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    Iglc1 immunoglobulin lambda constant 1 [ Mus musculus (house mouse) ]

    Gene ID: 110785, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Iglc1provided by MGI
    Official Full Name
    immunoglobulin lambda constant 1provided by MGI
    Primary source
    MGI:MGI:99546
    See related
    Ensembl:ENSMUSG00000105906 IMGT/GENE-DB:IGLC1; AllianceGenome:MGI:99546
    Gene type
    other
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Igl-C1; Clambda1
    Summary
    Predicted to enable antigen binding activity. Predicted to be involved in immunoglobulin mediated immune response. Located in external side of plasma membrane. Part of B cell receptor complex. Orthologous to several human genes including IGLC6 (immunoglobulin lambda constant 6). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Iglc1 in Genome Data Viewer
    Location:
    16 A3; 16 11.8 cM
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (18880502..18880821, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (19061752..19062071, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4160 Neighboring gene U2 small nuclear ribonucleoprotein B pseudogene Neighboring gene STARR-seq mESC enhancer starr_40292 Neighboring gene ubiquitin-conjugating enzyme E2 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr16:19053115-19053416 Neighboring gene immunoglobulin lambda chain complex Neighboring gene immunoglobulin lambda joining 1 Neighboring gene immunoglobulin lambda constant 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The constant region of the membrane immunoglobulin mediates B cell-receptor clustering and signaling in response to membrane antigens. Tolar P, et al. Immunity, 2009 Jan 16. PMID 19135393, Free PMC Article
    2. Wild mice express an Ig V lambda gene that differs from any V lambda in BALB/c but resembles a human V lambda subgroup. Reidl LS, et al. J Immunol, 1992 Jul 15. PMID 1378065
    3. A point mutation in the constant region of Ig lambda1 prevents normal B cell development due to defective BCR signaling. Sun T, et al. Immunity, 2002 Feb. PMID 11869685
    4. Lambda light chain constant and variable gene complements in wild-derived inbred mouse strains. Kindt TJ, et al. Eur J Immunol, 1985 Jun. PMID 3924628
    5. Scarcity of lambda 1 B cells in mice with a single point mutation in C lambda 1 is due to a low BCR signal caused by misfolded lambda 1 light chain. Volgina VV, et al. Mol Immunol, 2007 Feb. PMID 16860389

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Other Names

    • immunoglobulin lambda chain, constant region 1

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables antigen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in immunoglobulin mediated immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of B cell receptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of IgG immunoglobulin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of IgG immunoglobulin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_004051.1 

      Range
      199274..199593
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      18880502..18880821 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.