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SRX1667184: "whole-exome sequencing of Homo sapiens: breast cancer brain metastases, Sample pt_EXOME_DFBM463"
1 ION_TORRENT (Ion Torrent Proton) run: 45.4M spots, 7.4G bases, 5.4Gb downloads

Design: Libraries were constructed from genomic DNA using the Ion AmpliSeq Exome kit
Submitted by: DFCI-phs001063
Study: Patient-derived xenografts of HER2-positive breast cancer brain metastases facilitate discovery of a therapeutic strategy yielding durable remissions
show Abstracthide Abstract
"We have developed orthotopic patient-derived xenograft models of HER2 positive breast cancer metastasized into the brain of patients to test novel therapeutic strategies. In this study, we identified a novel combinatorial therapeutic strategy that has resulted in a durable remission and markedly increased overall survival in majority of patient-derived xenograft (PDX) models tested. We performed whole exome sequencing analysis of these PDX tumors and their matched blood and patient samples to investigate drug sensitive and resistance mechanisms. Our sequencing data revealed an interesting association of genotyping and phenotyping with tumors responses to drug treatment."
Sample: Tumor DNA sample from a human female participant in the dbGaP study "Genomic Characterization of PDX Models for Breast Cancer Brain Metastases"
SAMN04471848 • SRS1365508 • All experiments • All runs
Organism: Homo sapiens
Library:
Name: pt_EXOME_DFBM463
Instrument: Ion Torrent Proton
Strategy: WXS
Source: GENOMIC
Selection: PCR
Layout: SINGLE
Spot descriptor:
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The SRA run(s) below contain human sequence (more...)(less...)

These data are available through the dbGaP authorized access system. Request access to:

  • Study:  phs001063
  • Consent Group: GRU-IRB-PUB

Runs: 1 run, 45.4M spots, 7.4G bases, 5.4Gb
Run# of Spots# of BasesSizePublished
SRR330606445,363,7567.4G5.4Gb2016-05-12

ID:
2392883

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