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Discovery of Checkpoint Kinase Inhibitor AZD7762 by Structure Based Design and Optimization of Thiophene Carboxamide Ureas[TRANSFERASE]
View in iCn3D Similar StructuresPubMedProteinsConserved DomainsPubChem Compound
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Synthesis and evaluation of triazolones as checkpoint kinase 1 inhibitors[TRANSFERASE]
X-ray crystal structure of compound 1 bound to human CHK1 kinase domain[TRANSFERASE/TRANSFERASE INHIBITOR]
View in iCn3D Similar StructuresProteinsConserved DomainsPubChem Compound
Novel kinase profile highlights the temporal basis of context dependent checkpoint pathways to cell death[TRANSFERASE/TRANSFERASE INHIBITOR]
X-ray crystal structure of compound 2a bound to human CHK1 kinase domain[TRANSFERASE/TRANSFERASE INHIBITOR]
X-ray crystal structure of compound 70 bound to human CHK1 kinase domain[TRANSFERASE/TRANSFERASE INHIBITOR]
X-ray crystal structure of compound 17r bound to human Chk1 kinase domain[TRANSFERASE/TRANSFERASE INHIBITOR]
X-ray crystal structure of compound 22k bound to human Chk1 kinase domain[TRANSFERASE/TRANSFERASE INHIBITOR]
Discovery of a Novel Class of triazolones as Checkpoint Kinase Inhibitors - Hit to Lead Exploration[TRANSFERASE]
Characterization of the Chk1 allosteric inhibitor binding site[TRANSFERASE]
Structure of h-CHK1 complexed with A859017[TRANSFERASE]
Identification of chemically diverse Chk1 inhibitors by receptor- based virtual screening[TRANSFERASE]
Identification of a buried pocket for potent and selective inhibition of Chk1: prediction and verification[TRANSFERASE]
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