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    Leash leash [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41320, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Leashprovided by FlyBase
    Official Full Name
    leashprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037856
    Locus tag
    Dmel_CG4674
    See related
    AllianceGenome:FB:FBgn0037856
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG32471; CG4674; Dmel\CG4674; leash
    Summary
    Predicted to enable ubiquitin protein ligase binding activity. Involved in positive regulation of hippo signaling. Located in cytoplasmic vesicle. Is expressed in organism. Orthologous to human ARRDC5 (arrestin domain containing 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Leash in Genome Data Viewer
    Location:
    86C7-86C7; 3-50 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (10885540..10896418)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (6711262..6722140)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Thiamine pyrophosphate carrier protein 1 Neighboring gene uncharacterized protein Neighboring gene Adenylate kinase 3 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45577 Neighboring gene long non-coding RNA:CR45578

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ARRDC3 suppresses colorectal cancer progression through destabilizing the oncoprotein YAP. Shen X, et al. FEBS Lett, 2018 Feb. PMID 29364502
    2. RNAi screening comes of age: improved techniques and complementary approaches. Mohr SE, et al. Nat Rev Mol Cell Biol, 2014 Sep. PMID 25145850, Free PMC Article
    3. Upstairs, downstairs: spatial regulation of Hippo signalling. Fulford A, et al. Curr Opin Cell Biol, 2018 Apr. PMID 29154163
    4. The Hippo pathway uses different machinery to control cell fate and organ size. Pojer JM, et al. iScience, 2021 Aug 20. PMID 34355153, Free PMC Article
    5. A Drosophila gain-of-function screen for candidate genes involved in steroid-dependent neuroendocrine cell remodeling. Zhao T, et al. Genetics, 2008 Feb. PMID 18245346, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin protein ligase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of hippo signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    leash
    Names
    CG4674-PA
    Leash-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      10885540..10896418
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141780.4 → NP_650037.2  leash [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650037.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SZ39, Q9VGU4
      Related
      FBpp0081801
      Conserved Domains (2) summary
      pfam02752
      Location:178 → 305
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      cl22903
      Location:6 → 152
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SZ39 Q8SZ39
    Q9VGU4 Q9VGU4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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