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    Spag1 sperm associated antigen 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315033, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Spag1provided by RGD
    Official Full Name
    sperm associated antigen 1provided by RGD
    Primary source
    RGD:1310702
    See related
    EnsemblRapid:ENSRNOG00000010078 AllianceGenome:RGD:1310702
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTP binding activity and hydrolase activity. Predicted to be involved in axonemal dynein complex assembly. Predicted to be located in cytoplasm. Predicted to be part of protein folding chaperone complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 28. Orthologous to human SPAG1 (sperm associated antigen 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 49.6), Testes (RPKM 45.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Spag1 in Genome Data Viewer
    Location:
    7q22
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (69246301..69306483)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (67361474..67421369)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (74994379..75054294)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene F-box protein 43 Neighboring gene RNA polymerase II, I and III subunit K Neighboring gene U4 spliceosomal RNA Neighboring gene ring finger protein 19A, RBR E3 ubiquitin protein ligase Neighboring gene ring finger protein 19A, RBR E3 ubiquitin protein ligase like 1 Neighboring gene lactate dehydrogenase A, pseudogene 28

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Sperm-associated antigen 1 is expressed early in pancreatic tumorigenesis and promotes motility of cancer cells. Neesse A, et al. Oncogene, 2007 Mar 8. PMID 16983343
    2. Expression and function of the HSD-3.8 gene encoding a testis-specific protein. Lin W, et al. Mol Hum Reprod, 2001 Sep. PMID 11517287
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in axonemal dynein complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in single fertilization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dynein axonemal particle IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein folding chaperone complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein folding chaperone complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sperm-associated antigen 1
    Names
    HSD-3.8
    infertility-related sperm protein Spag-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012116.1 → NP_001012116.1  sperm-associated antigen 1

      See identical proteins and their annotated locations for NP_001012116.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085828
      UniProtKB/Swiss-Prot
      Q5U2X2
      UniProtKB/TrEMBL
      A0A8I6AD90
      Related
      ENSRNOP00000013801.5, ENSRNOT00000013801.7
      Conserved Domains (3) summary
      TIGR00990
      Location:141 → 303
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00006
      Location:217 → 241
      TPR; TPR repeat [structural motif]
      pfam13877
      Location:769 → 858
      RPAP3_C; Potential Monad-binding region of RPAP3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      69246301..69306483
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079213.2 → XP_038935141.1  sperm-associated antigen 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5U2X2
      UniProtKB/TrEMBL
      A0A8I6AD90
      Conserved Domains (3) summary
      TIGR00990
      Location:141 → 303
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00006
      Location:217 → 241
      TPR; TPR repeat [structural motif]
      pfam13877
      Location:769 → 858
      RPAP3_C; Potential Monad-binding region of RPAP3

    2. XM_063263563.1 → XP_063119633.1  sperm-associated antigen 1 isoform X3

    3. XM_039079212.2 → XP_038935140.1  sperm-associated antigen 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5U2X2
      UniProtKB/TrEMBL
      A0A8I6AD90
      Related
      ENSRNOP00000089778.1, ENSRNOT00000111237.2
      Conserved Domains (3) summary
      TIGR00990
      Location:141 → 303
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00006
      Location:217 → 241
      TPR; TPR repeat [structural motif]
      pfam13877
      Location:769 → 858
      RPAP3_C; Potential Monad-binding region of RPAP3

    4. XM_039079214.1 → XP_038935142.1  sperm-associated antigen 1 isoform X2

      Conserved Domains (3) summary
      TIGR00990
      Location:199 → 336
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00006
      Location:373 → 400
      TPR; TPR repeat [structural motif]
      pfam13877
      Location:536 → 625
      RPAP3_C; Potential Monad-binding region of RPAP3

    5. XM_063263564.1 → XP_063119634.1  sperm-associated antigen 1 isoform X4

      UniProtKB/TrEMBL
      A6HR25
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U2X2.1 GenPept UniProtKB/Swiss-Prot:Q5U2X2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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