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    unc-77 Ion transport domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177379, updated on 9-Dec-2024

    Summary

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    Official Symbol
    unc-77
    Official Full Name
    Ion transport domain-containing protein
    Primary source
    WormBase:WBGene00006809
    Locus tag
    CELE_C11D2.6
    See related
    AllianceGenome:WB:WBGene00006809
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables monoatomic cation channel activity. Involved in positive regulation of GABAergic synaptic transmission; positive regulation of cholinergic synaptic transmission; and positive regulation of locomotion. Located in axon. Is expressed in intestine and nervous system. Used to study congenital limbs-face contractures-hypotonia-developmental delay syndrome. Human ortholog(s) of this gene implicated in congenital limbs-face contractures-hypotonia-developmental delay syndrome. Orthologous to human NALCN (sodium leak channel, non-selective). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See unc-77 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    31
    Sequence:
    Chromosome: IV; NC_003282.8 (6157306..6183857, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene BLOC-1-related complex subunit 5 Neighboring gene PUA domain-containing protein Neighboring gene Queuosine 5'-phosphate N-glycosylase/hydrolase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Gain-of-Function Mutation in NALCN in a Child with Intellectual Disability, Ataxia, and Arthrogryposis. Aoyagi K, et al. Hum Mutat, 2015 Aug. PMID 25864427
    2. NALCN Channels Are Not Major targets of Gα (o) or Gα (q) Modulation in the C. elegans Egg-Laying Behavior Circuit. Jose A, et al. MicroPubl Biol, 2024. PMID 38287929, Free PMC Article
    3. Corrigendum. . Genetics, 2017 Aug. PMID 28778879, Free PMC Article
    4. The SEK-1 p38 MAP Kinase Pathway Modulates Gq Signaling in Caenorhabditis elegans. Hoyt JM, et al. G3 (Bethesda), 2017 Sep 7. PMID 28696924, Free PMC Article
    5. De novo missense mutations in NALCN cause developmental and intellectual impairment with hypotonia. Fukai R, et al. J Hum Genet, 2016 May. PMID 26763878

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NCA-1 and UNC-80 regulate neuronal activity at least in part by transmitting depolarization signals to synapses in C. elegans neurons.
      Title: A putative cation channel, NCA-1, and a novel protein, UNC-80, transmit neuronal activity in C. elegans.
    2. UNC-80 is required for the proper localization of the NCA-1 and NCA-2 ion channel subunits.
      Title: UNC-80 and the NCA ion channels contribute to endocytosis defects in synaptojanin mutants.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables monoatomic cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables monoatomic cation channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables monoatomic cation channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of locomotion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of synaptic transmission, GABAergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of synaptic transmission, GABAergic IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of synaptic transmission, cholinergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of synaptic transmission, cholinergic IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ion transport domain-containing protein
    NP_001293818.1
    • Confirmed by transcript evidence
    NP_001293819.1
    • Confirmed by transcript evidence
    NP_001293820.1
    • Confirmed by transcript evidence
    NP_001293821.1
    • Confirmed by transcript evidence
    NP_001293822.1
    • Confirmed by transcript evidence
    NP_001293823.1
    • Confirmed by transcript evidence
    NP_001293824.1
    • Partially confirmed by transcript evidence
    NP_001293825.1
    • Partially confirmed by transcript evidence
    NP_001293826.1
    • Partially confirmed by transcript evidence
    NP_001293827.1
    • Partially confirmed by transcript evidence
    NP_001294631.1
    • Confirmed by transcript evidence
    NP_001294632.1
    • Confirmed by transcript evidence
    NP_500926.3
    • Confirmed by transcript evidence
    NP_500927.3
    • Confirmed by transcript evidence
    NP_741413.2
    • Confirmed by transcript evidence
    NP_741414.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      6157306..6183857 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068525.4 → NP_500926.3  Ion transport domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500926.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q06AY5, Q688B4
      Conserved Domains (1) summary
      pfam00520
      Location:449 → 654
      Ion_trans; Ion transport protein

    2. NM_171353.6 → NP_741414.2  Ion transport domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741414.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6Q762, Q8MXH5
      Conserved Domains (1) summary
      pfam00520
      Location:389 → 594
      Ion_trans; Ion transport protein

    3. NM_001307702.3 → NP_001294631.1  Ion transport domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294631.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q06AY5, U4PCH9
      Conserved Domains (1) summary
      pfam00520
      Location:449 → 654
      Ion_trans; Ion transport protein

    4. NM_001306896.3 → NP_001293825.1  Ion transport domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293825.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q06AY5, V6CLZ1
      Conserved Domains (1) summary
      pfam00520
      Location:434 → 660
      Ion_trans; Ion transport protein

    5. NM_001306897.3 → NP_001293826.1  Ion transport domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293826.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q06AY5, V6CLY6
      Conserved Domains (1) summary
      pfam00520
      Location:434 → 660
      Ion_trans; Ion transport protein

    6. NM_001306898.3 → NP_001293827.1  Ion transport domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293827.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6Q762, V6CLU1
      Conserved Domains (1) summary
      pfam00520
      Location:434 → 660
      Ion_trans; Ion transport protein

    7. NM_001306895.3 → NP_001293824.1  Ion transport domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293824.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6Q762, V6CKM5
      Conserved Domains (1) summary
      pfam00520
      Location:434 → 660
      Ion_trans; Ion transport protein

    8. NM_001306892.3 → NP_001293821.1  Ion transport domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293821.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q06AY5, V6CLY1
      Conserved Domains (1) summary
      pfam00520
      Location:416 → 642
      Ion_trans; Ion transport protein

    9. NM_001306893.3 → NP_001293822.1  Ion transport domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293822.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q06AY5, V6CLT6
      Conserved Domains (1) summary
      pfam00520
      Location:416 → 642
      Ion_trans; Ion transport protein

    10. NM_001306894.3 → NP_001293823.1  Ion transport domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293823.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6Q762, V6CJF9
      Conserved Domains (1) summary
      pfam00520
      Location:416 → 642
      Ion_trans; Ion transport protein

    11. NM_001306891.3 → NP_001293820.1  Ion transport domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293820.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6Q762, V6CLY7
      Conserved Domains (1) summary
      pfam00520
      Location:416 → 642
      Ion_trans; Ion transport protein

    12. NM_001306889.3 → NP_001293818.1  Ion transport domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293818.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6Q762, V6CJF5
      Conserved Domains (1) summary
      pfam00520
      Location:428 → 654
      Ion_trans; Ion transport protein

    13. NM_171352.5 → NP_741413.2  Ion transport domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741413.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q688B2, Q6Q762
      Conserved Domains (1) summary
      pfam00520
      Location:449 → 654
      Ion_trans; Ion transport protein

    14. NM_001307703.3 → NP_001294632.1  Ion transport domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294632.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q06AY5, U4PMX5
      Conserved Domains (1) summary
      pfam00520
      Location:389 → 594
      Ion_trans; Ion transport protein

    15. NM_068526.5 → NP_500927.3  Ion transport domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500927.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q06AY5, Q688B3
      Conserved Domains (1) summary
      pfam00520
      Location:389 → 594
      Ion_trans; Ion transport protein

    16. NM_001306890.3 → NP_001293819.1  Ion transport domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293819.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6Q762, V6CKL6
      Conserved Domains (1) summary
      pfam00520
      Location:368 → 594
      Ion_trans; Ion transport protein
    Nucleotide Protein
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