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    NUT2 mediator complex subunit NUT2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856297, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NUT2
    Official Full Name
    mediator complex subunit NUT2
    Primary source
    SGD:S000006372
    Locus tag
    YPR168W
    See related
    AllianceGenome:SGD:S000006372; FungiDB:YPR168W; VEuPathDB:YPR168W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MED10
    Summary
    Predicted to enable transcription coregulator activity. Involved in RNA polymerase II preinitiation complex assembly; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Part of core mediator complex. Orthologous to human MED10 (mediator complex subunit 10). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See NUT2 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (878076..878549)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene mitochondrial 37S ribosomal protein MRP2 Neighboring gene phosphoadenylyl-sulfate reductase (thioredoxin) Neighboring gene Jip5p Neighboring gene tRNA-Ile

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional and physical interactions within the middle domain of the yeast mediator. Hallberg M, et al. Mol Genet Genomics, 2006 Aug. PMID 16758199
    2. Role of Mediator in regulating Pol II elongation and nucleosome displacement in Saccharomyces cerevisiae. Kremer SB, et al. Genetics, 2012 May. PMID 22377631, Free PMC Article
    3. Identification of new mediator subunits in the RNA polymerase II holoenzyme from Saccharomyces cerevisiae. Gustafsson CM, et al. J Biol Chem, 1998 Nov 20. PMID 9812975
    4. A conserved mediator hinge revealed in the structure of the MED7.MED21 (Med7.Srb7) heterodimer. Baumli S, et al. J Biol Chem, 2005 May 6. PMID 15710619
    5. New suppressors of THO mutations identify Thp3 (Ypr045c)-Csn12 as a protein complex involved in transcription elongation. Jimeno S, et al. Mol Cell Biol, 2011 Feb. PMID 21149575, Free PMC Article

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA polymerase II preinitiation complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of core mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mediator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mediator complex subunit NUT2
    NP_015494.1
    • Subunit of the RNA polymerase II mediator complex; conserved from yeast to human; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for transcriptional activation and has a role in basal transcription; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      878076..878549
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184265.1 → NP_015494.1  TPA: mediator complex subunit NUT2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015494.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W4G9, Q06213
      UniProtKB/TrEMBL
      A6ZX44, B3LKC9, C7GP51, C8ZJJ4, G2WPY1, N1NW65
      Conserved Domains (1) summary
      pfam09748
      Location:19 → 142
      Med10; Transcription factor subunit Med10 of Mediator complex
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06213.1

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