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    murD UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase [ Enterococcus faecium ]

    Gene ID: 66453704, updated on 3-Dec-2024

    Summary

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    Gene symbol
    murD
    Gene description
    UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase
    Locus tag
    E6A31_RS03485
    Gene type
    protein coding
    Organism
    Enterococcus faecium (strain: SRR24, nat-host: Homo sapiens)
    Lineage
    Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae; Enterococcus
    Old locus tag
    E6A31_03795
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    Genomic context

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    NZ_CP038996.1Genomic Context describing neighboring genes Neighboring gene penicillin-binding transpeptidase domain-containing protein Neighboring gene phospho-N-acetylmuramoyl-pentapeptide-transferase Neighboring gene undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase Neighboring gene cell division protein FtsQ/DivIB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NZ_CP038996.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Top-Down Genomic Surveillance Approach To Investigate the Genomic Epidemiology and Antibiotic Resistance Patterns of Enterococcus faecium Detected in Cancer Patients in Arkansas. Udaondo Z, et al. Microbiol Spectr, 2023 Jun 15. PMID 36995227, Free PMC Article
    2. Determination of the MurD mechanism through crystallographic analysis of enzyme complexes. Bertrand JA, et al. J Mol Biol, 1999 Jun 11. PMID 10356330
    3. The biology of Mur ligases as an antibacterial target. Kouidmi I, et al. Mol Microbiol, 2014 Oct. PMID 25130693
    4. Crystal structure of UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase from Escherichia coli. Bertrand JA, et al. EMBO J, 1997 Jun 16. PMID 9218784, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General protein information

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    Preferred Names
    UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase
    WP_002286638.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NZ_CP038996.1 Reference assembly

      Range
      741544..742905
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      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. WP_002286638.1 MULTISPECIES: UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase [Enterococcus]

      UniProtKB/TrEMBL
      A0A133CIV0, A0A1E9VXI8, A0A829F253, A0A9P2S6P3, A0AAV3DMC8, A0AAV3E2T0, A0AAV3GS06, Q3Y2H7
      Conserved Domains (1) summary
      PRK02472
      Location:5 → 453
      murD; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional
    Nucleotide Protein
    Heading Accession and Version