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    Zfp458 zinc finger protein 458 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499563, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp458provided by RGD
    Official Full Name
    zinc finger protein 458provided by RGD
    Primary source
    RGD:1559684
    See related
    EnsemblRapid:ENSRNOG00000017986 AllianceGenome:RGD:1559684
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZNF43 (zinc finger protein 43). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 32.2), Lung (RPKM 29.1) and 9 other tissues See more
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    Genomic context

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    See Zfp458 in Genome Data Viewer
    Location:
    2q23
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (86369495..86410904)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (84661150..84705631)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (86971129..86980519)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 455 Neighboring gene zinc finger protein 457 Neighboring gene uncharacterized LOC134485874 Neighboring gene zinc finger protein 728-like Neighboring gene regulator of sex limited protein 1 Neighboring gene zinc finger protein 431 like 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 458

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024299.1 → NP_001019470.1  zinc finger protein 458 isoform 2

      See identical proteins and their annotated locations for NP_001019470.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice pattern in the 5' region, compared to variant 1. The resulting isoform (2) is translated from a downstream AUG and has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      BC085784
      UniProtKB/TrEMBL
      F1M968, Q5U307
      Related
      ENSRNOP00000038258.6, ENSRNOT00000032909.6
      Conserved Domains (3) summary
      COG5048
      Location:74 → 487
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:414 → 434
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:315 → 339
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001142962.1 → NP_001136434.1  zinc finger protein 458 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1).
      Source sequence(s)
      JAXUCZ010000002
      Related
      ENSRNOP00000072605.3, ENSRNOT00000081966.3
      Conserved Domains (4) summary
      smart00349
      Location:5 → 63
      KRAB; krueppel associated box
      COG5048
      Location:107 → 520
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:497 → 576
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:447 → 467
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      86369495..86410904
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102853.2 → XP_038958781.1  zinc finger protein 458 isoform X1

      Conserved Domains (4) summary
      smart00349
      Location:5 → 63
      KRAB; krueppel associated box
      COG5048
      Location:107 → 520
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:497 → 576
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:447 → 467
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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