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    Ccne2 cyclin E2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362485, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ccne2provided by RGD
    Official Full Name
    cyclin E2provided by RGD
    Primary source
    RGD:1307783
    See related
    EnsemblRapid:ENSRNOG00000008055 AllianceGenome:RGD:1307783
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables protein kinase binding activity. Predicted to be involved in G1/S transition of mitotic cell cycle and positive regulation of G1/S transition of mitotic cell cycle. Predicted to act upstream of or within several processes, including DNA replication initiation; chromosome organization; and regulation of protein localization. Predicted to be part of cyclin E1-CDK2 complex and cyclin E2-CDK2 complex. Predicted to be active in cytoplasm; microtubule organizing center; and nucleus. Human ortholog(s) of this gene implicated in castration-resistant prostate carcinoma. Orthologous to human CCNE2 (cyclin E2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 95.5), Thymus (RPKM 93.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ccne2 in Genome Data Viewer
    Location:
    5q13
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (29082169..29094879)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (24285078..24298258)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (24434077..24446406)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 6 Neighboring gene tumor protein p53 inducible nuclear protein 1 Neighboring gene integrator complex subunit 8 Neighboring gene dpy-19 like 4 Neighboring gene epithelial splicing regulatory protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Dietary tomato and lycopene impact androgen signaling- and carcinogenesis-related gene expression during early TRAMP prostate carcinogenesis. Wan L, et al. Cancer Prev Res (Phila), 2014 Dec. PMID 25315431, Free PMC Article
    2. miRNA-30a functions as a tumor suppressor by downregulating cyclin E2 expression in castration-resistant prostate cancer. Zhang L, et al. Mol Med Rep, 2016 Sep. PMID 27431942
    3. Mammalian E-type cyclins control chromosome pairing, telomere stability and CDK2 localization in male meiosis. Martinerie L, et al. PLoS Genet, 2014 Feb. PMID 24586195, Free PMC Article
    4. D-type cyclins and G1 progression during liver development in the rat. Boylan JM, et al. Biochem Biophys Res Commun, 2005 May 13. PMID 15809057
    5. Cyclin E2: a novel CDK2 partner in the late G1 and S phases of the mammalian cell cycle. Lauper N, et al. Oncogene, 1998 Nov 19. PMID 9840927

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA replication initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chromosome organization involved in meiotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within homologous chromosome pairing at meiosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within telomere maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of cyclin E1-CDK2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cyclin E2-CDK2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cyclin E2-CDK2 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    G1/S-specific cyclin-E2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108656.1 → NP_001102126.1  G1/S-specific cyclin-E2

      See identical proteins and their annotated locations for NP_001102126.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473984
      UniProtKB/TrEMBL
      A6JFS7, D3ZQ41
      Conserved Domains (1) summary
      cl40454
      Location:101 → 237
      CYCLIN_SF; Cyclin box fold superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      29082169..29094879
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287900.1 → XP_063143970.1  G1/S-specific cyclin-E2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A291

    2. XM_039110217.2 → XP_038966145.1  G1/S-specific cyclin-E2 isoform X1

      UniProtKB/TrEMBL
      A6JFS7, D3ZQ41
      Conserved Domains (1) summary
      cl40454
      Location:101 → 237
      CYCLIN_SF; Cyclin box fold superfamily

    3. XM_006237873.3 → XP_006237935.1  G1/S-specific cyclin-E2 isoform X1

      See identical proteins and their annotated locations for XP_006237935.1

      UniProtKB/TrEMBL
      A6JFS7, D3ZQ41
      Related
      ENSRNOP00000010696.4, ENSRNOT00000010696.7
      Conserved Domains (1) summary
      cl40454
      Location:101 → 237
      CYCLIN_SF; Cyclin box fold superfamily

    4. XM_017593468.3 → XP_017448957.1  G1/S-specific cyclin-E2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A291
      Conserved Domains (2) summary
      pfam00134
      Location:112 → 239
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:241 → 361
      Cyclin_C; Cyclin, C-terminal domain

    5. XM_006237874.4 → XP_006237936.1  G1/S-specific cyclin-E2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A291
      Conserved Domains (2) summary
      pfam00134
      Location:112 → 239
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:241 → 361
      Cyclin_C; Cyclin, C-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version

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