005787.1

Status: REVIEWED

Source sequence(s)

BX647782, X07315

Consensus CDS

CCDS10848.1

UniProtKB/Swiss-Prot

B2R4G7, P13662, P61970, Q6IB67

UniProtKB/TrEMBL

H3BRV9

Related

ENSP00000219169.4, ENST00000219169.9

Conserved Domains (1) summary

cd00780
Location:7 → 122

NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...