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    Lrr1 leucine rich repeat protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 685860, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lrr1provided by RGD
    Official Full Name
    leucine rich repeat protein 1provided by RGD
    Primary source
    RGD:1589026
    See related
    EnsemblRapid:ENSRNOG00000004216 AllianceGenome:RGD:1589026
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ppil5
    Summary
    Predicted to be involved in intracellular signal transduction. Orthologous to human LRR1 (leucine rich repeat protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 26.1), Spleen (RPKM 16.0) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lrr1 in Genome Data Viewer
    Location:
    6q24
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (93379159..93387950)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (87643195..87651894)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (91463205..91472308)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S29 Neighboring gene RNA component of signal recognition particle 7SL1 Neighboring gene ribosomal protein L36A like 1 Neighboring gene alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat protein 1
    Names
    peptidylprolyl isomerase (cyclophilin) like 5
    peptidylprolyl isomerase-like 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109483.1 → NP_001102953.1  leucine-rich repeat protein 1

      See identical proteins and their annotated locations for NP_001102953.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473947
      UniProtKB/TrEMBL
      A6HBU4, D3ZE86
      Related
      ENSRNOP00000005595.4, ENSRNOT00000005595.6
      Conserved Domains (3) summary
      cd00116
      Location:162 → 314
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:164 → 186
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:163 → 220
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      93379159..93387950
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112934.2 → XP_038968862.1  leucine-rich repeat protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6ALP8
      Related
      ENSRNOP00000089761.1, ENSRNOT00000111612.2

    2. XM_008764719.4 → XP_008762941.1  leucine-rich repeat protein 1 isoform X1

      Related
      ENSRNOP00000107404.1, ENSRNOT00000139777.1
      Conserved Domains (3) summary
      cd00116
      Location:129 → 281
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:131 → 153
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:130 → 187
      LRR_8; Leucine rich repeat
    Nucleotide Protein Strain
    Heading Accession and Version

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