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    pns pinstripe [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38178, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pnsprovided by FlyBase
    Official Full Name
    pinstripeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035229
    Locus tag
    Dmel_CG7852
    See related
    AllianceGenome:FB:FBgn0035229
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7852; Dmel\CG7852
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in regulation of Rab protein signal transduction. Predicted to be located in Golgi apparatus. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 49. Orthologous to several human genes including DENND5B (DENN domain containing 5B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See pns in Genome Data Viewer
    Location:
    62A3-62A3; 3-0.5 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1537137..1544823)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1537137..1544823)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Increased minichromosome loss 1 Neighboring gene Ionotropic receptor 62a Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Phosphocholine cytidylyltransferase 1 Neighboring gene antisense RNA:CR45813

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. uDENN, DENN, and dDENN: indissociable domains in Rab and MAP kinases signaling pathways. Levivier E, et al. Biochem Biophys Res Commun, 2001 Sep 28. PMID 11563850
    2. RUN domains: a new family of domains involved in Ras-like GTPase signaling. Callebaut I, et al. Trends Biochem Sci, 2001 Feb. PMID 11166556
    3. Cct1, a phosphatidylcholine biosynthesis enzyme, is required for Drosophila oogenesis and ovarian morphogenesis. Gupta T, et al. Development, 2003 Dec. PMID 14597574
    4. The two TRAPP complexes of metazoans have distinct roles and act on different Rab GTPases. Riedel F, et al. J Cell Biol, 2018 Feb 5. PMID 29273580, Free PMC Article
    5. Normal dynactin complex function during synapse growth in Drosophila requires membrane binding by Arfaptin. Chang L, et al. Mol Biol Cell, 2013 Jun. PMID 23596322, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of Rab protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    pinstripe
    Names
    CG7852-PA
    CG7852-PB
    CG7852-PC
    pns-PA
    pns-PB
    pns-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1537137..1544823
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206232.2 → NP_995954.1  pinstripe, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995954.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MQP7
      Conserved Domains (3) summary
      smart00801
      Location:626 → 701
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:243 → 435
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:70 → 171
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    2. NM_139363.2 → NP_647620.1  pinstripe, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647620.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W0E1
      Related
      FBpp0072618
      Conserved Domains (6) summary
      smart00801
      Location:626 → 701
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00593
      Location:1376 → 1436
      RUN; domain involved in Ras-like GTPase signaling
      smart00799
      Location:243 → 435
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:70 → 171
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      cd01757
      Location:1095 → 1203
      PLAT_RAB6IP1; PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed ...
      cl02689
      Location:989 → 1083
      RUN; RUN domain

    3. NM_167890.2 → NP_728624.1  pinstripe, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728624.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W0E1
      Related
      FBpp0072619
      Conserved Domains (6) summary
      smart00801
      Location:626 → 701
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00593
      Location:1376 → 1436
      RUN; domain involved in Ras-like GTPase signaling
      smart00799
      Location:243 → 435
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:70 → 171
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      cd01757
      Location:1095 → 1203
      PLAT_RAB6IP1; PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed ...
      cl02689
      Location:989 → 1083
      RUN; RUN domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MQP7 Q8MQP7
    Q9W0E1 Q9W0E1

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