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    mazF6 type II toxin-antitoxin system toxin endoribonuclease MazF6 [ Mycobacterium canettii CIPT 140010059 ]

    Gene ID: 45425969, updated on 11-Dec-2024

    Summary

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    Gene symbol
    mazF6
    Gene description
    type II toxin-antitoxin system toxin endoribonuclease MazF6
    Locus tag
    MCAN_RS10500
    Gene type
    protein coding
    Organism
    Mycobacterium canettii CIPT 140010059 (strain: CIPT 140010059)
    Lineage
    Bacteria; Bacillati; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
    Also known as
    mazF-mt3
    Old locus tag
    MCAN_20111
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    Genomic context

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    Sequence:
    NC_015848.1 (2281465..2281809, complement)

    NC_015848.1Genomic Context describing neighboring genes Neighboring gene PIN domain-containing protein Neighboring gene pseudo Neighboring gene hypothetical protein Neighboring gene ribbon-helix-helix protein, CopG family Neighboring gene cation transporter ATPase CptG Neighboring gene DUF1490 family protein Neighboring gene Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_015848.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An RNA-seq method for defining endoribonuclease cleavage specificity identifies dual rRNA substrates for toxin MazF-mt3. Schifano JM, et al. Nat Commun, 2014 Apr 8. PMID 24709835, Free PMC Article
    2. The mRNA interferases, MazF-mt3 and MazF-mt7 from Mycobacterium tuberculosis target unique pentad sequences in single-stranded RNA. Zhu L, et al. Mol Microbiol, 2008 Aug. PMID 18485066, Free PMC Article
    3. Expression of Mycobacterium tuberculosis Rv1991c using an arabinose-inducible promoter demonstrates its role as a toxin. Carroll P, et al. FEMS Microbiol Lett, 2007 Sep. PMID 17623030
    4. MazF6 toxin of Mycobacterium tuberculosis demonstrates antitoxin specificity and is coupled to regulation of cell growth by a Soj-like protein. Ramirez MV, et al. BMC Microbiol, 2013 Oct 31. PMID 24172039, Free PMC Article
    5. Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis. Supply P, et al. Nat Genet, 2013 Feb. PMID 23291586, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    General protein information

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    Preferred Names
    type II toxin-antitoxin system toxin endoribonuclease MazF6
    WP_003410010.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_015848.1 Reference assembly

      Range
      2281465..2281809 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. WP_003410010.1 MULTISPECIES: type II toxin-antitoxin system toxin endoribonuclease MazF6 [Mycobacterium]

      See identical proteins and their annotated locations for WP_003410010.1

      UniProtKB/Swiss-Prot
      A0A1R3XZY5, L0T8B0, P64911, P64912, P9WII2, P9WII3, Q10867, X2BJU0
      UniProtKB/TrEMBL
      A0A045JJA9, A0A0H3MED4, A0A679LF73, A0A7W0AI90, A0A829C7V6, A0A9P2H8C5, A0AAU0Q2P6, A0AAW8I1F3, A0AAX1PVA6, A5U415, R4M6P9, R4MER6
      Conserved Domains (1) summary
      COG2337
      Location:1 → 114
      MazF; mRNA-degrading endonuclease, toxin component of the MazEF toxin-antitoxin module [Defense mechanisms]
    Nucleotide Protein
    Heading Accession and Version

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