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    mthl10 methuselah-like 10 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38057, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mthl10provided by FlyBase
    Official Full Name
    methuselah-like 10provided by FlyBase
    Primary source
    FLYBASE:FBgn0035132
    Locus tag
    Dmel_CG17061
    See related
    AllianceGenome:FB:FBgn0035132
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0170980.166; anon-WO0170980.167; CG17061; Dmel\CG17061; mth2; mthl-10; Mthl10
    Summary
    Predicted to enable G protein-coupled peptide receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; determination of adult lifespan; and response to starvation. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including anterior-posterior subdivision of organism; central nervous system; epithelium; gut; and imaginal disc. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mthl10 in Genome Data Viewer
    Location:
    61C1-61C1; 3-0.5 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (332801..342915, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (332801..342915, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Ada2a-containing complex component 3 Neighboring gene Protein tyrosine phosphatase Meg Neighboring gene methuselah-like 9 Neighboring gene methuselah Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila cytokine GBP2 exerts immune responses and regulates GBP1 expression through GPCR receptor Mthl10. Ono M, et al. Insect Biochem Mol Biol, 2024 Apr. PMID 38295885,
    2. Clines and adaptive evolution in the methuselah gene region in Drosophila melanogaster. Duvernell DD, et al. Mol Ecol, 2003 May. PMID 12694290
    3. Transcriptional regulation of the methuselah gene by dorsal protein in Drosophila melanogaster. Kim H, et al. Mol Cells, 2006 Apr 30. PMID 16682822
    4. After wounding, a G-protein coupled receptor promotes the restoration of tension in epithelial cells. Han IS, et al. Mol Biol Cell, 2024 May 1. PMID 38536445, Free PMC Article
    5. A mathematical model of calcium signals around laser-induced epithelial wounds. Stevens AC, et al. Mol Biol Cell, 2023 May 15. PMID 36322412, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Proteolytic activation of Growth-blocking peptides triggers calcium responses through the GPCR Mthl10 during epithelial wound detection.
      Title: Proteolytic activation of Growth-blocking peptides triggers calcium responses through the GPCR Mthl10 during epithelial wound detection.
    2. the metabolic, immunological, and stress-protecting roles of GBP all interconnect through Mthl10.
      Title: Cytokine signaling through Drosophila Mthl10 ties lifespan to environmental stress.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G protein-coupled receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in determination of adult lifespan ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to starvation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    methuselah-like 10
    Names
    CG17061-PA
    CG17061-PB
    CG17061-PC
    CG17061-PD
    CG17061-PE
    CG17061-PF
    CG17061-PG
    Methuselah-like 10
    Methuselah-like10
    Mth-like 10
    mthl10-PA
    mthl10-PB
    mthl10-PC
    mthl10-PD
    mthl10-PE
    mthl10-PF
    mthl10-PG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      332801..342915 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274277.1 → NP_001261206.1  methuselah-like 10, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261206.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGK2
      Conserved Domains (2) summary
      pfam06652
      Location:56 → 236
      Methuselah_N; Methuselah N-terminus
      cl21561
      Location:244 → 504
      7tm_4; Olfactory receptor

    2. NM_001259605.2 → NP_001246534.1  methuselah-like 10, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246534.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGK2
      Conserved Domains (2) summary
      pfam06652
      Location:56 → 236
      Methuselah_N; Methuselah N-terminus
      cl21561
      Location:244 → 504
      7tm_4; Olfactory receptor

    3. NM_001274276.1 → NP_001261205.1  methuselah-like 10, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261205.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGK2
      Conserved Domains (2) summary
      pfam06652
      Location:56 → 236
      Methuselah_N; Methuselah N-terminus
      cl21561
      Location:244 → 504
      7tm_4; Olfactory receptor

    4. NM_001259603.2 → NP_001246532.1  methuselah-like 10, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246532.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9ND17
      Conserved Domains (2) summary
      pfam06652
      Location:56 → 236
      Methuselah_N; Methuselah N-terminus
      cl21561
      Location:302 → 514
      7tm_4; Olfactory receptor

    5. NM_176268.3 → NP_788446.2  methuselah-like 10, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788446.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7YWL1, Q86BK3, Q95NU7, Q95YN4, Q9W0R5
      Conserved Domains (2) summary
      pfam06652
      Location:56 → 236
      Methuselah_N; Methuselah N-terminus
      cl21561
      Location:244 → 514
      7tm_4; Olfactory receptor

    6. NM_001259604.1 → NP_001246533.1  methuselah-like 10, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246533.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NEX4
      Conserved Domains (2) summary
      pfam06652
      Location:56 → 236
      Methuselah_N; Methuselah N-terminus
      cl21561
      Location:302 → 504
      7tm_4; Olfactory receptor

    7. NM_138186.3 → NP_612030.2  methuselah-like 10, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_612030.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W0R5
      Conserved Domains (2) summary
      pfam06652
      Location:56 → 236
      Methuselah_N; Methuselah N-terminus
      cl21561
      Location:302 → 504
      7tm_4; Olfactory receptor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9ND17 M9ND17
    M9NEX4 M9NEX4
    M9PGK2 M9PGK2
    Q9W0R5.3 Q9W0R5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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