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    Dcp1b decapping mRNA 1B [ Mus musculus (house mouse) ]

    Gene ID: 319618, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Dcp1bprovided by MGI
    Official Full Name
    decapping mRNA 1Bprovided by MGI
    Primary source
    MGI:MGI:2442404
    See related
    Ensembl:ENSMUSG00000041477 AllianceGenome:MGI:2442404
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B930050E02Rik
    Summary
    Predicted to enable mRNA binding activity. Involved in cellular response to interleukin-17; protein localization to P-body; and protein localization to nucleus. Located in P-body. Is expressed in embryo. Orthologous to human DCP1B (decapping mRNA 1B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 25.1), thymus adult (RPKM 8.1) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dcp1b in Genome Data Viewer
    Location:
    6 F1; 6 56.55 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (119152214..119198575)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (119175253..119221614)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, L type, alpha 1C subunit Neighboring gene predicted gene, 53338 Neighboring gene predicted gene, 50599 Neighboring gene STARR-seq mESC enhancer starr_17143 Neighboring gene STARR-positive B cell enhancer ABC_E10404 Neighboring gene calcium channel, voltage-dependent, alpha 2/delta subunit 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:119286263-119286553 Neighboring gene predicted gene, 52874 Neighboring gene leucine-rich repeats and transmembrane domains 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. mRNA decapping factor Dcp1a is essential for embryonic growth in mice. Ibayashi M, et al. Biochem Biophys Res Commun, 2021 May 28. PMID 33813271
    2. IL-17-receptor-associated adaptor Act1 directly stabilizes mRNAs to mediate IL-17 inflammatory signaling. Herjan T, et al. Nat Immunol, 2018 Apr. PMID 29563620, Free PMC Article
    3. MicroRNA-23a promotes myelination in the central nervous system. Lin ST, et al. Proc Natl Acad Sci U S A, 2013 Oct 22. PMID 24101522, Free PMC Article
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to interleukin-17 IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in deadenylation-independent decapping of nuclear-transcribed mRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to P-body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein localization to nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mRNA-decapping enzyme 1B
    Names
    DCP1 decapping enzyme homolog B
    NP_001028551.2
    XP_006506301.1
    XP_017177110.1
    XP_017177111.1
    XP_030111300.1
    XP_030111301.1
    XP_030111303.1
    XP_036022105.1
    XP_036022106.1
    XP_036022107.1
    XP_036022108.1
    XP_036022109.1
    XP_036022110.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033379.3 → NP_001028551.2  mRNA-decapping enzyme 1B

      See identical proteins and their annotated locations for NP_001028551.2

      Status: VALIDATED

      Source sequence(s)
      AC126453, AK047334, AK049193, AK053525
      Consensus CDS
      CCDS39610.1
      UniProtKB/Swiss-Prot
      B2RUI2, Q3U564, Q3V333
      UniProtKB/TrEMBL
      B9EIX0
      Related
      ENSMUSP00000108397.3, ENSMUST00000112777.9
      Conserved Domains (2) summary
      cd09804
      Location:16 → 131
      Dcp1; mRNA decapping enzyme 1 (Dcp1)
      pfam16741
      Location:536 → 575
      mRNA_decap_C; mRNA-decapping enzyme C-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      119152214..119198575
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506238.4 → XP_006506301.1  mRNA-decapping enzyme 1B isoform X1

      UniProtKB/Swiss-Prot
      B2RUI2, Q3U564, Q3V333
      Conserved Domains (2) summary
      cd09804
      Location:16 → 131
      Dcp1; mRNA decapping enzyme 1 (Dcp1)
      pfam16741
      Location:559 → 598
      mRNA_decap_C; mRNA-decapping enzyme C-terminus

    2. XM_030255443.1 → XP_030111303.1  mRNA-decapping enzyme 1B isoform X5

      Conserved Domains (1) summary
      pfam16741
      Location:375 → 414
      mRNA_decap_C; mRNA-decapping enzyme C-terminus

    3. XM_030255440.1 → XP_030111300.1  mRNA-decapping enzyme 1B isoform X4

      Conserved Domains (1) summary
      pfam16741
      Location:398 → 437
      mRNA_decap_C; mRNA-decapping enzyme C-terminus

    4. XM_017321622.2 → XP_017177111.1  mRNA-decapping enzyme 1B isoform X5

      Conserved Domains (1) summary
      pfam16741
      Location:375 → 414
      mRNA_decap_C; mRNA-decapping enzyme C-terminus

    5. XM_036166216.1 → XP_036022109.1  mRNA-decapping enzyme 1B isoform X5

      Conserved Domains (1) summary
      pfam16741
      Location:375 → 414
      mRNA_decap_C; mRNA-decapping enzyme C-terminus

    6. XM_030255441.1 → XP_030111301.1  mRNA-decapping enzyme 1B isoform X4

      Conserved Domains (1) summary
      pfam16741
      Location:398 → 437
      mRNA_decap_C; mRNA-decapping enzyme C-terminus

    7. XM_036166215.1 → XP_036022108.1  mRNA-decapping enzyme 1B isoform X5

      Conserved Domains (1) summary
      pfam16741
      Location:375 → 414
      mRNA_decap_C; mRNA-decapping enzyme C-terminus

    8. XM_036166212.1 → XP_036022105.1  mRNA-decapping enzyme 1B isoform X2

      Conserved Domains (1) summary
      pfam16741
      Location:433 → 472
      mRNA_decap_C; mRNA-decapping enzyme C-terminus

    9. XM_036166213.1 → XP_036022106.1  mRNA-decapping enzyme 1B isoform X3

      Conserved Domains (1) summary
      pfam16741
      Location:410 → 449
      mRNA_decap_C; mRNA-decapping enzyme C-terminus

    10. XM_036166217.1 → XP_036022110.1  mRNA-decapping enzyme 1B isoform X5

      Conserved Domains (1) summary
      pfam16741
      Location:375 → 414
      mRNA_decap_C; mRNA-decapping enzyme C-terminus

    11. XM_017321621.3 → XP_017177110.1  mRNA-decapping enzyme 1B isoform X2

      Conserved Domains (1) summary
      pfam16741
      Location:433 → 472
      mRNA_decap_C; mRNA-decapping enzyme C-terminus

    12. XM_036166214.1 → XP_036022107.1  mRNA-decapping enzyme 1B isoform X3

      Conserved Domains (1) summary
      pfam16741
      Location:410 → 449
      mRNA_decap_C; mRNA-decapping enzyme C-terminus
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U564.1 GenPept UniProtKB/Swiss-Prot:Q3U564

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