Per1 period circadian clock 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Per1provided by MGI
Official Full Name: period circadian clock 1provided by MGI
Primary source: MGI:MGI:1098283
See related: Ensembl:ENSMUSG00000020893 AllianceGenome:MGI:1098283
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Per; Hftm; mPer1; m-rigui
Summary: This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene may increase the risk of getting certain cancers. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2014]
Expression: Ubiquitous expression in testis adult (RPKM 28.8), adrenal adult (RPKM 16.3) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B3; 11 42.37 cM

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (68985934..69000791)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (69095108..69109965)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hepatocyte Period 1 dictates oxidative substrate selection independent of the core circadian clock.
Title: Hepatocyte Period 1 dictates oxidative substrate selection independent of the core circadian clock.
Rhythm gene PER1 mediates ferroptosis and lipid metabolism through SREBF2/ALOX15 axis in polycystic ovary syndrome.
Title: Rhythm gene PER1 mediates ferroptosis and lipid metabolism through SREBF2/ALOX15 axis in polycystic ovary syndrome.
Cellular iron depletion enhances behavioral rhythm by limiting brain Per1 expression in mice.
Title: Cellular iron depletion enhances behavioral rhythm by limiting brain Per1 expression in mice.
DNA polymerase beta connects tumorigenicity with the circadian clock in liver cancer through the epigenetic demethylation of Per1.
Title: DNA polymerase beta connects tumorigenicity with the circadian clock in liver cancer through the epigenetic demethylation of Per1.
The circadian regulator PER1 promotes cell reprogramming by inhibiting inflammatory signaling from macrophages.
Title: The circadian regulator PER1 promotes cell reprogramming by inhibiting inflammatory signaling from macrophages.
The clock gene Per1 may exert diurnal control over hippocampal memory consolidation.
Title: The clock gene Per1 may exert diurnal control over hippocampal memory consolidation.
Circadian PER1 controls daily fat absorption with the regulation of PER1-PKA on phosphorylation of bile acid synthetase.
Title: Circadian PER1 controls daily fat absorption with the regulation of PER1-PKA on phosphorylation of bile acid synthetase.
The clock gene Per1 is necessary in the retrosplenial cortex-but not in the suprachiasmatic nucleus-for incidental learning in young and aging male mice.
Title: The clock gene Per1 is necessary in the retrosplenial cortex-but not in the suprachiasmatic nucleus-for incidental learning in young and aging male mice.
FMRP binds Per1 mRNA and downregulates its protein expression in mice.
Title: FMRP binds Per1 mRNA and downregulates its protein expression in mice.
Endogenous circadian reporters reveal functional differences of PERIOD paralogs and the significance of PERIOD:CK1 stable interaction.
Title: Endogenous circadian reporters reveal functional differences of PERIOD paralogs and the significance of PERIOD:CK1 stable interaction.

Submit: New GeneRIF Correction See all GeneRIFs (201)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (3)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Per1 (e-PCR), detects polymorphism
- UniSTS:496741

Per1 (e-PCR), detects polymorphism
- UniSTS:527485

Per1 (e-PCR), detects polymorphism
- UniSTS:547571

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables E-box binding	IEA Inferred from Electronic Annotation more info
enables E-box binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription cis-regulatory region binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription corepressor binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in circadian regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in circadian regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in circadian regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
involved_in circadian rhythm	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within circadian rhythm	TAS Traceable Author Statement more info	PubMed
involved_in entrainment of circadian clock by photoperiod	IBA Inferred from Biological aspect of Ancestor more info
involved_in entrainment of circadian clock by photoperiod	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of JNK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of glucocorticoid receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neural retina development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in post-transcriptional regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cytokine production involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytokine production involved in inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of hair cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of hair cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of p38MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of p38MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of sodium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to cAMP	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: period circadian protein homolog 1

Names: circadian clock protein PERIOD 1; circadian pacemaker protein Rigui; period homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159367.2 → NP_001152839.1 period circadian protein homolog 1

See identical proteins and their annotated locations for NP_001152839.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AF022992, AK148202, BC091645, BP772916

Consensus CDS

CCDS24882.1

UniProtKB/Swiss-Prot

B1ASX0, O35973

UniProtKB/TrEMBL

Q3UFZ7

Related

ENSMUSP00000132635.2, ENSMUST00000166748.8

Conserved Domains (3) summary

pfam08447
Location:373 → 457

PAS_3; PAS fold

pfam12114
Location:1082 → 1223

Period_C; Period protein 2/3C-terminal region

pfam15761
Location:6 → 59

IMUP; Immortalisation up-regulated protein
NM_011065.5 → NP_035195.2 period circadian protein homolog 1

See identical proteins and their annotated locations for NP_035195.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

AF022992, BC091645, BP772916

Consensus CDS

CCDS24882.1

UniProtKB/Swiss-Prot

B1ASX0, O35973

UniProtKB/TrEMBL

Q3UFZ7

Related

ENSMUSP00000021271.8, ENSMUST00000021271.14

Conserved Domains (3) summary

pfam08447
Location:373 → 457

PAS_3; PAS fold

pfam12114
Location:1082 → 1223

Period_C; Period protein 2/3C-terminal region

pfam15761
Location:6 → 59

IMUP; Immortalisation up-regulated protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

68985934..69000791

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006532480.4 → XP_006532543.1 period circadian protein homolog 1 isoform X1

See identical proteins and their annotated locations for XP_006532543.1

UniProtKB/Swiss-Prot

B1ASX0, O35973

UniProtKB/TrEMBL

Q3UFZ7

Conserved Domains (3) summary

pfam08447
Location:373 → 457

PAS_3; PAS fold

pfam12114
Location:1082 → 1223

Period_C; Period protein 2/3C-terminal region

pfam15761
Location:6 → 59

IMUP; Immortalisation up-regulated protein
XM_030245657.2 → XP_030101517.1 period circadian protein homolog 1 isoform X2

UniProtKB/TrEMBL

Q3UFZ7

Conserved Domains (3) summary

pfam08447
Location:373 → 457

PAS_3; PAS fold

pfam12114
Location:1078 → 1219

Period_C; Period protein 2/3C-terminal region

pfam15761
Location:6 → 59

IMUP; Immortalisation up-regulated protein
XM_036156420.1 → XP_036012313.1 period circadian protein homolog 1 isoform X3

UniProtKB/TrEMBL

Q3UFZ7

Conserved Domains (3) summary

pfam08447
Location:373 → 457

PAS_3; PAS fold

pfam12114
Location:1051 → 1154

Period_C; Period protein 2/3C-terminal region

NF033845
Location:8 → 137

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
XM_006532481.5 → XP_006532544.1 period circadian protein homolog 1 isoform X2

UniProtKB/TrEMBL

Q3UFZ7

Conserved Domains (3) summary

pfam08447
Location:373 → 457

PAS_3; PAS fold

pfam12114
Location:1078 → 1219

Period_C; Period protein 2/3C-terminal region

pfam15761
Location:6 → 59

IMUP; Immortalisation up-regulated protein
XM_036156421.1 → XP_036012314.1 period circadian protein homolog 1 isoform X4

UniProtKB/TrEMBL

Q3UFZ7

Conserved Domains (3) summary

pfam08447
Location:373 → 457

PAS_3; PAS fold

pfam12114
Location:1022 → 1163

Period_C; Period protein 2/3C-terminal region

NF033845
Location:13 → 137

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB