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    MMT1 Mmt1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855215, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MMT1
    Official Full Name
    Mmt1p
    Primary source
    SGD:S000004789
    Locus tag
    YMR177W
    See related
    AllianceGenome:SGD:S000004789; FungiDB:YMR177W; VEuPathDB:YMR177W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MFT1
    Summary
    Predicted to enable monoatomic cation transmembrane transporter activity. Involved in intracellular iron ion homeostasis. Located in mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MMT1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (616566..618098)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ecm5p Neighboring gene Fpy1p Neighboring gene Spt21p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mechanism of iron transport to the site of heme synthesis inside yeast mitochondria. Lange H, et al. J Biol Chem, 1999 Jul 2. PMID 10383398
    2. Characterization of two homologous yeast genes that encode mitochondrial iron transporters. Li L, et al. J Biol Chem, 1997 Nov 7. PMID 9353309
    3. Altered sterol metabolism in budding yeast affects mitochondrial iron-sulfur (Fe-S) cluster synthesis. Ward DM, et al. J Biol Chem, 2018 Jul 6. PMID 29773647, Free PMC Article
    4. Mutations in Saccharomyces cerevisiae iron-sulfur cluster assembly genes and oxidative stress relevant to Cu,Zn superoxide dismutase. Jensen LT, et al. J Biol Chem, 2004 Jul 16. PMID 15107423
    5. Expression of the yeast cation diffusion facilitators Mmt1 and Mmt2 affects mitochondrial and cellular iron homeostasis: evidence for mitochondrial iron export. Li L, et al. J Biol Chem, 2014 Jun 13. PMID 24798331, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The mitochondrial iron exporter genes MMT1 and MMT2 in yeast are transcriptionally regulated by Aft1 and Yap1.
      Title: The mitochondrial iron exporter genes MMT1 and MMT2 in yeast are transcriptionally regulated by Aft1 and Yap1.
    2. Overexpression of MMT1 affects cytosolic iron independent of CCC1.
      Title: Expression of the yeast cation diffusion facilitators Mmt1 and Mmt2 affects mitochondrial and cellular iron homeostasis: evidence for mitochondrial iron export.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables monoatomic cation transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables monoatomic cation transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in inorganic ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular iron ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular iron ion homeostasis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intracellular iron ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular monoatomic cation homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in iron ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic cation transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mmt1p
    NP_013902.1
    • Putative metal transporter involved in mitochondrial iron accumulation; MMT1 has a paralog, MMT2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      616566..618098
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182683.1 → NP_013902.1  TPA: Mmt1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013902.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W000, Q03218, Q66R35
      UniProtKB/TrEMBL
      B3LM63, B5VPU5, C7GTS4, C8ZF40, G2WKN1, N1NYX1
      Conserved Domains (1) summary
      COG0053
      Location:150 → 488
      FieF; Divalent metal cation (Fe/Co/Zn/Cd) transporter [Inorganic ion transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03218.1

    Gene LinkOut

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