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Links from GEO DataSets

Items: 19

1.

Transcriptomic profiling of Aspergillus flavus in response to 5-azacytidine & gallic acid

(Submitter supplied) Aspergillus flavus is a common saprophyte and opportunistic pathogen producing aflatoxin (AF) and many other secondary metabolites. 5-Azacytidine (5-AC), a derivative of nucleoside cytidine, is widely used for studies in epigenetics and cancer biology as an inactivator of DNA methyltransferase and is also used for studying secondary metabolism in fungi. Our previous studies showed that 5-AC affects development and inhibits AF production in A. more...
Organism:
Aspergillus flavus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL15956
3 Samples
Download data: TXT
Series
Accession:
GSE40202
ID:
200040202
2.

Aspergillus flavus transcriptome under different temperature conditions

(Submitter supplied) To better understand the effect of temperature on mycotoxin biosynthesis, RNA-Seq technology was used to profile the Aspergillus flavus transcriptome under different temperature conditions. This approachallowed us to quantify transcript abundance for over 80% of fungal genes including 1,153 genes that were differentially expressed at 30°C and 37°C. Wleven of the 55 secondary metabolite clusters were up-regulated at the lower temperature, including aflatoxin biosynthesis genes, which were among the most highly up-expressed genes. more...
Organism:
Aspergillus flavus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13733
2 Samples
Download data: TXT
Series
Accession:
GSE30031
ID:
200030031
3.

Genes Differentially Expressed by Aspergillus flavus Strains After Loss of Aflatoxin Production by Serial Transfers

(Submitter supplied) Aflatoxins are carcinogenic fungal secondary metabolites. Levels of aflatoxins in agricultural commodities are stringently regulated by many countries. A cluster of genes is responsible for aflatoxin biosynthesis by Aspergillus flavus and other closely related species. Expression of the clustered aflatoxin genes is governed by a complex network of regulatory mechanisms. To better understand the molecular events that are associated with aflatoxin production, transcription profiling by microarray analyses which compared three independent aflatoxigenic A. more...
Organism:
Aspergillus flavus
Type:
Expression profiling by array
Platform:
GPL2122
12 Samples
Download data: TXT
Series
Accession:
GSE8185
ID:
200008185
4.

Trp Amino acid supplementation of Aspergillus flavus NRRL 3357 and Aspergillus parasiticus SRRC 143

(Submitter supplied) Aflatoxins are toxic and carcinogenic secondary metabolites produced by the fungi Aspergillus flavus and A. parasiticus. In order to better understand the molecular mechanisms that regulate aflatoxin production, the biosynthesis of the toxin in A. flavus and A. parasticus grown in yeast extract sucrose media supplemented with 50 mM tryptophan (Trp) were examined. A. flavus grown in the presence of 50 mM tryptophan was found to have significantly reduced aflatoxin B1 and B2 biosynthesis, while A. more...
Organism:
Aspergillus flavus; Aspergillus flavus NRRL3357; Aspergillus parasiticus
Type:
Expression profiling by array
Platform:
GPL2122
12 Samples
Download data
Series
Accession:
GSE6182
ID:
200006182
5.

GAP aflR- vs WT timecourse

(Submitter supplied) The carcinogen aflatoxin is synthesized by a cluster of genes that are regulated by the transcriptional factor, AflR. Most, but not all of these genes, have a consensus binding site for AflR in their 5’ untranslated region. Because aflR resides within the biosynthetic cluster, is has been suggested that it regulates only genes within the cluster. The objective of this study was to identify those genes transcriptionally regulated by AflR and to determine if any of those genes reside outside the aflatoxin biosynthetic cluster. more...
Organism:
Aspergillus parasiticus; Aspergillus flavus
Type:
Expression profiling by array
Platform:
GPL2122
12 Samples
Download data
Series
Accession:
GSE2709
ID:
200002709
6.

Effect of sexual recombination on population diversity in aflatoxin production by Aspergillus flavus and evidence for cryptic heterokaryosis

(Submitter supplied) Aspergillus flavus is the major producer of carcinogenic aflatoxins in crops worldwide. Natural populations of A. flavus show tremendous variation in aflatoxin production some of which can be attributed to extreme environmental conditions (e.g., drought), differential regulation of the aflatoxin biosynthetic pathway, missing cluster genes or loss-of-function mutations. Understanding the evolutionary processes that generate genetic diversity in A. more...
Organism:
Zea mays; Aspergillus flavus; Aspergillus oryzae
Type:
Genome variation profiling by array
Platform:
GPL13221
19 Samples
Download data: CEL
Series
Accession:
GSE27484
ID:
200027484
7.

Genome-wide analyses for the cellular and chemical development regulator WetA in Aspergillus flavus

(Submitter supplied) Linking cell reproduction and survival is a key task of all life forms. All fungi in the genus Aspergillus reproduce by forming asexual spores called conidia, of which formation is governed by the central regulatory circuit, BrlA->AbaA->WetA. Here, we report that WetA is a key multi-functional regulator that bridged spore differentiation, long-term survival, and chemical development in Aspergillus flavus.
Organism:
Aspergillus flavus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL23153
6 Samples
Download data: TXT
Series
Accession:
GSE95711
ID:
200095711
8.

Genotypic and Phenotypic Versatility of Aspergillus flavus during Maize Exploitation

(Submitter supplied) Several are the inputs which are able to modulate mycotoxin synthesis. In particular, when a fungus receives an external stimulus reacts by activating, through a quite well-defined signal cascade, an evident switch in its lifestyle. This profound change is also due to the activation of global gene regulators and, in particular, of transcription factors able to switch on the mycotoxin gene clusters expression. more...
Organism:
Aspergillus flavus; Aspergillus oryzae; Zea mays
Type:
Expression profiling by array
Platform:
GPL8345
12 Samples
Download data: CEL
Series
Accession:
GSE28163
ID:
200028163
9.

Transcriptomic analysis of Aspergillus flavus in response to the solvent Dimethyl Sulfoxide

(Submitter supplied) Dimethyl sulfoxide (DSMO) is a simple molecule widely used because of its great solvating ability. Beyond its physico-chemical properties, it is also biologically active, including on fungal species. Aspergillus flavus is a saprophytic and famous pathogenic fungus able to produce Aflatoxin B1 (AFB1), a potent carcinogenic mycotoxin which may contaminate many food crops. The aim of this study was to characterize the effect of DMSO on A. more...
Organism:
Aspergillus flavus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL30985
18 Samples
Download data: TXT
Series
Accession:
GSE189211
ID:
200189211
10.

The effect of temperature on Natural Antisense Transcript (NAT) expression in Aspergillus flavus

(Submitter supplied) Naturally occurring Antisense Transcripts (NATs) compose an emerging group of regulatory RNAs. These regulatory elements appear in all organisms examined, but little is known about global expression of NATs in fungi. Analysis of currently available EST sequences suggests that 352 cis NATs are present in Aspergillus flavus. An Affymetrix GeneChip® microarray containing probes for these cis NATs, as well as all predicted genes in A. more...
Organism:
Zea mays; Aspergillus flavus
Type:
Expression profiling by array
Platform:
GPL7216
6 Samples
Download data: CEL
Series
Accession:
GSE12594
ID:
200012594
11.

Unraveling the Gene Regulatory Networks of the Global Regulators VeA and LaeA in Aspergillus nidulans

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Aspergillus nidulans
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL20839 GPL32392
21 Samples
Download data: TXT
Series
Accession:
GSE217820
ID:
200217820
12.

Unraveling the Gene Regulatory Networks of the Global Regulators VeA and LaeA in Aspergillus nidulans [ChIP-seq]

(Submitter supplied) In the filamentous fungus Aspergillus nidulans, the velvet family protein VeA and the global regulator of secondary metabolism LaeA govern fungal development and secondary metabolism mostly by acting as the VelB/VeA/LaeA heterotrimeric complex. While functions of these highly conserved controllers have been well studied, the genome-wide regulatory networks governing cellular and chemical development remain to be uncovered. more...
Organism:
Aspergillus nidulans
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL20839
12 Samples
Download data: TXT
Series
Accession:
GSE217819
ID:
200217819
13.

Unraveling the Gene Regulatory Networks of the Global Regulators VeA and LaeA in Aspergillus nidulans [RNA-seq]

(Submitter supplied) In the filamentous fungus Aspergillus nidulans, the velvet family protein VeA and the global regulator of secondary metabolism LaeA govern fungal development and secondary metabolism mostly by acting as the VelB/VeA/LaeA heterotrimeric complex. While functions of these highly conserved controllers have been well studied, the genome-wide regulatory networks governing cellular and chemical development remain to be uncovered. more...
Organism:
Aspergillus nidulans
Type:
Expression profiling by high throughput sequencing
Platform:
GPL32392
9 Samples
Download data: TXT
Series
Accession:
GSE217815
ID:
200217815
14.

Transcriptomic analysis of Aspergillus flavus and its ASPES transcription factor deletion strains

(Submitter supplied) RNA-seq was used to compare differential gene expressions for Aspergillus flavus wild type strain and ASPES transcription factor deletion strains.The goals of this study are to explore the aflatoxin regulation pathway in A. flavus.
Organism:
Aspergillus flavus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24281
12 Samples
Download data: TXT
Series
Accession:
GSE107025
ID:
200107025
15.

Bisulfite Sequencing Reveals that Aspergillus flavus Holds A Hollow in DNA Methylation

(Submitter supplied) Aspergillus flavus first gained scientific attention for its production of aflatoxin, the most potent naturally occurring toxin and hepatocarcinogenic secondary metabolite. For several decades, The DNA methylation status of A. flavus remains to be controversial. We first applied bisulfite sequencing, the gold standard at present, in conjunction with a biological replicate strategy to investigate the DNA methylation profiling of A. more...
Organism:
Aspergillus flavus
Type:
Methylation profiling by high throughput sequencing
Platform:
GPL13733
2 Samples
Download data: TXT
Series
Accession:
GSE32177
ID:
200032177
16.

A Network Approach of Gene Co-Expression in the Zea mays/Aspergillus flavus Pathosystem to Map Host/Pathogen Interaction Pathways

(Submitter supplied) A gene co-expression network was generated using a dual RNA-seq study with the fungal pathogen A. flavus and its plant host Z. mays during the initial 3 days of infection. The analysis deciphered novel pathways and mapped genes of interest in both organisms during the infection. This network revealed a high degree of connectivity in many of the previously recognized pathways in Z. mays such as jasmonic acid, ethylene, and reactive oxygen species (ROS). more...
Organism:
Zea mays; Aspergillus flavus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL22349
22 Samples
Download data: XLSX
Series
Accession:
GSE85860
ID:
200085860
17.

Expression of immune response genes in human corneal epithelial cells interacting with Asperrgillus flavus conidia

(Submitter supplied) Human corneal epithelial cells internalize Aspergillus flavus conidia. But the biochemical response of corneal epithelial cells in response to A.flavus is not clear. In this study, NanoString analysis was used to study the immune genes expression in primary corneal epithelial cells and cell line infected with A. flavus conidia. The study revealed the differential expression of immune genes associated with TNF, Th17, NF-kB signaling and B cell receptor signaling in corneal epithelial cells. more...
Organism:
Homo sapiens
Type:
Other
Platform:
GPL18649
12 Samples
Download data: RCC, XLSX
Series
Accession:
GSE175824
ID:
200175824
18.

The global transcriptional effect of exogenously added butyrolactone I on Aspergillus terreus under submerged culture

(Submitter supplied) The filamentous fungus Aspergillus terreus is known to produce both industrially and pharmaceutically important secondary metabolites. The objective of this study is to investigate the effect of exogenously added butyrolactone I (BI) on the submerged culture of A. terreus, especially on the possible regulation of the secondary metabolism on the transcriptional level. In order to elucidate the presumed regulative role of butyrolactone I, a large-scale microarray gene expression study was designed and conducted with an industrially utilised A. more...
Organism:
Aspergillus terreus NIH2624; Aspergillus terreus
Type:
Expression profiling by array
Platform:
GPL22914
72 Samples
Download data: TXT
Series
Accession:
GSE93552
ID:
200093552
19.

Identification of AflR binding sites in the genome of Aspergillus flavus by ChIP-seq

(Submitter supplied) We report here the AflR binding motif of Aspergillus flavus for the first time with the aid of ChIP-seq analysis. Of the 540 peak sequences associated with AflR binding events, 66.8% were located within 2 kb upstream (promoter region) of translational start sites. The identified 18-bp binding motif was a perfect palindromic sequence, 5′-CSSGGGWTCGAWCCCSSG’3′ with S representing G or C and W representing A or T. more...
Organism:
Aspergillus flavus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL23153
2 Samples
Download data: TAR, TXT
Series
Accession:
GSE149696
ID:
200149696
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