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Links from GEO DataSets

Items: 20

1.

Trp Amino acid supplementation of Aspergillus flavus NRRL 3357 and Aspergillus parasiticus SRRC 143

(Submitter supplied) Aflatoxins are toxic and carcinogenic secondary metabolites produced by the fungi Aspergillus flavus and A. parasiticus. In order to better understand the molecular mechanisms that regulate aflatoxin production, the biosynthesis of the toxin in A. flavus and A. parasticus grown in yeast extract sucrose media supplemented with 50 mM tryptophan (Trp) were examined. A. flavus grown in the presence of 50 mM tryptophan was found to have significantly reduced aflatoxin B1 and B2 biosynthesis, while A. more...
Organism:
Aspergillus parasiticus; Aspergillus flavus; Aspergillus flavus NRRL3357
Type:
Expression profiling by array
Platform:
GPL2122
12 Samples
Download data
Series
Accession:
GSE6182
ID:
200006182
2.

Aflatoxin formation and gene expression in response to carbon source media shift in Aspergillus parasiticus

(Submitter supplied) Aflatoxins are toxic and carcinogenic polyketide metabolites produced by fungal species, including Aspergillus flavus and A. parasiticus. The biosynthesis of aflatoxins is modulated by many environmental factors, including the availability of a carbon source. The gene expression profile of A. parasiticus was evaluated during a shift from a medium with low concentration of simple sugars, Yeast Extract (YE), to a similar medium with sucrose, Yeast Extract Sucrose (YES). more...
Organism:
Aspergillus parasiticus; Aspergillus flavus
Type:
Expression profiling by array
Platform:
GPL2122
22 Samples
Download data: TXT
Series
Accession:
GSE8038
ID:
200008038
3.

GAP aflR- vs WT timecourse

(Submitter supplied) The carcinogen aflatoxin is synthesized by a cluster of genes that are regulated by the transcriptional factor, AflR. Most, but not all of these genes, have a consensus binding site for AflR in their 5’ untranslated region. Because aflR resides within the biosynthetic cluster, is has been suggested that it regulates only genes within the cluster. The objective of this study was to identify those genes transcriptionally regulated by AflR and to determine if any of those genes reside outside the aflatoxin biosynthetic cluster. more...
Organism:
Aspergillus parasiticus; Aspergillus flavus
Type:
Expression profiling by array
Platform:
GPL2122
12 Samples
Download data
Series
Accession:
GSE2709
ID:
200002709
4.

Genes Differentially Expressed by Aspergillus flavus Strains After Loss of Aflatoxin Production by Serial Transfers

(Submitter supplied) Aflatoxins are carcinogenic fungal secondary metabolites. Levels of aflatoxins in agricultural commodities are stringently regulated by many countries. A cluster of genes is responsible for aflatoxin biosynthesis by Aspergillus flavus and other closely related species. Expression of the clustered aflatoxin genes is governed by a complex network of regulatory mechanisms. To better understand the molecular events that are associated with aflatoxin production, transcription profiling by microarray analyses which compared three independent aflatoxigenic A. more...
Organism:
Aspergillus flavus
Type:
Expression profiling by array
Platform:
GPL2122
12 Samples
Download data: TXT
Series
Accession:
GSE8185
ID:
200008185
5.

Differential expression of Aspergillus genes during the induction of aflatoxin biosynthesis

(Submitter supplied) Gene expression analysis of A. parasiticus grown under conditions conducive and nonconductive for aflatoxin production was evaluated using glass slide microarrays containing the 753 ESTs. A complex regulatory network governs the biosynthesis of aflatoxin. While several genes involved in aflatoxin production are known, their action alone cannot account for its regulation. Arrays of clones from an Aspergillus flavus cDNA library and glass slide microarrays of ESTs were screened to identify additional genes. more...
Organism:
Aspergillus flavus; Aspergillus parasiticus
Type:
Expression profiling by array
Platform:
GPL225
4 Samples
Download data
Series
Accession:
GSE204
ID:
200000204
6.

Aspergillus flavus transcriptome under different temperature conditions

(Submitter supplied) To better understand the effect of temperature on mycotoxin biosynthesis, RNA-Seq technology was used to profile the Aspergillus flavus transcriptome under different temperature conditions. This approachallowed us to quantify transcript abundance for over 80% of fungal genes including 1,153 genes that were differentially expressed at 30°C and 37°C. Wleven of the 55 secondary metabolite clusters were up-regulated at the lower temperature, including aflatoxin biosynthesis genes, which were among the most highly up-expressed genes. more...
Organism:
Aspergillus flavus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13733
2 Samples
Download data: TXT
Series
Accession:
GSE30031
ID:
200030031
7.

Transcriptomic profiling of Aspergillus flavus in response to 5-azacytidine & gallic acid

(Submitter supplied) Aspergillus flavus is a common saprophyte and opportunistic pathogen producing aflatoxin (AF) and many other secondary metabolites. 5-Azacytidine (5-AC), a derivative of nucleoside cytidine, is widely used for studies in epigenetics and cancer biology as an inactivator of DNA methyltransferase and is also used for studying secondary metabolism in fungi. Our previous studies showed that 5-AC affects development and inhibits AF production in A. more...
Organism:
Aspergillus flavus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL15956
3 Samples
Download data: TXT
Series
Accession:
GSE40202
ID:
200040202
8.

GAP_Culture_conditions

(Submitter supplied) Gene expression analysis of A. parasiticus grown under conditions conducive and nonconductive for aflatoxin production was evaluated using glass slide microarrays containing 765 ESTs. Aflatoxins (AF) produced by Aspergillus flavus and A. parasiticus are responsible for approximately $270M in losses annually in the corn, peanut, cotton, and tree nut industries of the United States. In an attempt to develop effective control procedures, research has focused on elucidating the pathway of aflatoxin biosynthesis with the goal of identifying potential targets for intervention. more...
Organism:
Aspergillus flavus; Aspergillus parasiticus
Type:
Expression profiling by array
Platforms:
GPL1393 GPL1394
16 Samples
Download data
Series
Accession:
GSE1649
ID:
200001649
9.

Microarray analysis reveals novel regulatory genes associated with the non-aflatoxigenic Aspergillus parasiticus mutants obtained by 5-azacytosine treatment or serial mycelial transfer

(Submitter supplied) Aflatoxins are carcinogenic secondary metabolites produced by the fungi Aspergillus flavus and Aspergillus parasiticus. Repeated serial mycelial transfer or treatment of A. parasiticus with 5-azacytidine produced mutants with a fluffy phenotype and loss of aflatoxin production. To understand how these treatments affect aflatoxin production and development, we carried out expressed sequence tag (EST)-based microarray assays to identify differentially expressed genes in clones obtained from these treatments. more...
Organism:
Aspergillus flavus; Aspergillus parasiticus
Type:
Expression profiling by array
Platform:
GPL2122
18 Samples
Download data: TAV, XLS
Series
Accession:
GSE30756
ID:
200030756
10.

Effect of sexual recombination on population diversity in aflatoxin production by Aspergillus flavus and evidence for cryptic heterokaryosis

(Submitter supplied) Aspergillus flavus is the major producer of carcinogenic aflatoxins in crops worldwide. Natural populations of A. flavus show tremendous variation in aflatoxin production some of which can be attributed to extreme environmental conditions (e.g., drought), differential regulation of the aflatoxin biosynthetic pathway, missing cluster genes or loss-of-function mutations. Understanding the evolutionary processes that generate genetic diversity in A. more...
Organism:
Zea mays; Aspergillus flavus; Aspergillus oryzae
Type:
Genome variation profiling by array
Platform:
GPL13221
19 Samples
Download data: CEL
Series
Accession:
GSE27484
ID:
200027484
11.

Diverse expression patterns for secondary metabolism gene clusters from Aspergillus

(Submitter supplied) Diverse expression patterns for secondary metabolism gene clusters from Aspergillus flavus under different environmental conditions and in genetic mutants: Insights into regulation of cyclopiazonic acid along with aflatoxin Species of Aspergillus produce a diverse array of secondary metabolites, and recent genomic analysis predicts that these species have the capacity to synthesize many more compounds. more...
Organism:
Aspergillus oryzae; Zea mays; Aspergillus flavus
Type:
Expression profiling by array
Platform:
GPL8345
75 Samples
Download data: CEL
Series
Accession:
GSE15435
ID:
200015435
12.

SntB triggers the antioxidant pathways to regulate development and aflatoxin biosynthesis in Aspergillus flavus

(Submitter supplied) In this study, sntB gene deletion (ΔsntB), complementary (Com-sntB), and HA tag fused to snt2 strain (snt2-HA) strains were constructed by using the homologous recombination method, respectively. It was found in this study that SNTB plays a key role in development, secondary metabolism and pathogenicity of A. flavus. The mechanism was explored by Chromatin immunoprecipitation sequencing (ChIP-seq) and RNA sequencing (RNA-seq).
Organism:
Aspergillus flavus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL30388 GPL33281
14 Samples
Download data: TXT
Series
Accession:
GSE247683
ID:
200247683
13.

The effect of temperature on Natural Antisense Transcript (NAT) expression in Aspergillus flavus

(Submitter supplied) Naturally occurring Antisense Transcripts (NATs) compose an emerging group of regulatory RNAs. These regulatory elements appear in all organisms examined, but little is known about global expression of NATs in fungi. Analysis of currently available EST sequences suggests that 352 cis NATs are present in Aspergillus flavus. An Affymetrix GeneChip® microarray containing probes for these cis NATs, as well as all predicted genes in A. more...
Organism:
Zea mays; Aspergillus flavus
Type:
Expression profiling by array
Platform:
GPL7216
6 Samples
Download data: CEL
Series
Accession:
GSE12594
ID:
200012594
14.

Genotypic and Phenotypic Versatility of Aspergillus flavus during Maize Exploitation

(Submitter supplied) Several are the inputs which are able to modulate mycotoxin synthesis. In particular, when a fungus receives an external stimulus reacts by activating, through a quite well-defined signal cascade, an evident switch in its lifestyle. This profound change is also due to the activation of global gene regulators and, in particular, of transcription factors able to switch on the mycotoxin gene clusters expression. more...
Organism:
Aspergillus flavus; Zea mays; Aspergillus oryzae
Type:
Expression profiling by array
Platform:
GPL8345
12 Samples
Download data: CEL
Series
Accession:
GSE28163
ID:
200028163
15.

Effect of Streptomyces roseolus cell free supernatant on fungal development, transcriptome and aflatoxin B1 production of Aspergillus flavus

(Submitter supplied) Frequently observed in tropical and sub-tropical regions, crops contamination by aflatoxin B1 (AFB1) produced by Aspergillus flavus, is emerging in Europe, due to climate change. Many alternative methods are currently developed to reduce the use of chemical inputs to prevent mycotoxin contamination, such as biocontrol agents (BCAs). Actinobacteria are known to produce many bioactive compounds and some of them are able to reduce in vitro AFB1 concentration. more...
Organism:
Aspergillus flavus; Penicillium expansum
Type:
Expression profiling by array
Platform:
GPL28924
8 Samples
Download data: TXT
Series
Accession:
GSE232607
ID:
200232607
16.

A methanolic extract of Zanthoxylum bungeanum modulates secondary metabolism regulator genes in Aspergillus flavus and shuts down aflatoxin production

(Submitter supplied) Purpose: Aflatoxin B1 is the most toxic and carcinogenic compound in nature produced by Aspergillus fungi. In our study, we applied RNA-seq to compare the transcriptomic profiles of Aspergillus flavus strains in the presence and absence of medicinal plant Zanthoxylum bungeanum. Methods: mRNA profiles of Aspergillus flavus supplemented with 250 µg/ml of methanolic extract fraction (treated samples) or DMSO (control samples) were generated in triplicate, by an Illumina platform using paired-end 150 bp sequencing strategy. more...
Organism:
Aspergillus flavus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL30353
6 Samples
Download data: XLSX
Series
Accession:
GSE179477
ID:
200179477
17.

Bisulfite Sequencing Reveals that Aspergillus flavus Holds A Hollow in DNA Methylation

(Submitter supplied) Aspergillus flavus first gained scientific attention for its production of aflatoxin, the most potent naturally occurring toxin and hepatocarcinogenic secondary metabolite. For several decades, The DNA methylation status of A. flavus remains to be controversial. We first applied bisulfite sequencing, the gold standard at present, in conjunction with a biological replicate strategy to investigate the DNA methylation profiling of A. more...
Organism:
Aspergillus flavus
Type:
Methylation profiling by high throughput sequencing
Platform:
GPL13733
2 Samples
Download data: TXT
Series
Accession:
GSE32177
ID:
200032177
18.

Transcriptomic analysis of Aspergillus flavus and its ASPES transcription factor deletion strains

(Submitter supplied) RNA-seq was used to compare differential gene expressions for Aspergillus flavus wild type strain and ASPES transcription factor deletion strains.The goals of this study are to explore the aflatoxin regulation pathway in A. flavus.
Organism:
Aspergillus flavus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24281
12 Samples
Download data: TXT
Series
Accession:
GSE107025
ID:
200107025
19.

Transcriptomic analysis of Aspergillus flavus in response to the solvent Dimethyl Sulfoxide

(Submitter supplied) Dimethyl sulfoxide (DSMO) is a simple molecule widely used because of its great solvating ability. Beyond its physico-chemical properties, it is also biologically active, including on fungal species. Aspergillus flavus is a saprophytic and famous pathogenic fungus able to produce Aflatoxin B1 (AFB1), a potent carcinogenic mycotoxin which may contaminate many food crops. The aim of this study was to characterize the effect of DMSO on A. more...
Organism:
Aspergillus flavus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL30985
18 Samples
Download data: TXT
Series
Accession:
GSE189211
ID:
200189211
20.

Identification of AflR binding sites in the genome of Aspergillus flavus by ChIP-seq

(Submitter supplied) We report here the AflR binding motif of Aspergillus flavus for the first time with the aid of ChIP-seq analysis. Of the 540 peak sequences associated with AflR binding events, 66.8% were located within 2 kb upstream (promoter region) of translational start sites. The identified 18-bp binding motif was a perfect palindromic sequence, 5′-CSSGGGWTCGAWCCCSSG’3′ with S representing G or C and W representing A or T. more...
Organism:
Aspergillus flavus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL23153
2 Samples
Download data: TAR, TXT
Series
Accession:
GSE149696
ID:
200149696
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