U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Usp45 ubiquitin specific peptidase 45 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313098, updated on 9-Dec-2024

    Summary

    Official Symbol
    Usp45provided by RGD
    Official Full Name
    ubiquitin specific peptidase 45provided by RGD
    Primary source
    RGD:1310976
    See related
    EnsemblRapid:ENSRNOG00000008688 AllianceGenome:RGD:1310976
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in cell migration and photoreceptor cell maintenance. Predicted to act upstream of or within DNA repair and protein deubiquitination. Predicted to be located in cytosol; nucleoplasm; and photoreceptor inner segment. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 19. Orthologous to human USP45 (ubiquitin specific peptidase 45). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 90.2), Brain (RPKM 82.5) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Usp45 in Genome Data Viewer
    Location:
    5q21
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (40115394..40188861)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (35318621..35392090)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (35916763..35984525)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102842 Neighboring gene cyclin C Neighboring gene thiosulfate sulfurtransferase like domain containing 3 Neighboring gene uncharacterized LOC134478949 Neighboring gene large ribosomal subunit protein eL30-like Neighboring gene PNN interacting serine and arginine rich protein Neighboring gene lysine acetyltransferase 2B, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in photoreceptor cell maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in photoreceptor inner segment ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 45
    Names
    ubiquitin specific petidase 45
    ubiquitin specific protease 45
    NP_001382490.1
    XP_006238001.1
    XP_006238002.1
    XP_006238003.1
    XP_038965740.1
    XP_038965741.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395561.1NP_001382490.1  ubiquitin carboxyl-terminal hydrolase 45

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A0G2K4S7
      Conserved Domains (3) summary
      COG5207
      Location:71359
      UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
      cd02667
      Location:586810
      Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:192388
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      40115394..40188861
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006237941.5XP_006238003.1  ubiquitin carboxyl-terminal hydrolase 45 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AG99
      Related
      ENSRNOP00000092813.1, ENSRNOT00000108204.2
      Conserved Domains (3) summary
      cd02667
      Location:192762
      Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:192761
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:62132
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
    2. XM_006237940.5XP_006238002.1  ubiquitin carboxyl-terminal hydrolase 45 isoform X2

      Related
      ENSRNOP00000073155.2, ENSRNOT00000083132.3
      Conserved Domains (3) summary
      COG5207
      Location:70358
      UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
      cd02667
      Location:585809
      Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:191387
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    3. XM_006237939.5XP_006238001.1  ubiquitin carboxyl-terminal hydrolase 45 isoform X1

      See identical proteins and their annotated locations for XP_006238001.1

      UniProtKB/TrEMBL
      A0A0G2K4S7
      Conserved Domains (3) summary
      COG5207
      Location:71359
      UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
      cd02667
      Location:586810
      Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:192388
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    4. XM_039109812.2XP_038965740.1  ubiquitin carboxyl-terminal hydrolase 45 isoform X2

      Conserved Domains (3) summary
      COG5207
      Location:70358
      UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
      cd02667
      Location:585809
      Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:191387
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    5. XM_039109813.2XP_038965741.1  ubiquitin carboxyl-terminal hydrolase 45 isoform X4

      Conserved Domains (3) summary
      COG5533
      Location:30198
      COG5533; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd02667
      Location:339563
      Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:11141
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107918.1: Suppressed sequence

      Description
      NM_001107918.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.